Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ILX5_LEIDO

TriTrypDb:

LdBPK_366590.1 , LdCL_360073600 , LDHU3_36.8740

Length:

278

Annotations

LeishMANIAdb annotations

Appears to be a transporter for some unknown substrate

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3Q8ILX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ILX5

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016559	peroxisome fission	6	1
GO:0048285	organelle fission	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.631
CLV_MEL_PAP_1	178	184	PF00089	0.537
CLV_NRD_NRD_1	156	158	PF00675	0.548
CLV_NRD_NRD_1	55	57	PF00675	0.372
CLV_PCSK_FUR_1	53	57	PF00082	0.259
CLV_PCSK_KEX2_1	156	158	PF00082	0.547
CLV_PCSK_KEX2_1	255	257	PF00082	0.486
CLV_PCSK_KEX2_1	55	57	PF00082	0.372
CLV_PCSK_PC1ET2_1	255	257	PF00082	0.362
CLV_PCSK_SKI1_1	123	127	PF00082	0.591
CLV_PCSK_SKI1_1	131	135	PF00082	0.568
CLV_PCSK_SKI1_1	139	143	PF00082	0.557
CLV_PCSK_SKI1_1	157	161	PF00082	0.527
CLV_PCSK_SKI1_1	251	255	PF00082	0.474
CLV_PCSK_SKI1_1	36	40	PF00082	0.286
DOC_CYCLIN_RxL_1	139	147	PF00134	0.292
DOC_MAPK_HePTP_8	186	198	PF00069	0.366
DOC_MAPK_MEF2A_6	189	198	PF00069	0.364
DOC_MAPK_MEF2A_6	26	33	PF00069	0.504
DOC_PP1_RVXF_1	121	127	PF00149	0.385
DOC_PP1_RVXF_1	206	213	PF00149	0.276
DOC_PP2B_LxvP_1	108	111	PF13499	0.388
DOC_PP4_FxxP_1	74	77	PF00568	0.556
DOC_USP7_MATH_1	271	275	PF00917	0.707
DOC_USP7_MATH_1	7	11	PF00917	0.690
DOC_USP7_UBL2_3	251	255	PF12436	0.625
DOC_WW_Pin1_4	166	171	PF00397	0.395
DOC_WW_Pin1_4	232	237	PF00397	0.635
DOC_WW_Pin1_4	241	246	PF00397	0.781
LIG_14-3-3_CanoR_1	139	145	PF00244	0.292
LIG_14-3-3_CanoR_1	156	164	PF00244	0.351
LIG_14-3-3_CanoR_1	76	82	PF00244	0.511
LIG_BIR_II_1	1	5	PF00653	0.728
LIG_BRCT_BRCA1_1	136	140	PF00533	0.301
LIG_BRCT_BRCA1_2	136	142	PF00533	0.297
LIG_deltaCOP1_diTrp_1	95	101	PF00928	0.350
LIG_FHA_1	145	151	PF00498	0.325
LIG_FHA_1	228	234	PF00498	0.656
LIG_LIR_Gen_1	105	114	PF02991	0.309
LIG_LIR_Gen_1	193	202	PF02991	0.374
LIG_LIR_Gen_1	95	104	PF02991	0.405
LIG_LIR_Nem_3	105	110	PF02991	0.302
LIG_LIR_Nem_3	135	141	PF02991	0.290
LIG_LIR_Nem_3	193	198	PF02991	0.363
LIG_LIR_Nem_3	203	207	PF02991	0.199
LIG_LIR_Nem_3	95	100	PF02991	0.397
LIG_Pex14_1	200	204	PF04695	0.292
LIG_Pex14_1	97	101	PF04695	0.372
LIG_Pex14_2	136	140	PF04695	0.388
LIG_Pex14_2	212	216	PF04695	0.278
LIG_REV1ctd_RIR_1	104	110	PF16727	0.334
LIG_REV1ctd_RIR_1	138	146	PF16727	0.273
LIG_SH2_CRK	204	208	PF00017	0.327
LIG_SH2_STAT5	120	123	PF00017	0.381
LIG_SH2_STAT5	195	198	PF00017	0.303
LIG_SH2_STAT5	232	235	PF00017	0.610
LIG_SH2_STAT5	58	61	PF00017	0.608
LIG_SH3_3	230	236	PF00018	0.647
LIG_SUMO_SIM_par_1	17	23	PF11976	0.572
MOD_CDK_SPK_2	166	171	PF00069	0.420
MOD_CDK_SPxxK_3	166	173	PF00069	0.434
MOD_CK1_1	10	16	PF00069	0.551
MOD_CK1_1	2	8	PF00069	0.655
MOD_CK2_1	61	67	PF00069	0.577
MOD_CMANNOS	224	227	PF00535	0.417
MOD_GlcNHglycan	114	117	PF01048	0.575
MOD_GlcNHglycan	157	160	PF01048	0.530
MOD_GlcNHglycan	217	220	PF01048	0.297
MOD_GlcNHglycan	271	274	PF01048	0.498
MOD_GSK3_1	140	147	PF00069	0.262
MOD_GSK3_1	265	272	PF00069	0.648
MOD_N-GLC_1	7	12	PF02516	0.419
MOD_NEK2_1	1	6	PF00069	0.650
MOD_NEK2_1	134	139	PF00069	0.295
MOD_NEK2_1	140	145	PF00069	0.250
MOD_NEK2_1	152	157	PF00069	0.268
MOD_NEK2_1	180	185	PF00069	0.363
MOD_NEK2_1	34	39	PF00069	0.509
MOD_NEK2_1	61	66	PF00069	0.495
MOD_NEK2_1	79	84	PF00069	0.512
MOD_PIKK_1	260	266	PF00454	0.646
MOD_PIKK_1	79	85	PF00454	0.514
MOD_PKA_2	155	161	PF00069	0.360
MOD_PKA_2	180	186	PF00069	0.352
MOD_PKA_2	227	233	PF00069	0.590
MOD_Plk_1	7	13	PF00069	0.613
MOD_Plk_4	102	108	PF00069	0.302
MOD_Plk_4	34	40	PF00069	0.499
MOD_Plk_4	61	67	PF00069	0.617
MOD_ProDKin_1	166	172	PF00069	0.395
MOD_ProDKin_1	232	238	PF00069	0.641
MOD_ProDKin_1	241	247	PF00069	0.782
TRG_ENDOCYTIC_2	138	141	PF00928	0.377
TRG_ENDOCYTIC_2	195	198	PF00928	0.272
TRG_ENDOCYTIC_2	204	207	PF00928	0.316
TRG_ENDOCYTIC_2	58	61	PF00928	0.499
TRG_Pf-PMV_PEXEL_1	162	166	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDG3	Leptomonas seymouri	62%	100%
A0A0S4JRR1	Bodo saltans	32%	100%
A0A1X0NLN6	Trypanosomatidae	38%	100%
A0A422N9F2	Trypanosoma rangeli	39%	100%
A4HQF0	Leishmania braziliensis	77%	100%
A4IC87	Leishmania infantum	100%	100%
D0A3T7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AU67	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q0C7	Leishmania major	92%	100%
V5D8S7	Trypanosoma cruzi	36%	100%