Uncharacterized conserved protein H4 (DUF2046), putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IL47_LEIDO

TriTrypDb:

LdBPK_342130.1 , LdCL_340029000 , LDHU3_34.3560

Length:

431

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IL47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IL47

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.326
CLV_NRD_NRD_1	131	133	PF00675	0.395
CLV_NRD_NRD_1	138	140	PF00675	0.358
CLV_NRD_NRD_1	24	26	PF00675	0.430
CLV_NRD_NRD_1	309	311	PF00675	0.594
CLV_NRD_NRD_1	45	47	PF00675	0.424
CLV_NRD_NRD_1	75	77	PF00675	0.430
CLV_PCSK_FUR_1	22	26	PF00082	0.501
CLV_PCSK_KEX2_1	103	105	PF00082	0.404
CLV_PCSK_KEX2_1	24	26	PF00082	0.430
CLV_PCSK_KEX2_1	75	77	PF00082	0.430
CLV_PCSK_SKI1_1	103	107	PF00082	0.400
CLV_PCSK_SKI1_1	132	136	PF00082	0.376
CLV_PCSK_SKI1_1	415	419	PF00082	0.569
CLV_PCSK_SKI1_1	57	61	PF00082	0.492
DEG_APCC_DBOX_1	364	372	PF00400	0.598
DEG_APCC_DBOX_1	414	422	PF00400	0.628
DEG_SCF_FBW7_1	291	296	PF00400	0.750
DEG_SPOP_SBC_1	171	175	PF00917	0.670
DOC_CYCLIN_RxL_1	129	136	PF00134	0.378
DOC_CYCLIN_RxL_1	411	420	PF00134	0.610
DOC_CYCLIN_yCln2_LP_2	244	250	PF00134	0.734
DOC_MAPK_gen_1	152	160	PF00069	0.544
DOC_MAPK_gen_1	22	30	PF00069	0.460
DOC_MAPK_gen_1	310	317	PF00069	0.611
DOC_MAPK_MEF2A_6	152	160	PF00069	0.616
DOC_MIT_MIM_1	157	167	PF04212	0.556
DOC_PP2B_LxvP_1	199	202	PF13499	0.670
DOC_PP2B_LxvP_1	244	247	PF13499	0.683
DOC_USP7_MATH_1	206	210	PF00917	0.619
DOC_USP7_MATH_1	231	235	PF00917	0.819
DOC_USP7_MATH_1	260	264	PF00917	0.617
DOC_USP7_MATH_1	293	297	PF00917	0.718
DOC_USP7_MATH_1	352	356	PF00917	0.572
DOC_USP7_MATH_1	6	10	PF00917	0.787
DOC_WW_Pin1_4	183	188	PF00397	0.745
DOC_WW_Pin1_4	210	215	PF00397	0.783
DOC_WW_Pin1_4	248	253	PF00397	0.730
DOC_WW_Pin1_4	282	287	PF00397	0.700
DOC_WW_Pin1_4	289	294	PF00397	0.717
DOC_WW_Pin1_4	379	384	PF00397	0.682
DOC_WW_Pin1_4	8	13	PF00397	0.692
LIG_14-3-3_CanoR_1	109	119	PF00244	0.501
LIG_14-3-3_CanoR_1	139	148	PF00244	0.378
LIG_14-3-3_CanoR_1	279	286	PF00244	0.747
LIG_14-3-3_CanoR_1	325	335	PF00244	0.579
LIG_14-3-3_CanoR_1	86	91	PF00244	0.326
LIG_Actin_WH2_2	16	33	PF00022	0.430
LIG_BIR_II_1	1	5	PF00653	0.715
LIG_FHA_1	190	196	PF00498	0.741
LIG_FHA_1	211	217	PF00498	0.775
LIG_FHA_1	335	341	PF00498	0.580
LIG_FHA_1	412	418	PF00498	0.548
LIG_FHA_1	96	102	PF00498	0.403
LIG_FHA_2	111	117	PF00498	0.501
LIG_FHA_2	140	146	PF00498	0.501
LIG_FHA_2	345	351	PF00498	0.485
LIG_FHA_2	36	42	PF00498	0.436
LIG_FHA_2	48	54	PF00498	0.478
LIG_LIR_Gen_1	124	130	PF02991	0.430
LIG_LIR_Gen_1	26	35	PF02991	0.430
LIG_LIR_Nem_3	26	30	PF02991	0.430
LIG_NRBOX	311	317	PF00104	0.561
LIG_PTB_Apo_2	68	75	PF02174	0.430
LIG_SH2_CRK	87	91	PF00017	0.501
LIG_SH2_NCK_1	239	243	PF00017	0.570
LIG_SH2_PTP2	27	30	PF00017	0.430
LIG_SH2_SRC	155	158	PF00017	0.543
LIG_SH2_STAP1	35	39	PF00017	0.430
LIG_SH2_STAT5	125	128	PF00017	0.430
LIG_SH2_STAT5	155	158	PF00017	0.454
LIG_SH2_STAT5	239	242	PF00017	0.722
LIG_SH2_STAT5	27	30	PF00017	0.395
LIG_SH3_3	198	204	PF00018	0.767
LIG_SH3_3	246	252	PF00018	0.715
LIG_SH3_3	377	383	PF00018	0.640
LIG_SH3_3	418	424	PF00018	0.661
LIG_SUMO_SIM_par_1	246	251	PF11976	0.676
LIG_TRAF2_1	118	121	PF00917	0.424
LIG_TRAF2_1	342	345	PF00917	0.546
LIG_TRAF2_1	38	41	PF00917	0.430
LIG_UBA3_1	126	133	PF00899	0.430
LIG_UBA3_1	134	141	PF00899	0.430
LIG_UBA3_1	73	82	PF00899	0.404
MOD_CDK_SPK_2	282	287	PF00069	0.763
MOD_CDK_SPK_2	289	294	PF00069	0.706
MOD_CDK_SPxxK_3	210	217	PF00069	0.716
MOD_CK1_1	110	116	PF00069	0.501
MOD_CK1_1	174	180	PF00069	0.709
MOD_CK1_1	183	189	PF00069	0.710
MOD_CK1_1	209	215	PF00069	0.599
MOD_CK1_1	281	287	PF00069	0.690
MOD_CK1_1	29	35	PF00069	0.380
MOD_CK1_1	295	301	PF00069	0.501
MOD_CK1_1	388	394	PF00069	0.663
MOD_CK1_1	406	412	PF00069	0.475
MOD_CK2_1	110	116	PF00069	0.220
MOD_CK2_1	139	145	PF00069	0.376
MOD_CK2_1	170	176	PF00069	0.766
MOD_CK2_1	183	189	PF00069	0.579
MOD_CK2_1	324	330	PF00069	0.584
MOD_CK2_1	35	41	PF00069	0.430
MOD_CK2_1	406	412	PF00069	0.604
MOD_CK2_1	47	53	PF00069	0.478
MOD_CK2_1	93	99	PF00069	0.501
MOD_DYRK1A_RPxSP_1	8	12	PF00069	0.739
MOD_GlcNHglycan	262	265	PF01048	0.720
MOD_GlcNHglycan	276	279	PF01048	0.811
MOD_GlcNHglycan	280	283	PF01048	0.779
MOD_GlcNHglycan	287	290	PF01048	0.668
MOD_GlcNHglycan	326	329	PF01048	0.576
MOD_GlcNHglycan	390	393	PF01048	0.657
MOD_GlcNHglycan	401	404	PF01048	0.576
MOD_GSK3_1	170	177	PF00069	0.680
MOD_GSK3_1	202	209	PF00069	0.711
MOD_GSK3_1	26	33	PF00069	0.430
MOD_GSK3_1	262	269	PF00069	0.756
MOD_GSK3_1	270	277	PF00069	0.698
MOD_GSK3_1	278	285	PF00069	0.564
MOD_GSK3_1	289	296	PF00069	0.509
MOD_GSK3_1	35	42	PF00069	0.362
MOD_GSK3_1	384	391	PF00069	0.657
MOD_GSK3_1	393	400	PF00069	0.618
MOD_GSK3_1	4	11	PF00069	0.725
MOD_GSK3_1	93	100	PF00069	0.492
MOD_N-GLC_1	224	229	PF02516	0.811
MOD_N-GLC_1	266	271	PF02516	0.736
MOD_N-GLC_1	273	278	PF02516	0.629
MOD_N-GLC_1	393	398	PF02516	0.774
MOD_NEK2_1	215	220	PF00069	0.682
MOD_NEK2_1	266	271	PF00069	0.707
MOD_NEK2_1	280	285	PF00069	0.731
MOD_NEK2_1	30	35	PF00069	0.376
MOD_NEK2_1	323	328	PF00069	0.584
MOD_NEK2_1	384	389	PF00069	0.705
MOD_NEK2_1	390	395	PF00069	0.724
MOD_NEK2_1	397	402	PF00069	0.740
MOD_NEK2_1	4	9	PF00069	0.747
MOD_NEK2_1	417	422	PF00069	0.384
MOD_PIKK_1	107	113	PF00454	0.501
MOD_PIKK_1	180	186	PF00454	0.714
MOD_PIKK_1	231	237	PF00454	0.598
MOD_PK_1	52	58	PF00069	0.430
MOD_PKA_1	139	145	PF00069	0.430
MOD_PKA_2	278	284	PF00069	0.803
MOD_PKA_2	293	299	PF00069	0.602
MOD_PKA_2	324	330	PF00069	0.584
MOD_PKA_2	352	358	PF00069	0.633
MOD_PKA_2	366	372	PF00069	0.497
MOD_Plk_1	16	22	PF00069	0.602
MOD_Plk_1	175	181	PF00069	0.713
MOD_Plk_1	224	230	PF00069	0.628
MOD_Plk_1	344	350	PF00069	0.551
MOD_Plk_1	384	390	PF00069	0.720
MOD_Plk_1	39	45	PF00069	0.350
MOD_Plk_1	393	399	PF00069	0.771
MOD_Plk_1	52	58	PF00069	0.417
MOD_Plk_2-3	93	99	PF00069	0.420
MOD_Plk_4	224	230	PF00069	0.628
MOD_Plk_4	344	350	PF00069	0.513
MOD_Plk_4	385	391	PF00069	0.656
MOD_Plk_4	86	92	PF00069	0.504
MOD_ProDKin_1	183	189	PF00069	0.748
MOD_ProDKin_1	210	216	PF00069	0.782
MOD_ProDKin_1	248	254	PF00069	0.732
MOD_ProDKin_1	282	288	PF00069	0.699
MOD_ProDKin_1	289	295	PF00069	0.713
MOD_ProDKin_1	379	385	PF00069	0.681
MOD_ProDKin_1	8	14	PF00069	0.684
MOD_SUMO_for_1	357	360	PF00179	0.660
MOD_SUMO_for_1	64	67	PF00179	0.364
MOD_SUMO_for_1	91	94	PF00179	0.381
MOD_SUMO_rev_2	369	374	PF00179	0.675
TRG_DiLeu_BaEn_1	40	45	PF01217	0.501
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.762
TRG_ENDOCYTIC_2	125	128	PF00928	0.385
TRG_ENDOCYTIC_2	155	158	PF00928	0.472
TRG_ENDOCYTIC_2	27	30	PF00928	0.430
TRG_ENDOCYTIC_2	87	90	PF00928	0.430
TRG_ER_diArg_1	103	105	PF00400	0.326
TRG_ER_diArg_1	166	169	PF00400	0.622
TRG_ER_diArg_1	22	25	PF00400	0.433
TRG_ER_diArg_1	365	368	PF00400	0.543
TRG_ER_diArg_1	74	76	PF00400	0.430
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.326
TRG_Pf-PMV_PEXEL_1	132	136	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Y4	Leptomonas seymouri	52%	98%
A0A0S4JG85	Bodo saltans	30%	83%
A4IA15	Leishmania infantum	100%	100%
E9AI69	Leishmania braziliensis	78%	100%
E9B522	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q2W4	Leishmania major	93%	100%