LeishMANIAdb
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3'a2rel-related protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
3'a2rel-related protein
Gene product:
3'a2rel-related protein
Species:
Leishmania donovani
UniProt:
A0A3Q8ILH2_LEIDO
TriTrypDb:
LdBPK_220560.1 , LdCL_220011900 , LDHU3_22.1120
Length:
615

Annotations

LeishMANIAdb annotations

A very special family of kinetoplastid proteins, carrying multiply amyloid-like segments on their disordered extracellular domain, alongside with RGD motifs. Duplicated in Leishmaniids

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 4, no: 5
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

A0A3Q8ILH2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ILH2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 383 387 PF00656 0.683
CLV_C14_Caspase3-7 538 542 PF00656 0.769
CLV_NRD_NRD_1 175 177 PF00675 0.730
CLV_NRD_NRD_1 215 217 PF00675 0.704
CLV_NRD_NRD_1 246 248 PF00675 0.512
CLV_NRD_NRD_1 251 253 PF00675 0.484
CLV_NRD_NRD_1 331 333 PF00675 0.563
CLV_NRD_NRD_1 336 338 PF00675 0.530
CLV_PCSK_FUR_1 249 253 PF00082 0.437
CLV_PCSK_FUR_1 334 338 PF00082 0.509
CLV_PCSK_KEX2_1 175 177 PF00082 0.730
CLV_PCSK_KEX2_1 215 217 PF00082 0.704
CLV_PCSK_KEX2_1 246 248 PF00082 0.512
CLV_PCSK_KEX2_1 251 253 PF00082 0.484
CLV_PCSK_KEX2_1 333 335 PF00082 0.505
CLV_PCSK_KEX2_1 336 338 PF00082 0.486
CLV_PCSK_PC1ET2_1 251 253 PF00082 0.446
CLV_PCSK_PC1ET2_1 333 335 PF00082 0.505
CLV_PCSK_PC7_1 247 253 PF00082 0.428
CLV_PCSK_PC7_1 332 338 PF00082 0.508
CLV_PCSK_SKI1_1 176 180 PF00082 0.625
CLV_PCSK_SKI1_1 221 225 PF00082 0.596
CLV_PCSK_SKI1_1 25 29 PF00082 0.624
CLV_PCSK_SKI1_1 252 256 PF00082 0.488
CLV_PCSK_SKI1_1 461 465 PF00082 0.527
CLV_PCSK_SKI1_1 513 517 PF00082 0.477
DEG_APCC_DBOX_1 220 228 PF00400 0.361
DEG_Nend_UBRbox_4 1 3 PF02207 0.648
DEG_SCF_FBW7_1 151 157 PF00400 0.472
DEG_SPOP_SBC_1 128 132 PF00917 0.515
DEG_SPOP_SBC_1 154 158 PF00917 0.511
DEG_SPOP_SBC_1 201 205 PF00917 0.535
DEG_SPOP_SBC_1 437 441 PF00917 0.709
DOC_CKS1_1 151 156 PF01111 0.471
DOC_CKS1_1 43 48 PF01111 0.593
DOC_CYCLIN_RxL_1 173 182 PF00134 0.428
DOC_CYCLIN_RxL_1 249 262 PF00134 0.711
DOC_CYCLIN_RxL_1 458 468 PF00134 0.637
DOC_CYCLIN_yCln2_LP_2 230 236 PF00134 0.425
DOC_CYCLIN_yCln2_LP_2 80 86 PF00134 0.550
DOC_MAPK_gen_1 215 222 PF00069 0.431
DOC_MAPK_gen_1 249 259 PF00069 0.698
DOC_MAPK_gen_1 330 340 PF00069 0.691
DOC_MAPK_gen_1 69 78 PF00069 0.506
DOC_MAPK_MEF2A_6 215 224 PF00069 0.436
DOC_MAPK_MEF2A_6 25 32 PF00069 0.519
DOC_MAPK_MEF2A_6 69 78 PF00069 0.546
DOC_PP2B_LxvP_1 178 181 PF13499 0.418
DOC_PP2B_LxvP_1 230 233 PF13499 0.425
DOC_PP2B_LxvP_1 555 558 PF13499 0.772
DOC_PP2B_LxvP_1 71 74 PF13499 0.568
DOC_PP2B_LxvP_1 76 79 PF13499 0.557
DOC_SPAK_OSR1_1 301 305 PF12202 0.712
DOC_USP7_MATH_1 124 128 PF00917 0.553
DOC_USP7_MATH_1 129 133 PF00917 0.526
DOC_USP7_MATH_1 15 19 PF00917 0.593
DOC_USP7_MATH_1 154 158 PF00917 0.494
DOC_USP7_MATH_1 165 169 PF00917 0.478
DOC_USP7_MATH_1 170 174 PF00917 0.463
DOC_USP7_MATH_1 202 206 PF00917 0.535
DOC_USP7_MATH_1 402 406 PF00917 0.778
DOC_USP7_MATH_1 410 414 PF00917 0.721
DOC_USP7_MATH_1 423 427 PF00917 0.687
DOC_USP7_MATH_1 437 441 PF00917 0.652
DOC_USP7_MATH_1 490 494 PF00917 0.769
DOC_USP7_MATH_1 507 511 PF00917 0.645
DOC_USP7_UBL2_3 251 255 PF12436 0.657
DOC_WW_Pin1_4 11 16 PF00397 0.665
DOC_WW_Pin1_4 134 139 PF00397 0.545
DOC_WW_Pin1_4 150 155 PF00397 0.464
DOC_WW_Pin1_4 286 291 PF00397 0.667
DOC_WW_Pin1_4 360 365 PF00397 0.791
DOC_WW_Pin1_4 42 47 PF00397 0.627
LIG_14-3-3_CanoR_1 16 23 PF00244 0.572
LIG_14-3-3_CanoR_1 166 174 PF00244 0.508
LIG_14-3-3_CanoR_1 175 179 PF00244 0.486
LIG_14-3-3_CanoR_1 568 575 PF00244 0.754
LIG_EVH1_2 208 212 PF00568 0.524
LIG_FHA_1 38 44 PF00498 0.545
LIG_FHA_1 409 415 PF00498 0.784
LIG_FHA_1 437 443 PF00498 0.709
LIG_FHA_1 457 463 PF00498 0.721
LIG_FHA_1 52 58 PF00498 0.414
LIG_FHA_1 75 81 PF00498 0.543
LIG_FHA_2 568 574 PF00498 0.799
LIG_Integrin_isoDGR_2 141 143 PF01839 0.711
LIG_Integrin_RGD_1 47 49 PF01839 0.649
LIG_Integrin_RGD_1 536 538 PF01839 0.573
LIG_LIR_Gen_1 281 290 PF02991 0.745
LIG_LIR_Gen_1 35 43 PF02991 0.570
LIG_LIR_Gen_1 514 524 PF02991 0.704
LIG_LIR_Nem_3 281 285 PF02991 0.740
LIG_LIR_Nem_3 316 322 PF02991 0.663
LIG_LIR_Nem_3 514 519 PF02991 0.700
LIG_MYND_1 79 83 PF01753 0.468
LIG_NRBOX 28 34 PF00104 0.490
LIG_SH2_GRB2like 455 458 PF00017 0.733
LIG_SH2_SRC 611 614 PF00017 0.708
LIG_SH2_STAT5 432 435 PF00017 0.642
LIG_SH2_STAT5 455 458 PF00017 0.733
LIG_SH2_STAT5 467 470 PF00017 0.659
LIG_SH2_STAT5 611 614 PF00017 0.713
LIG_SH3_3 148 154 PF00018 0.476
LIG_SH3_3 40 46 PF00018 0.588
LIG_SH3_3 473 479 PF00018 0.769
LIG_SH3_3 506 512 PF00018 0.744
LIG_SH3_3 607 613 PF00018 0.673
LIG_SH3_3 81 87 PF00018 0.606
LIG_SUMO_SIM_anti_2 185 191 PF11976 0.528
LIG_SUMO_SIM_par_1 187 193 PF11976 0.586
LIG_TRAF2_1 119 122 PF00917 0.520
LIG_TRAF2_1 379 382 PF00917 0.783
LIG_WRC_WIRS_1 108 113 PF05994 0.501
LIG_WRC_WIRS_1 33 38 PF05994 0.516
LIG_WRC_WIRS_1 519 524 PF05994 0.676
MOD_CDK_SPK_2 11 16 PF00069 0.603
MOD_CDK_SPK_2 42 47 PF00069 0.526
MOD_CDK_SPxK_1 286 292 PF00069 0.670
MOD_CK1_1 127 133 PF00069 0.557
MOD_CK1_1 134 140 PF00069 0.514
MOD_CK1_1 157 163 PF00069 0.552
MOD_CK1_1 169 175 PF00069 0.454
MOD_CK1_1 363 369 PF00069 0.758
MOD_CK1_1 37 43 PF00069 0.534
MOD_CK1_1 441 447 PF00069 0.765
MOD_CK2_1 375 381 PF00069 0.789
MOD_CK2_1 495 501 PF00069 0.761
MOD_CK2_1 511 517 PF00069 0.625
MOD_CK2_1 567 573 PF00069 0.800
MOD_GlcNHglycan 121 125 PF01048 0.748
MOD_GlcNHglycan 133 136 PF01048 0.685
MOD_GlcNHglycan 168 171 PF01048 0.721
MOD_GlcNHglycan 181 184 PF01048 0.770
MOD_GlcNHglycan 204 207 PF01048 0.746
MOD_GlcNHglycan 365 368 PF01048 0.584
MOD_GlcNHglycan 394 397 PF01048 0.558
MOD_GlcNHglycan 404 407 PF01048 0.512
MOD_GlcNHglycan 426 429 PF01048 0.586
MOD_GlcNHglycan 470 473 PF01048 0.585
MOD_GlcNHglycan 480 483 PF01048 0.573
MOD_GlcNHglycan 497 500 PF01048 0.495
MOD_GlcNHglycan 503 506 PF01048 0.532
MOD_GlcNHglycan 547 550 PF01048 0.552
MOD_GlcNHglycan 57 60 PF01048 0.761
MOD_GlcNHglycan 606 609 PF01048 0.514
MOD_GlcNHglycan 91 94 PF01048 0.722
MOD_GSK3_1 11 18 PF00069 0.690
MOD_GSK3_1 120 127 PF00069 0.516
MOD_GSK3_1 130 137 PF00069 0.498
MOD_GSK3_1 150 157 PF00069 0.456
MOD_GSK3_1 165 172 PF00069 0.437
MOD_GSK3_1 286 293 PF00069 0.679
MOD_GSK3_1 37 44 PF00069 0.578
MOD_GSK3_1 382 389 PF00069 0.725
MOD_GSK3_1 437 444 PF00069 0.764
MOD_GSK3_1 507 514 PF00069 0.721
MOD_GSK3_1 51 58 PF00069 0.427
MOD_GSK3_1 600 607 PF00069 0.677
MOD_N-GLC_1 11 16 PF02516 0.716
MOD_N-GLC_1 259 264 PF02516 0.544
MOD_N-GLC_1 456 461 PF02516 0.523
MOD_NEK2_1 120 125 PF00069 0.505
MOD_NEK2_1 174 179 PF00069 0.527
MOD_NEK2_1 259 264 PF00069 0.776
MOD_NEK2_1 32 37 PF00069 0.601
MOD_NEK2_1 456 461 PF00069 0.743
MOD_NEK2_1 55 60 PF00069 0.498
MOD_NEK2_2 170 175 PF00069 0.507
MOD_NEK2_2 490 495 PF00069 0.729
MOD_PIKK_1 109 115 PF00454 0.498
MOD_PIKK_1 600 606 PF00454 0.677
MOD_PK_1 511 517 PF00069 0.623
MOD_PKA_2 142 148 PF00069 0.507
MOD_PKA_2 15 21 PF00069 0.562
MOD_PKA_2 165 171 PF00069 0.528
MOD_PKA_2 174 180 PF00069 0.464
MOD_PKA_2 245 251 PF00069 0.698
MOD_PKA_2 300 306 PF00069 0.710
MOD_PKA_2 465 471 PF00069 0.666
MOD_PKA_2 539 545 PF00069 0.694
MOD_PKA_2 567 573 PF00069 0.766
MOD_PKA_2 604 610 PF00069 0.678
MOD_Plk_1 315 321 PF00069 0.683
MOD_Plk_1 457 463 PF00069 0.648
MOD_Plk_1 490 496 PF00069 0.668
MOD_Plk_2-3 567 573 PF00069 0.757
MOD_Plk_4 410 416 PF00069 0.782
MOD_Plk_4 438 444 PF00069 0.755
MOD_Plk_4 511 517 PF00069 0.677
MOD_ProDKin_1 11 17 PF00069 0.656
MOD_ProDKin_1 134 140 PF00069 0.544
MOD_ProDKin_1 150 156 PF00069 0.465
MOD_ProDKin_1 286 292 PF00069 0.670
MOD_ProDKin_1 360 366 PF00069 0.792
MOD_ProDKin_1 42 48 PF00069 0.628
TRG_DiLeu_BaLyEn_6 76 81 PF01217 0.468
TRG_ER_diArg_1 174 176 PF00400 0.535
TRG_ER_diArg_1 246 249 PF00400 0.649
TRG_ER_diArg_1 334 337 PF00400 0.711
TRG_ER_diArg_1 560 563 PF00400 0.690
TRG_NLS_MonoExtC_3 250 255 PF00514 0.650
TRG_NLS_MonoExtC_3 331 336 PF00514 0.710
TRG_NLS_MonoExtN_4 249 256 PF00514 0.651
TRG_NLS_MonoExtN_4 330 337 PF00514 0.710

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7WX43 Leishmania donovani 99% 100%
A4HCB1 Leishmania braziliensis 63% 100%
A4HDA2 Leishmania braziliensis 57% 100%
E9AGZ2 Leishmania infantum 98% 100%
E9AGZ3 Leishmania infantum 98% 100%
E9AVQ1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
Q4QBR2 Leishmania major 88% 100%
Q4QBS8 Leishmania major 88% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS