LeishMANIAdb
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Protein phosphatase 2C-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein phosphatase 2C-like protein
Gene product:
protein phosphatase 2C-like protein
Species:
Leishmania donovani
UniProt:
A0A3Q8IL63_LEIDO
TriTrypDb:
LdBPK_342310.1 * , LdCL_340030800 , LDHU3_34.3830
Length:
391

Annotations

LeishMANIAdb annotations

This large family encompasses many diverse protein phosphatases. Some appear to have evolved transmembrane segments. Very tentatively they might regulate transmembrane receptor kinases.. The TM and non-TM groups diverged early in Eukaryota and appear to be distinct enough that they probably should not be part of the same cluster. This latter group has not expanded.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IL63
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IL63

Function

Biological processes
Term Name Level Count
GO:0006470 protein dephosphorylation 5 16
GO:0006793 phosphorus metabolic process 3 16
GO:0006796 phosphate-containing compound metabolic process 4 16
GO:0006807 nitrogen compound metabolic process 2 16
GO:0008152 metabolic process 1 16
GO:0009987 cellular process 1 16
GO:0016311 dephosphorylation 5 16
GO:0019538 protein metabolic process 3 16
GO:0036211 protein modification process 4 16
GO:0043170 macromolecule metabolic process 3 16
GO:0043412 macromolecule modification 4 16
GO:0044237 cellular metabolic process 2 16
GO:0044238 primary metabolic process 2 16
GO:0071704 organic substance metabolic process 2 16
GO:1901564 organonitrogen compound metabolic process 3 16
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 16
GO:0004721 phosphoprotein phosphatase activity 3 16
GO:0004722 protein serine/threonine phosphatase activity 4 16
GO:0005488 binding 1 16
GO:0016787 hydrolase activity 2 16
GO:0016788 hydrolase activity, acting on ester bonds 3 16
GO:0016791 phosphatase activity 5 16
GO:0017018 myosin phosphatase activity 5 13
GO:0042578 phosphoric ester hydrolase activity 4 16
GO:0043167 ion binding 2 16
GO:0043169 cation binding 3 16
GO:0046872 metal ion binding 4 16
GO:0140096 catalytic activity, acting on a protein 2 16

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 246 250 PF00656 0.350
CLV_C14_Caspase3-7 347 351 PF00656 0.303
CLV_C14_Caspase3-7 89 93 PF00656 0.675
CLV_NRD_NRD_1 178 180 PF00675 0.263
CLV_NRD_NRD_1 364 366 PF00675 0.473
CLV_PCSK_KEX2_1 364 366 PF00082 0.460
CLV_PCSK_SKI1_1 191 195 PF00082 0.400
DEG_APCC_DBOX_1 160 168 PF00400 0.440
DEG_SPOP_SBC_1 91 95 PF00917 0.465
DOC_CKS1_1 78 83 PF01111 0.693
DOC_CKS1_1 85 90 PF01111 0.712
DOC_CYCLIN_yCln2_LP_2 378 384 PF00134 0.357
DOC_MAPK_gen_1 161 169 PF00069 0.303
DOC_MAPK_HePTP_8 229 241 PF00069 0.346
DOC_MAPK_MEF2A_6 232 241 PF00069 0.346
DOC_PP2B_LxvP_1 72 75 PF13499 0.756
DOC_PP4_FxxP_1 85 88 PF00568 0.578
DOC_USP7_MATH_1 307 311 PF00917 0.473
DOC_USP7_MATH_1 66 70 PF00917 0.584
DOC_USP7_MATH_1 91 95 PF00917 0.561
DOC_USP7_MATH_1 98 102 PF00917 0.661
DOC_WW_Pin1_4 77 82 PF00397 0.672
DOC_WW_Pin1_4 84 89 PF00397 0.619
DOC_WW_Pin1_4 94 99 PF00397 0.611
LIG_14-3-3_CanoR_1 127 131 PF00244 0.364
LIG_14-3-3_CanoR_1 179 189 PF00244 0.383
LIG_14-3-3_CanoR_1 275 280 PF00244 0.399
LIG_14-3-3_CanoR_1 8 14 PF00244 0.545
LIG_Actin_WH2_2 160 177 PF00022 0.253
LIG_Actin_WH2_2 351 366 PF00022 0.346
LIG_BIR_II_1 1 5 PF00653 0.678
LIG_BRCT_BRCA1_1 100 104 PF00533 0.617
LIG_BRCT_BRCA1_1 182 186 PF00533 0.399
LIG_BRCT_BRCA1_1 34 38 PF00533 0.589
LIG_FHA_1 307 313 PF00498 0.390
LIG_FHA_1 340 346 PF00498 0.364
LIG_FHA_1 52 58 PF00498 0.749
LIG_FHA_1 85 91 PF00498 0.654
LIG_FHA_2 134 140 PF00498 0.349
LIG_FHA_2 84 90 PF00498 0.576
LIG_GBD_Chelix_1 10 18 PF00786 0.558
LIG_LIR_Apic_2 84 88 PF02991 0.508
LIG_LIR_Gen_1 101 110 PF02991 0.693
LIG_LIR_Gen_1 183 194 PF02991 0.383
LIG_LIR_Gen_1 317 328 PF02991 0.330
LIG_LIR_Gen_1 372 382 PF02991 0.393
LIG_LIR_Gen_1 68 78 PF02991 0.536
LIG_LIR_Nem_3 101 107 PF02991 0.629
LIG_LIR_Nem_3 141 147 PF02991 0.297
LIG_LIR_Nem_3 183 189 PF02991 0.383
LIG_LIR_Nem_3 317 323 PF02991 0.330
LIG_LIR_Nem_3 372 378 PF02991 0.351
LIG_LIR_Nem_3 68 73 PF02991 0.567
LIG_MLH1_MIPbox_1 100 104 PF16413 0.511
LIG_MYND_1 270 274 PF01753 0.372
LIG_PTB_Apo_2 42 49 PF02174 0.546
LIG_SH2_CRK 70 74 PF00017 0.534
LIG_SH2_GRB2like 295 298 PF00017 0.303
LIG_SH2_GRB2like 42 45 PF00017 0.583
LIG_SH2_SRC 334 337 PF00017 0.440
LIG_SH2_STAP1 334 338 PF00017 0.348
LIG_SH2_STAT5 159 162 PF00017 0.384
LIG_SH2_STAT5 295 298 PF00017 0.348
LIG_SH2_STAT5 344 347 PF00017 0.213
LIG_SH2_STAT5 42 45 PF00017 0.679
LIG_SH3_3 134 140 PF00018 0.303
LIG_SH3_3 264 270 PF00018 0.348
LIG_SH3_3 3 9 PF00018 0.460
LIG_SH3_3 85 91 PF00018 0.661
LIG_SUMO_SIM_anti_2 131 139 PF11976 0.303
LIG_SUMO_SIM_par_1 12 17 PF11976 0.562
LIG_SUMO_SIM_par_1 235 240 PF11976 0.319
LIG_SUMO_SIM_par_1 301 311 PF11976 0.440
MOD_CK1_1 105 111 PF00069 0.622
MOD_CK1_1 216 222 PF00069 0.363
MOD_CK1_1 29 35 PF00069 0.755
MOD_CK1_1 58 64 PF00069 0.682
MOD_CK1_1 94 100 PF00069 0.579
MOD_CK2_1 103 109 PF00069 0.524
MOD_CK2_1 111 117 PF00069 0.377
MOD_CK2_1 125 131 PF00069 0.183
MOD_CK2_1 133 139 PF00069 0.425
MOD_CK2_1 330 336 PF00069 0.363
MOD_CK2_1 49 55 PF00069 0.654
MOD_CK2_1 83 89 PF00069 0.576
MOD_GlcNHglycan 100 103 PF01048 0.634
MOD_GlcNHglycan 202 205 PF01048 0.330
MOD_GlcNHglycan 300 303 PF01048 0.329
MOD_GlcNHglycan 31 34 PF01048 0.724
MOD_GlcNHglycan 346 349 PF01048 0.444
MOD_GSK3_1 195 202 PF00069 0.405
MOD_GSK3_1 275 282 PF00069 0.329
MOD_GSK3_1 29 36 PF00069 0.697
MOD_GSK3_1 51 58 PF00069 0.727
MOD_GSK3_1 90 97 PF00069 0.602
MOD_GSK3_1 98 105 PF00069 0.599
MOD_N-GLC_1 369 374 PF02516 0.362
MOD_N-GLC_1 44 49 PF02516 0.547
MOD_N-GLC_1 59 64 PF02516 0.460
MOD_NEK2_1 103 108 PF00069 0.637
MOD_NEK2_1 19 24 PF00069 0.608
MOD_NEK2_1 279 284 PF00069 0.329
MOD_NEK2_1 328 333 PF00069 0.367
MOD_NEK2_2 33 38 PF00069 0.720
MOD_PKA_1 364 370 PF00069 0.303
MOD_PKA_2 126 132 PF00069 0.349
MOD_PKA_2 29 35 PF00069 0.602
MOD_PKA_2 364 370 PF00069 0.399
MOD_Plk_1 250 256 PF00069 0.303
MOD_Plk_1 369 375 PF00069 0.362
MOD_Plk_1 44 50 PF00069 0.549
MOD_Plk_2-3 133 139 PF00069 0.263
MOD_Plk_2-3 330 336 PF00069 0.329
MOD_Plk_2-3 350 356 PF00069 0.143
MOD_Plk_2-3 49 55 PF00069 0.697
MOD_Plk_4 111 117 PF00069 0.420
MOD_Plk_4 133 139 PF00069 0.433
MOD_Plk_4 213 219 PF00069 0.325
MOD_Plk_4 9 15 PF00069 0.650
MOD_ProDKin_1 77 83 PF00069 0.674
MOD_ProDKin_1 84 90 PF00069 0.617
MOD_ProDKin_1 94 100 PF00069 0.612
MOD_SUMO_for_1 290 293 PF00179 0.303
TRG_DiLeu_BaEn_1 317 322 PF01217 0.372
TRG_DiLeu_BaEn_1 68 73 PF01217 0.527
TRG_ENDOCYTIC_2 70 73 PF00928 0.531
TRG_ER_diArg_1 160 163 PF00400 0.303
TRG_ER_diArg_1 363 365 PF00400 0.303

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8F8 Leptomonas seymouri 29% 100%
A0A0N1I0H9 Leptomonas seymouri 30% 100%
A0A0N1I8W9 Leptomonas seymouri 48% 90%
A0A0N1IHU6 Leptomonas seymouri 30% 96%
A0A0N1PAL8 Leptomonas seymouri 31% 100%
A0A0N1PEL9 Leptomonas seymouri 63% 100%
A0A0N1PET0 Leptomonas seymouri 28% 67%
A0A0S4ILP4 Bodo saltans 25% 75%
A0A0S4IY95 Bodo saltans 28% 100%
A0A0S4J0A6 Bodo saltans 31% 96%
A0A0S4J8Y7 Bodo saltans 30% 76%
A0A0S4JHB4 Bodo saltans 30% 100%
A0A0S4JPC3 Bodo saltans 30% 100%
A0A0S4KIS4 Bodo saltans 29% 86%
A0A0S4KJV9 Bodo saltans 31% 90%
A0A1X0NRG3 Trypanosomatidae 30% 100%
A0A1X0NUB7 Trypanosomatidae 31% 82%
A0A1X0NVC4 Trypanosomatidae 28% 95%
A0A1X0P2A0 Trypanosomatidae 33% 100%
A0A1X0P568 Trypanosomatidae 29% 96%
A0A1X0PAN4 Trypanosomatidae 49% 100%
A0A3Q8IEK6 Leishmania donovani 29% 100%
A0A3Q8IFG7 Leishmania donovani 30% 100%
A0A3Q8IGS1 Leishmania donovani 29% 69%
A0A3Q8IK65 Leishmania donovani 31% 100%
A0A3S7WZ14 Leishmania donovani 28% 96%
A0A3S7X808 Leishmania donovani 42% 87%
A0A422N8D7 Trypanosoma rangeli 46% 100%
A0A422NAJ1 Trypanosoma rangeli 27% 100%
A0A422NBV9 Trypanosoma rangeli 30% 96%
A0A422NS77 Trypanosoma rangeli 29% 95%
A0A422P293 Trypanosoma rangeli 28% 100%
A0BLX0 Paramecium tetraurelia 30% 100%
A0BQL0 Paramecium tetraurelia 28% 100%
A0CUB5 Paramecium tetraurelia 27% 100%
A0DSB3 Paramecium tetraurelia 26% 100%
A0DTY1 Paramecium tetraurelia 28% 100%
A3A8W2 Oryza sativa subsp. japonica 29% 100%
A4H7Y6 Leishmania braziliensis 26% 100%
A4HAW5 Leishmania braziliensis 85% 100%
A4HAW6 Leishmania braziliensis 48% 87%
A4HE10 Leishmania braziliensis 29% 100%
A4HG10 Leishmania braziliensis 27% 100%
A4HHY5 Leishmania braziliensis 29% 100%
A4HKF6 Leishmania braziliensis 28% 69%
A4HNR1 Leishmania braziliensis 31% 98%
A4I1B7 Leishmania infantum 28% 100%
A4I329 Leishmania infantum 29% 100%
A4I565 Leishmania infantum 30% 100%
A4I7Y4 Leishmania infantum 29% 69%
A4IA25 Leishmania infantum 100% 100%
A4IA26 Leishmania infantum 41% 100%
A4ICT4 Leishmania infantum 31% 100%
A5PJZ2 Bos taurus 32% 100%
C9ZJK2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
C9ZMJ7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 100%
C9ZNW4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 92%
C9ZQJ2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
D0A2L9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
D0A5L0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 96%
E9ACV0 Leishmania major 29% 100%
E9ASH0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9AXF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9AZD9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9B0G2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B2U5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 69%
E9B540 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
E9B541 Leishmania mexicana (strain MHOM/GT/2001/U1103) 50% 100%
O04719 Arabidopsis thaliana 29% 92%
O14189 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 88%
O62829 Bos taurus 29% 100%
O62830 Bos taurus 31% 81%
O75688 Homo sapiens 31% 82%
O80871 Arabidopsis thaliana 31% 99%
O81716 Arabidopsis thaliana 28% 100%
O81760 Arabidopsis thaliana 26% 100%
P20650 Rattus norvegicus 29% 100%
P35182 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 32% 100%
P35813 Homo sapiens 29% 100%
P35814 Oryctolagus cuniculus 29% 100%
P35815 Rattus norvegicus 30% 100%
P36982 Leishmania chagasi 28% 96%
P36993 Mus musculus 30% 100%
P38089 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 99%
P40371 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 32% 100%
P46014 Arabidopsis thaliana 25% 67%
P49443 Mus musculus 29% 100%
P49444 Paramecium tetraurelia 29% 100%
P49593 Homo sapiens 29% 86%
P49596 Caenorhabditis elegans 31% 100%
P49597 Arabidopsis thaliana 31% 90%
P49598 Arabidopsis thaliana 29% 98%
P49599 Arabidopsis thaliana 28% 100%
P93006 Arabidopsis thaliana 34% 100%
Q09173 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 30% 94%
Q0DBU3 Oryza sativa subsp. japonica 35% 100%
Q0IIF0 Bos taurus 27% 100%
Q0J2L7 Oryza sativa subsp. japonica 31% 100%
Q0J2R1 Oryza sativa subsp. japonica 31% 100%
Q0JL75 Oryza sativa subsp. japonica 32% 100%
Q0JLP9 Oryza sativa subsp. japonica 32% 84%
Q0V7V2 Arabidopsis thaliana 27% 100%
Q0WRB2 Arabidopsis thaliana 31% 100%
Q10MX1 Oryza sativa subsp. japonica 35% 100%
Q10S32 Oryza sativa subsp. japonica 26% 98%
Q19775 Caenorhabditis elegans 27% 84%
Q2PC20 Bos taurus 31% 100%
Q2QN36 Oryza sativa subsp. japonica 28% 100%
Q2QWE3 Oryza sativa subsp. japonica 32% 93%
Q2RBJ6 Oryza sativa subsp. japonica 27% 93%
Q3EAF9 Arabidopsis thaliana 30% 100%
Q4PSE8 Arabidopsis thaliana 36% 87%
Q4Q225 Leishmania major 30% 100%
Q4Q2U5 Leishmania major 45% 100%
Q4Q2U6 Leishmania major 94% 100%
Q4Q5B1 Leishmania major 29% 69%
Q4Q7S1 Leishmania major 30% 100%
Q4QA19 Leishmania major 29% 100%
Q4QFG7 Leishmania major 27% 100%
Q501F9 Arabidopsis thaliana 30% 100%
Q53Q11 Oryza sativa subsp. japonica 33% 98%
Q5JKN1 Oryza sativa subsp. japonica 30% 100%
Q5MFV5 Oryza sativa subsp. indica 30% 100%
Q5N9N2 Oryza sativa subsp. japonica 30% 94%
Q5PNS9 Arabidopsis thaliana 26% 98%
Q5SGD2 Homo sapiens 32% 100%
Q5SMK6 Oryza sativa subsp. japonica 31% 100%
Q5SN75 Oryza sativa subsp. japonica 32% 97%
Q5Z6F5 Oryza sativa subsp. japonica 36% 100%
Q5Z8P0 Oryza sativa subsp. japonica 25% 100%
Q652Z7 Oryza sativa subsp. japonica 33% 100%
Q653S3 Oryza sativa subsp. japonica 28% 100%
Q65XG6 Oryza sativa subsp. japonica 29% 94%
Q67J17 Oryza sativa subsp. japonica 28% 93%
Q67UP9 Oryza sativa subsp. japonica 30% 100%
Q67UX7 Oryza sativa subsp. japonica 33% 100%
Q69QZ0 Oryza sativa subsp. japonica 32% 100%
Q69VD9 Oryza sativa subsp. japonica 30% 100%
Q6AUQ4 Oryza sativa subsp. japonica 31% 100%
Q6EN45 Oryza sativa subsp. japonica 34% 100%
Q6ETK3 Oryza sativa subsp. japonica 29% 100%
Q6ING9 Xenopus laevis 29% 100%
Q6K1U4 Oryza sativa subsp. japonica 25% 75%
Q6K5I0 Oryza sativa subsp. japonica 26% 76%
Q6L482 Oryza sativa subsp. japonica 31% 100%
Q6L4R7 Oryza sativa subsp. japonica 32% 88%
Q6L5C4 Oryza sativa subsp. japonica 33% 80%
Q6L5H6 Oryza sativa subsp. japonica 29% 100%
Q6ZHC8 Oryza sativa subsp. japonica 27% 100%
Q7XCJ7 Oryza sativa subsp. japonica 23% 99%
Q7XHN8 Oryza sativa subsp. japonica 27% 100%
Q7XJ53 Arabidopsis thaliana 27% 100%
Q7XR06 Oryza sativa subsp. japonica 33% 100%
Q7XU84 Oryza sativa subsp. japonica 26% 100%
Q7XUC5 Oryza sativa subsp. japonica 27% 100%
Q8BGL1 Mus musculus 31% 97%
Q8BHN0 Mus musculus 32% 100%
Q8BXN7 Mus musculus 30% 100%
Q8CGA0 Mus musculus 29% 87%
Q8GY60 Arabidopsis thaliana 26% 84%
Q8H063 Oryza sativa subsp. japonica 27% 100%
Q8LAY8 Arabidopsis thaliana 35% 100%
Q8N3J5 Homo sapiens 30% 100%
Q8N819 Homo sapiens 32% 91%
Q8R0F6 Mus musculus 28% 100%
Q8RX37 Arabidopsis thaliana 30% 100%
Q8RXV3 Arabidopsis thaliana 35% 100%
Q8VZN9 Arabidopsis thaliana 36% 100%
Q94AT1 Arabidopsis thaliana 33% 93%
Q94CL8 Arabidopsis thaliana 29% 100%
Q94H98 Oryza sativa subsp. japonica 30% 100%
Q9CAJ0 Arabidopsis thaliana 29% 77%
Q9FIF5 Arabidopsis thaliana 30% 95%
Q9FLI3 Arabidopsis thaliana 27% 94%
Q9FXE4 Arabidopsis thaliana 35% 88%
Q9FYN7 Oryza sativa subsp. japonica 30% 100%
Q9H0C8 Homo sapiens 28% 100%
Q9LHJ9 Arabidopsis thaliana 28% 100%
Q9LMT1 Arabidopsis thaliana 31% 100%
Q9LNF4 Arabidopsis thaliana 30% 100%
Q9LNP9 Arabidopsis thaliana 29% 77%
Q9LR65 Arabidopsis thaliana 26% 85%
Q9LRZ4 Arabidopsis thaliana 28% 100%
Q9LUS8 Arabidopsis thaliana 25% 79%
Q9LUU7 Arabidopsis thaliana 29% 93%
Q9M9W9 Arabidopsis thaliana 29% 100%
Q9SD02 Arabidopsis thaliana 32% 100%
Q9SLA1 Arabidopsis thaliana 33% 100%
Q9SZ53 Arabidopsis thaliana 29% 100%
Q9WVR7 Rattus norvegicus 30% 87%
Q9XEE8 Arabidopsis thaliana 28% 100%
Q9Z1Z6 Rattus norvegicus 27% 100%
Q9ZW21 Arabidopsis thaliana 29% 100%
V5BCX6 Trypanosoma cruzi 30% 100%
V5BH00 Trypanosoma cruzi 30% 100%
V5BSS7 Trypanosoma cruzi 29% 96%
V5DCR6 Trypanosoma cruzi 29% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS