Putative ACR, YggU family, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised ACR, YggU family COG1872, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IKV6_LEIDO

TriTrypDb:

LdBPK_341240.1 , LdCL_340018300 , LDHU3_34.1960

Length:

204

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IKV6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IKV6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	181	185	PF00082	0.659
CLV_PCSK_SKI1_1	22	26	PF00082	0.336
CLV_PCSK_SKI1_1	79	83	PF00082	0.555
CLV_Separin_Metazoa	65	69	PF03568	0.400
DEG_APCC_DBOX_1	190	198	PF00400	0.612
DEG_APCC_DBOX_1	4	12	PF00400	0.460
DEG_SCF_FBW7_1	41	47	PF00400	0.400
DOC_CKS1_1	41	46	PF01111	0.404
DOC_CYCLIN_RxL_1	19	26	PF00134	0.495
DOC_MAPK_gen_1	179	187	PF00069	0.534
DOC_MAPK_MEF2A_6	179	187	PF00069	0.589
DOC_PP4_FxxP_1	38	41	PF00568	0.400
DOC_USP7_MATH_1	102	106	PF00917	0.664
DOC_USP7_MATH_1	132	136	PF00917	0.598
DOC_USP7_MATH_1	137	141	PF00917	0.635
DOC_USP7_MATH_1	152	156	PF00917	0.596
DOC_USP7_MATH_1	29	33	PF00917	0.324
DOC_USP7_UBL2_3	120	124	PF12436	0.617
DOC_WW_Pin1_4	154	159	PF00397	0.685
DOC_WW_Pin1_4	40	45	PF00397	0.412
LIG_14-3-3_CanoR_1	179	184	PF00244	0.532
LIG_14-3-3_CanoR_1	34	42	PF00244	0.284
LIG_14-3-3_CanoR_1	79	88	PF00244	0.587
LIG_FHA_1	180	186	PF00498	0.647
LIG_FHA_1	193	199	PF00498	0.615
LIG_FHA_1	41	47	PF00498	0.463
LIG_FHA_2	45	51	PF00498	0.379
LIG_LIR_Apic_2	36	41	PF02991	0.400
LIG_LIR_Gen_1	92	102	PF02991	0.597
LIG_LIR_Nem_3	82	88	PF02991	0.441
LIG_LIR_Nem_3	92	97	PF02991	0.591
LIG_PCNA_yPIPBox_3	63	76	PF02747	0.317
LIG_SH2_CRK	94	98	PF00017	0.594
LIG_SH2_STAP1	85	89	PF00017	0.440
LIG_SH2_STAP1	94	98	PF00017	0.594
LIG_SH2_STAT5	23	26	PF00017	0.360
LIG_SH2_STAT5	69	72	PF00017	0.360
LIG_SH2_STAT5	88	91	PF00017	0.570
LIG_SH3_3	182	188	PF00018	0.575
LIG_SH3_3	38	44	PF00018	0.400
LIG_SUMO_SIM_anti_2	169	174	PF11976	0.654
LIG_SUMO_SIM_anti_2	182	187	PF11976	0.501
LIG_TYR_ITSM	90	97	PF00017	0.598
MOD_CK1_1	135	141	PF00069	0.662
MOD_CK1_1	93	99	PF00069	0.575
MOD_Cter_Amidation	122	125	PF01082	0.638
MOD_GlcNHglycan	104	107	PF01048	0.655
MOD_GlcNHglycan	115	118	PF01048	0.712
MOD_GlcNHglycan	121	124	PF01048	0.714
MOD_GlcNHglycan	143	146	PF01048	0.719
MOD_GlcNHglycan	159	162	PF01048	0.564
MOD_GlcNHglycan	31	34	PF01048	0.359
MOD_GlcNHglycan	35	38	PF01048	0.329
MOD_GSK3_1	132	139	PF00069	0.660
MOD_GSK3_1	175	182	PF00069	0.606
MOD_GSK3_1	29	36	PF00069	0.415
MOD_GSK3_1	40	47	PF00069	0.433
MOD_GSK3_1	89	96	PF00069	0.589
MOD_NEK2_1	1	6	PF00069	0.564
MOD_NEK2_1	111	116	PF00069	0.594
MOD_NEK2_1	136	141	PF00069	0.699
MOD_NEK2_2	23	28	PF00069	0.312
MOD_PKA_2	33	39	PF00069	0.284
MOD_Plk_1	168	174	PF00069	0.635
MOD_Plk_4	168	174	PF00069	0.575
MOD_Plk_4	179	185	PF00069	0.568
MOD_Plk_4	93	99	PF00069	0.601
MOD_ProDKin_1	154	160	PF00069	0.684
MOD_ProDKin_1	40	46	PF00069	0.412
MOD_SUMO_rev_2	114	122	PF00179	0.592
TRG_ENDOCYTIC_2	94	97	PF00928	0.595
TRG_NLS_MonoExtN_4	121	128	PF00514	0.584
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK74	Leptomonas seymouri	53%	100%
A0A1X0P9D1	Trypanosomatidae	31%	100%
A0A422NGS4	Trypanosoma rangeli	32%	100%
A4I9S6	Leishmania infantum	100%	100%
C9ZMV5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AI65	Leishmania braziliensis	73%	99%
E9B4T7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q389	Leishmania major	94%	100%