NADH_dehydrogenase_putative/GeneDB:LmjF.36.5380

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADH dehydrogenase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IL33_LEIDO

TriTrypDb:

LdBPK_365620.1 , LdCL_360063600 , LDHU3_36.7490

Length:

527

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0020023	kinetoplast	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IL33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IL33

Function

Biological processes
Term	Name	Level	Count
GO:0006116	NADH oxidation	3	12
GO:0006734	NADH metabolic process	2	12
GO:0008152	metabolic process	1	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0003954	NADH dehydrogenase activity	4	12
GO:0016491	oxidoreductase activity	2	12
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	156	158	PF00675	0.255
CLV_NRD_NRD_1	237	239	PF00675	0.305
CLV_NRD_NRD_1	251	253	PF00675	0.210
CLV_NRD_NRD_1	458	460	PF00675	0.454
CLV_NRD_NRD_1	490	492	PF00675	0.611
CLV_NRD_NRD_1	7	9	PF00675	0.549
CLV_PCSK_KEX2_1	158	160	PF00082	0.254
CLV_PCSK_KEX2_1	178	180	PF00082	0.253
CLV_PCSK_KEX2_1	237	239	PF00082	0.290
CLV_PCSK_KEX2_1	7	9	PF00082	0.602
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.269
CLV_PCSK_PC1ET2_1	178	180	PF00082	0.269
CLV_PCSK_PC7_1	154	160	PF00082	0.253
CLV_PCSK_PC7_1	3	9	PF00082	0.513
CLV_PCSK_SKI1_1	143	147	PF00082	0.441
CLV_PCSK_SKI1_1	178	182	PF00082	0.253
CLV_PCSK_SKI1_1	290	294	PF00082	0.343
CLV_PCSK_SKI1_1	431	435	PF00082	0.398
CLV_PCSK_SKI1_1	486	490	PF00082	0.563
CLV_PCSK_SKI1_1	7	11	PF00082	0.559
CLV_PCSK_SKI1_1	96	100	PF00082	0.334
DEG_APCC_DBOX_1	2	10	PF00400	0.632
DEG_APCC_DBOX_1	413	421	PF00400	0.323
DEG_Nend_Nbox_1	1	3	PF02207	0.541
DEG_SPOP_SBC_1	53	57	PF00917	0.269
DOC_CKS1_1	47	52	PF01111	0.253
DOC_MAPK_gen_1	178	186	PF00069	0.289
DOC_MAPK_gen_1	237	244	PF00069	0.274
DOC_MAPK_gen_1	252	259	PF00069	0.207
DOC_MAPK_gen_1	296	304	PF00069	0.232
DOC_MAPK_gen_1	414	421	PF00069	0.318
DOC_MAPK_gen_1	7	17	PF00069	0.432
DOC_MAPK_gen_1	96	105	PF00069	0.396
DOC_MAPK_MEF2A_6	243	251	PF00069	0.258
DOC_MAPK_MEF2A_6	414	421	PF00069	0.333
DOC_MAPK_MEF2A_6	7	16	PF00069	0.457
DOC_MAPK_MEF2A_6	96	105	PF00069	0.288
DOC_PP4_FxxP_1	117	120	PF00568	0.284
DOC_PP4_FxxP_1	135	138	PF00568	0.253
DOC_USP7_MATH_1	170	174	PF00917	0.347
DOC_USP7_MATH_1	339	343	PF00917	0.253
DOC_USP7_MATH_1	381	385	PF00917	0.427
DOC_USP7_MATH_1	517	521	PF00917	0.692
DOC_WW_Pin1_4	459	464	PF00397	0.454
DOC_WW_Pin1_4	46	51	PF00397	0.253
DOC_WW_Pin1_4	494	499	PF00397	0.658
LIG_14-3-3_CanoR_1	131	136	PF00244	0.246
LIG_14-3-3_CanoR_1	179	185	PF00244	0.313
LIG_14-3-3_CanoR_1	252	259	PF00244	0.334
LIG_14-3-3_CanoR_1	3	7	PF00244	0.598
LIG_14-3-3_CanoR_1	443	450	PF00244	0.410
LIG_14-3-3_CanoR_1	82	88	PF00244	0.347
LIG_BRCT_BRCA1_1	361	365	PF00533	0.458
LIG_BRCT_BRCA1_1	425	429	PF00533	0.337
LIG_EVH1_2	79	83	PF00568	0.259
LIG_FHA_1	114	120	PF00498	0.293
LIG_FHA_1	132	138	PF00498	0.253
LIG_FHA_1	164	170	PF00498	0.277
LIG_FHA_1	181	187	PF00498	0.362
LIG_FHA_1	210	216	PF00498	0.466
LIG_FHA_1	252	258	PF00498	0.334
LIG_FHA_1	272	278	PF00498	0.254
LIG_FHA_1	287	293	PF00498	0.256
LIG_FHA_1	47	53	PF00498	0.253
LIG_FHA_1	474	480	PF00498	0.677
LIG_FHA_1	55	61	PF00498	0.253
LIG_FHA_2	189	195	PF00498	0.259
LIG_FHA_2	219	225	PF00498	0.276
LIG_FHA_2	258	264	PF00498	0.372
LIG_FHA_2	517	523	PF00498	0.577
LIG_LIR_Apic_2	116	120	PF02991	0.284
LIG_LIR_Apic_2	134	138	PF02991	0.253
LIG_LIR_Gen_1	118	128	PF02991	0.288
LIG_LIR_Gen_1	404	413	PF02991	0.340
LIG_LIR_Gen_1	415	424	PF02991	0.314
LIG_LIR_Gen_1	442	453	PF02991	0.470
LIG_LIR_LC3C_4	274	278	PF02991	0.255
LIG_LIR_Nem_3	118	124	PF02991	0.288
LIG_LIR_Nem_3	404	409	PF02991	0.370
LIG_LIR_Nem_3	415	421	PF02991	0.317
LIG_LIR_Nem_3	442	448	PF02991	0.371
LIG_LIR_Nem_3	59	65	PF02991	0.262
LIG_Pex14_1	21	25	PF04695	0.253
LIG_Pex14_1	402	406	PF04695	0.298
LIG_REV1ctd_RIR_1	143	152	PF16727	0.269
LIG_REV1ctd_RIR_1	200	208	PF16727	0.313
LIG_SH2_CRK	121	125	PF00017	0.253
LIG_SH2_CRK	217	221	PF00017	0.325
LIG_SH2_CRK	239	243	PF00017	0.334
LIG_SH2_CRK	367	371	PF00017	0.394
LIG_SH2_CRK	445	449	PF00017	0.515
LIG_SH2_PTP2	418	421	PF00017	0.320
LIG_SH2_SRC	418	421	PF00017	0.414
LIG_SH2_STAP1	121	125	PF00017	0.253
LIG_SH2_STAP1	445	449	PF00017	0.515
LIG_SH2_STAP1	475	479	PF00017	0.579
LIG_SH2_STAP1	89	93	PF00017	0.360
LIG_SH2_STAT5	123	126	PF00017	0.396
LIG_SH2_STAT5	217	220	PF00017	0.325
LIG_SH2_STAT5	347	350	PF00017	0.320
LIG_SH2_STAT5	406	409	PF00017	0.340
LIG_SH2_STAT5	418	421	PF00017	0.345
LIG_SH2_STAT5	435	438	PF00017	0.353
LIG_SH2_STAT5	475	478	PF00017	0.687
LIG_SH3_3	44	50	PF00018	0.253
LIG_SH3_3	495	501	PF00018	0.620
LIG_SH3_3	62	68	PF00018	0.253
LIG_SUMO_SIM_par_1	13	19	PF11976	0.253
LIG_SUMO_SIM_par_1	380	387	PF11976	0.367
LIG_TRAF2_1	260	263	PF00917	0.386
LIG_TRAF2_1	449	452	PF00917	0.397
LIG_TYR_ITIM	119	124	PF00017	0.253
LIG_TYR_ITIM	215	220	PF00017	0.325
LIG_UBA3_1	409	416	PF00899	0.469
LIG_WRC_WIRS_1	114	119	PF05994	0.269
LIG_WRC_WIRS_1	229	234	PF05994	0.288
MOD_CK1_1	231	237	PF00069	0.221
MOD_CK1_1	369	375	PF00069	0.330
MOD_CK1_1	412	418	PF00069	0.418
MOD_CK1_1	473	479	PF00069	0.609
MOD_CK2_1	170	176	PF00069	0.272
MOD_CK2_1	188	194	PF00069	0.285
MOD_CK2_1	218	224	PF00069	0.253
MOD_CK2_1	257	263	PF00069	0.328
MOD_CK2_1	474	480	PF00069	0.679
MOD_CK2_1	516	522	PF00069	0.697
MOD_CK2_1	61	67	PF00069	0.313
MOD_GlcNHglycan	267	270	PF01048	0.388
MOD_GlcNHglycan	284	287	PF01048	0.390
MOD_GlcNHglycan	379	382	PF01048	0.316
MOD_GlcNHglycan	403	406	PF01048	0.306
MOD_GlcNHglycan	445	448	PF01048	0.452
MOD_GlcNHglycan	519	522	PF01048	0.560
MOD_GSK3_1	278	285	PF00069	0.374
MOD_GSK3_1	377	384	PF00069	0.353
MOD_GSK3_1	401	408	PF00069	0.319
MOD_GSK3_1	451	458	PF00069	0.483
MOD_GSK3_1	470	477	PF00069	0.596
MOD_GSK3_1	52	59	PF00069	0.253
MOD_N-GLC_1	210	215	PF02516	0.347
MOD_N-GLC_1	377	382	PF02516	0.434
MOD_N-GLC_1	473	478	PF02516	0.589
MOD_N-GLC_2	33	35	PF02516	0.308
MOD_N-GLC_2	394	396	PF02516	0.323
MOD_NEK2_1	1	6	PF00069	0.621
MOD_NEK2_1	180	185	PF00069	0.329
MOD_NEK2_1	493	498	PF00069	0.590
MOD_NEK2_1	83	88	PF00069	0.365
MOD_PIKK_1	423	429	PF00454	0.471
MOD_PIKK_1	506	512	PF00454	0.576
MOD_PKA_1	7	13	PF00069	0.533
MOD_PKA_2	2	8	PF00069	0.545
MOD_PKA_2	251	257	PF00069	0.334
MOD_PKA_2	300	306	PF00069	0.364
MOD_Plk_1	210	216	PF00069	0.347
MOD_Plk_1	377	383	PF00069	0.421
MOD_Plk_1	431	437	PF00069	0.345
MOD_Plk_2-3	61	67	PF00069	0.313
MOD_Plk_4	180	186	PF00069	0.313
MOD_Plk_4	210	216	PF00069	0.288
MOD_Plk_4	218	224	PF00069	0.219
MOD_Plk_4	405	411	PF00069	0.341
MOD_ProDKin_1	459	465	PF00069	0.459
MOD_ProDKin_1	46	52	PF00069	0.253
MOD_ProDKin_1	494	500	PF00069	0.657
MOD_SUMO_rev_2	173	180	PF00179	0.269
MOD_SUMO_rev_2	201	210	PF00179	0.347
MOD_SUMO_rev_2	520	527	PF00179	0.665
MOD_SUMO_rev_2	90	98	PF00179	0.347
TRG_DiLeu_BaEn_1	176	181	PF01217	0.253
TRG_DiLeu_BaEn_1	351	356	PF01217	0.455
TRG_DiLeu_BaEn_3	141	147	PF01217	0.373
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.253
TRG_DiLeu_LyEn_5	176	181	PF01217	0.253
TRG_ENDOCYTIC_2	121	124	PF00928	0.253
TRG_ENDOCYTIC_2	217	220	PF00928	0.325
TRG_ENDOCYTIC_2	239	242	PF00928	0.334
TRG_ENDOCYTIC_2	367	370	PF00928	0.381
TRG_ENDOCYTIC_2	406	409	PF00928	0.320
TRG_ENDOCYTIC_2	418	421	PF00928	0.320
TRG_ENDOCYTIC_2	445	448	PF00928	0.514
TRG_ER_diArg_1	156	159	PF00400	0.253
TRG_ER_diArg_1	236	238	PF00400	0.302
TRG_ER_diArg_1	299	302	PF00400	0.266
TRG_ER_diArg_1	6	8	PF00400	0.604
TRG_NLS_MonoExtC_3	458	463	PF00514	0.435
TRG_NLS_MonoExtN_4	154	161	PF00514	0.269
TRG_Pf-PMV_PEXEL_1	309	313	PF00026	0.396
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.746

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P920	Leptomonas seymouri	81%	99%
A0A0S4IWQ4	Bodo saltans	59%	100%
A0A1X0P0A4	Trypanosomatidae	61%	100%
A0A3R7KGC5	Trypanosoma rangeli	61%	100%
A4HQ53	Leishmania braziliensis	85%	100%
A4IDV2	Leishmania infantum	100%	100%
D0A465	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9ATX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
F2Z699	Yarrowia lipolytica (strain CLIB 122 / E 150)	32%	91%
M0ZYF3	Solanum tuberosum	42%	100%
O05267	Bacillus subtilis (strain 168)	31%	100%
O14121	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	96%
O43090	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	96%
O80874	Arabidopsis thaliana	42%	100%
P00393	Escherichia coli (strain K12)	29%	100%
P32340	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
P40215	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	94%
P44856	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	25%	100%
P73735	Synechocystis sp. (strain PCC 6803 / Kazusa)	25%	100%
P80861	Bacillus subtilis (strain 168)	24%	100%
P95160	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	28%	100%
P95200	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	29%	100%
Q07500	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	97%
Q2FID4	Staphylococcus aureus (strain USA300)	26%	100%
Q2FZV7	Staphylococcus aureus (strain NCTC 8325 / PS 47)	26%	100%
Q2YWP9	Staphylococcus aureus (strain bovine RF122 / ET3-1)	26%	100%
Q49W80	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	26%	100%
Q4L4V6	Staphylococcus haemolyticus (strain JCSC1435)	27%	100%
Q4Q0M3	Leishmania major	97%	100%
Q55CD9	Dictyostelium discoideum	38%	100%
Q58065	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	24%	100%
Q5HHE4	Staphylococcus aureus (strain COL)	26%	100%
Q5HQM1	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	25%	100%
Q6GAY5	Staphylococcus aureus (strain MSSA476)	26%	100%
Q6GIE7	Staphylococcus aureus (strain MRSA252)	26%	100%
Q7A6J4	Staphylococcus aureus (strain N315)	26%	100%
Q8CPV5	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	25%	100%
Q8GWA1	Arabidopsis thaliana	41%	100%
Q8GXR9	Arabidopsis thaliana	24%	100%
Q8NXG0	Staphylococcus aureus (strain MW2)	26%	100%
Q99VE0	Staphylococcus aureus (strain Mu50 / ATCC 700699)	26%	100%
Q9SKT7	Arabidopsis thaliana	36%	91%
Q9ST63	Solanum tuberosum	43%	100%
V5DLP7	Trypanosoma cruzi	62%	100%