Tartrate-sensitive acid phosphatase acp-3.2, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tartrate-sensitive acid phosphatase acp-3.2, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ILZ1_LEIDO

TriTrypDb:

LdBPK_366740.1 , LdCL_360075700 , LDHU3_36.8950

Length:

315

Annotations

LeishMANIAdb annotations

An extensively expanded family of exophosphatase enzymes presumed to be active at acidic pH

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 3
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ILZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ILZ1

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016311	dephosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.588
CLV_NRD_NRD_1	304	306	PF00675	0.567
CLV_PCSK_KEX2_1	303	305	PF00082	0.573
CLV_PCSK_PC7_1	299	305	PF00082	0.491
CLV_PCSK_SKI1_1	119	123	PF00082	0.380
CLV_PCSK_SKI1_1	239	243	PF00082	0.541
CLV_PCSK_SKI1_1	39	43	PF00082	0.557
CLV_Separin_Metazoa	66	70	PF03568	0.326
DEG_COP1_1	143	150	PF00400	0.553
DOC_CYCLIN_RxL_1	116	125	PF00134	0.306
DOC_CYCLIN_yCln2_LP_2	156	162	PF00134	0.344
DOC_MAPK_FxFP_2	298	301	PF00069	0.486
DOC_MAPK_gen_1	134	142	PF00069	0.371
DOC_MAPK_gen_1	76	84	PF00069	0.407
DOC_PP4_FxxP_1	298	301	PF00568	0.486
DOC_USP7_MATH_1	146	150	PF00917	0.465
DOC_USP7_MATH_1	17	21	PF00917	0.401
DOC_USP7_MATH_1	177	181	PF00917	0.425
DOC_USP7_MATH_1	196	200	PF00917	0.193
DOC_WW_Pin1_4	84	89	PF00397	0.491
LIG_14-3-3_CanoR_1	103	111	PF00244	0.403
LIG_14-3-3_CanoR_1	134	142	PF00244	0.519
LIG_14-3-3_CanoR_1	197	205	PF00244	0.341
LIG_BIR_II_1	1	5	PF00653	0.474
LIG_BIR_III_2	145	149	PF00653	0.516
LIG_BRCT_BRCA1_1	86	90	PF00533	0.326
LIG_eIF4E_1	79	85	PF01652	0.426
LIG_FHA_1	113	119	PF00498	0.396
LIG_FHA_1	136	142	PF00498	0.529
LIG_FHA_1	196	202	PF00498	0.389
LIG_FHA_1	245	251	PF00498	0.539
LIG_FHA_1	45	51	PF00498	0.438
LIG_LIR_Apic_2	124	129	PF02991	0.536
LIG_LIR_Gen_1	174	182	PF02991	0.379
LIG_LIR_Gen_1	283	292	PF02991	0.396
LIG_LIR_Gen_1	77	85	PF02991	0.429
LIG_LIR_LC3C_4	22	27	PF02991	0.357
LIG_LIR_Nem_3	124	130	PF02991	0.493
LIG_LIR_Nem_3	174	178	PF02991	0.416
LIG_LIR_Nem_3	283	288	PF02991	0.538
LIG_LIR_Nem_3	77	82	PF02991	0.490
LIG_LYPXL_S_1	127	131	PF13949	0.434
LIG_LYPXL_S_1	226	230	PF13949	0.461
LIG_LYPXL_yS_3	128	131	PF13949	0.428
LIG_LYPXL_yS_3	227	230	PF13949	0.493
LIG_Pex14_2	238	242	PF04695	0.485
LIG_Rb_pABgroove_1	199	207	PF01858	0.356
LIG_REV1ctd_RIR_1	295	300	PF16727	0.484
LIG_SH2_CRK	162	166	PF00017	0.319
LIG_SH2_CRK	278	282	PF00017	0.326
LIG_SH2_NCK_1	205	209	PF00017	0.352
LIG_SH2_STAP1	205	209	PF00017	0.352
LIG_SH2_STAT5	101	104	PF00017	0.427
LIG_SH2_STAT5	126	129	PF00017	0.515
LIG_SH2_STAT5	240	243	PF00017	0.447
LIG_SH3_3	82	88	PF00018	0.392
LIG_Sin3_3	10	17	PF02671	0.452
LIG_SUMO_SIM_anti_2	81	87	PF11976	0.407
MOD_CK1_1	104	110	PF00069	0.351
MOD_CK2_1	80	86	PF00069	0.438
MOD_GlcNHglycan	112	115	PF01048	0.383
MOD_GlcNHglycan	179	182	PF01048	0.421
MOD_GlcNHglycan	255	258	PF01048	0.519
MOD_GlcNHglycan	285	288	PF01048	0.455
MOD_GlcNHglycan	39	42	PF01048	0.551
MOD_GSK3_1	130	137	PF00069	0.492
MOD_GSK3_1	240	247	PF00069	0.527
MOD_GSK3_1	80	87	PF00069	0.405
MOD_GSK3_1	90	97	PF00069	0.314
MOD_N-GLC_1	134	139	PF02516	0.531
MOD_N-GLC_1	218	223	PF02516	0.336
MOD_N-GLC_1	244	249	PF02516	0.482
MOD_N-GLC_1	45	50	PF02516	0.532
MOD_N-GLC_1	95	100	PF02516	0.438
MOD_NEK2_1	151	156	PF00069	0.529
MOD_NEK2_1	250	255	PF00069	0.515
MOD_NEK2_1	261	266	PF00069	0.449
MOD_NEK2_1	280	285	PF00069	0.576
MOD_NEK2_1	74	79	PF00069	0.410
MOD_NEK2_1	99	104	PF00069	0.506
MOD_PIKK_1	104	110	PF00454	0.304
MOD_PIKK_1	250	256	PF00454	0.541
MOD_PIKK_1	90	96	PF00454	0.448
MOD_PKA_2	102	108	PF00069	0.391
MOD_PKA_2	135	141	PF00069	0.541
MOD_PKA_2	196	202	PF00069	0.380
MOD_Plk_1	80	86	PF00069	0.369
MOD_Plk_1	95	101	PF00069	0.331
MOD_Plk_2-3	171	177	PF00069	0.336
MOD_Plk_4	146	152	PF00069	0.493
MOD_Plk_4	261	267	PF00069	0.478
MOD_Plk_4	50	56	PF00069	0.593
MOD_Plk_4	80	86	PF00069	0.355
MOD_Plk_4	95	101	PF00069	0.361
MOD_ProDKin_1	84	90	PF00069	0.491
TRG_ENDOCYTIC_2	128	131	PF00928	0.428
TRG_ENDOCYTIC_2	162	165	PF00928	0.481
TRG_ENDOCYTIC_2	227	230	PF00928	0.455
TRG_ENDOCYTIC_2	278	281	PF00928	0.450
TRG_ENDOCYTIC_2	79	82	PF00928	0.426
TRG_ER_diArg_1	302	305	PF00400	0.572
TRG_ER_diArg_1	76	79	PF00400	0.394
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9G2	Leptomonas seymouri	37%	100%
A0A0N1PEH4	Leptomonas seymouri	60%	69%
A4HQG6	Leishmania braziliensis	79%	71%
A4ICA2	Leishmania infantum	100%	100%
Q4Q0A9	Leishmania major	63%	75%
Q4Q0B2	Leishmania major	61%	78%
V5BL75	Trypanosoma cruzi	28%	67%