NLI interacting factor-like phosphatase/Zinc finger C-x8-C-x5-C-x3-H type (And similar), putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase/Zinc finger C-x8-C-x5-C-x3-H type (and similar), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IM24_LEIDO

TriTrypDb:

LdBPK_351510.1 , LdCL_350020000 , LDHU3_35.2000

Length:

584

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IM24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IM24

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:0140096	catalytic activity, acting on a protein	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	520	524	PF00656	0.646
CLV_C14_Caspase3-7	566	570	PF00656	0.593
CLV_NRD_NRD_1	2	4	PF00675	0.481
CLV_NRD_NRD_1	220	222	PF00675	0.524
CLV_NRD_NRD_1	321	323	PF00675	0.501
CLV_NRD_NRD_1	346	348	PF00675	0.482
CLV_NRD_NRD_1	349	351	PF00675	0.488
CLV_NRD_NRD_1	385	387	PF00675	0.625
CLV_NRD_NRD_1	418	420	PF00675	0.665
CLV_NRD_NRD_1	528	530	PF00675	0.696
CLV_NRD_NRD_1	54	56	PF00675	0.359
CLV_NRD_NRD_1	550	552	PF00675	0.679
CLV_PCSK_KEX2_1	2	4	PF00082	0.481
CLV_PCSK_KEX2_1	220	222	PF00082	0.524
CLV_PCSK_KEX2_1	346	348	PF00082	0.498
CLV_PCSK_KEX2_1	384	386	PF00082	0.625
CLV_PCSK_KEX2_1	418	420	PF00082	0.659
CLV_PCSK_KEX2_1	528	530	PF00082	0.696
CLV_PCSK_KEX2_1	54	56	PF00082	0.359
CLV_PCSK_KEX2_1	550	552	PF00082	0.679
CLV_PCSK_PC7_1	380	386	PF00082	0.619
CLV_PCSK_SKI1_1	117	121	PF00082	0.338
CLV_PCSK_SKI1_1	203	207	PF00082	0.393
CLV_PCSK_SKI1_1	54	58	PF00082	0.345
CLV_PCSK_SKI1_1	86	90	PF00082	0.320
DEG_APCC_DBOX_1	54	62	PF00400	0.314
DEG_Nend_UBRbox_1	1	4	PF02207	0.472
DEG_SPOP_SBC_1	477	481	PF00917	0.587
DOC_MAPK_gen_1	332	342	PF00069	0.611
DOC_MAPK_gen_1	54	61	PF00069	0.335
DOC_MAPK_MEF2A_6	170	178	PF00069	0.314
DOC_MAPK_MEF2A_6	493	501	PF00069	0.628
DOC_MAPK_MEF2A_6	54	63	PF00069	0.404
DOC_PP4_FxxP_1	183	186	PF00568	0.314
DOC_SPAK_OSR1_1	5	9	PF12202	0.396
DOC_USP7_MATH_1	131	135	PF00917	0.386
DOC_USP7_MATH_1	255	259	PF00917	0.691
DOC_USP7_MATH_1	269	273	PF00917	0.562
DOC_USP7_MATH_1	375	379	PF00917	0.699
DOC_USP7_MATH_1	461	465	PF00917	0.647
DOC_USP7_MATH_1	477	481	PF00917	0.573
DOC_USP7_MATH_1	554	558	PF00917	0.680
DOC_USP7_MATH_1	79	83	PF00917	0.393
DOC_WW_Pin1_4	164	169	PF00397	0.314
LIG_14-3-3_CanoR_1	13	23	PF00244	0.388
LIG_14-3-3_CanoR_1	151	157	PF00244	0.314
LIG_14-3-3_CanoR_1	35	39	PF00244	0.426
LIG_14-3-3_CanoR_1	418	423	PF00244	0.733
LIG_14-3-3_CanoR_1	78	88	PF00244	0.314
LIG_APCC_ABBA_1	122	127	PF00400	0.314
LIG_BRCT_BRCA1_1	470	474	PF00533	0.623
LIG_Clathr_ClatBox_1	58	62	PF01394	0.338
LIG_deltaCOP1_diTrp_1	394	402	PF00928	0.625
LIG_EH1_1	156	164	PF00400	0.314
LIG_eIF4E_1	116	122	PF01652	0.314
LIG_FHA_1	159	165	PF00498	0.348
LIG_FHA_1	196	202	PF00498	0.405
LIG_FHA_1	48	54	PF00498	0.387
LIG_FHA_1	490	496	PF00498	0.624
LIG_FHA_1	569	575	PF00498	0.641
LIG_FHA_1	96	102	PF00498	0.458
LIG_FHA_2	25	31	PF00498	0.394
LIG_FHA_2	334	340	PF00498	0.542
LIG_GBD_Chelix_1	573	581	PF00786	0.550
LIG_GBD_Chelix_1	59	67	PF00786	0.314
LIG_IBAR_NPY_1	137	139	PF08397	0.314
LIG_Integrin_RGD_1	304	306	PF01839	0.323
LIG_LIR_Gen_1	155	164	PF02991	0.334
LIG_LIR_Gen_1	407	414	PF02991	0.629
LIG_LIR_Gen_1	82	92	PF02991	0.314
LIG_LIR_Gen_1	9	16	PF02991	0.491
LIG_LIR_Nem_3	110	116	PF02991	0.338
LIG_LIR_Nem_3	155	159	PF02991	0.378
LIG_LIR_Nem_3	82	87	PF02991	0.314
LIG_LIR_Nem_3	9	14	PF02991	0.481
LIG_MLH1_MIPbox_1	470	474	PF16413	0.623
LIG_MYND_1	485	489	PF01753	0.692
LIG_PCNA_yPIPBox_3	103	113	PF02747	0.289
LIG_SH2_GRB2like	410	413	PF00017	0.636
LIG_SH2_PTP2	11	14	PF00017	0.363
LIG_SH2_STAP1	410	414	PF00017	0.636
LIG_SH2_STAP1	44	48	PF00017	0.403
LIG_SH2_STAT5	11	14	PF00017	0.354
LIG_SH3_2	371	376	PF14604	0.607
LIG_SH3_3	247	253	PF00018	0.623
LIG_SH3_3	261	267	PF00018	0.553
LIG_SH3_3	368	374	PF00018	0.624
LIG_SH3_3	43	49	PF00018	0.412
LIG_SH3_3	483	489	PF00018	0.686
LIG_SH3_3	491	497	PF00018	0.590
LIG_SH3_4	373	380	PF00018	0.627
LIG_SUMO_SIM_anti_2	204	210	PF11976	0.467
LIG_SUMO_SIM_par_1	160	167	PF11976	0.314
LIG_SUMO_SIM_par_1	204	210	PF11976	0.388
LIG_SUMO_SIM_par_1	497	503	PF11976	0.631
LIG_SUMO_SIM_par_1	57	62	PF11976	0.314
LIG_SUMO_SIM_par_1	92	99	PF11976	0.314
LIG_TRAF2_1	336	339	PF00917	0.541
LIG_TRFH_1	75	79	PF08558	0.314
LIG_UBA3_1	195	203	PF00899	0.393
LIG_WW_3	373	377	PF00397	0.617
MOD_CDC14_SPxK_1	167	170	PF00782	0.314
MOD_CDK_SPxK_1	164	170	PF00069	0.314
MOD_CK1_1	155	161	PF00069	0.393
MOD_CK1_1	248	254	PF00069	0.724
MOD_CK1_1	321	327	PF00069	0.521
MOD_CK1_1	421	427	PF00069	0.586
MOD_CK1_1	448	454	PF00069	0.775
MOD_CK1_1	464	470	PF00069	0.698
MOD_CK2_1	278	284	PF00069	0.583
MOD_CK2_1	333	339	PF00069	0.539
MOD_GlcNHglycan	133	136	PF01048	0.346
MOD_GlcNHglycan	209	212	PF01048	0.396
MOD_GlcNHglycan	250	253	PF01048	0.700
MOD_GlcNHglycan	257	260	PF01048	0.632
MOD_GlcNHglycan	323	326	PF01048	0.608
MOD_GlcNHglycan	420	423	PF01048	0.663
MOD_GlcNHglycan	448	451	PF01048	0.731
MOD_GlcNHglycan	480	483	PF01048	0.635
MOD_GlcNHglycan	50	53	PF01048	0.368
MOD_GlcNHglycan	519	522	PF01048	0.684
MOD_GlcNHglycan	98	101	PF01048	0.318
MOD_GSK3_1	251	258	PF00069	0.766
MOD_GSK3_1	269	276	PF00069	0.522
MOD_GSK3_1	375	382	PF00069	0.781
MOD_GSK3_1	396	403	PF00069	0.614
MOD_GSK3_1	421	428	PF00069	0.594
MOD_GSK3_1	44	51	PF00069	0.398
MOD_GSK3_1	460	467	PF00069	0.719
MOD_GSK3_1	473	480	PF00069	0.544
MOD_N-GLC_1	523	528	PF02516	0.656
MOD_N-GLC_1	79	84	PF02516	0.445
MOD_NEK2_1	101	106	PF00069	0.314
MOD_NEK2_1	120	125	PF00069	0.285
MOD_NEK2_1	207	212	PF00069	0.403
MOD_NEK2_1	288	293	PF00069	0.318
MOD_NEK2_1	437	442	PF00069	0.672
MOD_NEK2_1	473	478	PF00069	0.615
MOD_NEK2_1	517	522	PF00069	0.612
MOD_NEK2_1	87	92	PF00069	0.314
MOD_NEK2_2	269	274	PF00069	0.551
MOD_PIKK_1	357	363	PF00454	0.518
MOD_PIKK_1	461	467	PF00454	0.705
MOD_PIKK_1	503	509	PF00454	0.607
MOD_PIKK_1	554	560	PF00454	0.683
MOD_PKA_1	418	424	PF00069	0.643
MOD_PKA_2	102	108	PF00069	0.314
MOD_PKA_2	14	20	PF00069	0.439
MOD_PKA_2	245	251	PF00069	0.608
MOD_PKA_2	321	327	PF00069	0.521
MOD_PKA_2	34	40	PF00069	0.263
MOD_PKA_2	375	381	PF00069	0.681
MOD_PKA_2	418	424	PF00069	0.643
MOD_PKA_2	515	521	PF00069	0.628
MOD_PKA_2	71	77	PF00069	0.294
MOD_Plk_1	44	50	PF00069	0.396
MOD_Plk_1	568	574	PF00069	0.658
MOD_Plk_2-3	278	284	PF00069	0.583
MOD_Plk_2-3	34	40	PF00069	0.394
MOD_Plk_4	158	164	PF00069	0.428
MOD_Plk_4	269	275	PF00069	0.619
MOD_Plk_4	468	474	PF00069	0.688
MOD_Plk_4	71	77	PF00069	0.323
MOD_ProDKin_1	164	170	PF00069	0.314
TRG_DiLeu_BaLyEn_6	210	215	PF01217	0.387
TRG_ENDOCYTIC_2	11	14	PF00928	0.363
TRG_ENDOCYTIC_2	116	119	PF00928	0.314
TRG_ENDOCYTIC_2	410	413	PF00928	0.636
TRG_ER_diArg_1	1	3	PF00400	0.519
TRG_ER_diArg_1	12	15	PF00400	0.353
TRG_ER_diArg_1	220	222	PF00400	0.524
TRG_ER_diArg_1	353	356	PF00400	0.532
TRG_ER_diArg_1	384	386	PF00400	0.625
TRG_ER_diArg_1	53	55	PF00400	0.360
TRG_NES_CRM1_1	197	209	PF08389	0.314
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P590	Leptomonas seymouri	50%	88%
A4HMH2	Leishmania braziliensis	78%	100%
A4IB52	Leishmania infantum	100%	100%
E9AEX3	Leishmania major	94%	100%
E9B629	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%