Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ILB9_LEIDO

TriTrypDb:

LdBPK_364470.1 , LdCL_360051900 , LDHU3_36.6080

Length:

431

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ILB9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ILB9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	225	229	PF00656	0.460
CLV_C14_Caspase3-7	9	13	PF00656	0.499
CLV_NRD_NRD_1	124	126	PF00675	0.423
CLV_NRD_NRD_1	197	199	PF00675	0.477
CLV_NRD_NRD_1	309	311	PF00675	0.391
CLV_NRD_NRD_1	332	334	PF00675	0.383
CLV_NRD_NRD_1	339	341	PF00675	0.362
CLV_NRD_NRD_1	355	357	PF00675	0.387
CLV_NRD_NRD_1	405	407	PF00675	0.482
CLV_NRD_NRD_1	90	92	PF00675	0.664
CLV_PCSK_KEX2_1	124	126	PF00082	0.454
CLV_PCSK_KEX2_1	197	199	PF00082	0.477
CLV_PCSK_KEX2_1	309	311	PF00082	0.406
CLV_PCSK_KEX2_1	332	334	PF00082	0.383
CLV_PCSK_KEX2_1	35	37	PF00082	0.705
CLV_PCSK_KEX2_1	355	357	PF00082	0.433
CLV_PCSK_KEX2_1	405	407	PF00082	0.466
CLV_PCSK_KEX2_1	90	92	PF00082	0.623
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.705
CLV_PCSK_SKI1_1	127	131	PF00082	0.456
CLV_PCSK_SKI1_1	187	191	PF00082	0.409
CLV_PCSK_SKI1_1	197	201	PF00082	0.433
CLV_PCSK_SKI1_1	260	264	PF00082	0.385
DEG_APCC_DBOX_1	126	134	PF00400	0.431
DEG_MDM2_SWIB_1	211	219	PF02201	0.355
DEG_Nend_UBRbox_3	1	3	PF02207	0.589
DOC_CKS1_1	22	27	PF01111	0.567
DOC_CYCLIN_RxL_1	172	183	PF00134	0.377
DOC_CYCLIN_RxL_1	254	265	PF00134	0.412
DOC_MAPK_gen_1	124	130	PF00069	0.516
DOC_MAPK_gen_1	338	348	PF00069	0.374
DOC_MAPK_gen_1	366	374	PF00069	0.411
DOC_MAPK_MEF2A_6	340	348	PF00069	0.393
DOC_USP7_MATH_1	11	15	PF00917	0.628
DOC_USP7_MATH_1	129	133	PF00917	0.473
DOC_USP7_MATH_1	302	306	PF00917	0.437
DOC_USP7_MATH_1	354	358	PF00917	0.396
DOC_USP7_MATH_1	421	425	PF00917	0.640
DOC_USP7_MATH_1	60	64	PF00917	0.577
DOC_WW_Pin1_4	21	26	PF00397	0.623
LIG_14-3-3_CanoR_1	187	194	PF00244	0.484
LIG_14-3-3_CanoR_1	21	25	PF00244	0.734
LIG_14-3-3_CanoR_1	257	263	PF00244	0.473
LIG_14-3-3_CanoR_1	303	307	PF00244	0.426
LIG_14-3-3_CanoR_1	355	359	PF00244	0.509
LIG_14-3-3_CanoR_1	412	418	PF00244	0.607
LIG_14-3-3_CanoR_1	65	75	PF00244	0.519
LIG_Actin_WH2_2	241	259	PF00022	0.417
LIG_Actin_WH2_2	396	414	PF00022	0.432
LIG_AP_GAE_1	116	122	PF02883	0.570
LIG_BRCT_BRCA1_1	395	399	PF00533	0.468
LIG_eIF4E_1	164	170	PF01652	0.379
LIG_FHA_1	2	8	PF00498	0.617
LIG_FHA_1	25	31	PF00498	0.673
LIG_FHA_1	367	373	PF00498	0.393
LIG_FHA_1	385	391	PF00498	0.470
LIG_FHA_2	133	139	PF00498	0.626
LIG_FHA_2	154	160	PF00498	0.453
LIG_FHA_2	325	331	PF00498	0.435
LIG_FHA_2	7	13	PF00498	0.503
LIG_Integrin_RGD_1	85	87	PF01839	0.667
LIG_LIR_Gen_1	116	126	PF02991	0.428
LIG_LIR_Nem_3	116	122	PF02991	0.441
LIG_LIR_Nem_3	207	211	PF02991	0.417
LIG_NRBOX	343	349	PF00104	0.394
LIG_Pex14_2	211	215	PF04695	0.350
LIG_SH2_CRK	34	38	PF00017	0.542
LIG_SH2_GRB2like	351	354	PF00017	0.382
LIG_SH2_SRC	351	354	PF00017	0.406
LIG_SH2_STAP1	258	262	PF00017	0.441
LIG_SH2_STAT3	168	171	PF00017	0.499
LIG_SH2_STAT3	339	342	PF00017	0.489
LIG_SH2_STAT5	168	171	PF00017	0.448
LIG_SH2_STAT5	278	281	PF00017	0.454
LIG_SH2_STAT5	335	338	PF00017	0.511
LIG_SH2_STAT5	351	354	PF00017	0.346
LIG_SH3_3	104	110	PF00018	0.631
LIG_SH3_3	19	25	PF00018	0.561
LIG_SH3_3	27	33	PF00018	0.592
LIG_SUMO_SIM_anti_2	146	153	PF11976	0.500
LIG_SUMO_SIM_anti_2	230	235	PF11976	0.500
LIG_SUMO_SIM_anti_2	343	348	PF11976	0.366
LIG_TRAF2_1	221	224	PF00917	0.403
MOD_CK1_1	102	108	PF00069	0.588
MOD_CK1_1	132	138	PF00069	0.488
MOD_CK1_1	153	159	PF00069	0.481
MOD_CK1_1	20	26	PF00069	0.594
MOD_CK1_1	3	9	PF00069	0.717
MOD_CK1_1	357	363	PF00069	0.518
MOD_CK1_1	393	399	PF00069	0.485
MOD_CK1_1	54	60	PF00069	0.590
MOD_CK1_1	63	69	PF00069	0.562
MOD_CK2_1	132	138	PF00069	0.542
MOD_CK2_1	153	159	PF00069	0.453
MOD_CK2_1	258	264	PF00069	0.462
MOD_CK2_1	302	308	PF00069	0.433
MOD_CK2_1	324	330	PF00069	0.447
MOD_DYRK1A_RPxSP_1	21	25	PF00069	0.494
MOD_GlcNHglycan	383	387	PF01048	0.478
MOD_GlcNHglycan	392	395	PF01048	0.474
MOD_GlcNHglycan	421	424	PF01048	0.702
MOD_GlcNHglycan	56	59	PF01048	0.561
MOD_GlcNHglycan	66	69	PF01048	0.749
MOD_GSK3_1	1	8	PF00069	0.736
MOD_GSK3_1	13	20	PF00069	0.728
MOD_GSK3_1	258	265	PF00069	0.402
MOD_GSK3_1	324	331	PF00069	0.502
MOD_GSK3_1	60	67	PF00069	0.736
MOD_LATS_1	185	191	PF00433	0.409
MOD_N-GLC_1	1	6	PF02516	0.575
MOD_N-GLC_1	366	371	PF02516	0.467
MOD_NEK2_1	1	6	PF00069	0.797
MOD_NEK2_1	211	216	PF00069	0.479
MOD_NEK2_1	256	261	PF00069	0.493
MOD_NEK2_1	262	267	PF00069	0.413
MOD_NEK2_1	390	395	PF00069	0.489
MOD_NEK2_1	411	416	PF00069	0.539
MOD_NEK2_1	71	76	PF00069	0.633
MOD_NEK2_2	302	307	PF00069	0.429
MOD_NEK2_2	421	426	PF00069	0.571
MOD_NEK2_2	60	65	PF00069	0.517
MOD_PIKK_1	357	363	PF00454	0.449
MOD_PIKK_1	411	417	PF00454	0.676
MOD_PIKK_1	46	52	PF00454	0.740
MOD_PKA_2	20	26	PF00069	0.736
MOD_PKA_2	256	262	PF00069	0.493
MOD_PKA_2	302	308	PF00069	0.433
MOD_PKA_2	354	360	PF00069	0.512
MOD_PKA_2	411	417	PF00069	0.599
MOD_PKA_2	64	70	PF00069	0.537
MOD_Plk_1	11	17	PF00069	0.512
MOD_Plk_4	26	32	PF00069	0.662
MOD_Plk_4	302	308	PF00069	0.433
MOD_Plk_4	368	374	PF00069	0.408
MOD_Plk_4	398	404	PF00069	0.628
MOD_ProDKin_1	21	27	PF00069	0.624
TRG_DiLeu_BaEn_1	343	348	PF01217	0.390
TRG_DiLeu_BaEn_4	195	201	PF01217	0.485
TRG_DiLeu_BaLyEn_6	251	256	PF01217	0.560
TRG_ER_diArg_1	124	127	PF00400	0.488
TRG_ER_diArg_1	197	199	PF00400	0.532
TRG_ER_diArg_1	332	334	PF00400	0.439
TRG_Pf-PMV_PEXEL_1	175	180	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	197	201	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.374
TRG_Pf-PMV_PEXEL_1	332	337	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J8	Leptomonas seymouri	65%	100%
A0A0S4JG62	Bodo saltans	51%	100%
A0A1X0P1T1	Trypanosomatidae	54%	100%
A0A422P583	Trypanosoma rangeli	56%	100%
A4HPU5	Leishmania braziliensis	79%	100%
A4IE48	Leishmania infantum	100%	100%
E9ATL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q0Y8	Leishmania major	93%	100%
V5BQ98	Trypanosoma cruzi	57%	100%