Cytidine and deoxycytidylate deaminase zinc-binding region family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cytidine and deoxycytidylate deaminase zinc-binding region, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IL67_LEIDO

TriTrypDb:

LdBPK_322210.1 , LdCL_320027500 , LDHU3_32.2750

Length:

542

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IL67

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IL67

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	54	56	PF00675	0.584
CLV_PCSK_FUR_1	52	56	PF00082	0.575
CLV_PCSK_KEX2_1	393	395	PF00082	0.761
CLV_PCSK_KEX2_1	49	51	PF00082	0.525
CLV_PCSK_KEX2_1	54	56	PF00082	0.585
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.732
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.525
CLV_PCSK_PC7_1	50	56	PF00082	0.560
CLV_PCSK_SKI1_1	280	284	PF00082	0.384
CLV_PCSK_SKI1_1	404	408	PF00082	0.550
CLV_PCSK_SKI1_1	498	502	PF00082	0.278
CLV_PCSK_SKI1_1	55	59	PF00082	0.590
DEG_APCC_DBOX_1	513	521	PF00400	0.382
DEG_Nend_UBRbox_1	1	4	PF02207	0.412
DEG_SCF_FBW7_1	69	76	PF00400	0.658
DEG_SPOP_SBC_1	356	360	PF00917	0.444
DOC_ANK_TNKS_1	183	190	PF00023	0.580
DOC_CKS1_1	70	75	PF01111	0.660
DOC_CYCLIN_yClb5_NLxxxL_5	31	40	PF00134	0.534
DOC_CYCLIN_yCln2_LP_2	407	413	PF00134	0.392
DOC_MAPK_gen_1	49	59	PF00069	0.579
DOC_MAPK_MEF2A_6	316	325	PF00069	0.573
DOC_MAPK_MEF2A_6	32	40	PF00069	0.493
DOC_PP1_RVXF_1	127	133	PF00149	0.577
DOC_PP1_RVXF_1	496	502	PF00149	0.500
DOC_PP2B_LxvP_1	255	258	PF13499	0.528
DOC_PP2B_LxvP_1	36	39	PF13499	0.500
DOC_PP2B_PxIxI_1	320	326	PF00149	0.548
DOC_PP4_FxxP_1	442	445	PF00568	0.577
DOC_USP7_MATH_1	102	106	PF00917	0.588
DOC_USP7_MATH_1	118	122	PF00917	0.499
DOC_USP7_MATH_1	137	141	PF00917	0.640
DOC_USP7_MATH_1	155	159	PF00917	0.399
DOC_USP7_MATH_1	175	179	PF00917	0.408
DOC_USP7_MATH_1	223	227	PF00917	0.498
DOC_USP7_MATH_1	357	361	PF00917	0.450
DOC_USP7_MATH_1	455	459	PF00917	0.650
DOC_USP7_MATH_1	464	468	PF00917	0.526
DOC_USP7_MATH_2	243	249	PF00917	0.565
DOC_WW_Pin1_4	11	16	PF00397	0.532
DOC_WW_Pin1_4	317	322	PF00397	0.670
DOC_WW_Pin1_4	380	385	PF00397	0.585
DOC_WW_Pin1_4	64	69	PF00397	0.577
LIG_14-3-3_CanoR_1	304	311	PF00244	0.582
LIG_14-3-3_CanoR_1	429	433	PF00244	0.560
LIG_14-3-3_CanoR_1	462	471	PF00244	0.557
LIG_14-3-3_CanoR_1	54	60	PF00244	0.636
LIG_BIR_III_4	107	111	PF00653	0.612
LIG_BRCT_BRCA1_1	150	154	PF00533	0.460
LIG_BRCT_BRCA1_1	225	229	PF00533	0.469
LIG_deltaCOP1_diTrp_1	245	253	PF00928	0.500
LIG_FHA_1	12	18	PF00498	0.527
LIG_FHA_1	155	161	PF00498	0.524
LIG_FHA_1	269	275	PF00498	0.382
LIG_FHA_1	350	356	PF00498	0.496
LIG_FHA_1	92	98	PF00498	0.597
LIG_FHA_2	133	139	PF00498	0.568
LIG_FHA_2	381	387	PF00498	0.512
LIG_IRF3_LxIS_1	15	22	PF10401	0.477
LIG_LIR_Gen_1	226	236	PF02991	0.487
LIG_LIR_Gen_1	537	542	PF02991	0.453
LIG_LIR_Nem_3	537	542	PF02991	0.453
LIG_NRBOX	76	82	PF00104	0.635
LIG_PCNA_PIPBox_1	520	529	PF02747	0.419
LIG_PDZ_Class_1	537	542	PF00595	0.475
LIG_REV1ctd_RIR_1	498	508	PF16727	0.559
LIG_SH2_CRK	376	380	PF00017	0.628
LIG_SH2_STAT5	200	203	PF00017	0.640
LIG_SH2_STAT5	376	379	PF00017	0.561
LIG_SH2_STAT5	470	473	PF00017	0.403
LIG_SH2_STAT5	478	481	PF00017	0.461
LIG_SH2_STAT5	539	542	PF00017	0.644
LIG_SH3_3	254	260	PF00018	0.528
LIG_SH3_3	344	350	PF00018	0.369
LIG_SH3_3	364	370	PF00018	0.361
LIG_SH3_3	397	403	PF00018	0.574
LIG_SH3_3	62	68	PF00018	0.612
LIG_SH3_CIN85_PxpxPR_1	254	259	PF14604	0.598
LIG_SUMO_SIM_anti_2	342	349	PF11976	0.402
LIG_SUMO_SIM_anti_2	75	81	PF11976	0.636
LIG_SUMO_SIM_par_1	16	23	PF11976	0.453
LIG_TRAF2_1	326	329	PF00917	0.633
MOD_CK1_1	171	177	PF00069	0.497
MOD_CK1_1	202	208	PF00069	0.613
MOD_CK1_1	303	309	PF00069	0.620
MOD_CK1_1	360	366	PF00069	0.484
MOD_CK1_1	454	460	PF00069	0.590
MOD_CK1_1	96	102	PF00069	0.617
MOD_CK2_1	132	138	PF00069	0.573
MOD_CK2_1	321	327	PF00069	0.653
MOD_CK2_1	525	531	PF00069	0.379
MOD_CK2_1	72	78	PF00069	0.649
MOD_GlcNHglycan	115	118	PF01048	0.573
MOD_GlcNHglycan	170	173	PF01048	0.443
MOD_GlcNHglycan	177	180	PF01048	0.556
MOD_GlcNHglycan	247	250	PF01048	0.567
MOD_GlcNHglycan	266	269	PF01048	0.340
MOD_GlcNHglycan	359	362	PF01048	0.457
MOD_GlcNHglycan	453	456	PF01048	0.576
MOD_GlcNHglycan	527	530	PF01048	0.370
MOD_GSK3_1	149	156	PF00069	0.557
MOD_GSK3_1	171	178	PF00069	0.495
MOD_GSK3_1	194	201	PF00069	0.730
MOD_GSK3_1	210	217	PF00069	0.537
MOD_GSK3_1	230	237	PF00069	0.365
MOD_GSK3_1	264	271	PF00069	0.444
MOD_GSK3_1	300	307	PF00069	0.535
MOD_GSK3_1	312	319	PF00069	0.627
MOD_GSK3_1	356	363	PF00069	0.441
MOD_GSK3_1	428	435	PF00069	0.667
MOD_GSK3_1	440	447	PF00069	0.529
MOD_GSK3_1	450	457	PF00069	0.568
MOD_GSK3_1	60	67	PF00069	0.623
MOD_GSK3_1	69	76	PF00069	0.643
MOD_GSK3_1	93	100	PF00069	0.606
MOD_N-GLC_1	100	105	PF02516	0.530
MOD_N-GLC_1	464	469	PF02516	0.573
MOD_NEK2_1	154	159	PF00069	0.556
MOD_NEK2_1	166	171	PF00069	0.341
MOD_NEK2_1	491	496	PF00069	0.349
MOD_NEK2_1	519	524	PF00069	0.369
MOD_NEK2_2	361	366	PF00069	0.464
MOD_PKA_2	300	306	PF00069	0.559
MOD_PKA_2	428	434	PF00069	0.593
MOD_Plk_1	137	143	PF00069	0.544
MOD_Plk_1	386	392	PF00069	0.614
MOD_Plk_4	26	32	PF00069	0.437
MOD_Plk_4	55	61	PF00069	0.560
MOD_Plk_4	93	99	PF00069	0.609
MOD_ProDKin_1	11	17	PF00069	0.531
MOD_ProDKin_1	317	323	PF00069	0.671
MOD_ProDKin_1	380	386	PF00069	0.588
MOD_ProDKin_1	64	70	PF00069	0.573
MOD_SUMO_rev_2	22	27	PF00179	0.467
TRG_DiLeu_BaEn_1	336	341	PF01217	0.600
TRG_DiLeu_BaLyEn_6	126	131	PF01217	0.583
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.350
TRG_DiLeu_BaLyEn_6	401	406	PF01217	0.529
TRG_ENDOCYTIC_2	376	379	PF00928	0.626
TRG_ENDOCYTIC_2	539	542	PF00928	0.502
TRG_ER_diArg_1	50	53	PF00400	0.543
TRG_NLS_MonoExtC_3	48	53	PF00514	0.538
TRG_Pf-PMV_PEXEL_1	148	153	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	404	408	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXU5	Leptomonas seymouri	43%	100%
A4HKJ8	Leishmania braziliensis	70%	99%
A4I830	Leishmania infantum	100%	100%
E9B2Y8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q568	Leishmania major	90%	100%