Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IKZ7_LEIDO

TriTrypDb:

LdBPK_321380.1 , LdCL_320019500 , LDHU3_32.1750

Length:

543

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IKZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IKZ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	96	100	PF00656	0.507
CLV_NRD_NRD_1	203	205	PF00675	0.745
CLV_NRD_NRD_1	291	293	PF00675	0.601
CLV_NRD_NRD_1	338	340	PF00675	0.601
CLV_NRD_NRD_1	513	515	PF00675	0.522
CLV_PCSK_FUR_1	336	340	PF00082	0.687
CLV_PCSK_KEX2_1	203	205	PF00082	0.745
CLV_PCSK_KEX2_1	222	224	PF00082	0.742
CLV_PCSK_KEX2_1	291	293	PF00082	0.668
CLV_PCSK_KEX2_1	338	340	PF00082	0.595
CLV_PCSK_KEX2_1	495	497	PF00082	0.541
CLV_PCSK_KEX2_1	513	515	PF00082	0.399
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.748
CLV_PCSK_PC1ET2_1	495	497	PF00082	0.550
CLV_PCSK_SKI1_1	133	137	PF00082	0.577
CLV_PCSK_SKI1_1	222	226	PF00082	0.803
CLV_PCSK_SKI1_1	408	412	PF00082	0.627
CLV_PCSK_SKI1_1	41	45	PF00082	0.541
CLV_PCSK_SKI1_1	434	438	PF00082	0.601
CLV_PCSK_SKI1_1	456	460	PF00082	0.607
CLV_PCSK_SKI1_1	484	488	PF00082	0.629
CLV_PCSK_SKI1_1	71	75	PF00082	0.507
DEG_APCC_DBOX_1	337	345	PF00400	0.600
DEG_Nend_UBRbox_3	1	3	PF02207	0.689
DEG_SPOP_SBC_1	315	319	PF00917	0.730
DOC_CDC14_PxL_1	388	396	PF14671	0.499
DOC_CYCLIN_RxL_1	233	246	PF00134	0.624
DOC_CYCLIN_RxL_1	66	78	PF00134	0.614
DOC_PP2B_LxvP_1	136	139	PF13499	0.577
DOC_PP2B_LxvP_1	187	190	PF13499	0.742
DOC_PP2B_LxvP_1	37	40	PF13499	0.531
DOC_USP7_MATH_1	147	151	PF00917	0.730
DOC_USP7_MATH_1	307	311	PF00917	0.765
DOC_USP7_MATH_1	315	319	PF00917	0.805
DOC_USP7_MATH_1	499	503	PF00917	0.497
DOC_WW_Pin1_4	166	171	PF00397	0.711
DOC_WW_Pin1_4	173	178	PF00397	0.742
DOC_WW_Pin1_4	316	321	PF00397	0.735
LIG_14-3-3_CanoR_1	105	111	PF00244	0.500
LIG_14-3-3_CanoR_1	309	314	PF00244	0.716
LIG_14-3-3_CanoR_1	456	464	PF00244	0.560
LIG_14-3-3_CanoR_1	58	62	PF00244	0.559
LIG_14-3-3_CanoR_1	93	98	PF00244	0.521
LIG_BIR_III_2	99	103	PF00653	0.580
LIG_BIR_III_4	197	201	PF00653	0.733
LIG_BRCT_BRCA1_1	525	529	PF00533	0.604
LIG_CaM_IQ_9	225	241	PF13499	0.629
LIG_EVH1_1	142	146	PF00568	0.693
LIG_EVH1_1	187	191	PF00568	0.743
LIG_FHA_1	223	229	PF00498	0.672
LIG_FHA_1	244	250	PF00498	0.805
LIG_FHA_1	398	404	PF00498	0.501
LIG_FHA_1	442	448	PF00498	0.675
LIG_FHA_1	452	458	PF00498	0.472
LIG_FHA_2	118	124	PF00498	0.719
LIG_FHA_2	162	168	PF00498	0.765
LIG_FHA_2	45	51	PF00498	0.622
LIG_FHA_2	488	494	PF00498	0.539
LIG_FHA_2	517	523	PF00498	0.581
LIG_FHA_2	58	64	PF00498	0.416
LIG_FHA_2	94	100	PF00498	0.500
LIG_LIR_Gen_1	8	17	PF02991	0.475
LIG_LIR_Nem_3	231	235	PF02991	0.796
LIG_LIR_Nem_3	27	32	PF02991	0.482
LIG_LIR_Nem_3	459	464	PF02991	0.637
LIG_LIR_Nem_3	69	73	PF02991	0.615
LIG_LIR_Nem_3	8	14	PF02991	0.471
LIG_MYND_1	140	144	PF01753	0.690
LIG_PDZ_Class_2	538	543	PF00595	0.759
LIG_Pex14_1	420	424	PF04695	0.639
LIG_PTAP_UEV_1	303	308	PF05743	0.730
LIG_SH2_CRK	235	239	PF00017	0.723
LIG_SH2_CRK	29	33	PF00017	0.594
LIG_SH2_GRB2like	11	14	PF00017	0.478
LIG_SH2_STAP1	285	289	PF00017	0.597
LIG_SH2_STAT3	505	508	PF00017	0.568
LIG_SH2_STAT5	11	14	PF00017	0.550
LIG_SH2_STAT5	260	263	PF00017	0.781
LIG_SH2_STAT5	38	41	PF00017	0.626
LIG_SH2_STAT5	59	62	PF00017	0.510
LIG_SH3_1	137	143	PF00018	0.801
LIG_SH3_2	304	309	PF14604	0.741
LIG_SH3_3	135	141	PF00018	0.722
LIG_SH3_3	183	189	PF00018	0.753
LIG_SH3_3	251	257	PF00018	0.646
LIG_SH3_3	301	307	PF00018	0.720
LIG_SUMO_SIM_anti_2	49	58	PF11976	0.655
LIG_TRAF2_1	124	127	PF00917	0.721
LIG_TRAF2_1	425	428	PF00917	0.594
LIG_UBA3_1	264	273	PF00899	0.639
LIG_UBA3_1	36	41	PF00899	0.535
LIG_WW_2	140	143	PF00397	0.689
MOD_CDK_SPxxK_3	173	180	PF00069	0.819
MOD_CK1_1	206	212	PF00069	0.754
MOD_CK1_1	283	289	PF00069	0.701
MOD_CK1_1	302	308	PF00069	0.625
MOD_CK2_1	117	123	PF00069	0.771
MOD_CK2_1	361	367	PF00069	0.673
MOD_CK2_1	415	421	PF00069	0.552
MOD_CK2_1	44	50	PF00069	0.617
MOD_CK2_1	487	493	PF00069	0.557
MOD_CK2_1	57	63	PF00069	0.418
MOD_GlcNHglycan	205	208	PF01048	0.758
MOD_GlcNHglycan	301	304	PF01048	0.788
MOD_GlcNHglycan	480	483	PF01048	0.626
MOD_GlcNHglycan	529	532	PF01048	0.637
MOD_GSK3_1	117	124	PF00069	0.693
MOD_GSK3_1	189	196	PF00069	0.809
MOD_GSK3_1	199	206	PF00069	0.678
MOD_GSK3_1	237	244	PF00069	0.581
MOD_GSK3_1	298	305	PF00069	0.723
MOD_GSK3_1	44	51	PF00069	0.607
MOD_GSK3_1	469	476	PF00069	0.473
MOD_GSK3_1	487	494	PF00069	0.322
MOD_GSK3_1	523	530	PF00069	0.600
MOD_GSK3_1	62	69	PF00069	0.321
MOD_LATS_1	351	357	PF00433	0.561
MOD_LATS_1	485	491	PF00433	0.538
MOD_NEK2_1	241	246	PF00069	0.582
MOD_NEK2_1	264	269	PF00069	0.649
MOD_NEK2_1	478	483	PF00069	0.635
MOD_NEK2_1	491	496	PF00069	0.528
MOD_NEK2_1	516	521	PF00069	0.579
MOD_NEK2_1	523	528	PF00069	0.539
MOD_PIKK_1	189	195	PF00454	0.837
MOD_PIKK_1	222	228	PF00454	0.817
MOD_PIKK_1	248	254	PF00454	0.766
MOD_PIKK_1	451	457	PF00454	0.598
MOD_PKA_1	203	209	PF00069	0.746
MOD_PKA_1	222	228	PF00069	0.742
MOD_PKA_1	527	533	PF00069	0.712
MOD_PKA_2	104	110	PF00069	0.592
MOD_PKA_2	203	209	PF00069	0.746
MOD_PKA_2	222	228	PF00069	0.817
MOD_PKA_2	283	289	PF00069	0.634
MOD_PKA_2	299	305	PF00069	0.738
MOD_PKA_2	308	314	PF00069	0.692
MOD_PKA_2	415	421	PF00069	0.620
MOD_PKA_2	516	522	PF00069	0.564
MOD_PKA_2	57	63	PF00069	0.507
MOD_PKB_1	439	447	PF00069	0.594
MOD_PKB_1	64	72	PF00069	0.626
MOD_Plk_1	280	286	PF00069	0.617
MOD_Plk_2-3	119	125	PF00069	0.683
MOD_Plk_4	473	479	PF00069	0.498
MOD_Plk_4	487	493	PF00069	0.431
MOD_ProDKin_1	166	172	PF00069	0.708
MOD_ProDKin_1	173	179	PF00069	0.743
MOD_ProDKin_1	316	322	PF00069	0.731
MOD_SUMO_rev_2	266	275	PF00179	0.633
MOD_SUMO_rev_2	360	369	PF00179	0.639
MOD_SUMO_rev_2	421	430	PF00179	0.612
MOD_SUMO_rev_2	489	497	PF00179	0.639
MOD_SUMO_rev_2	78	86	PF00179	0.586
TRG_DiLeu_BaEn_1	52	57	PF01217	0.657
TRG_DiLeu_BaLyEn_6	260	265	PF01217	0.691
TRG_DiLeu_BaLyEn_6	453	458	PF01217	0.636
TRG_ENDOCYTIC_2	11	14	PF00928	0.425
TRG_ENDOCYTIC_2	235	238	PF00928	0.800
TRG_ENDOCYTIC_2	29	32	PF00928	0.483
TRG_ER_diArg_1	291	294	PF00400	0.639
TRG_ER_diArg_1	335	338	PF00400	0.689
TRG_Pf-PMV_PEXEL_1	109	113	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	353	357	PF00026	0.637
TRG_Pf-PMV_PEXEL_1	363	367	PF00026	0.593
TRG_Pf-PMV_PEXEL_1	456	460	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	514	518	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HKC0	Leishmania braziliensis	69%	100%
A4I7U9	Leishmania infantum	99%	100%
D0AA07	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	96%
E9B2Q7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q5F0	Leishmania major	92%	100%
V5BL88	Trypanosoma cruzi	25%	87%