Defective in cullin neddylation protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cullin binding, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ILQ1_LEIDO

TriTrypDb:

LdBPK_365960.1 , LdCL_360067000 , LDHU3_36.7880

Length:

265

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A0A3Q8ILQ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ILQ1

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0019538	protein metabolic process	3	1
GO:0031396	regulation of protein ubiquitination	8	1
GO:0031398	positive regulation of protein ubiquitination	9	1
GO:0031399	regulation of protein modification process	6	1
GO:0031401	positive regulation of protein modification process	7	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043085	positive regulation of catalytic activity	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044093	positive regulation of molecular function	3	1
GO:0044238	primary metabolic process	2	1
GO:0045116	protein neddylation	7	1
GO:0048518	positive regulation of biological process	3	1
GO:0050789	regulation of biological process	2	1
GO:0050790	regulation of catalytic activity	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051247	positive regulation of protein metabolic process	6	1
GO:0051338	regulation of transferase activity	4	1
GO:0051347	positive regulation of transferase activity	5	1
GO:0051438	regulation of ubiquitin-protein transferase activity	5	1
GO:0051443	positive regulation of ubiquitin-protein transferase activity	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1903320	regulation of protein modification by small protein conjugation or removal	7	1
GO:1903322	positive regulation of protein modification by small protein conjugation or removal	8	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0031624	ubiquitin conjugating enzyme binding	5	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0044390	ubiquitin-like protein conjugating enzyme binding	4	1
GO:0097602	cullin family protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.436
CLV_NRD_NRD_1	178	180	PF00675	0.434
CLV_NRD_NRD_1	256	258	PF00675	0.523
CLV_PCSK_KEX2_1	132	134	PF00082	0.416
CLV_PCSK_KEX2_1	178	180	PF00082	0.409
CLV_PCSK_KEX2_1	74	76	PF00082	0.528
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.438
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.577
CLV_PCSK_SKI1_1	179	183	PF00082	0.404
DOC_MAPK_gen_1	178	187	PF00069	0.386
DOC_USP7_MATH_1	204	208	PF00917	0.372
DOC_WW_Pin1_4	165	170	PF00397	0.423
LIG_14-3-3_CanoR_1	178	188	PF00244	0.450
LIG_14-3-3_CanoR_1	78	85	PF00244	0.371
LIG_BRCT_BRCA1_1	161	165	PF00533	0.423
LIG_deltaCOP1_diTrp_1	159	165	PF00928	0.303
LIG_deltaCOP1_diTrp_1	222	230	PF00928	0.303
LIG_deltaCOP1_diTrp_1	240	252	PF00928	0.314
LIG_FHA_1	180	186	PF00498	0.411
LIG_FHA_1	223	229	PF00498	0.444
LIG_FHA_2	171	177	PF00498	0.372
LIG_FHA_2	246	252	PF00498	0.372
LIG_LIR_Gen_1	134	145	PF02991	0.413
LIG_LIR_Gen_1	159	169	PF02991	0.360
LIG_LIR_Gen_1	182	190	PF02991	0.342
LIG_LIR_Gen_1	195	204	PF02991	0.271
LIG_LIR_Gen_1	20	30	PF02991	0.434
LIG_LIR_Gen_1	222	231	PF02991	0.318
LIG_LIR_Gen_1	38	46	PF02991	0.452
LIG_LIR_Nem_3	105	111	PF02991	0.420
LIG_LIR_Nem_3	134	140	PF02991	0.309
LIG_LIR_Nem_3	159	164	PF02991	0.303
LIG_LIR_Nem_3	182	187	PF02991	0.312
LIG_LIR_Nem_3	195	199	PF02991	0.246
LIG_LIR_Nem_3	20	25	PF02991	0.380
LIG_LIR_Nem_3	222	227	PF02991	0.310
LIG_LIR_Nem_3	234	239	PF02991	0.334
LIG_LIR_Nem_3	250	255	PF02991	0.295
LIG_LIR_Nem_3	38	43	PF02991	0.430
LIG_MLH1_MIPbox_1	161	165	PF16413	0.423
LIG_Pex14_1	161	165	PF04695	0.303
LIG_Pex14_2	139	143	PF04695	0.303
LIG_SH2_CRK	108	112	PF00017	0.499
LIG_SH2_CRK	137	141	PF00017	0.303
LIG_SH2_NCK_1	26	30	PF00017	0.428
LIG_SH2_STAT5	184	187	PF00017	0.403
LIG_SH2_STAT5	24	27	PF00017	0.447
LIG_SH2_STAT5	255	258	PF00017	0.405
LIG_SH2_STAT5	63	66	PF00017	0.379
LIG_SH3_3	182	188	PF00018	0.415
LIG_SUMO_SIM_anti_2	195	202	PF11976	0.352
LIG_SUMO_SIM_par_1	31	36	PF11976	0.569
LIG_TRAF2_1	173	176	PF00917	0.423
MOD_CK1_1	168	174	PF00069	0.406
MOD_CK1_1	217	223	PF00069	0.466
MOD_CK1_1	48	54	PF00069	0.460
MOD_CK2_1	153	159	PF00069	0.360
MOD_CK2_1	170	176	PF00069	0.119
MOD_GlcNHglycan	155	158	PF01048	0.421
MOD_GlcNHglycan	165	168	PF01048	0.360
MOD_GlcNHglycan	208	211	PF01048	0.425
MOD_GlcNHglycan	215	219	PF01048	0.420
MOD_GlcNHglycan	70	74	PF01048	0.511
MOD_GSK3_1	159	166	PF00069	0.423
MOD_GSK3_1	202	209	PF00069	0.374
MOD_GSK3_1	241	248	PF00069	0.392
MOD_N-GLC_1	122	127	PF02516	0.450
MOD_N-GLC_2	142	144	PF02516	0.423
MOD_NEK2_1	122	127	PF00069	0.440
MOD_NEK2_1	259	264	PF00069	0.556
MOD_NEK2_2	2	7	PF00069	0.629
MOD_PIKK_1	222	228	PF00454	0.411
MOD_PKA_1	179	185	PF00069	0.372
MOD_PKA_2	77	83	PF00069	0.381
MOD_Plk_1	122	128	PF00069	0.440
MOD_Plk_1	241	247	PF00069	0.382
MOD_Plk_1	58	64	PF00069	0.346
MOD_Plk_4	2	8	PF00069	0.485
MOD_Plk_4	58	64	PF00069	0.352
MOD_ProDKin_1	165	171	PF00069	0.423
MOD_SUMO_rev_2	202	210	PF00179	0.405
TRG_ENDOCYTIC_2	108	111	PF00928	0.505
TRG_ENDOCYTIC_2	137	140	PF00928	0.303
TRG_ENDOCYTIC_2	184	187	PF00928	0.309
TRG_ENDOCYTIC_2	26	29	PF00928	0.514
TRG_NES_CRM1_1	58	71	PF08389	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC74	Leptomonas seymouri	63%	98%
A0A0S4IZZ0	Bodo saltans	26%	100%
A0A1X0P053	Trypanosomatidae	29%	100%
A0A422NSC3	Trypanosoma rangeli	26%	100%
A4HQ87	Leishmania braziliensis	83%	100%
A4IDY5	Leishmania infantum	100%	100%
D0A424	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AU05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
P0CN06	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	26%	95%
P0CN07	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	26%	95%
Q4Q0J0	Leishmania major	92%	100%
V5DK31	Trypanosoma cruzi	27%	100%