CobW/HypB/UreG, nucleotide-binding domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CobW/HypB/UreG, nucleotide-binding domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ILT9_LEIDO

TriTrypDb:

LdBPK_221500.1 , LdCL_220022300 , LDHU3_22.2150

Length:

386

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ILT9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ILT9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.444
CLV_C14_Caspase3-7	46	50	PF00656	0.401
CLV_NRD_NRD_1	190	192	PF00675	0.254
CLV_NRD_NRD_1	284	286	PF00675	0.479
CLV_NRD_NRD_1	331	333	PF00675	0.493
CLV_PCSK_KEX2_1	190	192	PF00082	0.358
CLV_PCSK_KEX2_1	284	286	PF00082	0.479
CLV_PCSK_KEX2_1	331	333	PF00082	0.419
CLV_PCSK_PC1ET2_1	331	333	PF00082	0.419
CLV_PCSK_PC7_1	186	192	PF00082	0.336
CLV_PCSK_SKI1_1	149	153	PF00082	0.187
CLV_PCSK_SKI1_1	190	194	PF00082	0.254
CLV_PCSK_SKI1_1	267	271	PF00082	0.388
CLV_PCSK_SKI1_1	284	288	PF00082	0.430
CLV_PCSK_SKI1_1	293	297	PF00082	0.528
CLV_PCSK_SKI1_1	358	362	PF00082	0.374
DEG_APCC_DBOX_1	292	300	PF00400	0.379
DEG_Nend_Nbox_1	1	3	PF02207	0.437
DOC_CDC14_PxL_1	117	125	PF14671	0.454
DOC_CYCLIN_RxL_1	282	289	PF00134	0.378
DOC_MAPK_gen_1	262	268	PF00069	0.446
DOC_MAPK_gen_1	32	40	PF00069	0.454
DOC_MAPK_MEF2A_6	32	40	PF00069	0.454
DOC_MAPK_MEF2A_6	7	14	PF00069	0.280
DOC_PP1_RVXF_1	319	326	PF00149	0.449
DOC_PP1_RVXF_1	356	362	PF00149	0.365
DOC_USP7_MATH_1	137	141	PF00917	0.484
DOC_USP7_MATH_1	151	155	PF00917	0.531
DOC_USP7_MATH_1	196	200	PF00917	0.415
DOC_USP7_MATH_1	214	218	PF00917	0.273
DOC_USP7_MATH_1	380	384	PF00917	0.354
DOC_USP7_MATH_1	58	62	PF00917	0.448
DOC_WW_Pin1_4	286	291	PF00397	0.379
LIG_14-3-3_CanoR_1	267	272	PF00244	0.382
LIG_14-3-3_CanoR_1	326	331	PF00244	0.439
LIG_Actin_WH2_2	270	286	PF00022	0.385
LIG_Clathr_ClatBox_1	268	272	PF01394	0.398
LIG_FHA_1	175	181	PF00498	0.454
LIG_FHA_1	18	24	PF00498	0.454
LIG_FHA_1	268	274	PF00498	0.579
LIG_FHA_1	278	284	PF00498	0.455
LIG_FHA_1	3	9	PF00498	0.333
LIG_FHA_2	143	149	PF00498	0.454
LIG_FXI_DFP_1	362	366	PF00024	0.407
LIG_Integrin_RGD_1	159	161	PF01839	0.220
LIG_LIR_Gen_1	376	386	PF02991	0.312
LIG_LIR_Nem_3	210	215	PF02991	0.365
LIG_LIR_Nem_3	335	339	PF02991	0.459
LIG_LIR_Nem_3	376	381	PF02991	0.289
LIG_Pex14_2	361	365	PF04695	0.406
LIG_PTB_Apo_2	170	177	PF02174	0.444
LIG_PTB_Phospho_1	170	176	PF10480	0.444
LIG_SH2_NCK_1	238	242	PF00017	0.466
LIG_SH2_NCK_1	99	103	PF00017	0.435
LIG_SH2_PTP2	343	346	PF00017	0.512
LIG_SH2_STAP1	176	180	PF00017	0.444
LIG_SH2_STAT5	176	179	PF00017	0.444
LIG_SH2_STAT5	206	209	PF00017	0.388
LIG_SH2_STAT5	212	215	PF00017	0.354
LIG_SH2_STAT5	305	308	PF00017	0.377
LIG_SH2_STAT5	343	346	PF00017	0.512
LIG_SH3_1	25	31	PF00018	0.435
LIG_SH3_3	104	110	PF00018	0.444
LIG_SH3_3	25	31	PF00018	0.435
LIG_SH3_3	336	342	PF00018	0.485
LIG_SUMO_SIM_anti_2	153	159	PF11976	0.452
LIG_SUMO_SIM_par_1	139	146	PF11976	0.453
LIG_SUMO_SIM_par_1	68	73	PF11976	0.430
LIG_TRAF2_1	253	256	PF00917	0.536
LIG_TRAF2_1	31	34	PF00917	0.454
LIG_TYR_ITIM	334	339	PF00017	0.455
LIG_UBA3_1	26	35	PF00899	0.287
LIG_UBA3_1	268	276	PF00899	0.386
LIG_WRC_WIRS_1	230	235	PF05994	0.407
MOD_CDK_SPxxK_3	286	293	PF00069	0.365
MOD_CK1_1	140	146	PF00069	0.381
MOD_CK1_1	17	23	PF00069	0.287
MOD_CK1_1	314	320	PF00069	0.474
MOD_CK1_1	56	62	PF00069	0.287
MOD_CK2_1	142	148	PF00069	0.213
MOD_CK2_1	316	322	PF00069	0.458
MOD_CK2_1	97	103	PF00069	0.260
MOD_GlcNHglycan	16	19	PF01048	0.340
MOD_GlcNHglycan	306	309	PF01048	0.381
MOD_GlcNHglycan	310	316	PF01048	0.443
MOD_GlcNHglycan	318	321	PF01048	0.426
MOD_GlcNHglycan	350	353	PF01048	0.476
MOD_GlcNHglycan	378	381	PF01048	0.333
MOD_GlcNHglycan	55	58	PF01048	0.286
MOD_GlcNHglycan	62	65	PF01048	0.202
MOD_GlcNHglycan	72	75	PF01048	0.230
MOD_GlcNHglycan	90	93	PF01048	0.351
MOD_GSK3_1	136	143	PF00069	0.343
MOD_GSK3_1	14	21	PF00069	0.287
MOD_GSK3_1	376	383	PF00069	0.365
MOD_GSK3_1	56	63	PF00069	0.281
MOD_N-GLC_1	59	64	PF02516	0.260
MOD_NEK2_1	14	19	PF00069	0.287
MOD_NEK2_1	142	147	PF00069	0.287
MOD_PIKK_1	277	283	PF00454	0.333
MOD_PKA_2	348	354	PF00069	0.488
MOD_Plk_1	180	186	PF00069	0.246
MOD_Plk_4	137	143	PF00069	0.287
MOD_Plk_4	18	24	PF00069	0.329
MOD_Plk_4	180	186	PF00069	0.361
MOD_Plk_4	214	220	PF00069	0.384
MOD_Plk_4	229	235	PF00069	0.352
MOD_Plk_4	373	379	PF00069	0.295
MOD_Plk_4	97	103	PF00069	0.260
MOD_ProDKin_1	286	292	PF00069	0.373
MOD_SUMO_rev_2	255	264	PF00179	0.480
TRG_DiLeu_BaEn_3	33	39	PF01217	0.287
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.260
TRG_ENDOCYTIC_2	212	215	PF00928	0.361
TRG_ENDOCYTIC_2	336	339	PF00928	0.454
TRG_ENDOCYTIC_2	343	346	PF00928	0.472
TRG_ENDOCYTIC_2	99	102	PF00928	0.485
TRG_ER_diArg_1	189	191	PF00400	0.287
TRG_ER_diArg_1	283	285	PF00400	0.393
TRG_Pf-PMV_PEXEL_1	190	194	PF00026	0.287

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J8A6	Bodo saltans	28%	100%
A4HCK6	Leishmania braziliensis	83%	100%
A4I024	Leishmania infantum	99%	100%
E9AVZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P31521	Pseudomonas chlororaphis	27%	92%
P94400	Bacillus subtilis (strain 168)	28%	97%
Q4QBI2	Leishmania major	94%	100%