LeishMANIAdb
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Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein, pseudogene
Species:
Leishmania donovani
UniProt:
A0A3Q8ILG5_LEIDO
TriTrypDb:
LdBPK_343430.1 * , LdCL_340043700 , LDHU3_34.5660
Length:
107

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 9
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 3, no: 5
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

A0A3Q8ILG5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ILG5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 4 6 PF00675 0.663
DEG_SCF_FBW7_2 86 93 PF00400 0.657
DEG_SPOP_SBC_1 23 27 PF00917 0.618
DOC_USP7_UBL2_3 76 80 PF12436 0.716
DOC_WW_Pin1_4 28 33 PF00397 0.440
DOC_WW_Pin1_4 86 91 PF00397 0.678
LIG_APCC_ABBAyCdc20_2 30 36 PF00400 0.394
LIG_BIR_II_1 1 5 PF00653 0.520
LIG_eIF4E_1 58 64 PF01652 0.585
LIG_GBD_Chelix_1 52 60 PF00786 0.410
LIG_LIR_Nem_3 59 64 PF02991 0.588
LIG_PDZ_Class_3 102 107 PF00595 0.633
LIG_SH2_STAT5 58 61 PF00017 0.575
MOD_CDK_SPK_2 86 91 PF00069 0.598
MOD_CDK_SPxK_1 86 92 PF00069 0.598
MOD_GlcNHglycan 102 105 PF01048 0.624
MOD_GlcNHglycan 68 71 PF01048 0.705
MOD_GSK3_1 22 29 PF00069 0.721
MOD_GSK3_1 66 73 PF00069 0.703
MOD_N-GLC_1 86 91 PF02516 0.594
MOD_NEK2_1 56 61 PF00069 0.426
MOD_NEK2_1 72 77 PF00069 0.641
MOD_Plk_4 48 54 PF00069 0.452
MOD_Plk_4 56 62 PF00069 0.484
MOD_ProDKin_1 28 34 PF00069 0.543
MOD_ProDKin_1 86 92 PF00069 0.598
MOD_SUMO_for_1 90 93 PF00179 0.639
TRG_DiLeu_BaLyEn_6 59 64 PF01217 0.419
TRG_ER_diArg_1 65 68 PF00400 0.574

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P279 Leptomonas seymouri 48% 68%
A0A3S7X8E8 Leishmania donovani 76% 66%
A4HB83 Leishmania braziliensis 61% 100%
A4IAD0 Leishmania infantum 76% 66%
E9AEH7 Leishmania major 72% 98%
E9B5F4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 68% 100%
Q4Q2I0 Leishmania major 60% 66%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS