SET_domain_containing_protein_putative/Pfam:PF008 56

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ILA8_LEIDO

TriTrypDb:

LdBPK_212120.1 , LdCL_210026900 , LDHU3_21.2520

Length:

385

Annotations

Annotations by Jardim et al.

Metal Binding, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ILA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ILA8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.636
CLV_C14_Caspase3-7	48	52	PF00656	0.348
CLV_NRD_NRD_1	145	147	PF00675	0.416
CLV_NRD_NRD_1	203	205	PF00675	0.482
CLV_NRD_NRD_1	23	25	PF00675	0.496
CLV_NRD_NRD_1	297	299	PF00675	0.523
CLV_PCSK_KEX2_1	145	147	PF00082	0.422
CLV_PCSK_KEX2_1	149	151	PF00082	0.422
CLV_PCSK_KEX2_1	23	25	PF00082	0.522
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.543
CLV_PCSK_PC7_1	145	151	PF00082	0.477
CLV_PCSK_SKI1_1	146	150	PF00082	0.479
CLV_PCSK_SKI1_1	252	256	PF00082	0.442
CLV_PCSK_SKI1_1	64	68	PF00082	0.474
DEG_SPOP_SBC_1	173	177	PF00917	0.586
DOC_MAPK_gen_1	145	154	PF00069	0.486
DOC_MAPK_gen_1	298	308	PF00069	0.444
DOC_PP4_FxxP_1	194	197	PF00568	0.429
DOC_WW_Pin1_4	134	139	PF00397	0.595
DOC_WW_Pin1_4	193	198	PF00397	0.490
DOC_WW_Pin1_4	273	278	PF00397	0.371
DOC_WW_Pin1_4	72	77	PF00397	0.521
LIG_14-3-3_CanoR_1	302	306	PF00244	0.426
LIG_BIR_II_1	1	5	PF00653	0.550
LIG_BRCT_BRCA1_1	198	202	PF00533	0.463
LIG_deltaCOP1_diTrp_1	53	58	PF00928	0.467
LIG_FHA_1	274	280	PF00498	0.360
LIG_FHA_1	28	34	PF00498	0.465
LIG_FHA_1	37	43	PF00498	0.433
LIG_FHA_1	44	50	PF00498	0.367
LIG_FHA_2	151	157	PF00498	0.532
LIG_FHA_2	174	180	PF00498	0.637
LIG_FHA_2	32	38	PF00498	0.515
LIG_FHA_2	355	361	PF00498	0.470
LIG_FHA_2	46	52	PF00498	0.459
LIG_FHA_2	6	12	PF00498	0.440
LIG_FHA_2	89	95	PF00498	0.444
LIG_Integrin_isoDGR_2	300	302	PF01839	0.532
LIG_LIR_Apic_2	128	132	PF02991	0.464
LIG_LIR_Apic_2	192	197	PF02991	0.444
LIG_LIR_Apic_2	351	356	PF02991	0.456
LIG_LIR_Gen_1	266	275	PF02991	0.423
LIG_LIR_Gen_1	53	63	PF02991	0.417
LIG_LIR_Nem_3	266	271	PF02991	0.376
LIG_LIR_Nem_3	273	278	PF02991	0.396
LIG_LIR_Nem_3	318	324	PF02991	0.516
LIG_LIR_Nem_3	362	368	PF02991	0.453
LIG_LIR_Nem_3	53	58	PF02991	0.434
LIG_MYND_1	3	7	PF01753	0.578
LIG_Pex14_1	27	31	PF04695	0.414
LIG_Pex14_2	264	268	PF04695	0.403
LIG_PTAP_UEV_1	131	136	PF05743	0.428
LIG_PTB_Apo_2	262	269	PF02174	0.372
LIG_SH2_CRK	321	325	PF00017	0.454
LIG_SH2_GRB2like	263	266	PF00017	0.384
LIG_SH2_NCK_1	258	262	PF00017	0.418
LIG_SH2_SRC	114	117	PF00017	0.543
LIG_SH2_STAP1	31	35	PF00017	0.430
LIG_SH2_STAP1	333	337	PF00017	0.441
LIG_SH2_STAT5	114	117	PF00017	0.483
LIG_SH2_STAT5	193	196	PF00017	0.475
LIG_SH2_STAT5	235	238	PF00017	0.385
LIG_SH2_STAT5	263	266	PF00017	0.441
LIG_SH2_STAT5	331	334	PF00017	0.480
LIG_SH2_STAT5	368	371	PF00017	0.378
LIG_SH2_STAT5	378	381	PF00017	0.416
LIG_SH2_STAT5	87	90	PF00017	0.409
LIG_SH3_1	129	135	PF00018	0.556
LIG_SH3_3	1	7	PF00018	0.571
LIG_SH3_3	129	135	PF00018	0.557
LIG_SH3_3	320	326	PF00018	0.446
LIG_SH3_3	96	102	PF00018	0.570
LIG_SUMO_SIM_par_1	2	8	PF11976	0.545
LIG_TRAF2_1	357	360	PF00917	0.511
LIG_TYR_ITIM	319	324	PF00017	0.452
LIG_UBA3_1	182	187	PF00899	0.510
MOD_CK1_1	196	202	PF00069	0.447
MOD_CK2_1	134	140	PF00069	0.630
MOD_CK2_1	31	37	PF00069	0.516
MOD_CK2_1	354	360	PF00069	0.459
MOD_CK2_1	5	11	PF00069	0.499
MOD_CK2_1	88	94	PF00069	0.494
MOD_GlcNHglycan	131	135	PF01048	0.505
MOD_GlcNHglycan	239	242	PF01048	0.412
MOD_GSK3_1	130	137	PF00069	0.556
MOD_GSK3_1	185	192	PF00069	0.521
MOD_GSK3_1	27	34	PF00069	0.421
MOD_GSK3_1	43	50	PF00069	0.407
MOD_GSK3_1	68	75	PF00069	0.513
MOD_N-GLC_1	11	16	PF02516	0.491
MOD_N-GLC_1	27	32	PF02516	0.433
MOD_N-GLC_1	94	99	PF02516	0.544
MOD_NEK2_1	189	194	PF00069	0.400
MOD_NEK2_1	271	276	PF00069	0.368
MOD_NEK2_2	88	93	PF00069	0.381
MOD_PK_1	68	74	PF00069	0.448
MOD_PKA_2	301	307	PF00069	0.363
MOD_Plk_1	11	17	PF00069	0.413
MOD_Plk_1	27	33	PF00069	0.332
MOD_Plk_1	315	321	PF00069	0.493
MOD_Plk_1	36	42	PF00069	0.461
MOD_Plk_2-3	47	53	PF00069	0.510
MOD_Plk_4	185	191	PF00069	0.475
MOD_Plk_4	301	307	PF00069	0.374
MOD_Plk_4	348	354	PF00069	0.504
MOD_ProDKin_1	134	140	PF00069	0.595
MOD_ProDKin_1	193	199	PF00069	0.485
MOD_ProDKin_1	273	279	PF00069	0.371
MOD_ProDKin_1	72	78	PF00069	0.525
MOD_SUMO_rev_2	179	189	PF00179	0.501
MOD_SUMO_rev_2	281	288	PF00179	0.563
MOD_SUMO_rev_2	75	84	PF00179	0.451
TRG_DiLeu_BaEn_1	185	190	PF01217	0.427
TRG_ENDOCYTIC_2	235	238	PF00928	0.416
TRG_ENDOCYTIC_2	253	256	PF00928	0.263
TRG_ENDOCYTIC_2	321	324	PF00928	0.461
TRG_ER_diArg_1	23	25	PF00400	0.499
TRG_Pf-PMV_PEXEL_1	201	206	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	309	313	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVT0	Leptomonas seymouri	69%	99%
A0A0S4IW33	Bodo saltans	52%	94%
A0A1X0P992	Trypanosomatidae	51%	99%
A0A422NY07	Trypanosoma rangeli	50%	99%
A4HC39	Leishmania braziliensis	90%	100%
A4HZI1	Leishmania infantum	100%	100%
C9ZL06	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	77%
E9AVH1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QC08	Leishmania major	95%	100%
V5C212	Trypanosoma cruzi	50%	100%