Thioredoxin-like_fold domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ILB8_LEIDO

TriTrypDb:

LdBPK_322640.1 , LdCL_320032100 , LDHU3_32.3300

Length:

162

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A0A3Q8ILB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ILB8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.672
CLV_NRD_NRD_1	147	149	PF00675	0.429
CLV_NRD_NRD_1	63	65	PF00675	0.629
CLV_PCSK_KEX2_1	147	149	PF00082	0.429
CLV_PCSK_KEX2_1	63	65	PF00082	0.629
CLV_PCSK_SKI1_1	15	19	PF00082	0.642
CLV_PCSK_SKI1_1	22	26	PF00082	0.603
DEG_APCC_DBOX_1	14	22	PF00400	0.350
DOC_CYCLIN_RxL_1	11	20	PF00134	0.345
DOC_MAPK_MEF2A_6	39	48	PF00069	0.449
DOC_PP1_RVXF_1	103	109	PF00149	0.401
LIG_14-3-3_CanoR_1	139	145	PF00244	0.622
LIG_14-3-3_CanoR_1	22	29	PF00244	0.446
LIG_Actin_WH2_2	77	92	PF00022	0.424
LIG_APCC_ABBAyCdc20_2	147	153	PF00400	0.618
LIG_BIR_II_1	1	5	PF00653	0.445
LIG_BIR_III_3	1	5	PF00653	0.464
LIG_deltaCOP1_diTrp_1	107	113	PF00928	0.282
LIG_EVH1_2	5	9	PF00568	0.481
LIG_FHA_1	12	18	PF00498	0.421
LIG_FHA_1	84	90	PF00498	0.418
LIG_FHA_2	23	29	PF00498	0.432
LIG_LIR_Gen_1	40	51	PF02991	0.415
LIG_LIR_Nem_3	107	111	PF02991	0.264
LIG_LIR_Nem_3	40	46	PF02991	0.430
LIG_LIR_Nem_3	79	84	PF02991	0.433
LIG_NRBOX	128	134	PF00104	0.596
LIG_NRP_CendR_1	160	162	PF00754	0.458
LIG_Pex14_1	124	128	PF04695	0.362
LIG_SH2_STAP1	115	119	PF00017	0.333
LIG_SH2_STAP1	151	155	PF00017	0.625
LIG_SH2_STAT3	65	68	PF00017	0.436
LIG_SH2_STAT5	121	124	PF00017	0.314
LIG_SH2_STAT5	128	131	PF00017	0.494
LIG_SH2_STAT5	155	158	PF00017	0.722
LIG_SH2_STAT5	43	46	PF00017	0.420
LIG_SH2_STAT5	65	68	PF00017	0.469
LIG_TRAF2_2	102	107	PF00917	0.405
LIG_WRC_WIRS_1	21	26	PF05994	0.471
MOD_CMANNOS	110	113	PF00535	0.333
MOD_GSK3_1	5	12	PF00069	0.456
MOD_NEK2_1	52	57	PF00069	0.395
MOD_NEK2_1	89	94	PF00069	0.411
MOD_NEK2_1	9	14	PF00069	0.404
MOD_PKA_2	66	72	PF00069	0.529
MOD_PKA_2	89	95	PF00069	0.416
MOD_Plk_4	128	134	PF00069	0.596
MOD_Plk_4	5	11	PF00069	0.474
MOD_Plk_4	89	95	PF00069	0.412
MOD_SUMO_rev_2	79	84	PF00179	0.513
TRG_ENDOCYTIC_2	115	118	PF00928	0.307
TRG_ENDOCYTIC_2	43	46	PF00928	0.438
TRG_ENDOCYTIC_2	59	62	PF00928	0.383
TRG_ER_diArg_1	159	162	PF00400	0.678
TRG_ER_diArg_1	62	64	PF00400	0.434
TRG_Pf-PMV_PEXEL_1	15	20	PF00026	0.697
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.634

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5P2	Leptomonas seymouri	86%	100%
A0A1X0NS66	Trypanosomatidae	72%	100%
A0A3R7L0F6	Trypanosoma rangeli	68%	99%
A4HKP0	Leishmania braziliensis	89%	100%
A4I871	Leishmania infantum	99%	100%
D0AAE0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
E9B329	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q525	Leishmania major	98%	100%