NUDIX hydrolase dihydroneopterin triphosphate pyrophosphohydrolase/hydrolase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NUDIX hydrolase dihydroneopterin triphosphate pyrophosphohydrolase/hydrolase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IL17_LEIDO

TriTrypDb:

LdBPK_321610.1 , LdCL_320021700 , LDHU3_32.2030

Length:

261

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IL17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IL17

Function

Biological processes
Term	Name	Level	Count
GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA	8	1
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0048519	negative regulation of biological process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0110154	RNA decapping	6	1
GO:0110156	methylguanosine-cap decapping	7	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016787	hydrolase activity	2	8
GO:0016462	pyrophosphatase activity	5	5
GO:0016817	hydrolase activity, acting on acid anhydrides	3	5
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	5
GO:0050072	obsolete m7G(5')pppN diphosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.523
CLV_NRD_NRD_1	212	214	PF00675	0.401
CLV_NRD_NRD_1	219	221	PF00675	0.434
CLV_NRD_NRD_1	31	33	PF00675	0.548
CLV_NRD_NRD_1	47	49	PF00675	0.545
CLV_NRD_NRD_1	61	63	PF00675	0.546
CLV_PCSK_FUR_1	217	221	PF00082	0.338
CLV_PCSK_KEX2_1	118	120	PF00082	0.499
CLV_PCSK_KEX2_1	212	214	PF00082	0.377
CLV_PCSK_KEX2_1	219	221	PF00082	0.391
CLV_PCSK_KEX2_1	254	256	PF00082	0.647
CLV_PCSK_KEX2_1	33	35	PF00082	0.547
CLV_PCSK_KEX2_1	47	49	PF00082	0.546
CLV_PCSK_KEX2_1	61	63	PF00082	0.546
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.361
CLV_PCSK_PC1ET2_1	254	256	PF00082	0.626
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.547
CLV_PCSK_SKI1_1	102	106	PF00082	0.412
CLV_PCSK_SKI1_1	177	181	PF00082	0.496
DEG_Nend_UBRbox_3	1	3	PF02207	0.541
DOC_MAPK_gen_1	219	228	PF00069	0.396
DOC_MAPK_gen_1	85	92	PF00069	0.451
DOC_PP1_RVXF_1	140	146	PF00149	0.213
DOC_USP7_MATH_1	138	142	PF00917	0.267
DOC_USP7_MATH_1	15	19	PF00917	0.521
DOC_USP7_MATH_1	185	189	PF00917	0.303
DOC_USP7_MATH_1	25	29	PF00917	0.544
DOC_USP7_MATH_1	40	44	PF00917	0.557
DOC_USP7_MATH_1	54	58	PF00917	0.537
DOC_USP7_UBL2_3	221	225	PF12436	0.517
DOC_WW_Pin1_4	155	160	PF00397	0.496
DOC_WW_Pin1_4	16	21	PF00397	0.514
DOC_WW_Pin1_4	3	8	PF00397	0.513
DOC_WW_Pin1_4	68	73	PF00397	0.546
LIG_14-3-3_CanoR_1	118	122	PF00244	0.428
LIG_14-3-3_CanoR_1	146	150	PF00244	0.442
LIG_14-3-3_CanoR_1	32	38	PF00244	0.549
LIG_14-3-3_CanoR_1	47	56	PF00244	0.537
LIG_14-3-3_CanoR_1	81	87	PF00244	0.475
LIG_14-3-3_CanoR_1	98	106	PF00244	0.405
LIG_BRCT_BRCA1_1	128	132	PF00533	0.267
LIG_eIF4E_1	234	240	PF01652	0.320
LIG_FHA_1	128	134	PF00498	0.240
LIG_FHA_1	138	144	PF00498	0.260
LIG_FHA_1	87	93	PF00498	0.458
LIG_FHA_2	165	171	PF00498	0.339
LIG_LIR_Gen_1	166	175	PF02991	0.496
LIG_LIR_Nem_3	166	171	PF02991	0.496
LIG_LIR_Nem_3	232	237	PF02991	0.541
LIG_LYPXL_S_1	233	237	PF13949	0.545
LIG_LYPXL_yS_3	234	237	PF13949	0.546
LIG_PDZ_Class_1	256	261	PF00595	0.388
LIG_SH2_STAT5	238	241	PF00017	0.411
LIG_SH3_3	1	7	PF00018	0.523
LIG_SH3_3	18	24	PF00018	0.513
LIG_TRAF2_1	158	161	PF00917	0.267
LIG_TRAF2_1	167	170	PF00917	0.496
LIG_UBA3_1	236	241	PF00899	0.385
MOD_CK1_1	242	248	PF00069	0.325
MOD_CK1_1	43	49	PF00069	0.552
MOD_CK1_1	6	12	PF00069	0.524
MOD_CK2_1	155	161	PF00069	0.303
MOD_CK2_1	164	170	PF00069	0.298
MOD_CK2_1	68	74	PF00069	0.544
MOD_CK2_1	97	103	PF00069	0.420
MOD_Cter_Amidation	74	77	PF01082	0.529
MOD_GlcNHglycan	187	190	PF01048	0.391
MOD_GlcNHglycan	191	194	PF01048	0.413
MOD_GlcNHglycan	28	31	PF01048	0.534
MOD_GlcNHglycan	63	66	PF01048	0.554
MOD_GSK3_1	155	162	PF00069	0.496
MOD_GSK3_1	185	192	PF00069	0.427
MOD_GSK3_1	2	9	PF00069	0.519
MOD_LATS_1	31	37	PF00433	0.550
MOD_N-GLC_1	126	131	PF02516	0.278
MOD_NEK2_1	145	150	PF00069	0.321
MOD_PIKK_1	127	133	PF00454	0.213
MOD_PIKK_1	40	46	PF00454	0.551
MOD_PKA_1	32	38	PF00069	0.549
MOD_PKA_1	61	67	PF00069	0.542
MOD_PKA_2	117	123	PF00069	0.482
MOD_PKA_2	138	144	PF00069	0.293
MOD_PKA_2	145	151	PF00069	0.436
MOD_PKA_2	164	170	PF00069	0.265
MOD_PKA_2	33	39	PF00069	0.547
MOD_PKA_2	61	67	PF00069	0.542
MOD_PKA_2	80	86	PF00069	0.491
MOD_PKA_2	97	103	PF00069	0.531
MOD_Plk_1	127	133	PF00069	0.221
MOD_Plk_1	177	183	PF00069	0.496
MOD_Plk_4	177	183	PF00069	0.496
MOD_ProDKin_1	155	161	PF00069	0.496
MOD_ProDKin_1	16	22	PF00069	0.515
MOD_ProDKin_1	3	9	PF00069	0.514
MOD_ProDKin_1	68	74	PF00069	0.544
MOD_SUMO_for_1	240	243	PF00179	0.357
MOD_SUMO_rev_2	100	107	PF00179	0.384
TRG_DiLeu_BaEn_2	127	133	PF01217	0.496
TRG_DiLeu_LyEn_5	232	237	PF01217	0.366
TRG_ENDOCYTIC_2	234	237	PF00928	0.546
TRG_ER_diArg_1	117	119	PF00400	0.496
TRG_NLS_MonoExtN_4	217	223	PF00514	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IFW7	Leishmania donovani	47%	100%
A4HKE1	Leishmania braziliensis	63%	100%
A4I7W9	Leishmania infantum	47%	100%
E9B2T0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
Q4Q5C7	Leishmania major	45%	100%
Q4Q5C8	Leishmania major	84%	100%