LeishMANIAdb
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Vps54-like protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Vps54-like protein, putative
Gene product:
Vps54-like protein, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8ILA5_LEIDO
TriTrypDb:
LdBPK_366470.1 * , LdCL_360072200 , LDHU3_36.8570
Length:
1195

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
TermNameLevelCount
GO:0000938 GARP complex 3 11
GO:0005829 cytosol 2 11
GO:0032991 protein-containing complex 1 11
GO:0099023 vesicle tethering complex 2 11
GO:0110165 cellular anatomical entity 1 11
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Expansion

Sequence features

A0A3Q8ILA5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ILA5

Function

Biological processes
TermNameLevelCount
GO:0006810 transport 3 11
GO:0006892 post-Golgi vesicle-mediated transport 6 1
GO:0006896 Golgi to vacuole transport 5 1
GO:0007034 vacuolar transport 4 1
GO:0008104 protein localization 4 11
GO:0009987 cellular process 1 11
GO:0015031 protein transport 4 11
GO:0016192 vesicle-mediated transport 4 11
GO:0016197 endosomal transport 4 11
GO:0016482 cytosolic transport 4 11
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Molecular functions
TermNameLevelCount
GO:0000149 SNARE binding 3 1
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0019905 syntaxin binding 4 1
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 223 227 PF00656 0.570
CLV_NRD_NRD_1 1049 1051 PF00675 0.542
CLV_NRD_NRD_1 381 383 PF00675 0.529
CLV_NRD_NRD_1 400 402 PF00675 0.514
CLV_NRD_NRD_1 461 463 PF00675 0.491
CLV_NRD_NRD_1 464 466 PF00675 0.465
CLV_PCSK_KEX2_1 1062 1064 PF00082 0.602
CLV_PCSK_KEX2_1 380 382 PF00082 0.559
CLV_PCSK_KEX2_1 400 402 PF00082 0.255
CLV_PCSK_KEX2_1 740 742 PF00082 0.503
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I3S8 Leptomonas seymouri 61% 94%
A0A1X0NN72 Trypanosomatidae 31% 100%
A0A3R7N8Z7 Trypanosoma rangeli 33% 100%
A4HQE1 Leishmania braziliensis 80% 100%
A4IE32 Leishmania infantum 100% 100%
D0A3V6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
E9AU56 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q0D9 Leishmania major 92% 100%
V5BT53 Trypanosoma cruzi 32% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS