U6 snRNA-associated Sm-like protein LSm4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U6 snRNA-associated Sm-like protein LSm4p

Species:

Leishmania donovani

UniProt:

A0A3Q8IKS2_LEIDO

TriTrypDb:

LdBPK_320750.1 , LdCL_320013100 , LDHU3_32.0950

Length:

116

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	7
GO:0032991	protein-containing complex	1	7
GO:0140513	nuclear protein-containing complex	2	7
GO:1990904	ribonucleoprotein complex	2	7

Expansion

Sequence features

A0A3Q8IKS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IKS2

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	7
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	7
GO:0000398	mRNA splicing, via spliceosome	8	7
GO:0000956	nuclear-transcribed mRNA catabolic process	7	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006397	mRNA processing	7	7
GO:0006401	RNA catabolic process	5	7
GO:0006402	mRNA catabolic process	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0008380	RNA splicing	7	7
GO:0009056	catabolic process	2	7
GO:0009057	macromolecule catabolic process	4	7
GO:0009892	negative regulation of metabolic process	4	7
GO:0009987	cellular process	1	7
GO:0010468	regulation of gene expression	5	7
GO:0010605	negative regulation of macromolecule metabolic process	5	7
GO:0010629	negative regulation of gene expression	6	7
GO:0016070	RNA metabolic process	5	7
GO:0016071	mRNA metabolic process	6	7
GO:0019222	regulation of metabolic process	3	7
GO:0019439	aromatic compound catabolic process	4	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0034655	nucleobase-containing compound catabolic process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044248	cellular catabolic process	3	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0044265	obsolete cellular macromolecule catabolic process	4	7
GO:0044270	cellular nitrogen compound catabolic process	4	7
GO:0046483	heterocycle metabolic process	3	7
GO:0046700	heterocycle catabolic process	4	7
GO:0048519	negative regulation of biological process	3	7
GO:0050789	regulation of biological process	2	7
GO:0060255	regulation of macromolecule metabolic process	4	7
GO:0065007	biological regulation	1	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:1901361	organic cyclic compound catabolic process	4	7
GO:1901575	organic substance catabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	25	29	PF00656	0.505
CLV_C14_Caspase3-7	53	57	PF00656	0.505
CLV_NRD_NRD_1	114	116	PF00675	0.650
CLV_NRD_NRD_1	5	7	PF00675	0.500
CLV_NRD_NRD_1	91	93	PF00675	0.668
CLV_PCSK_KEX2_1	112	114	PF00082	0.637
CLV_PCSK_KEX2_1	5	7	PF00082	0.564
CLV_PCSK_KEX2_1	91	93	PF00082	0.619
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.637
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.654
CLV_PCSK_SKI1_1	6	10	PF00082	0.423
CLV_Separin_Metazoa	12	16	PF03568	0.387
DOC_ANK_TNKS_1	51	58	PF00023	0.474
DOC_CKS1_1	7	12	PF01111	0.438
DOC_MAPK_DCC_7	5	13	PF00069	0.422
DOC_MAPK_gen_1	15	24	PF00069	0.433
DOC_MAPK_gen_1	38	47	PF00069	0.433
DOC_MAPK_gen_1	5	13	PF00069	0.422
DOC_MAPK_MEF2A_6	18	26	PF00069	0.433
DOC_MAPK_MEF2A_6	38	47	PF00069	0.301
DOC_USP7_MATH_1	87	91	PF00917	0.546
DOC_USP7_UBL2_3	112	116	PF12436	0.729
DOC_WW_Pin1_4	6	11	PF00397	0.422
LIG_14-3-3_CanoR_1	69	74	PF00244	0.451
LIG_14-3-3_CanoR_1	77	84	PF00244	0.526
LIG_BIR_II_1	1	5	PF00653	0.540
LIG_deltaCOP1_diTrp_1	58	67	PF00928	0.505
LIG_FHA_2	100	106	PF00498	0.595
LIG_FHA_2	51	57	PF00498	0.474
LIG_FHA_2	7	13	PF00498	0.407
LIG_SH3_3	4	10	PF00018	0.537
LIG_SH3_3	81	87	PF00018	0.557
LIG_SUMO_SIM_anti_2	9	15	PF11976	0.391
MOD_CK2_1	6	12	PF00069	0.520
MOD_CK2_1	99	105	PF00069	0.706
MOD_Cter_Amidation	110	113	PF01082	0.689
MOD_DYRK1A_RPxSP_1	6	10	PF00069	0.532
MOD_GlcNHglycan	80	83	PF01048	0.528
MOD_GSK3_1	28	35	PF00069	0.429
MOD_GSK3_1	56	63	PF00069	0.528
MOD_N-GLC_1	32	37	PF02516	0.251
MOD_NEK2_1	78	83	PF00069	0.490
MOD_PK_1	104	110	PF00069	0.603
MOD_PK_1	20	26	PF00069	0.433
MOD_PK_1	69	75	PF00069	0.433
MOD_PKA_2	76	82	PF00069	0.484
MOD_Plk_1	104	110	PF00069	0.756
MOD_Plk_1	20	26	PF00069	0.502
MOD_Plk_4	32	38	PF00069	0.442
MOD_Plk_4	56	62	PF00069	0.468
MOD_ProDKin_1	6	12	PF00069	0.420
TRG_ER_diArg_1	5	7	PF00400	0.576
TRG_NLS_MonoCore_2	111	116	PF00514	0.718
TRG_NLS_MonoExtC_3	111	116	PF00514	0.711
TRG_NLS_MonoExtN_4	89	95	PF00514	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7M3	Leptomonas seymouri	75%	100%
A0A0S4KRF8	Bodo saltans	32%	93%
A0A1X0NUP3	Trypanosomatidae	54%	100%
A0A3R7L1D6	Trypanosoma rangeli	55%	99%
A0A3S7X8L1	Leishmania donovani	33%	100%
A4HBA7	Leishmania braziliensis	31%	100%
A4HK52	Leishmania braziliensis	90%	100%
A4IAF5	Leishmania infantum	33%	100%
D0A9T9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	91%
E9B5H9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
F4K4E3	Arabidopsis thaliana	34%	90%
O14352	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	96%
Q3ZBK6	Bos taurus	33%	83%
Q43582	Nicotiana tabacum	32%	79%
Q4Q2F6	Leishmania major	33%	100%
Q9LGE6	Oryza sativa subsp. japonica	34%	79%
Q9QXA5	Mus musculus	33%	85%
Q9Y4Z0	Homo sapiens	33%	83%
Q9ZRU9	Fagus sylvatica	32%	78%