CNNM transmembrane domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function DUF21, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IL77_LEIDO

TriTrypDb:

LdBPK_342480.1 , LdCL_340032400 , LDHU3_34.4060

Length:

608

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 5
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	8
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8IL77

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IL77

Function

Biological processes
Term	Name	Level	Count
GO:0010960	magnesium ion homeostasis	8	12
GO:0042592	homeostatic process	3	12
GO:0048878	chemical homeostasis	4	12
GO:0050801	monoatomic ion homeostasis	5	12
GO:0055065	obsolete metal ion homeostasis	7	12
GO:0055080	monoatomic cation homeostasis	6	12
GO:0065007	biological regulation	1	12
GO:0065008	regulation of biological quality	2	12
GO:0072507	obsolete divalent inorganic cation homeostasis	7	12
GO:0098771	inorganic ion homeostasis	6	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	73	77	PF00656	0.367
CLV_NRD_NRD_1	21	23	PF00675	0.536
CLV_NRD_NRD_1	347	349	PF00675	0.431
CLV_NRD_NRD_1	443	445	PF00675	0.482
CLV_NRD_NRD_1	55	57	PF00675	0.632
CLV_NRD_NRD_1	600	602	PF00675	0.540
CLV_PCSK_KEX2_1	21	23	PF00082	0.536
CLV_PCSK_KEX2_1	347	349	PF00082	0.441
CLV_PCSK_KEX2_1	432	434	PF00082	0.561
CLV_PCSK_KEX2_1	443	445	PF00082	0.477
CLV_PCSK_KEX2_1	55	57	PF00082	0.498
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.561
CLV_PCSK_SKI1_1	240	244	PF00082	0.365
CLV_PCSK_SKI1_1	325	329	PF00082	0.437
CLV_PCSK_SKI1_1	337	341	PF00082	0.416
CLV_Separin_Metazoa	577	581	PF03568	0.293
DEG_APCC_DBOX_1	11	19	PF00400	0.420
DEG_APCC_DBOX_1	234	242	PF00400	0.165
DEG_COP1_1	549	557	PF00400	0.256
DEG_Nend_Nbox_1	1	3	PF02207	0.409
DOC_CKS1_1	276	281	PF01111	0.228
DOC_MAPK_gen_1	10	17	PF00069	0.558
DOC_MAPK_gen_1	21	29	PF00069	0.388
DOC_MAPK_MEF2A_6	10	17	PF00069	0.432
DOC_MAPK_MEF2A_6	198	205	PF00069	0.208
DOC_MAPK_MEF2A_6	315	323	PF00069	0.215
DOC_MAPK_MEF2A_6	337	344	PF00069	0.248
DOC_MAPK_MEF2A_6	530	537	PF00069	0.280
DOC_MAPK_NFAT4_5	10	18	PF00069	0.421
DOC_MAPK_NFAT4_5	530	538	PF00069	0.264
DOC_PP1_RVXF_1	237	244	PF00149	0.165
DOC_PP2B_LxvP_1	13	16	PF13499	0.439
DOC_PP2B_LxvP_1	552	555	PF13499	0.265
DOC_USP7_MATH_1	186	190	PF00917	0.415
DOC_USP7_MATH_1	246	250	PF00917	0.174
DOC_USP7_MATH_1	490	494	PF00917	0.322
DOC_USP7_MATH_1	547	551	PF00917	0.287
DOC_USP7_UBL2_3	223	227	PF12436	0.263
DOC_WW_Pin1_4	275	280	PF00397	0.227
LIG_14-3-3_CanoR_1	10	16	PF00244	0.598
LIG_14-3-3_CanoR_1	22	28	PF00244	0.461
LIG_14-3-3_CanoR_1	55	59	PF00244	0.280
LIG_14-3-3_CanoR_1	601	606	PF00244	0.333
LIG_APCC_ABBA_1	504	509	PF00400	0.334
LIG_BIR_III_4	76	80	PF00653	0.333
LIG_BRCT_BRCA1_1	405	409	PF00533	0.258
LIG_BRCT_BRCA1_1	512	516	PF00533	0.220
LIG_BRCT_BRCA1_1	549	553	PF00533	0.303
LIG_Clathr_ClatBox_1	104	108	PF01394	0.463
LIG_Clathr_ClatBox_1	393	397	PF01394	0.202
LIG_Clathr_ClatBox_1	83	87	PF01394	0.199
LIG_EH1_1	387	395	PF00400	0.210
LIG_eIF4E_1	388	394	PF01652	0.208
LIG_FHA_1	107	113	PF00498	0.429
LIG_FHA_1	141	147	PF00498	0.236
LIG_FHA_1	24	30	PF00498	0.398
LIG_FHA_1	294	300	PF00498	0.270
LIG_FHA_1	334	340	PF00498	0.230
LIG_FHA_1	354	360	PF00498	0.165
LIG_FHA_1	515	521	PF00498	0.197
LIG_FHA_1	543	549	PF00498	0.279
LIG_FHA_1	99	105	PF00498	0.278
LIG_FHA_2	270	276	PF00498	0.226
LIG_FHA_2	393	399	PF00498	0.199
LIG_FHA_2	44	50	PF00498	0.285
LIG_LIR_Gen_1	513	524	PF02991	0.203
LIG_LIR_Gen_1	539	548	PF02991	0.215
LIG_LIR_Gen_1	573	581	PF02991	0.264
LIG_LIR_Gen_1	78	86	PF02991	0.262
LIG_LIR_LC3C_4	517	520	PF02991	0.292
LIG_LIR_Nem_3	385	390	PF02991	0.247
LIG_LIR_Nem_3	406	412	PF02991	0.269
LIG_LIR_Nem_3	513	519	PF02991	0.203
LIG_LIR_Nem_3	539	543	PF02991	0.214
LIG_LIR_Nem_3	78	83	PF02991	0.265
LIG_NRBOX	28	34	PF00104	0.327
LIG_PCNA_yPIPBox_3	134	145	PF02747	0.365
LIG_PDZ_Class_3	603	608	PF00595	0.352
LIG_Pex14_2	206	210	PF04695	0.183
LIG_Pex14_2	553	557	PF04695	0.255
LIG_Pex14_2	93	97	PF04695	0.194
LIG_SH2_STAP1	126	130	PF00017	0.382
LIG_SH2_STAT5	364	367	PF00017	0.223
LIG_SH2_STAT5	575	578	PF00017	0.304
LIG_SH3_3	210	216	PF00018	0.229
LIG_SH3_3	273	279	PF00018	0.219
LIG_SH3_3	484	490	PF00018	0.259
LIG_SUMO_SIM_anti_2	101	106	PF11976	0.125
LIG_SUMO_SIM_anti_2	111	118	PF11976	0.365
LIG_SUMO_SIM_anti_2	258	263	PF11976	0.237
LIG_SUMO_SIM_anti_2	26	31	PF11976	0.506
LIG_SUMO_SIM_anti_2	336	342	PF11976	0.223
LIG_SUMO_SIM_anti_2	370	377	PF11976	0.215
LIG_SUMO_SIM_anti_2	82	88	PF11976	0.188
LIG_SUMO_SIM_par_1	108	113	PF11976	0.424
LIG_SUMO_SIM_par_1	281	287	PF11976	0.237
LIG_SUMO_SIM_par_1	516	521	PF11976	0.204
LIG_SUMO_SIM_par_1	82	88	PF11976	0.266
LIG_SxIP_EBH_1	303	314	PF03271	0.251
LIG_TYR_ITIM	447	452	PF00017	0.228
LIG_UBA3_1	358	363	PF00899	0.228
LIG_WRC_WIRS_1	554	559	PF05994	0.236
MOD_CK1_1	249	255	PF00069	0.327
MOD_CK1_1	439	445	PF00069	0.366
MOD_CK1_1	514	520	PF00069	0.300
MOD_CK1_1	587	593	PF00069	0.373
MOD_CK2_1	115	121	PF00069	0.365
MOD_CK2_1	269	275	PF00069	0.323
MOD_CK2_1	43	49	PF00069	0.277
MOD_CK2_1	459	465	PF00069	0.287
MOD_Cter_Amidation	19	22	PF01082	0.534
MOD_GlcNHglycan	117	120	PF01048	0.231
MOD_GlcNHglycan	18	21	PF01048	0.500
MOD_GlcNHglycan	188	191	PF01048	0.168
MOD_GlcNHglycan	198	201	PF01048	0.176
MOD_GlcNHglycan	248	251	PF01048	0.491
MOD_GlcNHglycan	4	7	PF01048	0.537
MOD_GlcNHglycan	469	474	PF01048	0.573
MOD_GlcNHglycan	520	523	PF01048	0.443
MOD_GlcNHglycan	594	597	PF01048	0.575
MOD_GlcNHglycan	76	80	PF01048	0.579
MOD_GSK3_1	166	173	PF00069	0.237
MOD_GSK3_1	353	360	PF00069	0.221
MOD_GSK3_1	435	442	PF00069	0.343
MOD_GSK3_1	510	517	PF00069	0.226
MOD_GSK3_1	538	545	PF00069	0.314
MOD_GSK3_1	587	594	PF00069	0.367
MOD_GSK3_1	75	82	PF00069	0.354
MOD_N-GLC_1	425	430	PF02516	0.626
MOD_NEK2_1	11	16	PF00069	0.509
MOD_NEK2_1	140	145	PF00069	0.195
MOD_NEK2_1	150	155	PF00069	0.293
MOD_NEK2_1	2	7	PF00069	0.422
MOD_NEK2_1	43	48	PF00069	0.481
MOD_NEK2_1	459	464	PF00069	0.235
MOD_NEK2_1	479	484	PF00069	0.313
MOD_NEK2_1	518	523	PF00069	0.222
MOD_NEK2_1	75	80	PF00069	0.314
MOD_NEK2_2	555	560	PF00069	0.212
MOD_PKA_1	601	607	PF00069	0.334
MOD_PKA_2	11	17	PF00069	0.396
MOD_PKA_2	54	60	PF00069	0.454
MOD_Plk_1	122	128	PF00069	0.403
MOD_Plk_1	269	275	PF00069	0.224
MOD_Plk_1	293	299	PF00069	0.254
MOD_Plk_1	464	470	PF00069	0.308
MOD_Plk_1	479	485	PF00069	0.272
MOD_Plk_1	563	569	PF00069	0.222
MOD_Plk_2-3	108	114	PF00069	0.365
MOD_Plk_2-3	117	123	PF00069	0.365
MOD_Plk_4	140	146	PF00069	0.237
MOD_Plk_4	150	156	PF00069	0.321
MOD_Plk_4	166	172	PF00069	0.274
MOD_Plk_4	215	221	PF00069	0.193
MOD_Plk_4	25	31	PF00069	0.404
MOD_Plk_4	269	275	PF00069	0.224
MOD_Plk_4	480	486	PF00069	0.288
MOD_Plk_4	511	517	PF00069	0.317
MOD_Plk_4	563	569	PF00069	0.220
MOD_Plk_4	79	85	PF00069	0.260
MOD_ProDKin_1	275	281	PF00069	0.231
MOD_SUMO_rev_2	234	241	PF00179	0.165
MOD_SUMO_rev_2	354	359	PF00179	0.209
MOD_SUMO_rev_2	385	393	PF00179	0.226
MOD_SUMO_rev_2	594	604	PF00179	0.392
TRG_DiLeu_BaEn_1	237	242	PF01217	0.165
TRG_DiLeu_BaEn_1	295	300	PF01217	0.251
TRG_DiLeu_BaEn_1	389	394	PF01217	0.199
TRG_ENDOCYTIC_2	387	390	PF00928	0.237
TRG_ENDOCYTIC_2	449	452	PF00928	0.358
TRG_ENDOCYTIC_2	575	578	PF00928	0.246
TRG_ER_diArg_1	10	13	PF00400	0.604
TRG_ER_diArg_1	443	445	PF00400	0.277
TRG_ER_diArg_1	485	488	PF00400	0.352
TRG_NES_CRM1_1	275	290	PF08389	0.255
TRG_Pf-PMV_PEXEL_1	134	139	PF00026	0.165
TRG_Pf-PMV_PEXEL_1	65	69	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0B7P9G0	Drosophila melanogaster	33%	73%
A0A0N1PDI6	Leptomonas seymouri	84%	100%
A0A0S4JSF9	Bodo saltans	69%	100%
A0A131MCZ8	Caenorhabditis elegans	31%	76%
A0A1X0PAL3	Trypanosomatidae	75%	100%
A0A3Q8IC75	Leishmania donovani	24%	100%
A0A3Q8ITK0	Leishmania donovani	23%	100%
A0A3S7WUR9	Leishmania donovani	30%	82%
A0A422NS01	Trypanosoma rangeli	71%	100%
A0JPA0	Xenopus tropicalis	36%	79%
A3QM97	Caenorhabditis elegans	31%	75%
A4HAY2	Leishmania braziliensis	90%	99%
A4HIN7	Leishmania braziliensis	23%	100%
A4HKU5	Leishmania braziliensis	23%	100%
A4HXP0	Leishmania infantum	30%	82%
A4I5Y4	Leishmania infantum	24%	100%
A4I8C4	Leishmania infantum	22%	100%
A4IA41	Leishmania infantum	100%	100%
C9ZM59	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
D0A017	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	82%
E9ARF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	82%
E9B177	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B383	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9B555	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
P0C588	Rattus norvegicus	35%	79%
Q32NY4	Mus musculus	28%	85%
Q3TWN3	Mus musculus	35%	69%
Q4Q2T0	Leishmania major	96%	100%
Q4Q4X2	Leishmania major	22%	100%
Q4Q6Y7	Leishmania major	24%	100%
Q4QE28	Leishmania major	29%	82%
Q4QE29	Leishmania major	31%	100%
Q5U2P1	Rattus norvegicus	35%	69%
Q69ZF7	Mus musculus	36%	79%
Q6P4Q7	Homo sapiens	36%	78%
Q8NE01	Homo sapiens	27%	86%
Q9GYL2	Caenorhabditis elegans	29%	80%
Q9H8M5	Homo sapiens	35%	69%
V5BKR5	Trypanosoma cruzi	73%	100%