Sterol_C-24_reductase_putative/GeneDB:LmjF.33.068 0

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

sterol C-24 reductase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IM20_LEIDO

TriTrypDb:

LdBPK_330730.1 , LdCL_330012800 , LDHU3_33.1020

Length:

496

Annotations

LeishMANIAdb annotations

Related to both fungal ergosterol C-24 reductases and to a lesser extent, animal delta-14 lanosterol reductases (all preferentially ER-localized).. The highly changed Ser/Arg rich N-terminus might point to a mitochondrial transit signal (ergosterols are essential for Kinetoplastid mitochondria).. Localization: ER (by homology) / Mitochondrial (by feature)

Annotations by Jardim et al.

Sterol metabolism/biosynthesis, sterol C-24 reductase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8IM20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IM20

Function

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Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	1
GO:0006629	lipid metabolic process	3	9
GO:0006694	steroid biosynthetic process	5	9
GO:0006696	ergosterol biosynthetic process	5	1
GO:0008152	metabolic process	1	9
GO:0008202	steroid metabolic process	4	9
GO:0008204	ergosterol metabolic process	4	1
GO:0008610	lipid biosynthetic process	4	9
GO:0009058	biosynthetic process	2	9
GO:0009987	cellular process	1	1

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Molecular functions
Term	Name	Level	Count
GO:0000246	delta24(24-1) sterol reductase activity	5	7
GO:0003824	catalytic activity	1	9
GO:0016491	oxidoreductase activity	2	9
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	9
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4	9

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.456
CLV_NRD_NRD_1	193	195	PF00675	0.439
CLV_NRD_NRD_1	221	223	PF00675	0.198
CLV_NRD_NRD_1	380	382	PF00675	0.279
CLV_NRD_NRD_1	424	426	PF00675	0.214
CLV_NRD_NRD_1	466	468	PF00675	0.236
CLV_NRD_NRD_1	47	49	PF00675	0.321
CLV_PCSK_FUR_1	378	382	PF00082	0.222
CLV_PCSK_FUR_1	464	468	PF00082	0.239
CLV_PCSK_KEX2_1	193	195	PF00082	0.439

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C6	Leptomonas seymouri	79%	99%
A0A0N1PBH8	Leptomonas seymouri	29%	100%
A0A0S4IS37	Bodo saltans	28%	100%
A0A0S4KLN5	Bodo saltans	28%	100%
A0A1D8PIC7	Candida albicans (strain SC5314 / ATCC MYA-2876)	28%	100%
A0A1D8PJ25	Candida albicans (strain SC5314 / ATCC MYA-2876)	37%	100%
A0A1X0NRH6	Trypanosomatidae	24%	100%
A0A1X0P0Q6	Trypanosomatidae	67%	100%
A0A3R7KUI7	Trypanosoma rangeli	65%	100%
A0A3R7N804	Trypanosoma rangeli	28%	100%

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