LeishMANIAdb
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V-type proton ATPase proteolipid subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
V-type proton ATPase proteolipid subunit
Gene product:
vacuolar type h+ ATPase subunit, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8ILV9_LEIDO
TriTrypDb:
LdBPK_230150.1 , LdCL_230006400 , LDHU3_23.0180
Length:
167

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 9, no: 20
NetGPI no yes: 0, no: 29
Cellular components
Term Name Level Count
GO:0005774 vacuolar membrane 5 30
GO:0016020 membrane 2 30
GO:0031090 organelle membrane 3 30
GO:0032991 protein-containing complex 1 30
GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain 3 30
GO:0033179 proton-transporting V-type ATPase, V0 domain 4 30
GO:0098588 bounding membrane of organelle 4 30
GO:0098796 membrane protein complex 2 30
GO:0110165 cellular anatomical entity 1 30

Expansion

Sequence features

A0A3Q8ILV9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ILV9

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 19
GO:0005215 transporter activity 1 30
GO:0008324 monoatomic cation transmembrane transporter activity 4 30
GO:0009678 pyrophosphate hydrolysis-driven proton transmembrane transporter activity 5 30
GO:0015075 monoatomic ion transmembrane transporter activity 3 30
GO:0015078 proton transmembrane transporter activity 5 30
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 30
GO:0015399 primary active transmembrane transporter activity 4 30
GO:0016787 hydrolase activity 2 19
GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 3 30
GO:0022804 active transmembrane transporter activity 3 30
GO:0022853 active monoatomic ion transmembrane transporter activity 4 30
GO:0022857 transmembrane transporter activity 2 30
GO:0022890 inorganic cation transmembrane transporter activity 4 30
GO:0042625 ATPase-coupled ion transmembrane transporter activity 3 30
GO:0042626 ATPase-coupled transmembrane transporter activity 2 30
GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 4 30
GO:0046961 proton-transporting ATPase activity, rotational mechanism 4 30
GO:0140657 ATP-dependent activity 1 30

Putative motif mimicry

Leishmania From To Domain/Motif Score
DOC_MAPK_DCC_7 127 135 PF00069 0.432
DOC_MAPK_DCC_7 51 61 PF00069 0.435
DOC_MAPK_gen_1 124 134 PF00069 0.436
DOC_MAPK_gen_1 51 59 PF00069 0.435
DOC_MAPK_MEF2A_6 124 132 PF00069 0.435
DOC_MAPK_MEF2A_6 54 61 PF00069 0.435
DOC_USP7_MATH_1 160 164 PF00917 0.266
LIG_APCC_ABBA_1 135 140 PF00400 0.278
LIG_BIR_II_1 1 5 PF00653 0.413
LIG_FHA_1 123 129 PF00498 0.432
LIG_FHA_1 147 153 PF00498 0.387
LIG_LIR_Gen_1 89 99 PF02991 0.224
LIG_LIR_Nem_3 83 88 PF02991 0.299
LIG_LIR_Nem_3 89 94 PF02991 0.256
LIG_SH2_CRK 68 72 PF00017 0.278
LIG_SH2_SRC 109 112 PF00017 0.275
LIG_SH2_SRC 120 123 PF00017 0.432
LIG_SH3_3 3 9 PF00018 0.446
LIG_UBA3_1 147 156 PF00899 0.387
MOD_CAAXbox 164 167 PF01239 0.426
MOD_GlcNHglycan 158 161 PF01048 0.475
MOD_GlcNHglycan 82 85 PF01048 0.497
MOD_GlcNHglycan 88 91 PF01048 0.448
MOD_GSK3_1 151 158 PF00069 0.435
MOD_GSK3_1 160 167 PF00069 0.391
MOD_NEK2_1 1 6 PF00069 0.399
MOD_NEK2_1 151 156 PF00069 0.415
MOD_NEK2_1 70 75 PF00069 0.290
MOD_NEK2_1 80 85 PF00069 0.291
MOD_Plk_4 70 76 PF00069 0.294
MOD_SUMO_for_1 123 126 PF00179 0.450
TRG_ENDOCYTIC_2 68 71 PF00928 0.278
TRG_ENDOCYTIC_2 85 88 PF00928 0.285
TRG_ENDOCYTIC_2 91 94 PF00928 0.269
TRG_NES_CRM1_1 126 140 PF08389 0.450

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3G9 Leptomonas seymouri 30% 75%
A0A0N0P7K0 Leptomonas seymouri 60% 85%
A0A0N1HSG6 Leptomonas seymouri 66% 88%
A0A0N1I3H6 Leptomonas seymouri 90% 100%
A0A0S4IU71 Bodo saltans 63% 97%
A0A0S4JFM4 Bodo saltans 79% 94%
A0A0S4KKA5 Bodo saltans 66% 86%
A0A1X0NGC8 Trypanosomatidae 85% 100%
A0A1X0NHL5 Trypanosomatidae 64% 87%
A0A1X0NZ73 Trypanosomatidae 60% 92%
A0A1X0P179 Trypanosomatidae 30% 75%
A0A3Q8II19 Leishmania donovani 59% 100%
A0A3Q8II88 Leishmania donovani 32% 100%
A0A3R7MQK8 Trypanosoma rangeli 27% 75%
A0A3R7RFU6 Trypanosoma rangeli 64% 86%
A0A3S7WX01 Leishmania donovani 64% 89%
A0A422N304 Trypanosoma rangeli 57% 84%
A0A422NW00 Trypanosoma rangeli 85% 100%
A2ZBW5 Oryza sativa subsp. indica 57% 100%
A4HCM7 Leishmania braziliensis 93% 100%
A4HGG2 Leishmania braziliensis 59% 100%
A4HIV2 Leishmania braziliensis 30% 100%
A4HLC1 Leishmania braziliensis 64% 100%
A4HZI5 Leishmania infantum 64% 100%
A4I051 Leishmania infantum 100% 100%
A4I3J4 Leishmania infantum 59% 100%
A4I657 Leishmania infantum 32% 100%
C0HLB3 Caenorhabditis elegans 46% 100%
C0HLB4 Caenorhabditis elegans 46% 100%
C0HLB5 Caenorhabditis briggsae 46% 100%
C0HLB6 Caenorhabditis briggsae 46% 100%
C9ZRH7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 75%
D0A0Y8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 68% 87%
D0A7U7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 59% 66%
E9AVH5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 65% 100%
E9AW14 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
E9AZT4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 58% 100%
E9B1E0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
G5EDB8 Caenorhabditis elegans 30% 78%
O14046 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 26% 84%
O16110 Aedes aegypti 51% 100%
O18882 Ovis aries 48% 100%
O22552 Vigna radiata var. radiata 57% 100%
O24011 Solanum lycopersicum 57% 100%
P0DH92 Arabidopsis thaliana 56% 100%
P0DH93 Arabidopsis thaliana 56% 100%
P0DH94 Arabidopsis thaliana 56% 100%
P23380 Drosophila melanogaster 50% 100%
P23956 Bos taurus 48% 100%
P23957 Avena sativa 57% 100%
P23968 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 30% 78%
P25515 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 47% 100%
P27449 Homo sapiens 47% 100%
P31403 Manduca sexta 48% 100%
P31413 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 52% 100%
P32842 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 46% 100%
P50515 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 52% 100%
P54642 Dictyostelium discoideum 44% 85%
P55277 Heliothis virescens 48% 100%
P59228 Arabidopsis thaliana 56% 100%
P59229 Arabidopsis thaliana 57% 100%
P63081 Rattus norvegicus 49% 100%
P63082 Mus musculus 49% 100%
P68161 Mesembryanthemum crystallinum 55% 100%
P68162 Beta vulgaris 55% 100%
Q00607 Candida tropicalis 45% 100%
Q03105 Torpedo marmorata 48% 100%
Q0IUB5 Oryza sativa subsp. japonica 57% 100%
Q17046 Ascaris suum 46% 100%
Q21898 Caenorhabditis elegans 45% 99%
Q24808 Entamoeba dispar 42% 95%
Q24810 Entamoeba histolytica 42% 94%
Q26250 Nephrops norvegicus 48% 100%
Q2TA24 Bos taurus 30% 81%
Q40585 Nicotiana tabacum 56% 100%
Q43362 Chrysotila carterae 54% 100%
Q43434 Gossypium hirsutum 57% 100%
Q4Q6S2 Leishmania major 33% 100%
Q4Q8F0 Leishmania major 59% 100%
Q4QBG2 Leishmania major 98% 100%
Q4QC03 Leishmania major 64% 100%
Q6BSB9 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 46% 100%
Q6CT28 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 45% 100%
Q6FUY5 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 47% 100%
Q755G4 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 45% 100%
Q91V37 Mus musculus 30% 81%
Q96473 Kalanchoe daigremontiana 57% 100%
Q99437 Homo sapiens 30% 81%
Q9SLA2 Arabidopsis thaliana 32% 94%
Q9SZY7 Arabidopsis thaliana 32% 93%
Q9URZ8 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 46% 100%
Q9Y874 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 43% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS