CNNM transmembrane domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function DUF21, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IL77_LEIDO

TriTrypDb:

LdBPK_342480.1 , LdCL_340032400 , LDHU3_34.4060

Length:

608

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 5
NetGPI	no	yes: 0, no: 11

Show entries

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	8
GO:0016020	membrane	2	12
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	12

Previous1Next

Expansion

Sequence features

A0A3Q8IL77

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IL77

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0010960	magnesium ion homeostasis	8	12
GO:0042592	homeostatic process	3	12
GO:0048878	chemical homeostasis	4	12
GO:0050801	monoatomic ion homeostasis	5	12
GO:0055065	obsolete metal ion homeostasis	7	12
GO:0055080	monoatomic cation homeostasis	6	12
GO:0065007	biological regulation	1	12
GO:0065008	regulation of biological quality	2	12
GO:0072507	obsolete divalent inorganic cation homeostasis	7	12
GO:0098771	inorganic ion homeostasis	6	12

Previous1Next

Could not find GO molecular_function term for this entry.

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	73	77	PF00656	0.367
CLV_NRD_NRD_1	21	23	PF00675	0.536
CLV_NRD_NRD_1	347	349	PF00675	0.431
CLV_NRD_NRD_1	443	445	PF00675	0.482
CLV_NRD_NRD_1	55	57	PF00675	0.632
CLV_NRD_NRD_1	600	602	PF00675	0.540
CLV_PCSK_KEX2_1	21	23	PF00082	0.536
CLV_PCSK_KEX2_1	347	349	PF00082	0.441
CLV_PCSK_KEX2_1	432	434	PF00082	0.561
CLV_PCSK_KEX2_1	443	445	PF00082	0.477

Previous1 2 3 4 5…18Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0B7P9G0	Drosophila melanogaster	33%	73%
A0A0N1PDI6	Leptomonas seymouri	84%	100%
A0A0S4JSF9	Bodo saltans	69%	100%
A0A131MCZ8	Caenorhabditis elegans	31%	76%
A0A1X0PAL3	Trypanosomatidae	75%	100%
A0A3Q8IC75	Leishmania donovani	24%	100%
A0A3Q8ITK0	Leishmania donovani	23%	100%
A0A3S7WUR9	Leishmania donovani	30%	82%
A0A422NS01	Trypanosoma rangeli	71%	100%
A0JPA0	Xenopus tropicalis	36%	79%

Previous1 2 3 4Next