DNA polymerase alpha subunit B

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA polymerase alpha/epsilon subunit B, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IL35_LEIDO

TriTrypDb:

LdBPK_321800.1 , LdCL_320023500 , LDHU3_32.2290

Length:

726

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	1
GO:0005634	nucleus	5	11
GO:0005658	alpha DNA polymerase:primase complex	4	1
GO:0030880	RNA polymerase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0042575	DNA polymerase complex	3	1
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11

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Expansion

Sequence features

A0A3Q8IL35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IL35

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006260	DNA replication	5	11
GO:0006270	DNA replication initiation	5	1
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003824	catalytic activity	1	1
GO:0005488	binding	1	12
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.699
CLV_C14_Caspase3-7	559	563	PF00656	0.816
CLV_C14_Caspase3-7	611	615	PF00656	0.755
CLV_C14_Caspase3-7	658	662	PF00656	0.683
CLV_NRD_NRD_1	343	345	PF00675	0.363
CLV_NRD_NRD_1	492	494	PF00675	0.344
CLV_NRD_NRD_1	554	556	PF00675	0.690
CLV_NRD_NRD_1	707	709	PF00675	0.517
CLV_NRD_NRD_1	71	73	PF00675	0.515
CLV_PCSK_KEX2_1	343	345	PF00082	0.363

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAT5	Leptomonas seymouri	64%	100%
A0A0S4JBE4	Bodo saltans	31%	100%
A0A1X0NW10	Trypanosomatidae	42%	100%
A0A3R7NGI8	Trypanosoma rangeli	42%	100%
A4HKF9	Leishmania braziliensis	76%	100%
A4I7Y7	Leishmania infantum	99%	100%
D0AA49	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B2U8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q5A8	Leishmania major	91%	100%
V5DFV4	Trypanosoma cruzi	41%	100%

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