Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IM05_LEIDO

TriTrypDb:

LdBPK_351280.1 , LdCL_350017700 , LDHU3_35.1700

Length:

358

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IM05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IM05

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	45	51	PF00089	0.543
CLV_NRD_NRD_1	267	269	PF00675	0.670
CLV_NRD_NRD_1	332	334	PF00675	0.535
CLV_NRD_NRD_1	336	338	PF00675	0.514
CLV_PCSK_FUR_1	330	334	PF00082	0.583
CLV_PCSK_KEX2_1	267	269	PF00082	0.677
CLV_PCSK_KEX2_1	332	334	PF00082	0.530
CLV_PCSK_KEX2_1	335	337	PF00082	0.515
CLV_PCSK_PC7_1	332	338	PF00082	0.588
CLV_PCSK_SKI1_1	136	140	PF00082	0.449
CLV_PCSK_SKI1_1	198	202	PF00082	0.606
CLV_PCSK_SKI1_1	344	348	PF00082	0.578
DEG_Nend_UBRbox_3	1	3	PF02207	0.541
DEG_SCF_FBW7_1	75	81	PF00400	0.622
DOC_ANK_TNKS_1	147	154	PF00023	0.447
DOC_CKS1_1	75	80	PF01111	0.639
DOC_CYCLIN_yCln2_LP_2	201	204	PF00134	0.617
DOC_MAPK_DCC_7	198	207	PF00069	0.620
DOC_MAPK_MEF2A_6	198	207	PF00069	0.620
DOC_PP2B_LxvP_1	188	191	PF13499	0.486
DOC_PP2B_LxvP_1	201	204	PF13499	0.617
DOC_USP7_MATH_1	273	277	PF00917	0.678
DOC_USP7_MATH_1	282	286	PF00917	0.605
DOC_USP7_MATH_1	89	93	PF00917	0.672
DOC_USP7_MATH_2	252	258	PF00917	0.557
DOC_WW_Pin1_4	226	231	PF00397	0.677
DOC_WW_Pin1_4	71	76	PF00397	0.678
DOC_WW_Pin1_4	85	90	PF00397	0.520
LIG_14-3-3_CanoR_1	136	146	PF00244	0.494
LIG_14-3-3_CanoR_1	14	20	PF00244	0.568
LIG_14-3-3_CanoR_1	22	28	PF00244	0.387
LIG_14-3-3_CanoR_1	226	230	PF00244	0.660
LIG_14-3-3_CanoR_1	288	297	PF00244	0.687
LIG_14-3-3_CanoR_1	303	310	PF00244	0.622
LIG_14-3-3_CanoR_1	41	49	PF00244	0.463
LIG_14-3-3_CanoR_1	82	91	PF00244	0.544
LIG_BRCT_BRCA1_1	146	150	PF00533	0.488
LIG_Clathr_ClatBox_1	166	170	PF01394	0.488
LIG_CtBP_PxDLS_1	204	208	PF00389	0.572
LIG_eIF4E_1	183	189	PF01652	0.413
LIG_FHA_1	56	62	PF00498	0.631
LIG_FHA_2	182	188	PF00498	0.471
LIG_FHA_2	314	320	PF00498	0.525
LIG_FHA_2	58	64	PF00498	0.655
LIG_LIR_Gen_1	299	309	PF02991	0.623
LIG_LIR_Nem_3	299	304	PF02991	0.631
LIG_SH2_CRK	135	139	PF00017	0.450
LIG_SH2_NCK_1	183	187	PF00017	0.390
LIG_SH2_SRC	116	119	PF00017	0.379
LIG_SH2_STAP1	116	120	PF00017	0.480
LIG_SH2_STAT3	118	121	PF00017	0.437
LIG_SH2_STAT5	114	117	PF00017	0.466
LIG_SH2_STAT5	183	186	PF00017	0.445
LIG_SH2_STAT5	297	300	PF00017	0.633
LIG_SH3_3	197	203	PF00018	0.543
LIG_SH3_3	227	233	PF00018	0.617
LIG_SH3_3	72	78	PF00018	0.635
LIG_SUMO_SIM_anti_2	184	190	PF11976	0.498
LIG_TRAF2_1	210	213	PF00917	0.624
LIG_WW_2	230	233	PF00397	0.571
MOD_CK1_1	192	198	PF00069	0.524
MOD_CK1_1	258	264	PF00069	0.637
MOD_CK1_1	26	32	PF00069	0.382
MOD_CK1_1	313	319	PF00069	0.587
MOD_CK1_1	73	79	PF00069	0.667
MOD_CK1_1	87	93	PF00069	0.453
MOD_CK2_1	181	187	PF00069	0.463
MOD_CK2_1	205	211	PF00069	0.595
MOD_CK2_1	215	221	PF00069	0.613
MOD_CK2_1	313	319	PF00069	0.523
MOD_CK2_1	351	357	PF00069	0.537
MOD_CK2_1	57	63	PF00069	0.557
MOD_DYRK1A_RPxSP_1	226	230	PF00069	0.682
MOD_GlcNHglycan	15	18	PF01048	0.514
MOD_GlcNHglycan	161	164	PF01048	0.604
MOD_GlcNHglycan	191	194	PF01048	0.578
MOD_GlcNHglycan	207	210	PF01048	0.624
MOD_GlcNHglycan	221	224	PF01048	0.626
MOD_GlcNHglycan	260	263	PF01048	0.600
MOD_GlcNHglycan	284	287	PF01048	0.681
MOD_GlcNHglycan	353	356	PF01048	0.594
MOD_GSK3_1	211	218	PF00069	0.606
MOD_GSK3_1	254	261	PF00069	0.570
MOD_GSK3_1	345	352	PF00069	0.524
MOD_GSK3_1	66	73	PF00069	0.676
MOD_GSK3_1	74	81	PF00069	0.615
MOD_GSK3_1	83	90	PF00069	0.501
MOD_GSK3_1	92	99	PF00069	0.342
MOD_N-GLC_1	263	268	PF02516	0.663
MOD_N-GLC_1	321	326	PF02516	0.523
MOD_N-GLC_1	342	347	PF02516	0.550
MOD_NEK2_1	137	142	PF00069	0.509
MOD_NEK2_1	156	161	PF00069	0.293
MOD_NEK2_1	23	28	PF00069	0.357
MOD_NEK2_1	263	268	PF00069	0.668
MOD_NEK2_1	318	323	PF00069	0.560
MOD_PIKK_1	211	217	PF00454	0.605
MOD_PIKK_1	303	309	PF00454	0.619
MOD_PKA_1	268	274	PF00069	0.677
MOD_PKA_2	13	19	PF00069	0.567
MOD_PKA_2	215	221	PF00069	0.619
MOD_PKA_2	225	231	PF00069	0.538
MOD_PKA_2	287	293	PF00069	0.620
MOD_PKA_2	40	46	PF00069	0.500
MOD_PKA_2	83	89	PF00069	0.670
MOD_PKB_1	82	90	PF00069	0.542
MOD_Plk_1	157	163	PF00069	0.437
MOD_Plk_1	321	327	PF00069	0.521
MOD_Plk_1	342	348	PF00069	0.550
MOD_Plk_2-3	57	63	PF00069	0.567
MOD_Plk_4	289	295	PF00069	0.648
MOD_Plk_4	313	319	PF00069	0.523
MOD_Plk_4	321	327	PF00069	0.521
MOD_Plk_4	342	348	PF00069	0.549
MOD_ProDKin_1	226	232	PF00069	0.675
MOD_ProDKin_1	71	77	PF00069	0.679
MOD_ProDKin_1	85	91	PF00069	0.515
MOD_SUMO_for_1	51	54	PF00179	0.673
TRG_AP2beta_CARGO_1	299	308	PF09066	0.625
TRG_DiLeu_BaLyEn_6	151	156	PF01217	0.433
TRG_ENDOCYTIC_2	135	138	PF00928	0.461
TRG_ENDOCYTIC_2	183	186	PF00928	0.445
TRG_ER_diArg_1	330	333	PF00400	0.544
TRG_ER_diArg_1	335	337	PF00400	0.506
TRG_Pf-PMV_PEXEL_1	154	158	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.631

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P694	Leptomonas seymouri	51%	100%
A4HME9	Leishmania braziliensis	81%	100%
A4IB21	Leishmania infantum	99%	100%
E9AEV0	Leishmania major	93%	100%
E9B606	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%