Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IKV5_LEIDO

TriTrypDb:

LdBPK_364810.1 , LdCL_360055200 , LDHU3_36.6470

Length:

452

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0030684	preribosome	3	1
GO:0032040	small-subunit processome	4	1
GO:0032991	protein-containing complex	1	1
GO:0034388	Pwp2p-containing subcomplex of 90S preribosome	3	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3Q8IKV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IKV5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	304	308	PF00656	0.348
CLV_C14_Caspase3-7	386	390	PF00656	0.403
CLV_C14_Caspase3-7	61	65	PF00656	0.665
CLV_NRD_NRD_1	218	220	PF00675	0.554
CLV_NRD_NRD_1	295	297	PF00675	0.427
CLV_NRD_NRD_1	74	76	PF00675	0.676
CLV_NRD_NRD_1	81	83	PF00675	0.665
CLV_NRD_NRD_1	95	97	PF00675	0.543
CLV_PCSK_KEX2_1	166	168	PF00082	0.427
CLV_PCSK_KEX2_1	218	220	PF00082	0.554
CLV_PCSK_KEX2_1	74	76	PF00082	0.585
CLV_PCSK_KEX2_1	83	85	PF00082	0.522
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.427
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.543
CLV_PCSK_SKI1_1	289	293	PF00082	0.447
CLV_PCSK_SKI1_1	303	307	PF00082	0.445
CLV_PCSK_SKI1_1	368	372	PF00082	0.384
DOC_ANK_TNKS_1	328	335	PF00023	0.520
DOC_CKS1_1	35	40	PF01111	0.654
DOC_CKS1_1	373	378	PF01111	0.463
DOC_MAPK_gen_1	404	413	PF00069	0.429
DOC_MAPK_MEF2A_6	404	413	PF00069	0.510
DOC_PP1_RVXF_1	125	132	PF00149	0.379
DOC_PP2B_LxvP_1	119	122	PF13499	0.417
DOC_USP7_MATH_1	122	126	PF00917	0.415
DOC_USP7_MATH_1	246	250	PF00917	0.423
DOC_USP7_MATH_1	320	324	PF00917	0.579
DOC_USP7_MATH_1	332	336	PF00917	0.262
DOC_USP7_MATH_1	354	358	PF00917	0.535
DOC_USP7_MATH_1	359	363	PF00917	0.508
DOC_USP7_MATH_1	418	422	PF00917	0.485
DOC_WW_Pin1_4	34	39	PF00397	0.649
DOC_WW_Pin1_4	372	377	PF00397	0.458
LIG_14-3-3_CanoR_1	107	116	PF00244	0.545
LIG_14-3-3_CanoR_1	247	252	PF00244	0.495
LIG_14-3-3_CanoR_1	74	80	PF00244	0.674
LIG_14-3-3_CanoR_1	84	93	PF00244	0.588
LIG_Actin_WH2_2	335	351	PF00022	0.516
LIG_BIR_II_1	1	5	PF00653	0.727
LIG_EH1_1	225	233	PF00400	0.539
LIG_FHA_1	168	174	PF00498	0.519
LIG_FHA_1	195	201	PF00498	0.417
LIG_FHA_1	267	273	PF00498	0.517
LIG_FHA_1	300	306	PF00498	0.439
LIG_FHA_1	433	439	PF00498	0.408
LIG_FHA_2	220	226	PF00498	0.628
LIG_FHA_2	54	60	PF00498	0.647
LIG_Integrin_isoDGR_2	216	218	PF01839	0.550
LIG_LIR_Nem_3	416	420	PF02991	0.433
LIG_NRBOX	89	95	PF00104	0.479
LIG_PDZ_Class_2	447	452	PF00595	0.356
LIG_REV1ctd_RIR_1	224	234	PF16727	0.547
LIG_REV1ctd_RIR_1	38	46	PF16727	0.661
LIG_RPA_C_Fungi	242	254	PF08784	0.516
LIG_SH2_NCK_1	343	347	PF00017	0.467
LIG_SH2_STAP1	147	151	PF00017	0.458
LIG_SH2_STAT3	188	191	PF00017	0.517
LIG_SH2_STAT5	147	150	PF00017	0.353
LIG_SH3_3	229	235	PF00018	0.427
LIG_SH3_3	412	418	PF00018	0.405
LIG_SH3_3	431	437	PF00018	0.383
LIG_SUMO_SIM_par_1	268	275	PF11976	0.511
LIG_SUMO_SIM_par_1	337	345	PF11976	0.455
LIG_SUMO_SIM_par_1	437	443	PF11976	0.357
LIG_UBA3_1	366	371	PF00899	0.513
LIG_WRC_WIRS_1	146	151	PF05994	0.473
MOD_CK1_1	125	131	PF00069	0.433
MOD_CK1_1	249	255	PF00069	0.375
MOD_CK1_1	257	263	PF00069	0.397
MOD_CK1_1	299	305	PF00069	0.506
MOD_CK1_1	321	327	PF00069	0.630
MOD_CK1_1	53	59	PF00069	0.575
MOD_CK2_1	219	225	PF00069	0.615
MOD_CK2_1	275	281	PF00069	0.464
MOD_CK2_1	437	443	PF00069	0.357
MOD_CK2_1	92	98	PF00069	0.543
MOD_Cter_Amidation	216	219	PF01082	0.555
MOD_GlcNHglycan	109	112	PF01048	0.613
MOD_GlcNHglycan	124	127	PF01048	0.248
MOD_GlcNHglycan	257	260	PF01048	0.436
MOD_GlcNHglycan	318	321	PF01048	0.484
MOD_GlcNHglycan	323	326	PF01048	0.569
MOD_GlcNHglycan	334	337	PF01048	0.245
MOD_GlcNHglycan	344	347	PF01048	0.396
MOD_GlcNHglycan	349	352	PF01048	0.456
MOD_GlcNHglycan	75	78	PF01048	0.619
MOD_GSK3_1	167	174	PF00069	0.495
MOD_GSK3_1	194	201	PF00069	0.449
MOD_GSK3_1	272	279	PF00069	0.473
MOD_GSK3_1	299	306	PF00069	0.424
MOD_GSK3_1	312	319	PF00069	0.345
MOD_GSK3_1	334	341	PF00069	0.375
MOD_GSK3_1	383	390	PF00069	0.434
MOD_GSK3_1	428	435	PF00069	0.382
MOD_LATS_1	105	111	PF00433	0.594
MOD_NEK2_1	100	105	PF00069	0.540
MOD_NEK2_1	226	231	PF00069	0.382
MOD_NEK2_1	311	316	PF00069	0.444
MOD_NEK2_1	318	323	PF00069	0.469
MOD_NEK2_1	41	46	PF00069	0.661
MOD_NEK2_1	426	431	PF00069	0.380
MOD_NEK2_1	52	57	PF00069	0.590
MOD_NEK2_2	13	18	PF00069	0.560
MOD_NEK2_2	338	343	PF00069	0.400
MOD_PIKK_1	383	389	PF00454	0.495
MOD_PK_1	247	253	PF00069	0.518
MOD_PKA_1	296	302	PF00069	0.520
MOD_PKA_2	122	128	PF00069	0.450
MOD_PKA_2	208	214	PF00069	0.504
MOD_PKA_2	246	252	PF00069	0.473
MOD_PKA_2	299	305	PF00069	0.386
MOD_PKA_2	321	327	PF00069	0.681
MOD_PKA_2	73	79	PF00069	0.720
MOD_PKB_1	82	90	PF00069	0.626
MOD_Plk_1	168	174	PF00069	0.443
MOD_Plk_1	272	278	PF00069	0.406
MOD_Plk_4	114	120	PF00069	0.420
MOD_Plk_4	257	263	PF00069	0.461
MOD_Plk_4	272	278	PF00069	0.383
MOD_Plk_4	338	344	PF00069	0.404
MOD_Plk_4	387	393	PF00069	0.441
MOD_Plk_4	89	95	PF00069	0.532
MOD_ProDKin_1	34	40	PF00069	0.651
MOD_ProDKin_1	372	378	PF00069	0.457
TRG_DiLeu_BaEn_1	369	374	PF01217	0.495
TRG_DiLeu_BaLyEn_6	96	101	PF01217	0.517
TRG_ER_diArg_1	73	75	PF00400	0.706
TRG_ER_diArg_1	82	85	PF00400	0.641
TRG_NLS_MonoExtC_3	81	86	PF00514	0.625
TRG_NLS_MonoExtN_4	82	87	PF00514	0.601
TRG_Pf-PMV_PEXEL_1	303	307	PF00026	0.423
TRG_Pf-PMV_PEXEL_1	365	369	PF00026	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8A9	Leptomonas seymouri	76%	100%
A0A0S4JN39	Bodo saltans	43%	100%
A0A1X0P106	Trypanosomatidae	53%	100%
A0A422P581	Trypanosoma rangeli	53%	100%
A4HPX6	Leishmania braziliensis	80%	100%
A4IDN7	Leishmania infantum	99%	100%
D0A4C3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9ATP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q0V6	Leishmania major	94%	100%
Q5SSI6	Mus musculus	24%	82%
V5B517	Trypanosoma cruzi	51%	100%