Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ILR1_LEIDO

TriTrypDb:

LdBPK_350340.1 , LdCL_350008400 , LDHU3_35.0440

Length:

497

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A0A3Q8ILR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ILR1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.617
CLV_C14_Caspase3-7	79	83	PF00656	0.547
CLV_MEL_PAP_1	311	317	PF00089	0.420
CLV_NRD_NRD_1	37	39	PF00675	0.550
CLV_NRD_NRD_1	471	473	PF00675	0.352
CLV_NRD_NRD_1	97	99	PF00675	0.612
CLV_PCSK_FUR_1	35	39	PF00082	0.565
CLV_PCSK_FUR_1	95	99	PF00082	0.572
CLV_PCSK_KEX2_1	368	370	PF00082	0.540
CLV_PCSK_KEX2_1	37	39	PF00082	0.547
CLV_PCSK_KEX2_1	418	420	PF00082	0.503
CLV_PCSK_KEX2_1	471	473	PF00082	0.339
CLV_PCSK_KEX2_1	97	99	PF00082	0.556
CLV_PCSK_PC1ET2_1	368	370	PF00082	0.597
CLV_PCSK_PC1ET2_1	418	420	PF00082	0.378
CLV_PCSK_PC7_1	467	473	PF00082	0.345
CLV_PCSK_SKI1_1	130	134	PF00082	0.692
CLV_PCSK_SKI1_1	180	184	PF00082	0.573
CLV_PCSK_SKI1_1	222	226	PF00082	0.278
CLV_PCSK_SKI1_1	285	289	PF00082	0.427
CLV_PCSK_SKI1_1	467	471	PF00082	0.497
DEG_APCC_DBOX_1	200	208	PF00400	0.512
DEG_APCC_DBOX_1	263	271	PF00400	0.413
DEG_SCF_FBW7_1	161	168	PF00400	0.358
DOC_ANK_TNKS_1	183	190	PF00023	0.624
DOC_CDC14_PxL_1	215	223	PF14671	0.313
DOC_CDC14_PxL_1	5	13	PF14671	0.565
DOC_CKS1_1	356	361	PF01111	0.568
DOC_CYCLIN_RxL_1	219	226	PF00134	0.351
DOC_CYCLIN_RxL_1	368	379	PF00134	0.403
DOC_CYCLIN_yCln2_LP_2	229	235	PF00134	0.388
DOC_MAPK_gen_1	261	270	PF00069	0.322
DOC_MAPK_gen_1	35	43	PF00069	0.504
DOC_MAPK_gen_1	368	378	PF00069	0.382
DOC_MAPK_gen_1	62	70	PF00069	0.392
DOC_MAPK_MEF2A_6	368	377	PF00069	0.391
DOC_PP1_RVXF_1	465	471	PF00149	0.364
DOC_PP2B_LxvP_1	216	219	PF13499	0.321
DOC_PP2B_LxvP_1	229	232	PF13499	0.276
DOC_PP4_FxxP_1	411	414	PF00568	0.316
DOC_PP4_FxxP_1	6	9	PF00568	0.567
DOC_USP7_MATH_1	132	136	PF00917	0.612
DOC_USP7_MATH_1	151	155	PF00917	0.370
DOC_USP7_MATH_1	165	169	PF00917	0.449
DOC_USP7_MATH_1	176	180	PF00917	0.683
DOC_USP7_MATH_1	208	212	PF00917	0.359
DOC_USP7_MATH_1	439	443	PF00917	0.549
DOC_USP7_MATH_1	452	456	PF00917	0.669
DOC_WW_Pin1_4	161	166	PF00397	0.343
DOC_WW_Pin1_4	345	350	PF00397	0.553
DOC_WW_Pin1_4	355	360	PF00397	0.464
DOC_WW_Pin1_4	401	406	PF00397	0.468
LIG_14-3-3_CanoR_1	201	205	PF00244	0.471
LIG_14-3-3_CanoR_1	222	232	PF00244	0.295
LIG_AP2alpha_1	377	381	PF02296	0.317
LIG_BRCT_BRCA1_1	391	395	PF00533	0.363
LIG_BRCT_BRCA1_1	99	103	PF00533	0.664
LIG_Clathr_ClatBox_1	267	271	PF01394	0.386
LIG_Clathr_ClatBox_1	375	379	PF01394	0.386
LIG_FHA_1	105	111	PF00498	0.560
LIG_FHA_1	139	145	PF00498	0.544
LIG_FHA_1	21	27	PF00498	0.480
LIG_FHA_1	288	294	PF00498	0.511
LIG_FHA_1	45	51	PF00498	0.429
LIG_FHA_2	117	123	PF00498	0.612
LIG_FHA_2	165	171	PF00498	0.465
LIG_FHA_2	389	395	PF00498	0.479
LIG_FHA_2	77	83	PF00498	0.550
LIG_LIR_Apic_2	3	9	PF02991	0.605
LIG_LIR_Apic_2	477	483	PF02991	0.484
LIG_LIR_Gen_1	153	163	PF02991	0.365
LIG_LIR_Gen_1	226	235	PF02991	0.346
LIG_LIR_Gen_1	374	382	PF02991	0.357
LIG_LIR_Gen_1	392	403	PF02991	0.416
LIG_LIR_Gen_1	72	78	PF02991	0.365
LIG_LIR_Nem_3	153	159	PF02991	0.479
LIG_LIR_Nem_3	226	231	PF02991	0.315
LIG_LIR_Nem_3	3	8	PF02991	0.572
LIG_LIR_Nem_3	374	380	PF02991	0.337
LIG_LIR_Nem_3	392	398	PF02991	0.428
LIG_LIR_Nem_3	72	77	PF02991	0.422
LIG_NRBOX	220	226	PF00104	0.315
LIG_PCNA_yPIPBox_3	276	288	PF02747	0.388
LIG_Pex14_2	377	381	PF04695	0.361
LIG_REV1ctd_RIR_1	3	8	PF16727	0.530
LIG_SH2_CRK	156	160	PF00017	0.487
LIG_SH2_CRK	434	438	PF00017	0.425
LIG_SH2_CRK	480	484	PF00017	0.423
LIG_SH2_NCK_1	484	488	PF00017	0.362
LIG_SH2_PTP2	74	77	PF00017	0.382
LIG_SH2_STAP1	156	160	PF00017	0.487
LIG_SH2_STAT5	215	218	PF00017	0.306
LIG_SH2_STAT5	220	223	PF00017	0.281
LIG_SH2_STAT5	257	260	PF00017	0.431
LIG_SH2_STAT5	303	306	PF00017	0.459
LIG_SH2_STAT5	310	313	PF00017	0.478
LIG_SH2_STAT5	4	7	PF00017	0.527
LIG_SH2_STAT5	74	77	PF00017	0.373
LIG_SUMO_SIM_par_1	22	28	PF11976	0.505
LIG_SUMO_SIM_par_1	266	271	PF11976	0.405
LIG_TRFH_1	228	232	PF08558	0.308
LIG_WRC_WIRS_1	70	75	PF05994	0.369
MOD_CDK_SPK_2	161	166	PF00069	0.343
MOD_CK1_1	104	110	PF00069	0.499
MOD_CK1_1	168	174	PF00069	0.552
MOD_CK1_1	330	336	PF00069	0.628
MOD_CK1_1	76	82	PF00069	0.453
MOD_CK2_1	388	394	PF00069	0.544
MOD_CK2_1	438	444	PF00069	0.511
MOD_CMANNOS	494	497	PF00535	0.402
MOD_GlcNHglycan	169	174	PF01048	0.573
MOD_GlcNHglycan	225	228	PF01048	0.293
MOD_GlcNHglycan	27	30	PF01048	0.525
MOD_GlcNHglycan	329	332	PF01048	0.652
MOD_GlcNHglycan	335	338	PF01048	0.665
MOD_GlcNHglycan	340	343	PF01048	0.580
MOD_GlcNHglycan	365	368	PF01048	0.560
MOD_GlcNHglycan	454	457	PF01048	0.641
MOD_GlcNHglycan	475	479	PF01048	0.476
MOD_GlcNHglycan	53	57	PF01048	0.433
MOD_GlcNHglycan	99	102	PF01048	0.644
MOD_GSK3_1	161	168	PF00069	0.445
MOD_GSK3_1	381	388	PF00069	0.521
MOD_GSK3_1	45	52	PF00069	0.608
MOD_GSK3_1	69	76	PF00069	0.328
MOD_GSK3_1	97	104	PF00069	0.566
MOD_N-GLC_1	104	109	PF02516	0.524
MOD_N-GLC_1	44	49	PF02516	0.331
MOD_NEK2_1	115	120	PF00069	0.680
MOD_NEK2_1	287	292	PF00069	0.504
MOD_NEK2_1	33	38	PF00069	0.576
MOD_NEK2_1	386	391	PF00069	0.350
MOD_NEK2_1	44	49	PF00069	0.381
MOD_NEK2_1	73	78	PF00069	0.399
MOD_NEK2_2	14	19	PF00069	0.507
MOD_PIKK_1	233	239	PF00454	0.364
MOD_PKA_1	97	103	PF00069	0.508
MOD_PKA_2	165	171	PF00069	0.689
MOD_PKA_2	200	206	PF00069	0.471
MOD_PKA_2	362	368	PF00069	0.703
MOD_PKA_2	399	405	PF00069	0.372
MOD_PKA_2	97	103	PF00069	0.625
MOD_PKB_1	95	103	PF00069	0.452
MOD_Plk_1	386	392	PF00069	0.295
MOD_Plk_1	44	50	PF00069	0.392
MOD_Plk_4	14	20	PF00069	0.629
MOD_Plk_4	200	206	PF00069	0.426
MOD_Plk_4	45	51	PF00069	0.528
MOD_Plk_4	88	94	PF00069	0.634
MOD_ProDKin_1	161	167	PF00069	0.349
MOD_ProDKin_1	345	351	PF00069	0.544
MOD_ProDKin_1	355	361	PF00069	0.464
MOD_ProDKin_1	401	407	PF00069	0.465
MOD_SUMO_for_1	50	53	PF00179	0.446
TRG_DiLeu_BaLyEn_6	139	144	PF01217	0.518
TRG_DiLeu_BaLyEn_6	464	469	PF01217	0.363
TRG_ENDOCYTIC_2	156	159	PF00928	0.335
TRG_ENDOCYTIC_2	220	223	PF00928	0.319
TRG_ENDOCYTIC_2	74	77	PF00928	0.398
TRG_ER_diArg_1	34	37	PF00400	0.476
TRG_ER_diArg_1	470	472	PF00400	0.350
TRG_ER_diArg_1	96	98	PF00400	0.609
TRG_NES_CRM1_1	372	385	PF08389	0.483
TRG_Pf-PMV_PEXEL_1	180	185	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3M2	Leptomonas seymouri	60%	95%
A0A0S4JN24	Bodo saltans	35%	100%
A0A1X0NKI9	Trypanosomatidae	41%	100%
A0A3R7NSD3	Trypanosoma rangeli	45%	100%
A4HM72	Leishmania braziliensis	79%	100%
A4IAT5	Leishmania infantum	99%	100%
D0A2C3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	96%
E9AEL1	Leishmania major	95%	100%
E9B5S2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BIP8	Trypanosoma cruzi	41%	100%