Hypothetical_protein_conserved

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ILH7_LEIDO

TriTrypDb:

LdBPK_365140.1 , LdCL_360058600 , LDHU3_36.6860

Length:

360

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0030990	intraciliary transport particle	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8ILH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ILH7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	149	151	PF00675	0.529
CLV_NRD_NRD_1	15	17	PF00675	0.448
CLV_NRD_NRD_1	157	159	PF00675	0.453
CLV_NRD_NRD_1	188	190	PF00675	0.480
CLV_NRD_NRD_1	220	222	PF00675	0.404
CLV_NRD_NRD_1	274	276	PF00675	0.407
CLV_NRD_NRD_1	295	297	PF00675	0.505
CLV_NRD_NRD_1	33	35	PF00675	0.420
CLV_NRD_NRD_1	332	334	PF00675	0.414
CLV_NRD_NRD_1	336	338	PF00675	0.408
CLV_NRD_NRD_1	63	65	PF00675	0.494
CLV_PCSK_KEX2_1	113	115	PF00082	0.478
CLV_PCSK_KEX2_1	15	17	PF00082	0.448
CLV_PCSK_KEX2_1	183	185	PF00082	0.431
CLV_PCSK_KEX2_1	220	222	PF00082	0.404
CLV_PCSK_KEX2_1	295	297	PF00082	0.611
CLV_PCSK_KEX2_1	332	334	PF00082	0.455
CLV_PCSK_KEX2_1	52	54	PF00082	0.545
CLV_PCSK_KEX2_1	63	65	PF00082	0.457
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.502
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.462
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.461
CLV_PCSK_PC7_1	48	54	PF00082	0.539
CLV_PCSK_SKI1_1	131	135	PF00082	0.526
CLV_PCSK_SKI1_1	16	20	PF00082	0.474
CLV_PCSK_SKI1_1	220	224	PF00082	0.427
CLV_PCSK_SKI1_1	263	267	PF00082	0.456
CLV_PCSK_SKI1_1	319	323	PF00082	0.514
CLV_PCSK_SKI1_1	43	47	PF00082	0.489
CLV_PCSK_SKI1_1	52	56	PF00082	0.479
DEG_APCC_DBOX_1	15	23	PF00400	0.551
DOC_CYCLIN_RxL_1	221	234	PF00134	0.420
DOC_USP7_MATH_1	314	318	PF00917	0.416
DOC_USP7_MATH_1	5	9	PF00917	0.549
DOC_USP7_MATH_1	66	70	PF00917	0.674
DOC_USP7_UBL2_3	179	183	PF12436	0.580
LIG_14-3-3_CanoR_1	131	136	PF00244	0.605
LIG_14-3-3_CanoR_1	24	32	PF00244	0.548
LIG_14-3-3_CanoR_1	295	303	PF00244	0.509
LIG_FHA_1	224	230	PF00498	0.441
LIG_FHA_1	99	105	PF00498	0.523
LIG_FHA_2	264	270	PF00498	0.461
LIG_FHA_2	351	357	PF00498	0.509
LIG_LIR_Apic_2	297	303	PF02991	0.448
LIG_LIR_Gen_1	115	124	PF02991	0.531
LIG_LIR_Nem_3	115	119	PF02991	0.544
LIG_LIR_Nem_3	317	321	PF02991	0.443
LIG_Pex14_2	280	284	PF04695	0.425
LIG_PTB_Apo_2	230	237	PF02174	0.436
LIG_SH2_CRK	116	120	PF00017	0.499
LIG_SH2_CRK	318	322	PF00017	0.441
LIG_SH2_NCK_1	252	256	PF00017	0.442
LIG_SH2_NCK_1	70	74	PF00017	0.539
LIG_SH2_SRC	252	255	PF00017	0.446
LIG_SH2_SRC	300	303	PF00017	0.465
LIG_SH2_STAP1	120	124	PF00017	0.527
LIG_SH2_STAP1	252	256	PF00017	0.561
LIG_TRAF2_1	167	170	PF00917	0.536
LIG_TRAF2_1	257	260	PF00917	0.446
LIG_TRAF2_1	266	269	PF00917	0.456
LIG_UBA3_1	340	347	PF00899	0.394
MOD_CK2_1	263	269	PF00069	0.458
MOD_GlcNHglycan	7	10	PF01048	0.541
MOD_GlcNHglycan	76	79	PF01048	0.734
MOD_GlcNHglycan	91	94	PF01048	0.533
MOD_GSK3_1	346	353	PF00069	0.568
MOD_GSK3_1	81	88	PF00069	0.691
MOD_N-GLC_1	223	228	PF02516	0.544
MOD_NEK2_1	178	183	PF00069	0.414
MOD_NEK2_1	25	30	PF00069	0.576
MOD_NEK2_1	294	299	PF00069	0.452
MOD_NEK2_1	304	309	PF00069	0.555
MOD_NEK2_1	89	94	PF00069	0.690
MOD_PIKK_1	25	31	PF00454	0.467
MOD_PKA_1	244	250	PF00069	0.388
MOD_PKA_2	25	31	PF00069	0.570
MOD_PKA_2	294	300	PF00069	0.515
MOD_PKA_2	350	356	PF00069	0.495
MOD_PKA_2	89	95	PF00069	0.751
MOD_PKB_1	261	269	PF00069	0.604
MOD_Plk_1	223	229	PF00069	0.542
MOD_Plk_1	98	104	PF00069	0.665
MOD_SUMO_rev_2	154	161	PF00179	0.506
TRG_DiLeu_BaEn_1	260	265	PF01217	0.331
TRG_DiLeu_LyEn_5	260	265	PF01217	0.331
TRG_ENDOCYTIC_2	116	119	PF00928	0.508
TRG_ENDOCYTIC_2	252	255	PF00928	0.446
TRG_ENDOCYTIC_2	318	321	PF00928	0.445
TRG_ER_diArg_1	220	222	PF00400	0.444
TRG_ER_diArg_1	24	27	PF00400	0.415
TRG_ER_diArg_1	261	264	PF00400	0.523
TRG_ER_diArg_1	294	296	PF00400	0.482
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	227	232	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	263	268	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBM7	Leptomonas seymouri	68%	100%
A0A1X0P2Z9	Trypanosomatidae	40%	100%
A0A3R7KX10	Trypanosoma rangeli	38%	100%
A4HQ08	Leishmania braziliensis	82%	100%
A4IDR9	Leishmania infantum	100%	100%
D0A8W4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9ATS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q0S1	Leishmania major	98%	100%
V5B8Z3	Trypanosoma cruzi	40%	100%