Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IL99_LEIDO

TriTrypDb:

LdBPK_322490.1 , LdCL_320030700 , LDHU3_32.3150

Length:

522

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IL99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IL99

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	94	98	PF00656	0.773
CLV_NRD_NRD_1	122	124	PF00675	0.662
CLV_NRD_NRD_1	138	140	PF00675	0.613
CLV_NRD_NRD_1	142	144	PF00675	0.636
CLV_NRD_NRD_1	146	148	PF00675	0.590
CLV_NRD_NRD_1	225	227	PF00675	0.662
CLV_NRD_NRD_1	317	319	PF00675	0.539
CLV_NRD_NRD_1	361	363	PF00675	0.565
CLV_NRD_NRD_1	454	456	PF00675	0.545
CLV_NRD_NRD_1	67	69	PF00675	0.590
CLV_PCSK_FUR_1	139	143	PF00082	0.665
CLV_PCSK_KEX2_1	122	124	PF00082	0.655
CLV_PCSK_KEX2_1	140	142	PF00082	0.553
CLV_PCSK_KEX2_1	145	147	PF00082	0.641
CLV_PCSK_KEX2_1	225	227	PF00082	0.618
CLV_PCSK_KEX2_1	319	321	PF00082	0.528
CLV_PCSK_KEX2_1	361	363	PF00082	0.669
CLV_PCSK_KEX2_1	383	385	PF00082	0.607
CLV_PCSK_KEX2_1	454	456	PF00082	0.558
CLV_PCSK_KEX2_1	464	466	PF00082	0.428
CLV_PCSK_KEX2_1	67	69	PF00082	0.535
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.669
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.508
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.607
CLV_PCSK_PC1ET2_1	464	466	PF00082	0.470
CLV_PCSK_PC7_1	141	147	PF00082	0.652
CLV_PCSK_SKI1_1	226	230	PF00082	0.597
CLV_PCSK_SKI1_1	331	335	PF00082	0.621
CLV_PCSK_SKI1_1	338	342	PF00082	0.713
CLV_PCSK_SKI1_1	413	417	PF00082	0.551
CLV_PCSK_SKI1_1	455	459	PF00082	0.516
CLV_PCSK_SKI1_1	464	468	PF00082	0.363
CLV_PCSK_SKI1_1	67	71	PF00082	0.585
CLV_Separin_Metazoa	148	152	PF03568	0.594
DEG_Kelch_Keap1_1	104	109	PF01344	0.626
DEG_SCF_FBW7_1	158	163	PF00400	0.448
DEG_SCF_FBW7_2	171	178	PF00400	0.554
DEG_SPOP_SBC_1	28	32	PF00917	0.650
DOC_CKS1_1	157	162	PF01111	0.463
DOC_CKS1_1	172	177	PF01111	0.551
DOC_CKS1_1	404	409	PF01111	0.654
DOC_MAPK_gen_1	140	152	PF00069	0.628
DOC_MAPK_gen_1	225	231	PF00069	0.607
DOC_MAPK_gen_1	383	391	PF00069	0.609
DOC_MAPK_gen_1	454	462	PF00069	0.425
DOC_MAPK_MEF2A_6	383	391	PF00069	0.631
DOC_PP2B_LxvP_1	187	190	PF13499	0.664
DOC_PP4_FxxP_1	157	160	PF00568	0.489
DOC_PP4_FxxP_1	353	356	PF00568	0.677
DOC_USP7_MATH_1	131	135	PF00917	0.685
DOC_USP7_MATH_1	20	24	PF00917	0.688
DOC_USP7_MATH_1	259	263	PF00917	0.631
DOC_USP7_MATH_1	26	30	PF00917	0.719
DOC_USP7_MATH_1	329	333	PF00917	0.528
DOC_USP7_MATH_1	390	394	PF00917	0.612
DOC_USP7_MATH_1	422	426	PF00917	0.699
DOC_USP7_MATH_1	431	435	PF00917	0.667
DOC_USP7_MATH_1	474	478	PF00917	0.490
DOC_USP7_UBL2_3	379	383	PF12436	0.645
DOC_USP7_UBL2_3	464	468	PF12436	0.399
DOC_WW_Pin1_4	156	161	PF00397	0.495
DOC_WW_Pin1_4	171	176	PF00397	0.536
DOC_WW_Pin1_4	24	29	PF00397	0.600
DOC_WW_Pin1_4	261	266	PF00397	0.535
DOC_WW_Pin1_4	403	408	PF00397	0.655
DOC_WW_Pin1_4	77	82	PF00397	0.589
LIG_14-3-3_CanoR_1	13	19	PF00244	0.640
LIG_14-3-3_CanoR_1	170	175	PF00244	0.480
LIG_14-3-3_CanoR_1	235	242	PF00244	0.594
LIG_14-3-3_CanoR_1	267	273	PF00244	0.505
LIG_14-3-3_CanoR_1	384	390	PF00244	0.611
LIG_14-3-3_CanoR_1	413	422	PF00244	0.566
LIG_14-3-3_CanoR_1	454	460	PF00244	0.496
LIG_14-3-3_CanoR_1	86	92	PF00244	0.541
LIG_BRCT_BRCA1_1	88	92	PF00533	0.564
LIG_FHA_1	164	170	PF00498	0.596
LIG_FHA_1	181	187	PF00498	0.469
LIG_FHA_1	205	211	PF00498	0.756
LIG_FHA_1	386	392	PF00498	0.649
LIG_FHA_1	40	46	PF00498	0.623
LIG_FHA_1	404	410	PF00498	0.523
LIG_FHA_2	190	196	PF00498	0.490
LIG_FHA_2	456	462	PF00498	0.481
LIG_FHA_2	483	489	PF00498	0.451
LIG_FHA_2	516	522	PF00498	0.456
LIG_LIR_Apic_2	155	160	PF02991	0.476
LIG_LIR_Apic_2	351	356	PF02991	0.672
LIG_LIR_Gen_1	177	187	PF02991	0.549
LIG_LIR_Gen_1	472	480	PF02991	0.470
LIG_LIR_Nem_3	153	157	PF02991	0.539
LIG_LIR_Nem_3	177	182	PF02991	0.544
LIG_LIR_Nem_3	516	522	PF02991	0.445
LIG_MLH1_MIPbox_1	88	92	PF16413	0.564
LIG_PCNA_yPIPBox_3	320	334	PF02747	0.467
LIG_SH2_CRK	5	9	PF00017	0.617
LIG_SH2_STAT5	44	47	PF00017	0.677
LIG_SH2_STAT5	91	94	PF00017	0.584
LIG_SH3_3	169	175	PF00018	0.641
LIG_SH3_3	401	407	PF00018	0.572
LIG_SH3_3	42	48	PF00018	0.623
LIG_SxIP_EBH_1	215	226	PF03271	0.503
LIG_TRAF2_1	485	488	PF00917	0.510
LIG_UBA3_1	459	464	PF00899	0.450
LIG_WRC_WIRS_1	330	335	PF05994	0.524
LIG_WW_3	80	84	PF00397	0.538
MOD_CDK_SPxK_1	261	267	PF00069	0.537
MOD_CDK_SPxK_1	77	83	PF00069	0.472
MOD_CK1_1	117	123	PF00069	0.682
MOD_CK1_1	177	183	PF00069	0.586
MOD_CK1_1	211	217	PF00069	0.657
MOD_CK1_1	246	252	PF00069	0.691
MOD_CK1_1	29	35	PF00069	0.622
MOD_CK1_1	392	398	PF00069	0.795
MOD_CK1_1	403	409	PF00069	0.609
MOD_CK1_1	436	442	PF00069	0.574
MOD_CK1_1	482	488	PF00069	0.483
MOD_CK1_1	513	519	PF00069	0.478
MOD_CK2_1	100	106	PF00069	0.731
MOD_CK2_1	158	164	PF00069	0.515
MOD_CK2_1	189	195	PF00069	0.612
MOD_CK2_1	455	461	PF00069	0.496
MOD_CK2_1	482	488	PF00069	0.457
MOD_GlcNHglycan	106	109	PF01048	0.626
MOD_GlcNHglycan	128	132	PF01048	0.639
MOD_GlcNHglycan	135	138	PF01048	0.700
MOD_GlcNHglycan	160	163	PF01048	0.705
MOD_GlcNHglycan	22	25	PF01048	0.662
MOD_GlcNHglycan	248	251	PF01048	0.688
MOD_GlcNHglycan	256	259	PF01048	0.635
MOD_GlcNHglycan	313	316	PF01048	0.661
MOD_GlcNHglycan	368	371	PF01048	0.669
MOD_GlcNHglycan	373	377	PF01048	0.777
MOD_GlcNHglycan	394	398	PF01048	0.669
MOD_GlcNHglycan	418	421	PF01048	0.625
MOD_GlcNHglycan	425	428	PF01048	0.623
MOD_GlcNHglycan	432	436	PF01048	0.431
MOD_GSK3_1	100	107	PF00069	0.599
MOD_GSK3_1	127	134	PF00069	0.594
MOD_GSK3_1	156	163	PF00069	0.506
MOD_GSK3_1	170	177	PF00069	0.638
MOD_GSK3_1	20	27	PF00069	0.650
MOD_GSK3_1	204	211	PF00069	0.769
MOD_GSK3_1	248	255	PF00069	0.639
MOD_GSK3_1	28	35	PF00069	0.662
MOD_GSK3_1	385	392	PF00069	0.686
MOD_GSK3_1	409	416	PF00069	0.585
MOD_GSK3_1	436	443	PF00069	0.465
MOD_GSK3_1	92	99	PF00069	0.556
MOD_N-GLC_1	24	29	PF02516	0.600
MOD_N-GLC_1	287	292	PF02516	0.665
MOD_NEK2_1	210	215	PF00069	0.667
MOD_NEK2_1	218	223	PF00069	0.573
MOD_NEK2_1	248	253	PF00069	0.587
MOD_NEK2_1	266	271	PF00069	0.632
MOD_NEK2_1	440	445	PF00069	0.451
MOD_NEK2_1	493	498	PF00069	0.413
MOD_NEK2_1	85	90	PF00069	0.570
MOD_NEK2_1	96	101	PF00069	0.537
MOD_PIKK_1	474	480	PF00454	0.639
MOD_PIKK_1	493	499	PF00454	0.310
MOD_PKA_2	234	240	PF00069	0.713
MOD_PKA_2	266	272	PF00069	0.529
MOD_PKA_2	400	406	PF00069	0.556
MOD_PKA_2	85	91	PF00069	0.525
MOD_Plk_1	177	183	PF00069	0.592
MOD_Plk_1	309	315	PF00069	0.576
MOD_Plk_1	92	98	PF00069	0.566
MOD_Plk_2-3	272	278	PF00069	0.616
MOD_Plk_2-3	433	439	PF00069	0.389
MOD_Plk_4	243	249	PF00069	0.616
MOD_Plk_4	440	446	PF00069	0.460
MOD_Plk_4	455	461	PF00069	0.490
MOD_ProDKin_1	156	162	PF00069	0.499
MOD_ProDKin_1	171	177	PF00069	0.543
MOD_ProDKin_1	24	30	PF00069	0.600
MOD_ProDKin_1	261	267	PF00069	0.537
MOD_ProDKin_1	403	409	PF00069	0.654
MOD_ProDKin_1	77	83	PF00069	0.593
MOD_SUMO_rev_2	269	276	PF00179	0.580
TRG_DiLeu_BaEn_2	152	158	PF01217	0.482
TRG_DiLeu_BaLyEn_6	214	219	PF01217	0.590
TRG_ENDOCYTIC_2	154	157	PF00928	0.588
TRG_ENDOCYTIC_2	179	182	PF00928	0.581
TRG_ENDOCYTIC_2	5	8	PF00928	0.620
TRG_ER_diArg_1	139	142	PF00400	0.669
TRG_ER_diArg_1	143	146	PF00400	0.640
TRG_ER_diArg_1	224	226	PF00400	0.616
TRG_ER_diArg_1	360	362	PF00400	0.568
TRG_ER_diArg_1	399	402	PF00400	0.550
TRG_ER_diArg_1	454	456	PF00400	0.498
TRG_ER_diArg_1	67	69	PF00400	0.590
TRG_NLS_Bipartite_1	122	144	PF00514	0.636
TRG_NLS_MonoCore_2	138	143	PF00514	0.668
TRG_NLS_MonoExtC_3	138	143	PF00514	0.668
TRG_NLS_MonoExtN_4	139	144	PF00514	0.664
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.598
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P596	Leptomonas seymouri	42%	96%
A4HKN0	Leishmania braziliensis	73%	100%
A4I857	Leishmania infantum	99%	100%
D0AAC7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9B318	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q536	Leishmania major	89%	100%