Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IKW8_LEIDO

TriTrypDb:

LdBPK_364990.1 , LdCL_360057100 , LDHU3_36.6710

Length:

617

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IKW8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IKW8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.766
CLV_C14_Caspase3-7	48	52	PF00656	0.541
CLV_C14_Caspase3-7	82	86	PF00656	0.462
CLV_NRD_NRD_1	249	251	PF00675	0.408
CLV_NRD_NRD_1	569	571	PF00675	0.420
CLV_NRD_NRD_1	602	604	PF00675	0.666
CLV_PCSK_FUR_1	603	607	PF00082	0.726
CLV_PCSK_KEX2_1	249	251	PF00082	0.408
CLV_PCSK_KEX2_1	569	571	PF00082	0.533
CLV_PCSK_KEX2_1	605	607	PF00082	0.697
CLV_PCSK_PC1ET2_1	605	607	PF00082	0.756
CLV_PCSK_SKI1_1	340	344	PF00082	0.379
CLV_PCSK_SKI1_1	375	379	PF00082	0.402
CLV_PCSK_SKI1_1	569	573	PF00082	0.522
CLV_PCSK_SKI1_1	580	584	PF00082	0.443
CLV_PCSK_SKI1_1	81	85	PF00082	0.591
CLV_Separin_Metazoa	530	534	PF03568	0.512
DEG_APCC_DBOX_1	275	283	PF00400	0.552
DEG_APCC_DBOX_1	32	40	PF00400	0.557
DEG_APCC_DBOX_1	339	347	PF00400	0.477
DEG_APCC_DBOX_1	353	361	PF00400	0.515
DEG_APCC_DBOX_1	568	576	PF00400	0.422
DEG_APCC_DBOX_1	579	587	PF00400	0.419
DOC_CYCLIN_RxL_1	337	345	PF00134	0.472
DOC_CYCLIN_RxL_1	78	85	PF00134	0.606
DOC_CYCLIN_yCln2_LP_2	318	324	PF00134	0.496
DOC_MAPK_gen_1	259	268	PF00069	0.496
DOC_MAPK_gen_1	569	577	PF00069	0.399
DOC_MAPK_MEF2A_6	354	361	PF00069	0.488
DOC_MAPK_MEF2A_6	569	577	PF00069	0.495
DOC_PP1_RVXF_1	449	456	PF00149	0.480
DOC_PP2B_LxvP_1	318	321	PF13499	0.456
DOC_USP7_MATH_1	153	157	PF00917	0.668
DOC_USP7_MATH_1	174	178	PF00917	0.735
DOC_USP7_MATH_1	182	186	PF00917	0.723
DOC_USP7_MATH_1	198	202	PF00917	0.363
DOC_USP7_MATH_1	370	374	PF00917	0.525
DOC_USP7_MATH_1	383	387	PF00917	0.362
DOC_USP7_MATH_1	471	475	PF00917	0.493
DOC_USP7_MATH_1	54	58	PF00917	0.542
DOC_USP7_UBL2_3	231	235	PF12436	0.511
DOC_WW_Pin1_4	112	117	PF00397	0.749
DOC_WW_Pin1_4	170	175	PF00397	0.723
DOC_WW_Pin1_4	219	224	PF00397	0.561
DOC_WW_Pin1_4	554	559	PF00397	0.310
DOC_WW_Pin1_4	74	79	PF00397	0.481
LIG_14-3-3_CanoR_1	154	161	PF00244	0.729
LIG_14-3-3_CanoR_1	354	358	PF00244	0.493
LIG_14-3-3_CanoR_1	402	410	PF00244	0.509
LIG_14-3-3_CanoR_1	9	17	PF00244	0.642
LIG_14-3-3_CanoR_1	90	95	PF00244	0.660
LIG_Actin_WH2_2	32	49	PF00022	0.519
LIG_APCC_ABBA_1	501	506	PF00400	0.462
LIG_BIR_II_1	1	5	PF00653	0.690
LIG_CtBP_PxDLS_1	426	430	PF00389	0.559
LIG_deltaCOP1_diTrp_1	363	368	PF00928	0.515
LIG_eIF4E_1	241	247	PF01652	0.429
LIG_eIF4E_1	338	344	PF01652	0.364
LIG_eIF4E_1	40	46	PF01652	0.438
LIG_FHA_1	202	208	PF00498	0.526
LIG_FHA_1	224	230	PF00498	0.500
LIG_FHA_1	354	360	PF00498	0.464
LIG_FHA_1	407	413	PF00498	0.481
LIG_FHA_1	468	474	PF00498	0.548
LIG_FHA_1	486	492	PF00498	0.499
LIG_FHA_1	555	561	PF00498	0.267
LIG_FHA_1	57	63	PF00498	0.546
LIG_FHA_2	11	17	PF00498	0.617
LIG_FHA_2	124	130	PF00498	0.538
LIG_FHA_2	210	216	PF00498	0.563
LIG_FHA_2	237	243	PF00498	0.541
LIG_FHA_2	292	298	PF00498	0.514
LIG_FHA_2	369	375	PF00498	0.514
LIG_LIR_Gen_1	524	532	PF02991	0.453
LIG_LIR_Gen_1	67	76	PF02991	0.476
LIG_LIR_Nem_3	129	134	PF02991	0.545
LIG_LIR_Nem_3	144	149	PF02991	0.592
LIG_LIR_Nem_3	505	511	PF02991	0.356
LIG_LIR_Nem_3	524	528	PF02991	0.301
LIG_LIR_Nem_3	67	72	PF02991	0.497
LIG_NRBOX	19	25	PF00104	0.607
LIG_NRBOX	41	47	PF00104	0.544
LIG_OCRL_FandH_1	266	278	PF00620	0.537
LIG_PCNA_yPIPBox_3	354	365	PF02747	0.515
LIG_PDZ_Class_3	612	617	PF00595	0.640
LIG_PTAP_UEV_1	115	120	PF05743	0.575
LIG_Rb_LxCxE_1	253	275	PF01857	0.318
LIG_RPA_C_Fungi	343	355	PF08784	0.412
LIG_SH2_CRK	146	150	PF00017	0.636
LIG_SH2_CRK	69	73	PF00017	0.559
LIG_SH2_GRB2like	238	241	PF00017	0.539
LIG_SH2_SRC	241	244	PF00017	0.487
LIG_SH2_STAP1	241	245	PF00017	0.488
LIG_SH2_STAP1	477	481	PF00017	0.508
LIG_SH2_STAP1	504	508	PF00017	0.472
LIG_SH2_STAT5	130	133	PF00017	0.579
LIG_SH2_STAT5	238	241	PF00017	0.478
LIG_SH2_STAT5	504	507	PF00017	0.431
LIG_SH3_1	328	334	PF00018	0.564
LIG_SH3_3	113	119	PF00018	0.578
LIG_SH3_3	328	334	PF00018	0.564
LIG_SUMO_SIM_anti_2	277	284	PF11976	0.557
LIG_TRAF2_1	527	530	PF00917	0.550
LIG_UBA3_1	134	139	PF00899	0.568
LIG_UBA3_1	229	235	PF00899	0.503
LIG_UBA3_1	266	272	PF00899	0.474
LIG_WRC_WIRS_1	522	527	PF05994	0.437
MOD_CDC14_SPxK_1	173	176	PF00782	0.726
MOD_CDK_SPxK_1	170	176	PF00069	0.726
MOD_CDK_SPxxK_3	74	81	PF00069	0.493
MOD_CK1_1	187	193	PF00069	0.737
MOD_CK1_1	201	207	PF00069	0.599
MOD_CK1_1	312	318	PF00069	0.528
MOD_CK1_1	386	392	PF00069	0.515
MOD_CK1_1	485	491	PF00069	0.548
MOD_CK1_1	56	62	PF00069	0.618
MOD_CK1_1	64	70	PF00069	0.550
MOD_CK1_1	93	99	PF00069	0.666
MOD_CK2_1	10	16	PF00069	0.706
MOD_CK2_1	123	129	PF00069	0.562
MOD_CK2_1	199	205	PF00069	0.605
MOD_CK2_1	209	215	PF00069	0.607
MOD_CK2_1	219	225	PF00069	0.398
MOD_CK2_1	236	242	PF00069	0.541
MOD_CK2_1	368	374	PF00069	0.509
MOD_CK2_1	54	60	PF00069	0.621
MOD_GlcNHglycan	116	119	PF01048	0.495
MOD_GlcNHglycan	176	179	PF01048	0.667
MOD_GlcNHglycan	188	193	PF01048	0.708
MOD_GlcNHglycan	253	257	PF01048	0.551
MOD_GlcNHglycan	312	315	PF01048	0.453
MOD_GlcNHglycan	334	337	PF01048	0.502
MOD_GlcNHglycan	388	391	PF01048	0.546
MOD_GlcNHglycan	99	102	PF01048	0.756
MOD_GSK3_1	110	117	PF00069	0.669
MOD_GSK3_1	170	177	PF00069	0.622
MOD_GSK3_1	184	191	PF00069	0.790
MOD_GSK3_1	219	226	PF00069	0.548
MOD_GSK3_1	287	294	PF00069	0.571
MOD_GSK3_1	308	315	PF00069	0.560
MOD_GSK3_1	467	474	PF00069	0.514
MOD_GSK3_1	490	497	PF00069	0.473
MOD_GSK3_1	88	95	PF00069	0.579
MOD_LATS_1	367	373	PF00433	0.462
MOD_N-GLC_1	236	241	PF02516	0.536
MOD_N-GLC_1	309	314	PF02516	0.575
MOD_N-GLC_1	74	79	PF02516	0.579
MOD_NEK2_1	10	15	PF00069	0.587
MOD_NEK2_1	199	204	PF00069	0.597
MOD_NEK2_1	229	234	PF00069	0.463
MOD_NEK2_1	236	241	PF00069	0.517
MOD_NEK2_1	299	304	PF00069	0.329
MOD_NEK2_1	3	8	PF00069	0.602
MOD_NEK2_1	342	347	PF00069	0.476
MOD_NEK2_1	427	432	PF00069	0.538
MOD_NEK2_1	459	464	PF00069	0.423
MOD_NEK2_1	53	58	PF00069	0.610
MOD_NEK2_1	593	598	PF00069	0.619
MOD_NEK2_1	61	66	PF00069	0.495
MOD_NEK2_1	79	84	PF00069	0.357
MOD_NEK2_2	223	228	PF00069	0.538
MOD_NEK2_2	446	451	PF00069	0.509
MOD_NEK2_2	477	482	PF00069	0.540
MOD_PIKK_1	299	305	PF00454	0.523
MOD_PIKK_1	312	318	PF00454	0.532
MOD_PIKK_1	593	599	PF00454	0.496
MOD_PIKK_1	88	94	PF00454	0.686
MOD_PK_1	90	96	PF00069	0.627
MOD_PKA_2	153	159	PF00069	0.705
MOD_PKA_2	275	281	PF00069	0.532
MOD_PKA_2	353	359	PF00069	0.435
MOD_PKA_2	401	407	PF00069	0.504
MOD_PKA_2	97	103	PF00069	0.578
MOD_Plk_1	15	21	PF00069	0.585
MOD_Plk_1	162	168	PF00069	0.765
MOD_Plk_2-3	487	493	PF00069	0.469
MOD_Plk_4	275	281	PF00069	0.432
MOD_Plk_4	383	389	PF00069	0.482
MOD_Plk_4	420	426	PF00069	0.474
MOD_Plk_4	433	439	PF00069	0.419
MOD_Plk_4	490	496	PF00069	0.469
MOD_Plk_4	79	85	PF00069	0.496
MOD_ProDKin_1	112	118	PF00069	0.746
MOD_ProDKin_1	170	176	PF00069	0.726
MOD_ProDKin_1	219	225	PF00069	0.556
MOD_ProDKin_1	554	560	PF00069	0.307
MOD_ProDKin_1	74	80	PF00069	0.476
MOD_SUMO_for_1	391	394	PF00179	0.498
TRG_DiLeu_BaEn_1	225	230	PF01217	0.397
TRG_DiLeu_BaEn_1	242	247	PF01217	0.403
TRG_DiLeu_BaLyEn_6	19	24	PF01217	0.608
TRG_DiLeu_BaLyEn_6	314	319	PF01217	0.525
TRG_ENDOCYTIC_2	146	149	PF00928	0.640
TRG_ENDOCYTIC_2	610	613	PF00928	0.651
TRG_ENDOCYTIC_2	69	72	PF00928	0.445
TRG_NES_CRM1_1	35	48	PF08389	0.556
TRG_NES_CRM1_1	489	502	PF08389	0.486
TRG_NLS_Bipartite_1	591	608	PF00514	0.661
TRG_NLS_MonoCore_2	602	607	PF00514	0.720
TRG_NLS_MonoExtN_4	603	608	PF00514	0.722
TRG_Pf-PMV_PEXEL_1	261	265	PF00026	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILX5	Leptomonas seymouri	56%	96%
A0A1X0P0I1	Trypanosomatidae	34%	100%
A0A3R7LEP3	Trypanosoma rangeli	34%	100%
A4HPZ3	Leishmania braziliensis	78%	96%
A4IDQ4	Leishmania infantum	100%	100%
D0A4E6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ATR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q0T7	Leishmania major	93%	100%
V5B501	Trypanosoma cruzi	34%	100%