Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IKU7_LEIDO

TriTrypDb:

LdBPK_210060.1 , LdCL_210005500 , LDHU3_21.0070

Length:

231

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 6
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0031253	cell projection membrane	4	1
GO:0060170	ciliary membrane	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098590	plasma membrane region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IKU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IKU7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	166	170	PF00656	0.510
CLV_C14_Caspase3-7	73	77	PF00656	0.515
CLV_NRD_NRD_1	1	3	PF00675	0.507
CLV_NRD_NRD_1	126	128	PF00675	0.549
CLV_NRD_NRD_1	148	150	PF00675	0.691
CLV_NRD_NRD_1	167	169	PF00675	0.513
CLV_NRD_NRD_1	223	225	PF00675	0.498
CLV_PCSK_KEX2_1	126	128	PF00082	0.650
CLV_PCSK_KEX2_1	167	169	PF00082	0.551
CLV_PCSK_KEX2_1	223	225	PF00082	0.669
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.651
CLV_PCSK_SKI1_1	180	184	PF00082	0.556
CLV_PCSK_SKI1_1	3	7	PF00082	0.582
CLV_PCSK_SKI1_1	9	13	PF00082	0.532
DEG_Nend_UBRbox_1	1	4	PF02207	0.588
DOC_MAPK_gen_1	223	231	PF00069	0.516
DOC_MAPK_MEF2A_6	91	100	PF00069	0.367
DOC_MAPK_RevD_3	111	127	PF00069	0.406
DOC_PP1_RVXF_1	15	22	PF00149	0.438
DOC_USP7_MATH_1	125	129	PF00917	0.508
DOC_USP7_MATH_1	206	210	PF00917	0.538
LIG_14-3-3_CanoR_1	48	55	PF00244	0.649
LIG_deltaCOP1_diTrp_1	20	23	PF00928	0.418
LIG_FHA_1	206	212	PF00498	0.609
LIG_FHA_2	101	107	PF00498	0.547
LIG_FHA_2	140	146	PF00498	0.677
LIG_FHA_2	183	189	PF00498	0.662
LIG_FHA_2	34	40	PF00498	0.616
LIG_FHA_2	54	60	PF00498	0.617
LIG_LIR_Gen_1	184	194	PF02991	0.551
LIG_LIR_Gen_1	84	92	PF02991	0.519
LIG_LIR_Nem_3	133	137	PF02991	0.527
LIG_LIR_Nem_3	184	189	PF02991	0.547
LIG_PCNA_PIPBox_1	198	207	PF02747	0.425
LIG_PDZ_Class_2	226	231	PF00595	0.675
LIG_SH2_STAP1	161	165	PF00017	0.542
LIG_SH2_STAT5	204	207	PF00017	0.638
LIG_UBA3_1	211	217	PF00899	0.561
LIG_UBA3_1	54	63	PF00899	0.428
MOD_CK1_1	57	63	PF00069	0.484
MOD_CK2_1	106	112	PF00069	0.591
MOD_CK2_1	139	145	PF00069	0.560
MOD_CK2_1	182	188	PF00069	0.540
MOD_CK2_1	39	45	PF00069	0.593
MOD_CK2_1	53	59	PF00069	0.460
MOD_GlcNHglycan	41	44	PF01048	0.628
MOD_GlcNHglycan	48	51	PF01048	0.592
MOD_GSK3_1	163	170	PF00069	0.584
MOD_GSK3_1	200	207	PF00069	0.560
MOD_GSK3_1	29	36	PF00069	0.561
MOD_GSK3_1	44	51	PF00069	0.594
MOD_GSK3_1	53	60	PF00069	0.503
MOD_N-GLC_1	33	38	PF02516	0.489
MOD_NEK2_1	155	160	PF00069	0.556
MOD_NEK2_1	182	187	PF00069	0.562
MOD_NEK2_1	205	210	PF00069	0.627
MOD_NEK2_1	211	216	PF00069	0.621
MOD_NEK2_1	219	224	PF00069	0.464
MOD_NEK2_1	5	10	PF00069	0.568
MOD_PIKK_1	206	212	PF00454	0.454
MOD_PIKK_1	48	54	PF00454	0.448
MOD_PKA_1	167	173	PF00069	0.562
MOD_PKA_2	125	131	PF00069	0.523
MOD_PKA_2	167	173	PF00069	0.565
MOD_Plk_1	106	112	PF00069	0.562
MOD_Plk_1	33	39	PF00069	0.687
MOD_Plk_2-3	106	112	PF00069	0.650
MOD_Plk_4	200	206	PF00069	0.579
MOD_Plk_4	57	63	PF00069	0.540
MOD_SUMO_rev_2	154	160	PF00179	0.616
MOD_SUMO_rev_2	179	185	PF00179	0.621
MOD_SUMO_rev_2	188	194	PF00179	0.546
MOD_SUMO_rev_2	20	27	PF00179	0.593
MOD_SUMO_rev_2	38	43	PF00179	0.434
MOD_SUMO_rev_2	95	103	PF00179	0.574
TRG_ENDOCYTIC_2	186	189	PF00928	0.465
TRG_NES_CRM1_1	52	66	PF08389	0.434
TRG_NLS_MonoExtC_3	148	153	PF00514	0.684
TRG_NLS_MonoExtN_4	191	196	PF00514	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S1	Leptomonas seymouri	31%	97%
A0A0N1PD85	Leptomonas seymouri	45%	100%
A0A1X0NEE3	Trypanosomatidae	25%	84%
A0A1X0NFG5	Trypanosomatidae	25%	84%
A0A1X0NXA6	Trypanosomatidae	29%	76%
A0A1X0NXA8	Trypanosomatidae	40%	99%
A0A3S5H792	Leishmania donovani	32%	94%
A0A3S5H7I1	Leishmania donovani	26%	68%
A0A422MZP2	Trypanosoma rangeli	29%	76%
A4HBJ9	Leishmania braziliensis	55%	100%
A4HBK0	Leishmania braziliensis	30%	100%
A4HFU7	Leishmania braziliensis	25%	68%
A4HZL5	Leishmania infantum	32%	100%
A4HZL6	Leishmania infantum	99%	100%
A4I2W4	Leishmania infantum	26%	68%
E9ADF0	Leishmania major	27%	68%
E9AUW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9AUW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AZ74	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	68%
Q4QCL3	Leishmania major	31%	100%
Q4QCL4	Leishmania major	93%	100%
V5BG41	Trypanosoma cruzi	34%	99%
V5BKK3	Trypanosoma cruzi	28%	76%