LeishMANIAdb
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Cytochrome b5-like Heme/Steroid binding domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Cytochrome b5-like Heme/Steroid binding domain containing protein, putative
Gene product:
Cytochrome b5-like Heme/Steroid binding domain containing protein, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8ILC3_LEIDO
TriTrypDb:
LdCL_220005100 , LDHU3_22.0050
Length:
123

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 22
NetGPI no yes: 0, no: 22
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9
GO:0043226 organelle 2 4
GO:0043227 membrane-bounded organelle 3 4
GO:0043229 intracellular organelle 3 4
GO:0043231 intracellular membrane-bounded organelle 4 4

Expansion

Sequence features

A0A3Q8ILC3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ILC3

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 4
GO:0020037 heme binding 4 4
GO:0046906 tetrapyrrole binding 3 4
GO:0097159 organic cyclic compound binding 2 4
GO:1901363 heterocyclic compound binding 2 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 100 102 PF00082 0.455
CLV_PCSK_PC1ET2_1 100 102 PF00082 0.418
DEG_Nend_UBRbox_3 1 3 PF02207 0.626
DOC_MAPK_gen_1 15 25 PF00069 0.457
DOC_MAPK_gen_1 98 107 PF00069 0.663
DOC_MAPK_MEF2A_6 100 109 PF00069 0.484
DOC_MAPK_MEF2A_6 18 25 PF00069 0.495
DOC_PP4_FxxP_1 114 117 PF00568 0.203
DOC_USP7_MATH_1 31 35 PF00917 0.472
DOC_USP7_MATH_1 5 9 PF00917 0.587
DOC_USP7_UBL2_3 47 51 PF12436 0.457
DOC_USP7_UBL2_3 94 98 PF12436 0.642
LIG_deltaCOP1_diTrp_1 64 72 PF00928 0.550
LIG_LIR_Gen_1 46 56 PF02991 0.499
LIG_LIR_Gen_1 99 109 PF02991 0.455
LIG_LIR_Nem_3 99 105 PF02991 0.609
LIG_SH2_CRK 19 23 PF00017 0.519
LIG_SH2_STAT5 3 6 PF00017 0.698
LIG_SH3_3 1 7 PF00018 0.586
MOD_CK1_1 78 84 PF00069 0.652
MOD_CK1_1 96 102 PF00069 0.597
MOD_GlcNHglycan 77 80 PF01048 0.471
MOD_N-GLC_1 52 57 PF02516 0.305
MOD_PKA_1 93 99 PF00069 0.669
MOD_Plk_1 52 58 PF00069 0.550
MOD_Plk_4 32 38 PF00069 0.529
MOD_SUMO_for_1 120 123 PF00179 0.385
TRG_NES_CRM1_1 50 64 PF08389 0.444

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3U0 Leptomonas seymouri 30% 92%
A0A0N1IH82 Leptomonas seymouri 37% 100%
A0A3Q8ICI2 Leishmania donovani 35% 98%
A0A3S7WPP2 Leishmania donovani 98% 100%
A0A3S7X4C9 Leishmania donovani 31% 100%
A4H4U1 Leishmania braziliensis 78% 100%
A4HJ97 Leishmania braziliensis 33% 100%
A4HJ98 Leishmania braziliensis 33% 97%
A4HJA1 Leishmania braziliensis 28% 100%
A4HT20 Leishmania infantum 99% 100%
A4I6P2 Leishmania infantum 31% 100%
A4I6P3 Leishmania infantum 35% 98%
A4I6P6 Leishmania infantum 31% 100%
E9ACS1 Leishmania major 88% 100%
E9AGY1 Leishmania infantum 100% 100%
E9AL09 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
E9AVI6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
E9B1R5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 99%
Q4Q6E5 Leishmania major 31% 76%
Q4Q6E6 Leishmania major 35% 99%
Q4QIU6 Leishmania major 87% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS