Phosphatidylinositol 4-phosphate 5-kinase alpha, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylinositol phosphate kinase alpha

Species:

Leishmania donovani

UniProt:

A0A3Q8ILB5_LEIDO

TriTrypDb:

LdBPK_044320.1 , LdCL_340037400 , LDHU3_34.4970

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0020016	ciliary pocket	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8ILB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ILB5

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0044237	cellular metabolic process	2	11
GO:0006629	lipid metabolic process	3	1
GO:0006644	phospholipid metabolic process	4	1
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0006661	phosphatidylinositol biosynthetic process	6	1
GO:0008610	lipid biosynthetic process	4	1
GO:0008654	phospholipid biosynthetic process	5	1
GO:0009058	biosynthetic process	2	1
GO:0019637	organophosphate metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0045017	glycerolipid biosynthetic process	4	1
GO:0046474	glycerophospholipid biosynthetic process	5	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0046488	phosphatidylinositol metabolic process	6	1
GO:0046854	phosphatidylinositol phosphate biosynthetic process	7	1
GO:0071704	organic substance metabolic process	2	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016307	phosphatidylinositol phosphate kinase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	431	435	PF00656	0.272
CLV_C14_Caspase3-7	450	454	PF00656	0.450
CLV_C14_Caspase3-7	455	459	PF00656	0.403
CLV_C14_Caspase3-7	467	471	PF00656	0.208
CLV_NRD_NRD_1	186	188	PF00675	0.708
CLV_NRD_NRD_1	285	287	PF00675	0.366
CLV_NRD_NRD_1	356	358	PF00675	0.328
CLV_NRD_NRD_1	377	379	PF00675	0.250
CLV_NRD_NRD_1	507	509	PF00675	0.308
CLV_NRD_NRD_1	521	523	PF00675	0.220
CLV_PCSK_FUR_1	184	188	PF00082	0.667
CLV_PCSK_KEX2_1	186	188	PF00082	0.708
CLV_PCSK_KEX2_1	355	357	PF00082	0.325
CLV_PCSK_KEX2_1	377	379	PF00082	0.247
CLV_PCSK_KEX2_1	393	395	PF00082	0.247
CLV_PCSK_KEX2_1	523	525	PF00082	0.398
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.325
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.325
CLV_PCSK_PC1ET2_1	523	525	PF00082	0.398
CLV_PCSK_SKI1_1	102	106	PF00082	0.618
CLV_PCSK_SKI1_1	190	194	PF00082	0.605
CLV_PCSK_SKI1_1	233	237	PF00082	0.313
CLV_PCSK_SKI1_1	275	279	PF00082	0.271
CLV_PCSK_SKI1_1	286	290	PF00082	0.229
CLV_PCSK_SKI1_1	378	382	PF00082	0.277
CLV_PCSK_SKI1_1	430	434	PF00082	0.314
CLV_PCSK_SKI1_1	472	476	PF00082	0.247
CLV_PCSK_SKI1_1	5	9	PF00082	0.625
CLV_PCSK_SKI1_1	508	512	PF00082	0.314
CLV_PCSK_SKI1_1	65	69	PF00082	0.321
CLV_PCSK_SKI1_1	70	74	PF00082	0.368
DEG_APCC_DBOX_1	4	12	PF00400	0.622
DEG_APCC_DBOX_1	507	515	PF00400	0.288
DEG_SCF_FBW7_1	255	261	PF00400	0.249
DOC_CKS1_1	255	260	PF01111	0.325
DOC_CYCLIN_RxL_1	2	10	PF00134	0.669
DOC_PP1_RVXF_1	534	541	PF00149	0.247
DOC_USP7_MATH_1	128	132	PF00917	0.677
DOC_USP7_MATH_1	188	192	PF00917	0.568
DOC_USP7_MATH_1	258	262	PF00917	0.247
DOC_USP7_MATH_1	37	41	PF00917	0.707
DOC_USP7_MATH_1	452	456	PF00917	0.311
DOC_USP7_MATH_1	457	461	PF00917	0.263
DOC_USP7_MATH_1	47	51	PF00917	0.596
DOC_USP7_MATH_1	539	543	PF00917	0.304
DOC_USP7_UBL2_3	338	342	PF12436	0.250
DOC_WW_Pin1_4	222	227	PF00397	0.285
DOC_WW_Pin1_4	254	259	PF00397	0.280
DOC_WW_Pin1_4	366	371	PF00397	0.406
LIG_14-3-3_CanoR_1	187	193	PF00244	0.693
LIG_14-3-3_CanoR_1	194	199	PF00244	0.635
LIG_14-3-3_CanoR_1	356	361	PF00244	0.303
LIG_14-3-3_CanoR_1	430	437	PF00244	0.404
LIG_14-3-3_CanoR_1	472	481	PF00244	0.290
LIG_14-3-3_CanoR_1	522	530	PF00244	0.312
LIG_14-3-3_CanoR_1	70	78	PF00244	0.471
LIG_Actin_WH2_1	270	288	PF00022	0.304
LIG_Actin_WH2_2	301	316	PF00022	0.314
LIG_BRCT_BRCA1_1	217	221	PF00533	0.378
LIG_EH_1	298	302	PF12763	0.314
LIG_EVH1_2	215	219	PF00568	0.532
LIG_FHA_1	193	199	PF00498	0.751
LIG_FHA_1	330	336	PF00498	0.352
LIG_FHA_1	427	433	PF00498	0.406
LIG_FHA_1	55	61	PF00498	0.387
LIG_FHA_2	195	201	PF00498	0.697
LIG_FHA_2	218	224	PF00498	0.380
LIG_FHA_2	274	280	PF00498	0.294
LIG_FHA_2	332	338	PF00498	0.290
LIG_FHA_2	359	365	PF00498	0.290
LIG_LIR_Gen_1	218	229	PF02991	0.423
LIG_LIR_Gen_1	250	258	PF02991	0.339
LIG_LIR_Gen_1	298	308	PF02991	0.290
LIG_LIR_Gen_1	319	330	PF02991	0.332
LIG_LIR_Gen_1	399	408	PF02991	0.247
LIG_LIR_Nem_3	165	171	PF02991	0.639
LIG_LIR_Nem_3	218	224	PF02991	0.320
LIG_LIR_Nem_3	234	238	PF02991	0.296
LIG_LIR_Nem_3	250	255	PF02991	0.201
LIG_LIR_Nem_3	298	304	PF02991	0.290
LIG_LIR_Nem_3	399	403	PF02991	0.247
LIG_LIR_Nem_3	492	498	PF02991	0.274
LIG_PDZ_Class_2	541	546	PF00595	0.247
LIG_Pex14_1	516	520	PF04695	0.272
LIG_REV1ctd_RIR_1	264	274	PF16727	0.265
LIG_SH2_CRK	168	172	PF00017	0.534
LIG_SH2_CRK	400	404	PF00017	0.247
LIG_SH2_PTP2	495	498	PF00017	0.247
LIG_SH2_STAP1	400	404	PF00017	0.247
LIG_SH2_STAT5	243	246	PF00017	0.358
LIG_SH2_STAT5	445	448	PF00017	0.421
LIG_SH2_STAT5	495	498	PF00017	0.291
LIG_SH3_1	80	86	PF00018	0.404
LIG_SH3_2	83	88	PF14604	0.410
LIG_SH3_3	80	86	PF00018	0.404
LIG_TRAF2_1	278	281	PF00917	0.290
LIG_TRFH_1	301	305	PF08558	0.280
LIG_TYR_ITIM	493	498	PF00017	0.247
LIG_UBA3_1	381	387	PF00899	0.263
MOD_CDK_SPxK_1	254	260	PF00069	0.247
MOD_CK1_1	254	260	PF00069	0.247
MOD_CK1_1	417	423	PF00069	0.320
MOD_CK1_1	460	466	PF00069	0.326
MOD_CK1_1	91	97	PF00069	0.581
MOD_CK2_1	200	206	PF00069	0.626
MOD_CK2_1	273	279	PF00069	0.275
MOD_CK2_1	331	337	PF00069	0.290
MOD_CK2_1	348	354	PF00069	0.247
MOD_CK2_1	73	79	PF00069	0.509
MOD_GlcNHglycan	16	19	PF01048	0.593
MOD_GlcNHglycan	173	176	PF01048	0.656
MOD_GlcNHglycan	260	263	PF01048	0.254
MOD_GlcNHglycan	33	36	PF01048	0.731
MOD_GlcNHglycan	417	420	PF01048	0.283
MOD_GlcNHglycan	453	457	PF01048	0.336
MOD_GlcNHglycan	98	101	PF01048	0.471
MOD_GSK3_1	145	152	PF00069	0.697
MOD_GSK3_1	188	195	PF00069	0.654
MOD_GSK3_1	215	222	PF00069	0.453
MOD_GSK3_1	247	254	PF00069	0.264
MOD_GSK3_1	275	282	PF00069	0.271
MOD_GSK3_1	408	415	PF00069	0.371
MOD_GSK3_1	417	424	PF00069	0.338
MOD_GSK3_1	426	433	PF00069	0.253
MOD_GSK3_1	460	467	PF00069	0.365
MOD_GSK3_1	88	95	PF00069	0.454
MOD_N-GLC_1	464	469	PF02516	0.369
MOD_NEK2_1	171	176	PF00069	0.604
MOD_NEK2_1	178	183	PF00069	0.502
MOD_NEK2_1	192	197	PF00069	0.507
MOD_NEK2_1	247	252	PF00069	0.247
MOD_NEK2_1	329	334	PF00069	0.303
MOD_NEK2_1	341	346	PF00069	0.193
MOD_NEK2_1	392	397	PF00069	0.252
MOD_NEK2_1	398	403	PF00069	0.241
MOD_NEK2_1	428	433	PF00069	0.312
MOD_NEK2_1	443	448	PF00069	0.161
MOD_NEK2_1	540	545	PF00069	0.247
MOD_NEK2_1	7	12	PF00069	0.682
MOD_NEK2_1	96	101	PF00069	0.524
MOD_NEK2_2	37	42	PF00069	0.598
MOD_PIKK_1	145	151	PF00454	0.656
MOD_PIKK_1	192	198	PF00454	0.603
MOD_PIKK_1	316	322	PF00454	0.272
MOD_PIKK_1	358	364	PF00454	0.247
MOD_PK_1	251	257	PF00069	0.382
MOD_PK_1	88	94	PF00069	0.533
MOD_PKA_1	355	361	PF00069	0.295
MOD_PKA_1	523	529	PF00069	0.298
MOD_PKA_2	128	134	PF00069	0.613
MOD_PKA_2	247	253	PF00069	0.272
MOD_PKA_2	355	361	PF00069	0.383
MOD_PKA_2	523	529	PF00069	0.330
MOD_PKB_1	312	320	PF00069	0.251
MOD_Plk_1	145	151	PF00069	0.687
MOD_Plk_1	178	184	PF00069	0.737
MOD_Plk_1	398	404	PF00069	0.247
MOD_Plk_1	88	94	PF00069	0.372
MOD_Plk_2-3	200	206	PF00069	0.628
MOD_Plk_4	128	134	PF00069	0.580
MOD_Plk_4	398	404	PF00069	0.267
MOD_Plk_4	515	521	PF00069	0.289
MOD_Plk_4	540	546	PF00069	0.257
MOD_ProDKin_1	222	228	PF00069	0.283
MOD_ProDKin_1	254	260	PF00069	0.280
MOD_ProDKin_1	366	372	PF00069	0.406
MOD_SUMO_for_1	11	14	PF00179	0.678
MOD_SUMO_rev_2	234	242	PF00179	0.347
MOD_SUMO_rev_2	337	344	PF00179	0.247
MOD_SUMO_rev_2	518	525	PF00179	0.314
TRG_DiLeu_BaEn_1	376	381	PF01217	0.380
TRG_ENDOCYTIC_2	168	171	PF00928	0.638
TRG_ENDOCYTIC_2	229	232	PF00928	0.299
TRG_ENDOCYTIC_2	243	246	PF00928	0.473
TRG_ENDOCYTIC_2	293	296	PF00928	0.269
TRG_ENDOCYTIC_2	400	403	PF00928	0.247
TRG_ENDOCYTIC_2	495	498	PF00928	0.247
TRG_ER_diArg_1	184	187	PF00400	0.672
TRG_ER_diArg_1	312	315	PF00400	0.370
TRG_ER_diArg_1	522	525	PF00400	0.367
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	378	383	PF00026	0.265
TRG_Pf-PMV_PEXEL_1	82	87	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCT9	Leptomonas seymouri	67%	100%
A0A0S4IZA7	Bodo saltans	47%	100%
A0A1X0P9B0	Trypanosomatidae	25%	100%
A0A1X0PB79	Trypanosomatidae	47%	100%
A0A381MTN1	Leishmania infantum	100%	100%
A4HB28	Leishmania braziliensis	79%	100%
A4HNP5	Leishmania braziliensis	22%	100%
C9ZM20	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9B598	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O13853	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	74%
O48709	Arabidopsis thaliana	31%	77%
Q4Q2N5	Leishmania major	94%	100%
Q56YP2	Arabidopsis thaliana	29%	73%
Q6EX42	Oryza sativa subsp. japonica	31%	68%
Q8L796	Arabidopsis thaliana	31%	72%
Q8RY89	Arabidopsis thaliana	31%	71%
Q9M149	Arabidopsis thaliana	26%	100%
Q9SUI2	Arabidopsis thaliana	31%	72%
V5BA13	Trypanosoma cruzi	27%	100%
V5BV28	Trypanosoma cruzi	47%	100%