Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ILJ1_LEIDO

TriTrypDb:

LdBPK_365260.1 , LdCL_360059800 , LDHU3_36.7040

Length:

388

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ILJ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ILJ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	116	118	PF00675	0.493
CLV_NRD_NRD_1	197	199	PF00675	0.516
CLV_NRD_NRD_1	368	370	PF00675	0.602
CLV_NRD_NRD_1	78	80	PF00675	0.506
CLV_PCSK_FUR_1	76	80	PF00082	0.517
CLV_PCSK_KEX2_1	197	199	PF00082	0.431
CLV_PCSK_KEX2_1	345	347	PF00082	0.498
CLV_PCSK_KEX2_1	368	370	PF00082	0.602
CLV_PCSK_KEX2_1	78	80	PF00082	0.515
CLV_PCSK_PC1ET2_1	345	347	PF00082	0.498
CLV_PCSK_SKI1_1	249	253	PF00082	0.434
CLV_PCSK_SKI1_1	262	266	PF00082	0.417
CLV_PCSK_SKI1_1	300	304	PF00082	0.513
CLV_PCSK_SKI1_1	368	372	PF00082	0.610
DEG_SPOP_SBC_1	150	154	PF00917	0.693
DOC_CYCLIN_RxL_1	297	304	PF00134	0.492
DOC_PP4_FxxP_1	139	142	PF00568	0.611
DOC_USP7_MATH_1	132	136	PF00917	0.577
DOC_USP7_MATH_1	150	154	PF00917	0.687
DOC_USP7_MATH_1	157	161	PF00917	0.405
DOC_USP7_UBL2_3	114	118	PF12436	0.450
DOC_USP7_UBL2_3	265	269	PF12436	0.498
DOC_WW_Pin1_4	130	135	PF00397	0.624
DOC_WW_Pin1_4	69	74	PF00397	0.534
LIG_14-3-3_CanoR_1	8	16	PF00244	0.675
LIG_14-3-3_CanoR_1	89	95	PF00244	0.484
LIG_Actin_WH2_2	101	119	PF00022	0.471
LIG_APCC_ABBA_1	170	175	PF00400	0.364
LIG_BIR_II_1	1	5	PF00653	0.674
LIG_FHA_1	217	223	PF00498	0.453
LIG_FHA_1	284	290	PF00498	0.456
LIG_FHA_1	355	361	PF00498	0.488
LIG_FHA_1	369	375	PF00498	0.559
LIG_FHA_2	105	111	PF00498	0.472
LIG_FHA_2	49	55	PF00498	0.613
LIG_LIR_Apic_2	137	142	PF02991	0.611
LIG_LIR_Gen_1	107	116	PF02991	0.449
LIG_LIR_Gen_1	175	184	PF02991	0.411
LIG_LIR_Gen_1	330	340	PF02991	0.474
LIG_LIR_Gen_1	50	59	PF02991	0.590
LIG_LIR_Nem_3	107	112	PF02991	0.554
LIG_LIR_Nem_3	175	181	PF02991	0.411
LIG_LIR_Nem_3	330	336	PF02991	0.480
LIG_LIR_Nem_3	50	56	PF02991	0.636
LIG_PCNA_yPIPBox_3	174	185	PF02747	0.532
LIG_Pex14_2	49	53	PF04695	0.655
LIG_PTAP_UEV_1	380	385	PF05743	0.618
LIG_SH2_CRK	178	182	PF00017	0.381
LIG_SH2_STAP1	178	182	PF00017	0.413
LIG_SH2_STAT3	184	187	PF00017	0.427
LIG_SH3_3	378	384	PF00018	0.619
LIG_TRAF2_1	243	246	PF00917	0.439
LIG_TRAF2_1	61	64	PF00917	0.651
MOD_CDK_SPxxK_3	69	76	PF00069	0.524
MOD_CK1_1	135	141	PF00069	0.668
MOD_CK1_1	153	159	PF00069	0.537
MOD_CK1_1	301	307	PF00069	0.483
MOD_CK1_1	359	365	PF00069	0.552
MOD_CK1_1	58	64	PF00069	0.654
MOD_CK1_1	7	13	PF00069	0.812
MOD_CK1_1	93	99	PF00069	0.483
MOD_CK2_1	104	110	PF00069	0.476
MOD_CK2_1	140	146	PF00069	0.643
MOD_CK2_1	346	352	PF00069	0.540
MOD_CK2_1	48	54	PF00069	0.641
MOD_CK2_1	58	64	PF00069	0.576
MOD_CK2_1	68	74	PF00069	0.435
MOD_Cter_Amidation	195	198	PF01082	0.444
MOD_GlcNHglycan	1	4	PF01048	0.704
MOD_GlcNHglycan	10	13	PF01048	0.597
MOD_GlcNHglycan	134	137	PF01048	0.735
MOD_GlcNHglycan	155	158	PF01048	0.549
MOD_GlcNHglycan	290	293	PF01048	0.478
MOD_GlcNHglycan	303	306	PF01048	0.405
MOD_GlcNHglycan	316	319	PF01048	0.392
MOD_GSK3_1	130	137	PF00069	0.619
MOD_GSK3_1	149	156	PF00069	0.586
MOD_GSK3_1	375	382	PF00069	0.596
MOD_GSK3_1	4	11	PF00069	0.627
MOD_N-GLC_1	4	9	PF02516	0.673
MOD_NEK2_1	158	163	PF00069	0.595
MOD_NEK2_1	216	221	PF00069	0.510
MOD_NEK2_1	375	380	PF00069	0.541
MOD_NEK2_1	4	9	PF00069	0.605
MOD_PIKK_1	283	289	PF00454	0.445
MOD_PKA_1	368	374	PF00069	0.618
MOD_PKA_2	258	264	PF00069	0.484
MOD_PKA_2	368	374	PF00069	0.618
MOD_PKA_2	7	13	PF00069	0.683
MOD_Plk_4	104	110	PF00069	0.429
MOD_Plk_4	90	96	PF00069	0.495
MOD_ProDKin_1	130	136	PF00069	0.627
MOD_ProDKin_1	69	75	PF00069	0.529
MOD_SUMO_rev_2	257	264	PF00179	0.508
TRG_AP2beta_CARGO_1	50	60	PF09066	0.602
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.531
TRG_ENDOCYTIC_2	109	112	PF00928	0.481
TRG_ENDOCYTIC_2	178	181	PF00928	0.417
TRG_ER_diArg_1	197	199	PF00400	0.427
TRG_ER_diArg_1	367	369	PF00400	0.598
TRG_ER_diArg_1	75	78	PF00400	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBK9	Leptomonas seymouri	39%	100%
A4HQ19	Leishmania braziliensis	69%	100%
A4IDS6	Leishmania infantum	99%	100%
E9ATT7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q0Q9	Leishmania major	91%	100%