SET domain/TPR repeat/Tetratricopeptide repeat, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat/SET domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IKU3_LEIDO

TriTrypDb:

LdBPK_341120.1 , LdCL_340016700 , LDHU3_34.1810

Length:

700

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IKU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IKU3

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	1
GO:0042054	histone methyltransferase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.785
CLV_C14_Caspase3-7	188	192	PF00656	0.645
CLV_NRD_NRD_1	101	103	PF00675	0.610
CLV_NRD_NRD_1	164	166	PF00675	0.384
CLV_NRD_NRD_1	403	405	PF00675	0.337
CLV_NRD_NRD_1	555	557	PF00675	0.532
CLV_NRD_NRD_1	664	666	PF00675	0.483
CLV_NRD_NRD_1	78	80	PF00675	0.510
CLV_PCSK_KEX2_1	100	102	PF00082	0.586
CLV_PCSK_KEX2_1	164	166	PF00082	0.382
CLV_PCSK_KEX2_1	555	557	PF00082	0.499
CLV_PCSK_KEX2_1	664	666	PF00082	0.481
CLV_PCSK_KEX2_1	78	80	PF00082	0.588
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.601
CLV_PCSK_SKI1_1	22	26	PF00082	0.738
CLV_PCSK_SKI1_1	229	233	PF00082	0.557
CLV_PCSK_SKI1_1	290	294	PF00082	0.272
CLV_PCSK_SKI1_1	328	332	PF00082	0.389
CLV_PCSK_SKI1_1	408	412	PF00082	0.296
CLV_PCSK_SKI1_1	641	645	PF00082	0.412
CLV_Separin_Metazoa	661	665	PF03568	0.478
DEG_APCC_DBOX_1	508	516	PF00400	0.560
DEG_SPOP_SBC_1	430	434	PF00917	0.561
DOC_CDC14_PxL_1	333	341	PF14671	0.562
DOC_CKS1_1	688	693	PF01111	0.717
DOC_MAPK_gen_1	164	174	PF00069	0.523
DOC_MAPK_gen_1	404	412	PF00069	0.539
DOC_MAPK_HePTP_8	162	174	PF00069	0.508
DOC_MAPK_MEF2A_6	165	174	PF00069	0.525
DOC_PP1_RVXF_1	639	645	PF00149	0.444
DOC_PP4_FxxP_1	293	296	PF00568	0.580
DOC_PP4_FxxP_1	666	669	PF00568	0.444
DOC_USP7_MATH_1	425	429	PF00917	0.560
DOC_USP7_MATH_1	430	434	PF00917	0.564
DOC_USP7_MATH_1	472	476	PF00917	0.513
DOC_USP7_MATH_2	427	433	PF00917	0.521
DOC_USP7_UBL2_3	90	94	PF12436	0.491
DOC_WW_Pin1_4	192	197	PF00397	0.602
DOC_WW_Pin1_4	292	297	PF00397	0.580
DOC_WW_Pin1_4	342	347	PF00397	0.563
DOC_WW_Pin1_4	645	650	PF00397	0.537
DOC_WW_Pin1_4	687	692	PF00397	0.728
LIG_14-3-3_CanoR_1	131	135	PF00244	0.395
LIG_14-3-3_CanoR_1	164	170	PF00244	0.525
LIG_14-3-3_CanoR_1	241	248	PF00244	0.566
LIG_14-3-3_CanoR_1	511	516	PF00244	0.447
LIG_14-3-3_CanoR_1	561	571	PF00244	0.373
LIG_Actin_WH2_2	388	406	PF00022	0.500
LIG_APCC_ABBAyCdc20_2	131	137	PF00400	0.489
LIG_BIR_II_1	1	5	PF00653	0.749
LIG_BRCT_BRCA1_1	131	135	PF00533	0.351
LIG_BRCT_BRCA1_1	288	292	PF00533	0.555
LIG_DLG_GKlike_1	165	172	PF00625	0.502
LIG_eIF4E_1	450	456	PF01652	0.537
LIG_FHA_1	110	116	PF00498	0.442
LIG_FHA_1	121	127	PF00498	0.434
LIG_FHA_1	205	211	PF00498	0.642
LIG_FHA_1	257	263	PF00498	0.526
LIG_FHA_1	436	442	PF00498	0.503
LIG_FHA_1	566	572	PF00498	0.464
LIG_FHA_1	84	90	PF00498	0.540
LIG_FHA_2	350	356	PF00498	0.562
LIG_FHA_2	394	400	PF00498	0.552
LIG_FHA_2	512	518	PF00498	0.510
LIG_HCF-1_HBM_1	138	141	PF13415	0.563
LIG_LIR_Gen_1	171	182	PF02991	0.528
LIG_LIR_Gen_1	250	261	PF02991	0.558
LIG_LIR_Gen_1	504	512	PF02991	0.472
LIG_LIR_Gen_1	573	581	PF02991	0.450
LIG_LIR_Gen_1	65	74	PF02991	0.536
LIG_LIR_Nem_3	157	162	PF02991	0.436
LIG_LIR_Nem_3	171	177	PF02991	0.417
LIG_LIR_Nem_3	250	256	PF02991	0.558
LIG_LIR_Nem_3	31	36	PF02991	0.564
LIG_LIR_Nem_3	494	500	PF02991	0.486
LIG_LIR_Nem_3	517	522	PF02991	0.519
LIG_LIR_Nem_3	573	577	PF02991	0.435
LIG_LIR_Nem_3	65	70	PF02991	0.531
LIG_LYPXL_S_1	32	36	PF13949	0.538
LIG_LYPXL_yS_3	33	36	PF13949	0.544
LIG_LYPXL_yS_3	336	339	PF13949	0.562
LIG_MYND_1	346	350	PF01753	0.580
LIG_NRBOX	123	129	PF00104	0.399
LIG_NRBOX	54	60	PF00104	0.543
LIG_Rb_LxCxE_1	110	133	PF01857	0.504
LIG_SH2_CRK	253	257	PF00017	0.558
LIG_SH2_CRK	327	331	PF00017	0.562
LIG_SH2_CRK	497	501	PF00017	0.579
LIG_SH2_GRB2like	111	114	PF00017	0.510
LIG_SH2_NCK_1	253	257	PF00017	0.562
LIG_SH2_PTP2	580	583	PF00017	0.507
LIG_SH2_SRC	141	144	PF00017	0.525
LIG_SH2_SRC	253	256	PF00017	0.574
LIG_SH2_SRC	450	453	PF00017	0.492
LIG_SH2_SRC	574	577	PF00017	0.440
LIG_SH2_SRC	667	670	PF00017	0.421
LIG_SH2_SRC	679	682	PF00017	0.423
LIG_SH2_STAP1	253	257	PF00017	0.546
LIG_SH2_STAP1	563	567	PF00017	0.403
LIG_SH2_STAP1	574	578	PF00017	0.357
LIG_SH2_STAT3	268	271	PF00017	0.562
LIG_SH2_STAT5	111	114	PF00017	0.405
LIG_SH2_STAT5	268	271	PF00017	0.495
LIG_SH2_STAT5	391	394	PF00017	0.562
LIG_SH2_STAT5	465	468	PF00017	0.523
LIG_SH2_STAT5	544	547	PF00017	0.430
LIG_SH2_STAT5	580	583	PF00017	0.453
LIG_SH2_STAT5	603	606	PF00017	0.482
LIG_SH2_STAT5	679	682	PF00017	0.516
LIG_SH3_1	685	691	PF00018	0.681
LIG_SH3_3	529	535	PF00018	0.604
LIG_SH3_3	581	587	PF00018	0.437
LIG_SH3_3	685	691	PF00018	0.700
LIG_SUMO_SIM_anti_2	122	128	PF11976	0.468
LIG_SUMO_SIM_anti_2	54	60	PF11976	0.553
LIG_SUMO_SIM_anti_2	565	571	PF11976	0.442
LIG_SUMO_SIM_par_1	259	267	PF11976	0.539
LIG_SUMO_SIM_par_1	54	60	PF11976	0.569
LIG_SUMO_SIM_par_1	567	573	PF11976	0.431
LIG_TRAF2_1	185	188	PF00917	0.556
LIG_TYR_ITIM	325	330	PF00017	0.449
LIG_TYR_ITIM	495	500	PF00017	0.413
LIG_UBA3_1	55	63	PF00899	0.514
LIG_WRC_WIRS_1	465	470	PF05994	0.344
LIG_WW_3	215	219	PF00397	0.577
MOD_CDK_SPxxK_3	645	652	PF00069	0.532
MOD_CK1_1	2	8	PF00069	0.724
MOD_CK1_1	208	214	PF00069	0.519
MOD_CK1_1	240	246	PF00069	0.406
MOD_CK1_1	264	270	PF00069	0.449
MOD_CK1_1	501	507	PF00069	0.514
MOD_CK2_1	165	171	PF00069	0.447
MOD_CK2_1	182	188	PF00069	0.456
MOD_CK2_1	393	399	PF00069	0.403
MOD_CK2_1	645	651	PF00069	0.478
MOD_Cter_Amidation	553	556	PF01082	0.502
MOD_GlcNHglycan	12	15	PF01048	0.745
MOD_GlcNHglycan	207	210	PF01048	0.550
MOD_GlcNHglycan	228	232	PF01048	0.547
MOD_GlcNHglycan	272	275	PF01048	0.376
MOD_GlcNHglycan	28	31	PF01048	0.597
MOD_GlcNHglycan	4	7	PF01048	0.762
MOD_GlcNHglycan	59	62	PF01048	0.487
MOD_GlcNHglycan	80	83	PF01048	0.546
MOD_GSK3_1	1	8	PF00069	0.757
MOD_GSK3_1	182	189	PF00069	0.607
MOD_GSK3_1	204	211	PF00069	0.573
MOD_GSK3_1	22	29	PF00069	0.680
MOD_GSK3_1	360	367	PF00069	0.457
MOD_GSK3_1	380	387	PF00069	0.145
MOD_GSK3_1	421	428	PF00069	0.413
MOD_GSK3_1	431	438	PF00069	0.358
MOD_GSK3_1	693	700	PF00069	0.744
MOD_N-GLC_1	129	134	PF02516	0.423
MOD_N-GLC_1	430	435	PF02516	0.474
MOD_NEK2_1	1	6	PF00069	0.783
MOD_NEK2_1	109	114	PF00069	0.481
MOD_NEK2_1	270	275	PF00069	0.344
MOD_NEK2_1	364	369	PF00069	0.441
MOD_NEK2_1	420	425	PF00069	0.487
MOD_NEK2_1	435	440	PF00069	0.325
MOD_NEK2_1	493	498	PF00069	0.449
MOD_NEK2_1	57	62	PF00069	0.486
MOD_NEK2_1	73	78	PF00069	0.465
MOD_NEK2_1	83	88	PF00069	0.524
MOD_NEK2_2	498	503	PF00069	0.545
MOD_NEK2_2	524	529	PF00069	0.481
MOD_OFUCOSY	523	528	PF10250	0.528
MOD_PKA_1	78	84	PF00069	0.566
MOD_PKA_2	130	136	PF00069	0.388
MOD_PKA_2	240	246	PF00069	0.392
MOD_PKA_2	421	427	PF00069	0.488
MOD_PKA_2	78	84	PF00069	0.488
MOD_PKB_1	509	517	PF00069	0.499
MOD_Plk_1	129	135	PF00069	0.417
MOD_Plk_1	340	346	PF00069	0.274
MOD_Plk_1	415	421	PF00069	0.400
MOD_Plk_1	430	436	PF00069	0.443
MOD_Plk_1	491	497	PF00069	0.342
MOD_Plk_1	637	643	PF00069	0.463
MOD_Plk_1	680	686	PF00069	0.570
MOD_Plk_1	83	89	PF00069	0.489
MOD_Plk_2-3	349	355	PF00069	0.392
MOD_Plk_4	130	136	PF00069	0.393
MOD_Plk_4	154	160	PF00069	0.490
MOD_Plk_4	380	386	PF00069	0.366
MOD_Plk_4	431	437	PF00069	0.428
MOD_Plk_4	565	571	PF00069	0.390
MOD_Plk_4	668	674	PF00069	0.474
MOD_ProDKin_1	192	198	PF00069	0.601
MOD_ProDKin_1	292	298	PF00069	0.474
MOD_ProDKin_1	342	348	PF00069	0.451
MOD_ProDKin_1	645	651	PF00069	0.536
MOD_ProDKin_1	687	693	PF00069	0.731
MOD_SUMO_for_1	684	687	PF00179	0.583
MOD_SUMO_rev_2	13	23	PF00179	0.774
MOD_SUMO_rev_2	648	654	PF00179	0.496
TRG_DiLeu_BaEn_1	54	59	PF01217	0.536
TRG_DiLeu_BaLyEn_6	475	480	PF01217	0.457
TRG_ENDOCYTIC_2	253	256	PF00928	0.443
TRG_ENDOCYTIC_2	327	330	PF00928	0.439
TRG_ENDOCYTIC_2	33	36	PF00928	0.541
TRG_ENDOCYTIC_2	336	339	PF00928	0.449
TRG_ENDOCYTIC_2	465	468	PF00928	0.435
TRG_ENDOCYTIC_2	497	500	PF00928	0.440
TRG_ENDOCYTIC_2	519	522	PF00928	0.486
TRG_ENDOCYTIC_2	574	577	PF00928	0.440
TRG_ENDOCYTIC_2	603	606	PF00928	0.517
TRG_ER_diArg_1	101	103	PF00400	0.530
TRG_ER_diArg_1	164	167	PF00400	0.441
TRG_ER_diArg_1	508	511	PF00400	0.449
TRG_ER_diArg_1	555	557	PF00400	0.499
TRG_ER_diArg_1	663	665	PF00400	0.466
TRG_ER_diArg_1	78	80	PF00400	0.588
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	555	560	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKN8	Leptomonas seymouri	75%	99%
A0A0S4JQY2	Bodo saltans	42%	100%
A0A1X0P998	Trypanosomatidae	36%	100%
A0A422N693	Trypanosoma rangeli	37%	100%
A4HAL8	Leishmania braziliensis	87%	100%
A4I9Q7	Leishmania infantum	100%	100%
C9ZMX7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B4S7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q3A0	Leishmania major	97%	100%
V5BJB7	Trypanosoma cruzi	36%	100%