Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IL86_LEIDO

TriTrypDb:

LdBPK_364090.1 , LdCL_360047900 , LDHU3_36.5480

Length:

275

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IL86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IL86

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.567
CLV_NRD_NRD_1	102	104	PF00675	0.664
CLV_PCSK_SKI1_1	223	227	PF00082	0.670
CLV_PCSK_SKI1_1	37	41	PF00082	0.601
DEG_Nend_Nbox_1	1	3	PF02207	0.657
DEG_SPOP_SBC_1	150	154	PF00917	0.585
DOC_CYCLIN_yCln2_LP_2	107	113	PF00134	0.643
DOC_MAPK_gen_1	166	175	PF00069	0.633
DOC_MAPK_gen_1	264	272	PF00069	0.616
DOC_MAPK_gen_1	34	43	PF00069	0.691
DOC_MAPK_MEF2A_6	37	45	PF00069	0.591
DOC_PP4_FxxP_1	45	48	PF00568	0.572
DOC_SPAK_OSR1_1	166	170	PF12202	0.661
DOC_USP7_MATH_1	130	134	PF00917	0.751
DOC_USP7_MATH_1	137	141	PF00917	0.730
DOC_USP7_MATH_1	146	150	PF00917	0.605
DOC_WW_Pin1_4	139	144	PF00397	0.742
DOC_WW_Pin1_4	192	197	PF00397	0.722
LIG_14-3-3_CanoR_1	37	42	PF00244	0.555
LIG_APCC_ABBA_1	64	69	PF00400	0.630
LIG_BRCT_BRCA1_1	171	175	PF00533	0.586
LIG_CaM_NSCaTE_8	95	102	PF13499	0.740
LIG_FHA_1	38	44	PF00498	0.589
LIG_FHA_1	85	91	PF00498	0.616
LIG_FHA_2	118	124	PF00498	0.640
LIG_FHA_2	150	156	PF00498	0.755
LIG_GBD_Chelix_1	169	177	PF00786	0.589
LIG_LIR_Apic_2	42	48	PF02991	0.567
LIG_LIR_Gen_1	268	274	PF02991	0.683
LIG_LIR_Nem_3	13	19	PF02991	0.591
LIG_LIR_Nem_3	268	272	PF02991	0.677
LIG_LIR_Nem_3	46	52	PF02991	0.697
LIG_NRBOX	172	178	PF00104	0.680
LIG_Pex14_2	45	49	PF04695	0.570
LIG_PTB_Apo_2	202	209	PF02174	0.716
LIG_SH2_SRC	55	58	PF00017	0.692
LIG_SH2_STAP1	11	15	PF00017	0.598
LIG_SH2_STAP1	16	20	PF00017	0.570
LIG_SH2_STAP1	55	59	PF00017	0.612
LIG_SH2_STAT5	19	22	PF00017	0.505
LIG_SH2_STAT5	269	272	PF00017	0.665
LIG_SH3_3	107	113	PF00018	0.745
LIG_SH3_3	190	196	PF00018	0.740
LIG_SH3_3	80	86	PF00018	0.572
LIG_SUMO_SIM_anti_2	40	46	PF11976	0.570
LIG_SUMO_SIM_par_1	86	91	PF11976	0.651
LIG_TRAF2_1	54	57	PF00917	0.594
LIG_TYR_ITIM	65	70	PF00017	0.740
MOD_CK1_1	149	155	PF00069	0.779
MOD_CK1_1	84	90	PF00069	0.665
MOD_CK2_1	117	123	PF00069	0.672
MOD_CK2_1	149	155	PF00069	0.758
MOD_CK2_1	50	56	PF00069	0.630
MOD_GlcNHglycan	132	135	PF01048	0.723
MOD_GlcNHglycan	148	151	PF01048	0.705
MOD_GlcNHglycan	196	199	PF01048	0.841
MOD_GlcNHglycan	272	275	PF01048	0.667
MOD_GlcNHglycan	34	37	PF01048	0.576
MOD_GlcNHglycan	51	55	PF01048	0.601
MOD_GlcNHglycan	83	86	PF01048	0.698
MOD_GSK3_1	117	124	PF00069	0.579
MOD_GSK3_1	146	153	PF00069	0.742
MOD_GSK3_1	18	25	PF00069	0.587
MOD_GSK3_1	84	91	PF00069	0.661
MOD_N-GLC_1	155	160	PF02516	0.724
MOD_NEK2_1	117	122	PF00069	0.746
MOD_NEK2_1	138	143	PF00069	0.710
MOD_NEK2_1	162	167	PF00069	0.674
MOD_NEK2_1	177	182	PF00069	0.633
MOD_NEK2_1	186	191	PF00069	0.670
MOD_NEK2_1	23	28	PF00069	0.577
MOD_NEK2_1	88	93	PF00069	0.652
MOD_Plk_1	187	193	PF00069	0.747
MOD_Plk_1	50	56	PF00069	0.630
MOD_Plk_4	238	244	PF00069	0.723
MOD_ProDKin_1	139	145	PF00069	0.743
MOD_ProDKin_1	192	198	PF00069	0.722
TRG_ENDOCYTIC_2	269	272	PF00928	0.618
TRG_ENDOCYTIC_2	67	70	PF00928	0.747

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6L2	Leptomonas seymouri	41%	100%
A4HPQ7	Leishmania braziliensis	73%	99%
A4ID06	Leishmania infantum	100%	100%
E9ATH2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q125	Leishmania major	90%	100%