PSP1 C-terminal conserved region containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PSP1 C-terminal conserved region, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ILF1_LEIDO

TriTrypDb:

LdBPK_364790.1 , LdCL_360055000 , LDHU3_36.6450

Length:

584

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8ILF1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ILF1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	580	584	PF00656	0.382
CLV_NRD_NRD_1	19	21	PF00675	0.435
CLV_NRD_NRD_1	472	474	PF00675	0.520
CLV_NRD_NRD_1	519	521	PF00675	0.293
CLV_PCSK_KEX2_1	409	411	PF00082	0.384
CLV_PCSK_KEX2_1	474	476	PF00082	0.478
CLV_PCSK_KEX2_1	519	521	PF00082	0.293
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.384
CLV_PCSK_PC1ET2_1	474	476	PF00082	0.478
CLV_PCSK_SKI1_1	379	383	PF00082	0.474
CLV_PCSK_SKI1_1	548	552	PF00082	0.310
CLV_Separin_Metazoa	564	568	PF03568	0.293
DEG_APCC_DBOX_1	11	19	PF00400	0.505
DEG_SPOP_SBC_1	271	275	PF00917	0.555
DOC_CYCLIN_RxL_1	189	200	PF00134	0.603
DOC_CYCLIN_RxL_1	32	43	PF00134	0.432
DOC_MAPK_gen_1	375	383	PF00069	0.460
DOC_MAPK_gen_1	473	482	PF00069	0.421
DOC_MAPK_gen_1	571	581	PF00069	0.339
DOC_MAPK_JIP1_4	377	383	PF00069	0.455
DOC_MAPK_MEF2A_6	399	408	PF00069	0.350
DOC_MAPK_MEF2A_6	434	442	PF00069	0.341
DOC_MAPK_MEF2A_6	473	482	PF00069	0.421
DOC_PP1_RVXF_1	546	553	PF00149	0.293
DOC_USP7_MATH_1	127	131	PF00917	0.656
DOC_USP7_MATH_1	348	352	PF00917	0.496
DOC_USP7_MATH_1	398	402	PF00917	0.395
DOC_USP7_MATH_1	4	8	PF00917	0.492
DOC_USP7_MATH_1	469	473	PF00917	0.500
DOC_WW_Pin1_4	105	110	PF00397	0.721
DOC_WW_Pin1_4	115	120	PF00397	0.609
DOC_WW_Pin1_4	185	190	PF00397	0.575
DOC_WW_Pin1_4	200	205	PF00397	0.617
DOC_WW_Pin1_4	245	250	PF00397	0.654
DOC_WW_Pin1_4	297	302	PF00397	0.610
DOC_WW_Pin1_4	320	325	PF00397	0.615
DOC_WW_Pin1_4	333	338	PF00397	0.520
DOC_WW_Pin1_4	387	392	PF00397	0.454
DOC_WW_Pin1_4	60	65	PF00397	0.537
LIG_14-3-3_CanoR_1	263	271	PF00244	0.540
LIG_14-3-3_CanoR_1	399	406	PF00244	0.358
LIG_14-3-3_CanoR_1	500	507	PF00244	0.293
LIG_Actin_WH2_2	484	502	PF00022	0.402
LIG_BIR_III_4	338	342	PF00653	0.614
LIG_BRCT_BRCA1_1	225	229	PF00533	0.587
LIG_BRCT_BRCA1_1	275	279	PF00533	0.740
LIG_FHA_1	126	132	PF00498	0.669
LIG_FHA_1	250	256	PF00498	0.541
LIG_FHA_1	34	40	PF00498	0.403
LIG_FHA_1	364	370	PF00498	0.422
LIG_FHA_2	511	517	PF00498	0.293
LIG_LIR_Apic_2	418	424	PF02991	0.377
LIG_LIR_Gen_1	40	48	PF02991	0.422
LIG_LIR_Gen_1	426	433	PF02991	0.359
LIG_LIR_Gen_1	78	87	PF02991	0.580
LIG_LIR_LC3C_4	437	442	PF02991	0.315
LIG_LIR_Nem_3	282	288	PF02991	0.586
LIG_LIR_Nem_3	40	44	PF02991	0.432
LIG_LIR_Nem_3	426	430	PF02991	0.352
LIG_LIR_Nem_3	561	565	PF02991	0.293
LIG_LIR_Nem_3	78	83	PF02991	0.620
LIG_MYND_1	309	313	PF01753	0.653
LIG_PCNA_yPIPBox_3	153	162	PF02747	0.639
LIG_PDZ_Class_2	579	584	PF00595	0.370
LIG_SH2_GRB2like	72	75	PF00017	0.626
LIG_SH2_PTP2	421	424	PF00017	0.361
LIG_SH2_PTP2	427	430	PF00017	0.344
LIG_SH2_SRC	427	430	PF00017	0.344
LIG_SH2_STAP1	304	308	PF00017	0.610
LIG_SH2_STAT3	554	557	PF00017	0.293
LIG_SH2_STAT5	161	164	PF00017	0.638
LIG_SH2_STAT5	304	307	PF00017	0.585
LIG_SH2_STAT5	421	424	PF00017	0.361
LIG_SH2_STAT5	427	430	PF00017	0.344
LIG_SH2_STAT5	443	446	PF00017	0.333
LIG_SH3_3	116	122	PF00018	0.671
LIG_SH3_3	184	190	PF00018	0.706
LIG_SH3_3	201	207	PF00018	0.558
LIG_SUMO_SIM_anti_2	256	262	PF11976	0.718
LIG_SUMO_SIM_par_1	256	262	PF11976	0.585
LIG_SUMO_SIM_par_1	535	540	PF11976	0.293
LIG_TYR_ITIM	39	44	PF00017	0.434
LIG_WRC_WIRS_1	570	575	PF05994	0.293
MOD_CDK_SPxK_1	115	121	PF00069	0.610
MOD_CDK_SPxK_1	185	191	PF00069	0.632
MOD_CDK_SPxK_1	387	393	PF00069	0.513
MOD_CDK_SPxxK_3	185	192	PF00069	0.559
MOD_CDK_SPxxK_3	320	327	PF00069	0.615
MOD_CK1_1	151	157	PF00069	0.598
MOD_CK1_1	178	184	PF00069	0.791
MOD_CK1_1	197	203	PF00069	0.577
MOD_CK1_1	205	211	PF00069	0.610
MOD_CK1_1	78	84	PF00069	0.612
MOD_CK2_1	253	259	PF00069	0.593
MOD_CK2_1	280	286	PF00069	0.567
MOD_CK2_1	37	43	PF00069	0.437
MOD_CK2_1	397	403	PF00069	0.419
MOD_CK2_1	510	516	PF00069	0.293
MOD_GlcNHglycan	150	153	PF01048	0.582
MOD_GlcNHglycan	225	228	PF01048	0.718
MOD_GlcNHglycan	267	270	PF01048	0.556
MOD_GlcNHglycan	276	279	PF01048	0.518
MOD_GlcNHglycan	342	345	PF01048	0.711
MOD_GlcNHglycan	469	472	PF01048	0.642
MOD_GlcNHglycan	80	83	PF01048	0.623
MOD_GlcNHglycan	94	97	PF01048	0.522
MOD_GSK3_1	121	128	PF00069	0.763
MOD_GSK3_1	142	149	PF00069	0.671
MOD_GSK3_1	237	244	PF00069	0.655
MOD_GSK3_1	245	252	PF00069	0.535
MOD_GSK3_1	270	277	PF00069	0.610
MOD_GSK3_1	33	40	PF00069	0.400
MOD_GSK3_1	465	472	PF00069	0.569
MOD_GSK3_1	60	67	PF00069	0.554
MOD_N-GLC_1	115	120	PF02516	0.609
MOD_N-GLC_1	200	205	PF02516	0.707
MOD_N-GLC_1	237	242	PF02516	0.683
MOD_N-GLC_1	264	269	PF02516	0.568
MOD_N-GLC_1	271	276	PF02516	0.581
MOD_N-GLC_1	494	499	PF02516	0.389
MOD_NEK2_1	131	136	PF00069	0.618
MOD_NEK2_1	148	153	PF00069	0.606
MOD_NEK2_1	194	199	PF00069	0.607
MOD_NEK2_1	229	234	PF00069	0.756
MOD_NEK2_1	264	269	PF00069	0.621
MOD_NEK2_1	365	370	PF00069	0.461
MOD_NEK2_1	37	42	PF00069	0.444
MOD_NEK2_1	465	470	PF00069	0.559
MOD_NEK2_1	482	487	PF00069	0.385
MOD_NEK2_1	510	515	PF00069	0.293
MOD_NEK2_1	530	535	PF00069	0.336
MOD_NEK2_1	569	574	PF00069	0.293
MOD_NEK2_1	92	97	PF00069	0.594
MOD_NEK2_2	353	358	PF00069	0.456
MOD_PIKK_1	194	200	PF00454	0.619
MOD_PIKK_1	249	255	PF00454	0.550
MOD_PIKK_1	28	34	PF00454	0.323
MOD_PIKK_1	295	301	PF00454	0.633
MOD_PIKK_1	510	516	PF00454	0.293
MOD_PKA_1	548	554	PF00069	0.293
MOD_PKA_2	398	404	PF00069	0.379
MOD_Plk_1	530	536	PF00069	0.293
MOD_Plk_4	14	20	PF00069	0.436
MOD_Plk_4	216	222	PF00069	0.562
MOD_Plk_4	241	247	PF00069	0.621
MOD_Plk_4	253	259	PF00069	0.545
MOD_Plk_4	280	286	PF00069	0.537
MOD_Plk_4	423	429	PF00069	0.361
MOD_Plk_4	494	500	PF00069	0.279
MOD_Plk_4	548	554	PF00069	0.293
MOD_Plk_4	75	81	PF00069	0.630
MOD_ProDKin_1	105	111	PF00069	0.721
MOD_ProDKin_1	115	121	PF00069	0.610
MOD_ProDKin_1	185	191	PF00069	0.578
MOD_ProDKin_1	200	206	PF00069	0.615
MOD_ProDKin_1	245	251	PF00069	0.648
MOD_ProDKin_1	297	303	PF00069	0.610
MOD_ProDKin_1	320	326	PF00069	0.615
MOD_ProDKin_1	333	339	PF00069	0.520
MOD_ProDKin_1	387	393	PF00069	0.458
MOD_ProDKin_1	60	66	PF00069	0.543
MOD_SUMO_rev_2	540	550	PF00179	0.293
TRG_DiLeu_BaEn_1	436	441	PF01217	0.323
TRG_ENDOCYTIC_2	285	288	PF00928	0.544
TRG_ENDOCYTIC_2	41	44	PF00928	0.450
TRG_ENDOCYTIC_2	427	430	PF00928	0.344
TRG_ENDOCYTIC_2	570	573	PF00928	0.348
TRG_ENDOCYTIC_2	72	75	PF00928	0.571
TRG_ER_diArg_1	375	378	PF00400	0.442
TRG_ER_diArg_1	410	413	PF00400	0.385
TRG_ER_diArg_1	51	54	PF00400	0.408
TRG_ER_diArg_1	573	576	PF00400	0.293
TRG_NES_CRM1_1	13	28	PF08389	0.411
TRG_NES_CRM1_1	43	57	PF08389	0.420
TRG_Pf-PMV_PEXEL_1	20	25	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	412	417	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P823	Leptomonas seymouri	60%	95%
A4HPX4	Leishmania braziliensis	80%	100%
E9ATP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q0V8	Leishmania major	93%	100%