LeishMANIAdb
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CLP1_P domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
CLP1_P domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8IL58_LEIDO
TriTrypDb:
LdBPK_363900.1 * , LdCL_360046000 , LDHU3_36.5240
Length:
452

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3Q8IL58
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IL58

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006396 RNA processing 6 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0016070 RNA metabolic process 5 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0043170 macromolecule metabolic process 3 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0046483 heterocycle metabolic process 3 12
GO:0071704 organic substance metabolic process 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:0000394 RNA splicing, via endonucleolytic cleavage and ligation 8 1
GO:0006378 mRNA polyadenylation 7 1
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation 9 1
GO:0006397 mRNA processing 7 1
GO:0006399 tRNA metabolic process 7 1
GO:0008033 tRNA processing 8 1
GO:0008380 RNA splicing 7 1
GO:0016071 mRNA metabolic process 6 1
GO:0031123 RNA 3'-end processing 7 1
GO:0031124 mRNA 3'-end processing 8 1
GO:0034470 ncRNA processing 7 1
GO:0034660 ncRNA metabolic process 6 1
GO:0043631 RNA polyadenylation 6 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0016301 kinase activity 4 12
GO:0016740 transferase activity 2 12
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 12
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 12
GO:0019205 nucleobase-containing compound kinase activity 5 12
GO:0051731 polynucleotide 5'-hydroxyl-kinase activity 5 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 422 424 PF00675 0.392
CLV_NRD_NRD_1 9 11 PF00675 0.418
CLV_NRD_NRD_1 95 97 PF00675 0.421
CLV_PCSK_KEX2_1 102 104 PF00082 0.385
CLV_PCSK_KEX2_1 422 424 PF00082 0.392
CLV_PCSK_KEX2_1 5 7 PF00082 0.630
CLV_PCSK_KEX2_1 9 11 PF00082 0.528
CLV_PCSK_KEX2_1 95 97 PF00082 0.444
CLV_PCSK_PC1ET2_1 102 104 PF00082 0.452
CLV_PCSK_PC1ET2_1 5 7 PF00082 0.550
CLV_PCSK_SKI1_1 135 139 PF00082 0.417
CLV_PCSK_SKI1_1 316 320 PF00082 0.563
CLV_PCSK_SKI1_1 341 345 PF00082 0.389
CLV_PCSK_SKI1_1 9 13 PF00082 0.406
CLV_PCSK_SKI1_1 96 100 PF00082 0.453
CLV_Separin_Metazoa 263 267 PF03568 0.279
CLV_Separin_Metazoa 317 321 PF03568 0.429
DEG_ODPH_VHL_1 353 365 PF01847 0.404
DEG_ODPH_VHL_1 390 402 PF01847 0.353
DOC_CYCLIN_RxL_1 335 348 PF00134 0.479
DOC_MAPK_gen_1 102 109 PF00069 0.356
DOC_MAPK_gen_1 134 142 PF00069 0.417
DOC_MAPK_gen_1 4 13 PF00069 0.574
DOC_PP1_RVXF_1 339 346 PF00149 0.436
DOC_PP2B_LxvP_1 149 152 PF13499 0.368
DOC_PP4_FxxP_1 302 305 PF00568 0.487
DOC_USP7_MATH_1 188 192 PF00917 0.431
DOC_USP7_MATH_1 339 343 PF00917 0.469
DOC_USP7_MATH_1 368 372 PF00917 0.414
DOC_USP7_MATH_2 309 315 PF00917 0.440
DOC_WW_Pin1_4 160 165 PF00397 0.351
DOC_WW_Pin1_4 169 174 PF00397 0.297
DOC_WW_Pin1_4 223 228 PF00397 0.410
DOC_WW_Pin1_4 323 328 PF00397 0.427
LIG_14-3-3_CanoR_1 113 119 PF00244 0.286
LIG_14-3-3_CanoR_1 282 287 PF00244 0.451
LIG_14-3-3_CanoR_1 312 319 PF00244 0.470
LIG_14-3-3_CanoR_1 437 446 PF00244 0.366
LIG_14-3-3_CanoR_1 47 52 PF00244 0.414
LIG_14-3-3_CanoR_1 57 63 PF00244 0.369
LIG_14-3-3_CanoR_1 9 14 PF00244 0.482
LIG_14-3-3_CanoR_1 96 106 PF00244 0.434
LIG_APCC_ABBA_1 51 56 PF00400 0.487
LIG_BRCT_BRCA1_1 341 345 PF00533 0.490
LIG_Clathr_ClatBox_1 62 66 PF01394 0.470
LIG_deltaCOP1_diTrp_1 280 286 PF00928 0.309
LIG_FHA_1 102 108 PF00498 0.428
LIG_FHA_1 301 307 PF00498 0.406
LIG_FHA_1 48 54 PF00498 0.410
LIG_FHA_2 342 348 PF00498 0.355
LIG_FHA_2 443 449 PF00498 0.515
LIG_LIR_Apic_2 299 305 PF02991 0.402
LIG_LIR_Gen_1 17 27 PF02991 0.408
LIG_LIR_Gen_1 280 291 PF02991 0.308
LIG_LIR_Gen_1 369 379 PF02991 0.453
LIG_LIR_Gen_1 447 452 PF02991 0.452
LIG_LIR_Nem_3 163 169 PF02991 0.339
LIG_LIR_Nem_3 17 22 PF02991 0.399
LIG_LIR_Nem_3 280 286 PF02991 0.308
LIG_LIR_Nem_3 326 331 PF02991 0.526
LIG_LIR_Nem_3 369 375 PF02991 0.465
LIG_LIR_Nem_3 447 452 PF02991 0.452
LIG_MYND_1 173 177 PF01753 0.289
LIG_NRBOX 122 128 PF00104 0.417
LIG_PCNA_yPIPBox_3 282 295 PF02747 0.350
LIG_PDZ_Class_2 447 452 PF00595 0.424
LIG_SH2_CRK 19 23 PF00017 0.397
LIG_SH2_CRK 200 204 PF00017 0.350
LIG_SH2_CRK 258 262 PF00017 0.472
LIG_SH2_NCK_1 19 23 PF00017 0.397
LIG_SH2_PTP2 449 452 PF00017 0.466
LIG_SH2_SRC 230 233 PF00017 0.302
LIG_SH2_STAP1 49 53 PF00017 0.442
LIG_SH2_STAT3 199 202 PF00017 0.417
LIG_SH2_STAT5 181 184 PF00017 0.394
LIG_SH2_STAT5 19 22 PF00017 0.464
LIG_SH2_STAT5 210 213 PF00017 0.395
LIG_SH2_STAT5 322 325 PF00017 0.322
LIG_SH2_STAT5 401 404 PF00017 0.483
LIG_SH2_STAT5 449 452 PF00017 0.466
LIG_SH2_STAT5 49 52 PF00017 0.401
LIG_SH3_3 161 167 PF00018 0.447
LIG_SH3_3 226 232 PF00018 0.302
LIG_SH3_3 240 246 PF00018 0.417
LIG_SH3_3 261 267 PF00018 0.394
LIG_SH3_3 303 309 PF00018 0.501
LIG_SH3_3 333 339 PF00018 0.391
LIG_SH3_3 362 368 PF00018 0.502
LIG_SH3_3 386 392 PF00018 0.358
LIG_SUMO_SIM_anti_2 104 110 PF11976 0.318
LIG_SUMO_SIM_anti_2 268 275 PF11976 0.368
LIG_SUMO_SIM_par_1 176 182 PF11976 0.290
LIG_SUMO_SIM_par_1 268 275 PF11976 0.290
LIG_TRAF2_1 15 18 PF00917 0.370
LIG_TRAF2_1 415 418 PF00917 0.570
LIG_TRAF2_1 445 448 PF00917 0.430
LIG_TYR_ITIM 256 261 PF00017 0.417
MOD_CDK_SPK_2 169 174 PF00069 0.350
MOD_CK1_1 114 120 PF00069 0.308
MOD_CK1_1 179 185 PF00069 0.365
MOD_CK2_1 230 236 PF00069 0.467
MOD_CK2_1 271 277 PF00069 0.398
MOD_CK2_1 311 317 PF00069 0.459
MOD_CK2_1 341 347 PF00069 0.517
MOD_CK2_1 377 383 PF00069 0.337
MOD_CK2_1 442 448 PF00069 0.454
MOD_GlcNHglycan 113 116 PF01048 0.326
MOD_GlcNHglycan 188 191 PF01048 0.370
MOD_GlcNHglycan 213 217 PF01048 0.453
MOD_GlcNHglycan 32 35 PF01048 0.512
MOD_GlcNHglycan 356 359 PF01048 0.588
MOD_GlcNHglycan 439 442 PF01048 0.568
MOD_GlcNHglycan 99 102 PF01048 0.487
MOD_GSK3_1 188 195 PF00069 0.433
MOD_GSK3_1 230 237 PF00069 0.460
MOD_GSK3_1 323 330 PF00069 0.542
MOD_GSK3_1 432 439 PF00069 0.395
MOD_GSK3_1 5 12 PF00069 0.519
MOD_GSK3_1 97 104 PF00069 0.479
MOD_NEK2_1 203 208 PF00069 0.427
MOD_NEK2_1 234 239 PF00069 0.338
MOD_NEK2_1 331 336 PF00069 0.491
MOD_NEK2_1 436 441 PF00069 0.449
MOD_NEK2_2 432 437 PF00069 0.502
MOD_PKA_1 4 10 PF00069 0.495
MOD_PKA_2 186 192 PF00069 0.417
MOD_PKA_2 265 271 PF00069 0.266
MOD_PKA_2 281 287 PF00069 0.307
MOD_PKA_2 311 317 PF00069 0.537
MOD_PKA_2 432 438 PF00069 0.487
MOD_PKA_2 5 11 PF00069 0.513
MOD_PKA_2 94 100 PF00069 0.404
MOD_Plk_1 17 23 PF00069 0.337
MOD_Plk_1 368 374 PF00069 0.504
MOD_Plk_4 133 139 PF00069 0.368
MOD_Plk_4 17 23 PF00069 0.398
MOD_Plk_4 176 182 PF00069 0.295
MOD_Plk_4 192 198 PF00069 0.235
MOD_Plk_4 203 209 PF00069 0.348
MOD_Plk_4 282 288 PF00069 0.315
MOD_Plk_4 341 347 PF00069 0.485
MOD_Plk_4 395 401 PF00069 0.500
MOD_Plk_4 47 53 PF00069 0.435
MOD_ProDKin_1 160 166 PF00069 0.351
MOD_ProDKin_1 169 175 PF00069 0.297
MOD_ProDKin_1 223 229 PF00069 0.410
MOD_ProDKin_1 323 329 PF00069 0.392
TRG_DiLeu_BaEn_1 17 22 PF01217 0.399
TRG_DiLeu_BaEn_1 408 413 PF01217 0.352
TRG_DiLeu_BaLyEn_6 416 421 PF01217 0.494
TRG_ENDOCYTIC_2 19 22 PF00928 0.397
TRG_ENDOCYTIC_2 200 203 PF00928 0.417
TRG_ENDOCYTIC_2 258 261 PF00928 0.417
TRG_ENDOCYTIC_2 449 452 PF00928 0.466
TRG_ER_diArg_1 421 423 PF00400 0.438
TRG_ER_diArg_1 9 11 PF00400 0.542
TRG_NLS_MonoExtN_4 2 8 PF00514 0.642
TRG_Pf-PMV_PEXEL_1 259 263 PF00026 0.294
TRG_Pf-PMV_PEXEL_1 293 297 PF00026 0.385
TRG_Pf-PMV_PEXEL_1 316 321 PF00026 0.440

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IJZ5 Leptomonas seymouri 77% 100%
A0A0S4JES6 Bodo saltans 30% 100%
A0A1X0P3J8 Trypanosomatidae 45% 100%
A0A422N1N1 Trypanosoma rangeli 45% 100%
A4HPN9 Leishmania braziliensis 94% 100%
A4ID25 Leishmania infantum 100% 100%
D0A8H5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
E9ATF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q4Q144 Leishmania major 97% 100%
V5AU86 Trypanosoma cruzi 45% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS