Amino acid permease, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amino acid permease, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ILE0_LEIDO

TriTrypDb:

LdBPK_220100.1 , LdCL_220007100 , LDHU3_22.0370

Length:

485

Annotations

LeishMANIAdb annotations

An enormously expanded group of various amino acid transporters.. Localization: Cell surface (by feature)

Annotations by Jardim et al.

Transporters, amino acid permease AAT22

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 8
Forrest at al. (procyclic)	yes	yes: 10
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 72

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 177
NetGPI	no	yes: 0, no: 178

Show entries

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	162
GO:0020016	ciliary pocket	2	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

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Expansion

Sequence features

A0A3Q8ILE0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ILE0

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0003333	amino acid transmembrane transport	5	17
GO:0006810	transport	3	17
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006820	monoatomic anion transport	5	1
GO:0006865	amino acid transport	5	17
GO:0009987	cellular process	1	17
GO:0015711	organic anion transport	5	1
GO:0015802	basic amino acid transport	6	1
GO:0015819	lysine transport	6	1

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	17
GO:0005342	organic acid transmembrane transporter activity	3	17
GO:0008324	monoatomic cation transmembrane transporter activity	4	1
GO:0008509	monoatomic anion transmembrane transporter activity	4	1
GO:0008514	organic anion transmembrane transporter activity	5	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015171	amino acid transmembrane transporter activity	5	17
GO:0015174	basic amino acid transmembrane transporter activity	6	1
GO:0015179	L-amino acid transmembrane transporter activity	6	17
GO:0015189	L-lysine transmembrane transporter activity	5	1

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Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	82	84	PF00675	0.513
CLV_PCSK_KEX2_1	82	84	PF00082	0.485
CLV_PCSK_SKI1_1	156	160	PF00082	0.367
CLV_PCSK_SKI1_1	210	214	PF00082	0.401
CLV_PCSK_SKI1_1	349	353	PF00082	0.567
DOC_ANK_TNKS_1	82	89	PF00023	0.622
DOC_CYCLIN_RxL_1	261	274	PF00134	0.426
DOC_CYCLIN_yCln2_LP_2	107	113	PF00134	0.424
DOC_CYCLIN_yCln2_LP_2	220	226	PF00134	0.365
DOC_MAPK_FxFP_2	436	439	PF00069	0.434

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P285	Leptomonas seymouri	33%	99%
A0A0N0P5D2	Leptomonas seymouri	43%	100%
A0A0N0P613	Leptomonas seymouri	29%	100%
A0A0N0P6F6	Leptomonas seymouri	73%	100%
A0A0N0P8T9	Leptomonas seymouri	42%	97%
A0A0N0P955	Leptomonas seymouri	40%	100%
A0A0N1I2L5	Leptomonas seymouri	40%	100%
A0A0N1I3F8	Leptomonas seymouri	44%	91%
A0A0N1I3H4	Leptomonas seymouri	42%	88%
A0A0N1I8K7	Leptomonas seymouri	37%	99%

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