Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ILA1_LEIDO

TriTrypDb:

LdBPK_364290.1 , LdCL_360050000 , LDHU3_36.5800

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ILA1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ILA1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	56	60	PF00656	0.674
CLV_NRD_NRD_1	133	135	PF00675	0.520
CLV_NRD_NRD_1	237	239	PF00675	0.678
CLV_NRD_NRD_1	333	335	PF00675	0.629
CLV_NRD_NRD_1	390	392	PF00675	0.580
CLV_NRD_NRD_1	396	398	PF00675	0.527
CLV_NRD_NRD_1	85	87	PF00675	0.492
CLV_PCSK_FUR_1	278	282	PF00082	0.672
CLV_PCSK_KEX2_1	133	135	PF00082	0.510
CLV_PCSK_KEX2_1	280	282	PF00082	0.770
CLV_PCSK_KEX2_1	396	398	PF00082	0.612
CLV_PCSK_KEX2_1	85	87	PF00082	0.492
CLV_PCSK_PC1ET2_1	280	282	PF00082	0.770
CLV_PCSK_SKI1_1	113	117	PF00082	0.470
CLV_PCSK_SKI1_1	255	259	PF00082	0.777
CLV_PCSK_SKI1_1	29	33	PF00082	0.617
CLV_PCSK_SKI1_1	419	423	PF00082	0.615
DEG_MDM2_SWIB_1	158	165	PF02201	0.471
DEG_Nend_UBRbox_1	1	4	PF02207	0.665
DEG_SPOP_SBC_1	191	195	PF00917	0.641
DEG_SPOP_SBC_1	51	55	PF00917	0.686
DOC_CYCLIN_RxL_1	252	261	PF00134	0.634
DOC_CYCLIN_yCln2_LP_2	135	141	PF00134	0.526
DOC_CYCLIN_yCln2_LP_2	31	34	PF00134	0.620
DOC_MAPK_DCC_7	293	303	PF00069	0.630
DOC_PP2B_LxvP_1	135	138	PF13499	0.589
DOC_PP2B_LxvP_1	265	268	PF13499	0.704
DOC_PP2B_LxvP_1	31	34	PF13499	0.620
DOC_USP7_MATH_1	120	124	PF00917	0.525
DOC_USP7_MATH_1	126	130	PF00917	0.508
DOC_USP7_MATH_1	139	143	PF00917	0.426
DOC_USP7_MATH_1	197	201	PF00917	0.627
DOC_USP7_MATH_1	289	293	PF00917	0.740
DOC_USP7_MATH_1	351	355	PF00917	0.643
DOC_USP7_MATH_1	356	360	PF00917	0.611
DOC_USP7_MATH_1	364	368	PF00917	0.522
DOC_USP7_MATH_1	51	55	PF00917	0.782
DOC_WW_Pin1_4	205	210	PF00397	0.680
DOC_WW_Pin1_4	258	263	PF00397	0.633
DOC_WW_Pin1_4	32	37	PF00397	0.586
LIG_14-3-3_CanoR_1	113	122	PF00244	0.482
LIG_14-3-3_CanoR_1	2	9	PF00244	0.574
LIG_14-3-3_CanoR_1	255	261	PF00244	0.636
LIG_14-3-3_CanoR_1	373	378	PF00244	0.648
LIG_14-3-3_CanoR_1	86	92	PF00244	0.632
LIG_BRCT_BRCA1_1	154	158	PF00533	0.469
LIG_eIF4E_1	9	15	PF01652	0.566
LIG_EVH1_2	68	72	PF00568	0.614
LIG_FHA_1	10	16	PF00498	0.578
LIG_FHA_1	114	120	PF00498	0.504
LIG_FHA_1	17	23	PF00498	0.514
LIG_FHA_1	298	304	PF00498	0.705
LIG_FHA_2	184	190	PF00498	0.561
LIG_FHA_2	35	41	PF00498	0.515
LIG_FHA_2	54	60	PF00498	0.527
LIG_LIR_Gen_1	155	166	PF02991	0.474
LIG_LIR_Nem_3	155	161	PF02991	0.470
LIG_NRBOX	40	46	PF00104	0.580
LIG_PCNA_yPIPBox_3	408	422	PF02747	0.595
LIG_Pex14_2	127	131	PF04695	0.496
LIG_Pex14_2	154	158	PF04695	0.469
LIG_SH2_STAT3	149	152	PF00017	0.489
LIG_SH2_STAT5	160	163	PF00017	0.452
LIG_SH2_STAT5	276	279	PF00017	0.647
LIG_SH2_STAT5	410	413	PF00017	0.596
LIG_SH3_3	116	122	PF00018	0.551
LIG_SH3_3	213	219	PF00018	0.635
LIG_SH3_3	30	36	PF00018	0.597
LIG_SH3_3	314	320	PF00018	0.797
LIG_SH3_3	333	339	PF00018	0.711
LIG_SUMO_SIM_anti_2	300	305	PF11976	0.605
LIG_SUMO_SIM_par_1	256	261	PF11976	0.632
LIG_SUMO_SIM_par_1	373	378	PF11976	0.612
LIG_WW_3	214	218	PF00397	0.563
MOD_CK1_1	192	198	PF00069	0.716
MOD_CK1_1	205	211	PF00069	0.637
MOD_CK1_1	354	360	PF00069	0.786
MOD_CK1_1	362	368	PF00069	0.643
MOD_CK1_1	5	11	PF00069	0.644
MOD_CK1_1	73	79	PF00069	0.530
MOD_CK2_1	34	40	PF00069	0.525
MOD_CK2_1	417	423	PF00069	0.562
MOD_Cter_Amidation	278	281	PF01082	0.720
MOD_GlcNHglycan	204	207	PF01048	0.829
MOD_GlcNHglycan	220	223	PF01048	0.555
MOD_GlcNHglycan	241	244	PF01048	0.715
MOD_GlcNHglycan	248	251	PF01048	0.709
MOD_GlcNHglycan	287	290	PF01048	0.725
MOD_GlcNHglycan	293	296	PF01048	0.624
MOD_GlcNHglycan	330	333	PF01048	0.800
MOD_GlcNHglycan	370	373	PF01048	0.540
MOD_GlcNHglycan	47	50	PF01048	0.725
MOD_GlcNHglycan	72	75	PF01048	0.585
MOD_GSK3_1	152	159	PF00069	0.477
MOD_GSK3_1	197	204	PF00069	0.770
MOD_GSK3_1	244	251	PF00069	0.682
MOD_GSK3_1	285	292	PF00069	0.731
MOD_GSK3_1	364	371	PF00069	0.663
MOD_GSK3_1	5	12	PF00069	0.616
MOD_GSK3_1	53	60	PF00069	0.797
MOD_GSK3_1	68	75	PF00069	0.505
MOD_N-GLC_1	239	244	PF02516	0.686
MOD_N-GLC_1	362	367	PF02516	0.594
MOD_NEK2_1	114	119	PF00069	0.448
MOD_NEK2_1	220	225	PF00069	0.722
MOD_NEK2_1	25	30	PF00069	0.554
MOD_NEK2_1	45	50	PF00069	0.490
MOD_NEK2_1	72	77	PF00069	0.511
MOD_NEK2_2	139	144	PF00069	0.520
MOD_NEK2_2	153	158	PF00069	0.448
MOD_PK_1	373	379	PF00069	0.477
MOD_Plk_1	16	22	PF00069	0.520
MOD_Plk_4	153	159	PF00069	0.448
MOD_Plk_4	95	101	PF00069	0.502
MOD_ProDKin_1	205	211	PF00069	0.681
MOD_ProDKin_1	258	264	PF00069	0.632
MOD_ProDKin_1	32	38	PF00069	0.580
MOD_SUMO_rev_2	174	182	PF00179	0.610
TRG_DiLeu_BaEn_1	10	15	PF01217	0.564
TRG_DiLeu_BaEn_1	178	183	PF01217	0.552
TRG_DiLeu_BaEn_1	40	45	PF01217	0.524
TRG_DiLeu_BaLyEn_6	167	172	PF01217	0.587
TRG_DiLeu_BaLyEn_6	253	258	PF01217	0.659
TRG_ER_diArg_1	133	135	PF00400	0.510
TRG_ER_diArg_1	395	397	PF00400	0.585
TRG_ER_diArg_1	85	87	PF00400	0.492
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	373	378	PF00026	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HPS7	Leishmania braziliensis	69%	100%
A4IE65	Leishmania infantum	99%	100%
E9ATJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q106	Leishmania major	89%	100%