B30.2/SPRY domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IKR6_LEIDO

TriTrypDb:

LdBPK_340750.1 , LdCL_340013000 , LDHU3_34.1230

Length:

768

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IKR6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IKR6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	583	587	PF00656	0.459
CLV_NRD_NRD_1	251	253	PF00675	0.456
CLV_NRD_NRD_1	351	353	PF00675	0.420
CLV_NRD_NRD_1	433	435	PF00675	0.473
CLV_NRD_NRD_1	463	465	PF00675	0.467
CLV_NRD_NRD_1	509	511	PF00675	0.589
CLV_PCSK_KEX2_1	251	253	PF00082	0.456
CLV_PCSK_KEX2_1	351	353	PF00082	0.420
CLV_PCSK_KEX2_1	433	435	PF00082	0.415
CLV_PCSK_KEX2_1	509	511	PF00082	0.491
CLV_PCSK_KEX2_1	605	607	PF00082	0.406
CLV_PCSK_KEX2_1	693	695	PF00082	0.468
CLV_PCSK_KEX2_1	758	760	PF00082	0.648
CLV_PCSK_PC1ET2_1	509	511	PF00082	0.491
CLV_PCSK_PC1ET2_1	605	607	PF00082	0.406
CLV_PCSK_PC1ET2_1	693	695	PF00082	0.468
CLV_PCSK_PC1ET2_1	758	760	PF00082	0.616
CLV_PCSK_SKI1_1	134	138	PF00082	0.319
CLV_PCSK_SKI1_1	216	220	PF00082	0.421
CLV_PCSK_SKI1_1	393	397	PF00082	0.544
CLV_PCSK_SKI1_1	413	417	PF00082	0.457
CLV_PCSK_SKI1_1	434	438	PF00082	0.453
CLV_PCSK_SKI1_1	465	469	PF00082	0.400
CLV_PCSK_SKI1_1	621	625	PF00082	0.591
CLV_PCSK_SKI1_1	676	680	PF00082	0.460
CLV_PCSK_SKI1_1	719	723	PF00082	0.439
DEG_APCC_DBOX_1	355	363	PF00400	0.368
DEG_APCC_DBOX_1	718	726	PF00400	0.446
DEG_SCF_FBW7_2	285	291	PF00400	0.443
DEG_SCF_FBW7_2	528	535	PF00400	0.412
DEG_SPOP_SBC_1	585	589	PF00917	0.459
DOC_CKS1_1	285	290	PF01111	0.450
DOC_CKS1_1	70	75	PF01111	0.436
DOC_CYCLIN_RxL_1	523	531	PF00134	0.434
DOC_CYCLIN_RxL_1	713	726	PF00134	0.436
DOC_MAPK_gen_1	433	443	PF00069	0.458
DOC_MAPK_gen_1	509	520	PF00069	0.565
DOC_MAPK_gen_1	564	572	PF00069	0.461
DOC_MAPK_gen_1	742	751	PF00069	0.585
DOC_MAPK_MEF2A_6	479	487	PF00069	0.366
DOC_MAPK_RevD_3	418	434	PF00069	0.446
DOC_PP1_RVXF_1	132	139	PF00149	0.337
DOC_PP4_FxxP_1	94	97	PF00568	0.430
DOC_USP7_MATH_1	182	186	PF00917	0.475
DOC_USP7_MATH_1	257	261	PF00917	0.640
DOC_USP7_MATH_1	314	318	PF00917	0.486
DOC_USP7_MATH_1	547	551	PF00917	0.553
DOC_USP7_MATH_1	632	636	PF00917	0.448
DOC_USP7_MATH_1	86	90	PF00917	0.446
DOC_USP7_UBL2_3	753	757	PF12436	0.638
DOC_WW_Pin1_4	284	289	PF00397	0.511
DOC_WW_Pin1_4	376	381	PF00397	0.417
DOC_WW_Pin1_4	406	411	PF00397	0.476
DOC_WW_Pin1_4	509	514	PF00397	0.462
DOC_WW_Pin1_4	528	533	PF00397	0.421
DOC_WW_Pin1_4	56	61	PF00397	0.619
DOC_WW_Pin1_4	69	74	PF00397	0.301
DOC_WW_Pin1_4	729	734	PF00397	0.536
LIG_14-3-3_CanoR_1	110	119	PF00244	0.442
LIG_14-3-3_CanoR_1	127	136	PF00244	0.450
LIG_14-3-3_CanoR_1	183	191	PF00244	0.412
LIG_14-3-3_CanoR_1	351	355	PF00244	0.455
LIG_14-3-3_CanoR_1	393	400	PF00244	0.588
LIG_14-3-3_CanoR_1	434	443	PF00244	0.468
LIG_14-3-3_CanoR_1	470	476	PF00244	0.468
LIG_14-3-3_CanoR_1	581	585	PF00244	0.356
LIG_14-3-3_CanoR_1	621	630	PF00244	0.537
LIG_14-3-3_CanoR_1	694	698	PF00244	0.487
LIG_14-3-3_CanoR_1	719	725	PF00244	0.416
LIG_14-3-3_CanoR_1	759	766	PF00244	0.613
LIG_Actin_WH2_2	153	170	PF00022	0.502
LIG_Actin_WH2_2	459	475	PF00022	0.426
LIG_APCC_ABBA_1	569	574	PF00400	0.441
LIG_BRCT_BRCA1_1	207	211	PF00533	0.413
LIG_deltaCOP1_diTrp_1	294	302	PF00928	0.408
LIG_FHA_1	13	19	PF00498	0.499
LIG_FHA_1	162	168	PF00498	0.404
LIG_FHA_1	218	224	PF00498	0.549
LIG_FHA_1	25	31	PF00498	0.529
LIG_FHA_1	327	333	PF00498	0.415
LIG_FHA_1	513	519	PF00498	0.462
LIG_FHA_1	529	535	PF00498	0.541
LIG_FHA_1	587	593	PF00498	0.350
LIG_FHA_1	699	705	PF00498	0.434
LIG_FHA_1	70	76	PF00498	0.499
LIG_FHA_2	139	145	PF00498	0.525
LIG_FHA_2	220	226	PF00498	0.456
LIG_FHA_2	285	291	PF00498	0.433
LIG_FHA_2	5	11	PF00498	0.527
LIG_FHA_2	586	592	PF00498	0.389
LIG_GBD_Chelix_1	75	83	PF00786	0.391
LIG_LIR_Gen_1	208	219	PF02991	0.417
LIG_LIR_Gen_1	567	577	PF02991	0.336
LIG_LIR_Gen_1	701	708	PF02991	0.421
LIG_LIR_Gen_1	761	768	PF02991	0.611
LIG_LIR_Nem_3	208	214	PF02991	0.421
LIG_LIR_Nem_3	567	572	PF02991	0.473
LIG_LIR_Nem_3	701	706	PF02991	0.464
LIG_LIR_Nem_3	734	740	PF02991	0.411
LIG_LIR_Nem_3	761	766	PF02991	0.621
LIG_NRBOX	171	177	PF00104	0.437
LIG_NRBOX	660	666	PF00104	0.427
LIG_NRBOX	720	726	PF00104	0.444
LIG_PAM2_1	439	451	PF00658	0.434
LIG_PCNA_yPIPBox_3	150	158	PF02747	0.473
LIG_Pex14_1	703	707	PF04695	0.373
LIG_Pex14_2	94	98	PF04695	0.427
LIG_REV1ctd_RIR_1	299	308	PF16727	0.398
LIG_REV1ctd_RIR_1	676	684	PF16727	0.437
LIG_RPA_C_Fungi	308	320	PF08784	0.334
LIG_SH2_STAP1	66	70	PF00017	0.439
LIG_SH2_STAT3	369	372	PF00017	0.425
LIG_SH2_STAT5	292	295	PF00017	0.442
LIG_SH2_STAT5	369	372	PF00017	0.394
LIG_SH2_STAT5	448	451	PF00017	0.460
LIG_SH2_STAT5	707	710	PF00017	0.359
LIG_SH2_STAT5	740	743	PF00017	0.429
LIG_SH3_3	282	288	PF00018	0.459
LIG_SUMO_SIM_anti_2	139	145	PF11976	0.455
LIG_SUMO_SIM_anti_2	550	559	PF11976	0.428
LIG_SUMO_SIM_anti_2	586	597	PF11976	0.437
LIG_SUMO_SIM_anti_2	720	728	PF11976	0.459
LIG_SUMO_SIM_par_1	550	559	PF11976	0.432
LIG_SUMO_SIM_par_1	586	597	PF11976	0.426
LIG_SUMO_SIM_par_1	720	728	PF11976	0.459
LIG_TRAF2_1	163	166	PF00917	0.433
LIG_TRAF2_1	288	291	PF00917	0.588
LIG_TRAF2_1	303	306	PF00917	0.451
LIG_TRFH_1	569	573	PF08558	0.338
LIG_UBA3_1	142	151	PF00899	0.440
LIG_UBA3_1	17	22	PF00899	0.511
LIG_UBA3_1	431	437	PF00899	0.448
LIG_WRC_WIRS_1	5	10	PF05994	0.537
LIG_WRC_WIRS_1	595	600	PF05994	0.428
MOD_CDK_SPK_2	406	411	PF00069	0.476
MOD_CDK_SPK_2	509	514	PF00069	0.456
MOD_CDK_SPxxK_3	406	413	PF00069	0.469
MOD_CK1_1	114	120	PF00069	0.421
MOD_CK1_1	258	264	PF00069	0.543
MOD_CK1_1	300	306	PF00069	0.520
MOD_CK1_1	31	37	PF00069	0.526
MOD_CK1_1	360	366	PF00069	0.431
MOD_CK1_1	474	480	PF00069	0.556
MOD_CK1_1	488	494	PF00069	0.416
MOD_CK1_1	54	60	PF00069	0.491
MOD_CK1_1	559	565	PF00069	0.523
MOD_CK1_1	587	593	PF00069	0.422
MOD_CK1_1	601	607	PF00069	0.441
MOD_CK1_1	635	641	PF00069	0.531
MOD_CK1_1	669	675	PF00069	0.475
MOD_CK1_1	720	726	PF00069	0.444
MOD_CK1_1	761	767	PF00069	0.663
MOD_CK2_1	138	144	PF00069	0.528
MOD_CK2_1	159	165	PF00069	0.500
MOD_CK2_1	219	225	PF00069	0.424
MOD_CK2_1	284	290	PF00069	0.469
MOD_CK2_1	300	306	PF00069	0.369
MOD_CK2_1	322	328	PF00069	0.533
MOD_CK2_1	37	43	PF00069	0.620
MOD_DYRK1A_RPxSP_1	731	735	PF00069	0.534
MOD_GlcNHglycan	161	164	PF01048	0.420
MOD_GlcNHglycan	235	238	PF01048	0.573
MOD_GlcNHglycan	255	258	PF01048	0.639
MOD_GlcNHglycan	316	319	PF01048	0.583
MOD_GlcNHglycan	323	327	PF01048	0.421
MOD_GlcNHglycan	33	36	PF01048	0.577
MOD_GlcNHglycan	373	376	PF01048	0.489
MOD_GlcNHglycan	38	42	PF01048	0.578
MOD_GlcNHglycan	43	47	PF01048	0.510
MOD_GlcNHglycan	443	446	PF01048	0.465
MOD_GlcNHglycan	487	490	PF01048	0.368
MOD_GlcNHglycan	624	627	PF01048	0.546
MOD_GlcNHglycan	687	690	PF01048	0.430
MOD_GSK3_1	106	113	PF00069	0.525
MOD_GSK3_1	138	145	PF00069	0.390
MOD_GSK3_1	24	31	PF00069	0.536
MOD_GSK3_1	251	258	PF00069	0.583
MOD_GSK3_1	280	287	PF00069	0.527
MOD_GSK3_1	305	312	PF00069	0.546
MOD_GSK3_1	322	329	PF00069	0.402
MOD_GSK3_1	357	364	PF00069	0.493
MOD_GSK3_1	435	442	PF00069	0.495
MOD_GSK3_1	580	587	PF00069	0.461
MOD_GSK3_1	594	601	PF00069	0.312
MOD_GSK3_1	632	639	PF00069	0.553
MOD_GSK3_1	713	720	PF00069	0.485
MOD_GSK3_1	725	732	PF00069	0.446
MOD_GSK3_1	747	754	PF00069	0.479
MOD_N-GLC_1	54	59	PF02516	0.398
MOD_N-GLC_1	547	552	PF02516	0.478
MOD_N-GLC_1	698	703	PF02516	0.422
MOD_NEK2_1	106	111	PF00069	0.625
MOD_NEK2_1	12	17	PF00069	0.492
MOD_NEK2_1	126	131	PF00069	0.440
MOD_NEK2_1	138	143	PF00069	0.318
MOD_NEK2_1	217	222	PF00069	0.423
MOD_NEK2_1	280	285	PF00069	0.488
MOD_NEK2_1	297	302	PF00069	0.228
MOD_NEK2_1	309	314	PF00069	0.415
MOD_NEK2_1	336	341	PF00069	0.549
MOD_NEK2_1	342	347	PF00069	0.341
MOD_NEK2_1	37	42	PF00069	0.558
MOD_NEK2_1	371	376	PF00069	0.447
MOD_NEK2_1	441	446	PF00069	0.487
MOD_NEK2_1	485	490	PF00069	0.451
MOD_NEK2_1	539	544	PF00069	0.477
MOD_NEK2_1	558	563	PF00069	0.248
MOD_NEK2_1	584	589	PF00069	0.503
MOD_NEK2_1	594	599	PF00069	0.355
MOD_NEK2_1	724	729	PF00069	0.522
MOD_NEK2_2	747	752	PF00069	0.466
MOD_PIKK_1	111	117	PF00454	0.500
MOD_PIKK_1	182	188	PF00454	0.421
MOD_PIKK_1	280	286	PF00454	0.536
MOD_PIKK_1	357	363	PF00454	0.460
MOD_PIKK_1	435	441	PF00454	0.574
MOD_PIKK_1	512	518	PF00454	0.375
MOD_PIKK_1	598	604	PF00454	0.408
MOD_PIKK_1	636	642	PF00454	0.443
MOD_PIKK_1	725	731	PF00454	0.473
MOD_PK_1	713	719	PF00069	0.382
MOD_PKA_1	251	257	PF00069	0.486
MOD_PKA_1	693	699	PF00069	0.420
MOD_PKA_1	758	764	PF00069	0.605
MOD_PKA_2	126	132	PF00069	0.476
MOD_PKA_2	182	188	PF00069	0.447
MOD_PKA_2	251	257	PF00069	0.524
MOD_PKA_2	350	356	PF00069	0.478
MOD_PKA_2	565	571	PF00069	0.418
MOD_PKA_2	580	586	PF00069	0.307
MOD_PKA_2	669	675	PF00069	0.475
MOD_PKA_2	693	699	PF00069	0.503
MOD_PKA_2	758	764	PF00069	0.579
MOD_Plk_1	12	18	PF00069	0.545
MOD_Plk_1	138	144	PF00069	0.429
MOD_Plk_1	224	230	PF00069	0.380
MOD_Plk_1	305	311	PF00069	0.527
MOD_Plk_1	357	363	PF00069	0.454
MOD_Plk_1	439	445	PF00069	0.483
MOD_Plk_1	54	60	PF00069	0.386
MOD_Plk_1	656	662	PF00069	0.435
MOD_Plk_1	698	704	PF00069	0.477
MOD_Plk_1	713	719	PF00069	0.291
MOD_Plk_1	761	767	PF00069	0.612
MOD_Plk_4	13	19	PF00069	0.598
MOD_Plk_4	138	144	PF00069	0.430
MOD_Plk_4	219	225	PF00069	0.447
MOD_Plk_4	297	303	PF00069	0.365
MOD_Plk_4	305	311	PF00069	0.426
MOD_Plk_4	565	571	PF00069	0.476
MOD_Plk_4	693	699	PF00069	0.422
MOD_Plk_4	720	726	PF00069	0.444
MOD_ProDKin_1	284	290	PF00069	0.504
MOD_ProDKin_1	376	382	PF00069	0.410
MOD_ProDKin_1	406	412	PF00069	0.467
MOD_ProDKin_1	509	515	PF00069	0.459
MOD_ProDKin_1	528	534	PF00069	0.416
MOD_ProDKin_1	56	62	PF00069	0.612
MOD_ProDKin_1	69	75	PF00069	0.296
MOD_ProDKin_1	729	735	PF00069	0.534
MOD_SUMO_rev_2	144	153	PF00179	0.466
MOD_SUMO_rev_2	162	170	PF00179	0.283
TRG_DiLeu_BaEn_1	152	157	PF01217	0.427
TRG_DiLeu_BaEn_1	306	311	PF01217	0.395
TRG_DiLeu_BaEn_1	481	486	PF01217	0.425
TRG_DiLeu_BaEn_1	535	540	PF01217	0.452
TRG_DiLeu_BaEn_1	657	662	PF01217	0.408
TRG_DiLeu_BaEn_2	304	310	PF01217	0.320
TRG_DiLeu_BaLyEn_6	529	534	PF01217	0.415
TRG_DiLeu_BaLyEn_6	660	665	PF01217	0.417
TRG_ER_diArg_1	276	279	PF00400	0.472
TRG_ER_diArg_1	350	352	PF00400	0.416
TRG_ER_diArg_1	432	434	PF00400	0.465
TRG_ER_FFAT_1	59	71	PF00635	0.468
TRG_LysEnd_GGAAcLL_1	762	768	PF00790	0.486
TRG_NES_CRM1_1	139	152	PF08389	0.453
TRG_NES_CRM1_1	641	654	PF08389	0.382
TRG_NLS_MonoExtC_3	508	513	PF00514	0.480
TRG_NLS_MonoExtC_3	756	762	PF00514	0.577
TRG_NLS_MonoExtN_4	755	761	PF00514	0.611
TRG_Pf-PMV_PEXEL_1	110	115	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	197	201	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.338
TRG_Pf-PMV_PEXEL_1	503	507	PF00026	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F0	Leptomonas seymouri	32%	84%
A4HAI0	Leishmania braziliensis	82%	100%
A4IAP1	Leishmania infantum	100%	100%
C9ZN12	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	92%
E9B4P1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q3D5	Leishmania major	94%	100%