Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IL79_LEIDO

TriTrypDb:

LdBPK_211760.1 , LdCL_210023400 , LDHU3_21.2070

Length:

283

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IL79

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IL79

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	277	281	PF00656	0.565
CLV_NRD_NRD_1	236	238	PF00675	0.633
CLV_NRD_NRD_1	75	77	PF00675	0.542
CLV_NRD_NRD_1	81	83	PF00675	0.486
CLV_PCSK_KEX2_1	148	150	PF00082	0.589
CLV_PCSK_KEX2_1	236	238	PF00082	0.690
CLV_PCSK_KEX2_1	266	268	PF00082	0.582
CLV_PCSK_KEX2_1	27	29	PF00082	0.755
CLV_PCSK_KEX2_1	77	79	PF00082	0.557
CLV_PCSK_KEX2_1	81	83	PF00082	0.529
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.589
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.582
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.608
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.530
DEG_Nend_UBRbox_2	1	3	PF02207	0.539
DOC_PP2B_LxvP_1	276	279	PF13499	0.560
DOC_USP7_MATH_1	107	111	PF00917	0.667
DOC_USP7_MATH_1	188	192	PF00917	0.690
DOC_USP7_MATH_1	207	211	PF00917	0.646
DOC_USP7_MATH_1	262	266	PF00917	0.568
DOC_USP7_MATH_1	59	63	PF00917	0.659
DOC_USP7_UBL2_3	234	238	PF12436	0.638
DOC_WW_Pin1_4	141	146	PF00397	0.552
DOC_WW_Pin1_4	210	215	PF00397	0.664
LIG_14-3-3_CanoR_1	221	227	PF00244	0.490
LIG_14-3-3_CanoR_1	249	258	PF00244	0.469
LIG_14-3-3_CanoR_1	51	60	PF00244	0.671
LIG_14-3-3_CanoR_1	81	91	PF00244	0.443
LIG_BIR_III_2	187	191	PF00653	0.683
LIG_FHA_2	110	116	PF00498	0.581
LIG_FHA_2	142	148	PF00498	0.522
LIG_LIR_Gen_1	139	146	PF02991	0.587
LIG_LIR_Gen_1	224	233	PF02991	0.450
LIG_LIR_Nem_3	224	229	PF02991	0.444
LIG_LIR_Nem_3	85	90	PF02991	0.420
LIG_SH2_NCK_1	259	263	PF00017	0.473
LIG_SH2_STAP1	151	155	PF00017	0.461
LIG_SH2_STAP1	259	263	PF00017	0.473
LIG_SH2_STAP1	87	91	PF00017	0.531
LIG_SH2_STAT5	90	93	PF00017	0.537
LIG_SH3_1	77	83	PF00018	0.505
LIG_SH3_3	189	195	PF00018	0.619
LIG_SH3_3	77	83	PF00018	0.489
LIG_TRAF2_1	252	255	PF00917	0.583
MOD_CDK_SPxxK_3	141	148	PF00069	0.524
MOD_CK1_1	157	163	PF00069	0.536
MOD_CK1_1	210	216	PF00069	0.621
MOD_CK1_1	222	228	PF00069	0.536
MOD_CK1_1	265	271	PF00069	0.545
MOD_CK1_1	45	51	PF00069	0.699
MOD_CK1_1	62	68	PF00069	0.512
MOD_CK1_1	69	75	PF00069	0.548
MOD_CK2_1	141	147	PF00069	0.527
MOD_CK2_1	249	255	PF00069	0.439
MOD_CK2_1	51	57	PF00069	0.625
MOD_CK2_1	82	88	PF00069	0.553
MOD_Cter_Amidation	234	237	PF01082	0.634
MOD_Cter_Amidation	25	28	PF01082	0.664
MOD_GlcNHglycan	170	173	PF01048	0.643
MOD_GlcNHglycan	180	183	PF01048	0.703
MOD_GlcNHglycan	251	254	PF01048	0.451
MOD_GlcNHglycan	276	279	PF01048	0.723
MOD_GlcNHglycan	53	56	PF01048	0.586
MOD_GlcNHglycan	61	64	PF01048	0.615
MOD_GlcNHglycan	84	87	PF01048	0.420
MOD_GSK3_1	164	171	PF00069	0.587
MOD_GSK3_1	270	277	PF00069	0.563
MOD_GSK3_1	42	49	PF00069	0.654
MOD_GSK3_1	62	69	PF00069	0.452
MOD_N-GLC_1	249	254	PF02516	0.569
MOD_N-GLC_1	46	51	PF02516	0.716
MOD_NEK2_1	272	277	PF00069	0.507
MOD_NEK2_2	46	51	PF00069	0.664
MOD_PIKK_1	194	200	PF00454	0.593
MOD_PIKK_1	270	276	PF00454	0.651
MOD_PKA_2	208	214	PF00069	0.583
MOD_Plk_1	46	52	PF00069	0.728
MOD_Plk_4	136	142	PF00069	0.589
MOD_ProDKin_1	141	147	PF00069	0.554
MOD_ProDKin_1	210	216	PF00069	0.663
MOD_SUMO_rev_2	252	258	PF00179	0.583
TRG_ER_diArg_1	75	78	PF00400	0.547
TRG_ER_diArg_1	80	82	PF00400	0.492
TRG_NLS_MonoExtC_3	75	80	PF00514	0.503
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.647
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.628

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAX4	Leptomonas seymouri	32%	94%
A4HC00	Leishmania braziliensis	60%	99%
A4HZE9	Leishmania infantum	99%	100%
E9AVD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QC43	Leishmania major	88%	100%