Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ILF7_LEIDO

TriTrypDb:

LdBPK_220280.1 , LdCL_220008900 , LDHU3_22.0560

Length:

727

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ILF7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ILF7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	617	621	PF00656	0.570
CLV_NRD_NRD_1	102	104	PF00675	0.577
CLV_NRD_NRD_1	128	130	PF00675	0.549
CLV_NRD_NRD_1	187	189	PF00675	0.397
CLV_NRD_NRD_1	293	295	PF00675	0.659
CLV_NRD_NRD_1	414	416	PF00675	0.439
CLV_NRD_NRD_1	418	420	PF00675	0.387
CLV_NRD_NRD_1	429	431	PF00675	0.343
CLV_NRD_NRD_1	530	532	PF00675	0.424
CLV_NRD_NRD_1	576	578	PF00675	0.438
CLV_NRD_NRD_1	623	625	PF00675	0.565
CLV_NRD_NRD_1	649	651	PF00675	0.486
CLV_NRD_NRD_1	70	72	PF00675	0.635
CLV_PCSK_FUR_1	412	416	PF00082	0.495
CLV_PCSK_KEX2_1	128	130	PF00082	0.579
CLV_PCSK_KEX2_1	293	295	PF00082	0.707
CLV_PCSK_KEX2_1	414	416	PF00082	0.439
CLV_PCSK_KEX2_1	418	420	PF00082	0.387
CLV_PCSK_KEX2_1	429	431	PF00082	0.343
CLV_PCSK_KEX2_1	530	532	PF00082	0.424
CLV_PCSK_KEX2_1	576	578	PF00082	0.438
CLV_PCSK_KEX2_1	622	624	PF00082	0.599
CLV_PCSK_KEX2_1	649	651	PF00082	0.486
CLV_PCSK_KEX2_1	70	72	PF00082	0.650
CLV_PCSK_PC7_1	414	420	PF00082	0.437
CLV_PCSK_SKI1_1	184	188	PF00082	0.374
CLV_PCSK_SKI1_1	429	433	PF00082	0.432
CLV_PCSK_SKI1_1	549	553	PF00082	0.482
CLV_PCSK_SKI1_1	632	636	PF00082	0.707
CLV_PCSK_SKI1_1	695	699	PF00082	0.516
CLV_PCSK_SKI1_1	706	710	PF00082	0.385
DEG_APCC_DBOX_1	506	514	PF00400	0.452
DEG_COP1_1	474	483	PF00400	0.548
DEG_SCF_FBW7_2	510	515	PF00400	0.451
DOC_CKS1_1	210	215	PF01111	0.696
DOC_CKS1_1	224	229	PF01111	0.500
DOC_CYCLIN_yCln2_LP_2	134	140	PF00134	0.452
DOC_MAPK_gen_1	128	138	PF00069	0.504
DOC_MAPK_HePTP_8	138	150	PF00069	0.411
DOC_MAPK_MEF2A_6	129	138	PF00069	0.503
DOC_MAPK_MEF2A_6	141	150	PF00069	0.402
DOC_MAPK_MEF2A_6	270	279	PF00069	0.567
DOC_MAPK_MEF2A_6	492	499	PF00069	0.388
DOC_MAPK_NFAT4_5	131	139	PF00069	0.467
DOC_MAPK_RevD_3	174	189	PF00069	0.416
DOC_PP2B_LxvP_1	134	137	PF13499	0.449
DOC_PP2B_LxvP_1	158	161	PF13499	0.459
DOC_PP2B_LxvP_1	225	228	PF13499	0.638
DOC_PP2B_LxvP_1	436	439	PF13499	0.415
DOC_PP2B_LxvP_1	74	77	PF13499	0.610
DOC_PP2B_LxvP_1	93	96	PF13499	0.618
DOC_USP7_MATH_1	110	114	PF00917	0.538
DOC_USP7_MATH_1	296	300	PF00917	0.640
DOC_USP7_MATH_1	443	447	PF00917	0.464
DOC_USP7_MATH_1	479	483	PF00917	0.648
DOC_USP7_MATH_1	566	570	PF00917	0.492
DOC_USP7_MATH_1	58	62	PF00917	0.626
DOC_USP7_MATH_1	615	619	PF00917	0.559
DOC_USP7_MATH_1	643	647	PF00917	0.552
DOC_USP7_MATH_1	96	100	PF00917	0.692
DOC_USP7_UBL2_3	36	40	PF12436	0.664
DOC_WW_Pin1_4	209	214	PF00397	0.698
DOC_WW_Pin1_4	223	228	PF00397	0.549
DOC_WW_Pin1_4	357	362	PF00397	0.502
DOC_WW_Pin1_4	508	513	PF00397	0.447
DOC_WW_Pin1_4	549	554	PF00397	0.503
DOC_WW_Pin1_4	559	564	PF00397	0.526
DOC_WW_Pin1_4	65	70	PF00397	0.689
LIG_14-3-3_CanoR_1	129	135	PF00244	0.422
LIG_14-3-3_CanoR_1	151	157	PF00244	0.392
LIG_14-3-3_CanoR_1	216	222	PF00244	0.650
LIG_14-3-3_CanoR_1	452	456	PF00244	0.565
LIG_14-3-3_CanoR_1	530	540	PF00244	0.460
LIG_14-3-3_CanoR_1	650	656	PF00244	0.394
LIG_APCC_ABBA_1	275	280	PF00400	0.560
LIG_APCC_ABBAyCdc20_2	684	690	PF00400	0.466
LIG_APCC_ABBAyCdc20_2	706	712	PF00400	0.437
LIG_BIR_III_2	281	285	PF00653	0.602
LIG_BIR_III_2	75	79	PF00653	0.569
LIG_BIR_III_4	372	376	PF00653	0.379
LIG_BRCT_BRCA1_1	644	648	PF00533	0.614
LIG_Clathr_ClatBox_1	22	26	PF01394	0.555
LIG_deltaCOP1_diTrp_1	598	606	PF00928	0.510
LIG_FHA_1	171	177	PF00498	0.484
LIG_FHA_1	224	230	PF00498	0.562
LIG_FHA_1	269	275	PF00498	0.648
LIG_FHA_1	302	308	PF00498	0.671
LIG_FHA_1	315	321	PF00498	0.490
LIG_FHA_1	392	398	PF00498	0.424
LIG_FHA_1	499	505	PF00498	0.495
LIG_FHA_2	167	173	PF00498	0.372
LIG_FHA_2	210	216	PF00498	0.749
LIG_FHA_2	452	458	PF00498	0.632
LIG_FHA_2	472	478	PF00498	0.622
LIG_FHA_2	6	12	PF00498	0.540
LIG_Integrin_RGD_1	577	579	PF01839	0.418
LIG_LIR_Gen_1	331	339	PF02991	0.397
LIG_LIR_Gen_1	661	671	PF02991	0.379
LIG_LIR_Gen_1	700	709	PF02991	0.494
LIG_LIR_Nem_3	126	130	PF02991	0.413
LIG_LIR_Nem_3	331	337	PF02991	0.410
LIG_LIR_Nem_3	360	366	PF02991	0.619
LIG_LIR_Nem_3	661	667	PF02991	0.370
LIG_LIR_Nem_3	690	694	PF02991	0.478
LIG_LIR_Nem_3	700	704	PF02991	0.490
LIG_MYND_1	559	563	PF01753	0.536
LIG_NRBOX	220	226	PF00104	0.646
LIG_Pex14_1	601	605	PF04695	0.506
LIG_SH2_CRK	694	698	PF00017	0.375
LIG_SH2_GRB2like	586	589	PF00017	0.499
LIG_SH2_PTP2	664	667	PF00017	0.366
LIG_SH2_STAP1	376	380	PF00017	0.398
LIG_SH2_STAP1	701	705	PF00017	0.480
LIG_SH2_STAT3	366	369	PF00017	0.423
LIG_SH2_STAT5	389	392	PF00017	0.408
LIG_SH2_STAT5	519	522	PF00017	0.346
LIG_SH2_STAT5	580	583	PF00017	0.405
LIG_SH2_STAT5	586	589	PF00017	0.475
LIG_SH2_STAT5	664	667	PF00017	0.371
LIG_SH3_3	207	213	PF00018	0.703
LIG_SH3_3	261	267	PF00018	0.567
LIG_SH3_3	557	563	PF00018	0.599
LIG_SH3_3	66	72	PF00018	0.669
LIG_SH3_3	662	668	PF00018	0.373
LIG_SUMO_SIM_anti_2	391	399	PF11976	0.569
LIG_SUMO_SIM_par_1	164	173	PF11976	0.406
LIG_SUMO_SIM_par_1	217	222	PF11976	0.632
LIG_SUMO_SIM_par_1	335	340	PF11976	0.361
LIG_SUMO_SIM_par_1	391	403	PF11976	0.579
LIG_TRAF2_1	461	464	PF00917	0.648
LIG_TRFH_1	366	370	PF08558	0.489
LIG_TRFH_1	664	668	PF08558	0.370
MOD_CDK_SPK_2	65	70	PF00069	0.665
MOD_CDK_SPxK_1	508	514	PF00069	0.381
MOD_CDK_SPxK_1	65	71	PF00069	0.665
MOD_CDK_SPxxK_3	209	216	PF00069	0.566
MOD_CK1_1	265	271	PF00069	0.677
MOD_CK1_1	357	363	PF00069	0.517
MOD_CK1_1	47	53	PF00069	0.716
MOD_CK1_1	482	488	PF00069	0.429
MOD_CK1_1	5	11	PF00069	0.704
MOD_CK1_1	60	66	PF00069	0.583
MOD_CK1_1	86	92	PF00069	0.619
MOD_CK2_1	166	172	PF00069	0.368
MOD_CK2_1	471	477	PF00069	0.632
MOD_CK2_1	5	11	PF00069	0.547
MOD_Cter_Amidation	620	623	PF01082	0.579
MOD_DYRK1A_RPxSP_1	549	553	PF00069	0.570
MOD_GlcNHglycan	100	103	PF01048	0.645
MOD_GlcNHglycan	294	297	PF01048	0.647
MOD_GlcNHglycan	339	342	PF01048	0.379
MOD_GlcNHglycan	444	448	PF01048	0.588
MOD_GlcNHglycan	638	641	PF01048	0.602
MOD_GlcNHglycan	64	67	PF01048	0.693
MOD_GSK3_1	110	117	PF00069	0.591
MOD_GSK3_1	166	173	PF00069	0.439
MOD_GSK3_1	284	291	PF00069	0.619
MOD_GSK3_1	292	299	PF00069	0.596
MOD_GSK3_1	301	308	PF00069	0.675
MOD_GSK3_1	310	317	PF00069	0.592
MOD_GSK3_1	389	396	PF00069	0.460
MOD_GSK3_1	482	489	PF00069	0.421
MOD_GSK3_1	53	60	PF00069	0.632
MOD_GSK3_1	611	618	PF00069	0.709
MOD_GSK3_1	628	635	PF00069	0.664
MOD_N-GLC_1	643	648	PF02516	0.512
MOD_NEK2_1	152	157	PF00069	0.417
MOD_NEK2_1	177	182	PF00069	0.595
MOD_NEK2_1	354	359	PF00069	0.484
MOD_NEK2_1	448	453	PF00069	0.610
MOD_NEK2_1	486	491	PF00069	0.320
MOD_NEK2_1	97	102	PF00069	0.549
MOD_NEK2_2	643	648	PF00069	0.623
MOD_PIKK_1	17	23	PF00454	0.574
MOD_PIKK_1	296	302	PF00454	0.635
MOD_PIKK_1	355	361	PF00454	0.475
MOD_PIKK_1	531	537	PF00454	0.466
MOD_PIKK_1	615	621	PF00454	0.648
MOD_PIKK_1	716	722	PF00454	0.494
MOD_PKA_1	623	629	PF00069	0.575
MOD_PKA_2	130	136	PF00069	0.552
MOD_PKA_2	292	298	PF00069	0.648
MOD_PKA_2	451	457	PF00069	0.613
MOD_PKA_2	615	621	PF00069	0.684
MOD_PKA_2	623	629	PF00069	0.542
MOD_Plk_1	324	330	PF00069	0.542
MOD_Plk_1	443	449	PF00069	0.532
MOD_Plk_1	643	649	PF00069	0.524
MOD_Plk_2-3	166	172	PF00069	0.368
MOD_Plk_4	111	117	PF00069	0.543
MOD_Plk_4	482	488	PF00069	0.586
MOD_Plk_4	500	506	PF00069	0.332
MOD_Plk_4	643	649	PF00069	0.542
MOD_Plk_4	651	657	PF00069	0.441
MOD_Plk_4	659	665	PF00069	0.506
MOD_ProDKin_1	209	215	PF00069	0.698
MOD_ProDKin_1	223	229	PF00069	0.552
MOD_ProDKin_1	357	363	PF00069	0.495
MOD_ProDKin_1	508	514	PF00069	0.453
MOD_ProDKin_1	549	555	PF00069	0.506
MOD_ProDKin_1	559	565	PF00069	0.523
MOD_ProDKin_1	65	71	PF00069	0.690
TRG_DiLeu_BaEn_1	393	398	PF01217	0.471
TRG_DiLeu_BaEn_1	543	548	PF01217	0.539
TRG_DiLeu_BaEn_4	143	149	PF01217	0.474
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.370
TRG_DiLeu_BaLyEn_6	158	163	PF01217	0.385
TRG_DiLeu_BaLyEn_6	225	230	PF01217	0.622
TRG_ENDOCYTIC_2	376	379	PF00928	0.415
TRG_ENDOCYTIC_2	519	522	PF00928	0.373
TRG_ENDOCYTIC_2	664	667	PF00928	0.366
TRG_ENDOCYTIC_2	694	697	PF00928	0.448
TRG_ENDOCYTIC_2	701	704	PF00928	0.460
TRG_ER_diArg_1	127	129	PF00400	0.502
TRG_ER_diArg_1	412	415	PF00400	0.454
TRG_ER_diArg_1	429	431	PF00400	0.316
TRG_ER_diArg_1	529	531	PF00400	0.414
TRG_ER_diArg_1	575	577	PF00400	0.445
TRG_ER_diArg_1	622	624	PF00400	0.586
TRG_ER_diArg_1	648	650	PF00400	0.501
TRG_ER_diArg_1	69	71	PF00400	0.654
TRG_NES_CRM1_1	165	178	PF08389	0.403
TRG_Pf-PMV_PEXEL_1	351	355	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	430	435	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	713	717	PF00026	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4U6	Leptomonas seymouri	41%	97%
A4HC89	Leishmania braziliensis	65%	100%
A4HZR8	Leishmania infantum	100%	100%
E9AVM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
Q4QBV5	Leishmania major	89%	100%