LeishMANIAdb
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Gamma-soluble NSF attachment protein (SNAP-gamma) (N-ethylmaleimide-sensitive factor attachment protein, gamma), putative

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Gamma-soluble NSF attachment protein (SNAP-gamma) (N-ethylmaleimide-sensitive factor attachment protein, gamma), putative
Gene product:
Gamma-soluble NSF attachment protein (SNAP-gamma) (N-ethylmaleimide-sensitive factor attachment protein, gamma), putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IKP9_LEIDO
TriTrypDb:
LdBPK_340560.1 * , LdCL_340011200 , LDHU3_34.0950
Length:
389

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0031201 SNARE complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0098796 membrane protein complex 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3Q8IKP9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IKP9

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 12
GO:0006886 intracellular protein transport 4 12
GO:0008104 protein localization 4 12
GO:0009987 cellular process 1 12
GO:0015031 protein transport 4 12
GO:0033036 macromolecule localization 2 12
GO:0045184 establishment of protein localization 3 12
GO:0046907 intracellular transport 3 12
GO:0051179 localization 1 12
GO:0051234 establishment of localization 2 12
GO:0051641 cellular localization 2 12
GO:0051649 establishment of localization in cell 3 12
GO:0070727 cellular macromolecule localization 3 12
GO:0071702 organic substance transport 4 12
GO:0071705 nitrogen compound transport 4 12
Molecular functions
Term Name Level Count
GO:0000149 SNARE binding 3 1
GO:0005483 soluble NSF attachment protein activity 3 1
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0019905 syntaxin binding 4 1
GO:0030674 protein-macromolecule adaptor activity 2 1
GO:0060090 molecular adaptor activity 1 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 381 385 PF00656 0.654
CLV_NRD_NRD_1 159 161 PF00675 0.518
CLV_PCSK_KEX2_1 159 161 PF00082 0.518
CLV_PCSK_KEX2_1 228 230 PF00082 0.375
CLV_PCSK_PC1ET2_1 228 230 PF00082 0.375
CLV_PCSK_SKI1_1 24 28 PF00082 0.225
CLV_PCSK_SKI1_1 247 251 PF00082 0.317
CLV_PCSK_SKI1_1 338 342 PF00082 0.341
DEG_SCF_FBW7_2 1 8 PF00400 0.423
DEG_SPOP_SBC_1 233 237 PF00917 0.466
DOC_CYCLIN_yClb5_NLxxxL_5 247 253 PF00134 0.431
DOC_MAPK_MEF2A_6 261 268 PF00069 0.252
DOC_PP4_FxxP_1 201 204 PF00568 0.430
DOC_USP7_MATH_1 161 165 PF00917 0.541
DOC_USP7_MATH_1 334 338 PF00917 0.436
DOC_USP7_MATH_1 364 368 PF00917 0.632
DOC_USP7_MATH_1 76 80 PF00917 0.318
DOC_USP7_UBL2_3 20 24 PF12436 0.364
DOC_USP7_UBL2_3 348 352 PF12436 0.585
DOC_WW_Pin1_4 1 6 PF00397 0.445
DOC_WW_Pin1_4 234 239 PF00397 0.556
LIG_14-3-3_CanoR_1 151 161 PF00244 0.535
LIG_BRCT_BRCA1_1 197 201 PF00533 0.478
LIG_CtBP_PxDLS_1 370 374 PF00389 0.443
LIG_eIF4E_1 207 213 PF01652 0.380
LIG_FHA_1 105 111 PF00498 0.395
LIG_FHA_1 169 175 PF00498 0.418
LIG_FHA_2 165 171 PF00498 0.621
LIG_FHA_2 240 246 PF00498 0.513
LIG_FHA_2 271 277 PF00498 0.422
LIG_FHA_2 381 387 PF00498 0.667
LIG_LIR_Apic_2 155 161 PF02991 0.440
LIG_LIR_Apic_2 198 204 PF02991 0.462
LIG_LIR_Gen_1 177 186 PF02991 0.232
LIG_LIR_Gen_1 209 215 PF02991 0.336
LIG_LIR_Gen_1 280 289 PF02991 0.439
LIG_LIR_Nem_3 177 181 PF02991 0.440
LIG_LIR_Nem_3 205 210 PF02991 0.317
LIG_LIR_Nem_3 280 284 PF02991 0.430
LIG_SH2_CRK 158 162 PF00017 0.472
LIG_SH2_CRK 47 51 PF00017 0.375
LIG_SH2_GRB2like 47 50 PF00017 0.375
LIG_SH2_NCK_1 122 126 PF00017 0.375
LIG_SH2_SRC 122 125 PF00017 0.375
LIG_SH2_SRC 243 246 PF00017 0.482
LIG_SH2_STAP1 178 182 PF00017 0.231
LIG_SH2_STAT5 173 176 PF00017 0.415
LIG_SH2_STAT5 279 282 PF00017 0.443
LIG_SH2_STAT5 47 50 PF00017 0.243
LIG_SH2_STAT5 90 93 PF00017 0.337
LIG_SUMO_SIM_anti_2 184 190 PF11976 0.426
LIG_SUMO_SIM_anti_2 265 270 PF11976 0.246
LIG_SUMO_SIM_par_1 184 190 PF11976 0.353
LIG_TRAF2_1 121 124 PF00917 0.375
LIG_TRAF2_1 298 301 PF00917 0.337
LIG_TRAF2_1 318 321 PF00917 0.190
MOD_CDK_SPxK_1 1 7 PF00069 0.433
MOD_CK1_1 102 108 PF00069 0.377
MOD_CK1_1 152 158 PF00069 0.513
MOD_CK1_1 164 170 PF00069 0.540
MOD_CK1_1 351 357 PF00069 0.629
MOD_CK1_1 94 100 PF00069 0.373
MOD_CK2_1 295 301 PF00069 0.299
MOD_CK2_1 380 386 PF00069 0.583
MOD_Cter_Amidation 17 20 PF01082 0.459
MOD_GlcNHglycan 16 19 PF01048 0.428
MOD_GlcNHglycan 163 166 PF01048 0.559
MOD_GlcNHglycan 216 219 PF01048 0.388
MOD_GlcNHglycan 365 369 PF01048 0.617
MOD_GlcNHglycan 99 102 PF01048 0.337
MOD_GSK3_1 104 111 PF00069 0.266
MOD_GSK3_1 133 140 PF00069 0.430
MOD_GSK3_1 160 167 PF00069 0.582
MOD_GSK3_1 239 246 PF00069 0.445
MOD_GSK3_1 378 385 PF00069 0.751
MOD_GSK3_1 93 100 PF00069 0.378
MOD_N-GLC_1 133 138 PF02516 0.294
MOD_N-GLC_1 296 301 PF02516 0.304
MOD_N-GLC_2 326 328 PF02516 0.363
MOD_NEK2_1 269 274 PF00069 0.289
MOD_PIKK_1 371 377 PF00454 0.552
MOD_PIKK_1 58 64 PF00454 0.294
MOD_PIKK_1 85 91 PF00454 0.375
MOD_PK_1 137 143 PF00069 0.174
MOD_PKA_1 341 347 PF00069 0.461
MOD_Plk_1 334 340 PF00069 0.322
MOD_Plk_1 354 360 PF00069 0.399
MOD_Plk_2-3 382 388 PF00069 0.669
MOD_Plk_4 137 143 PF00069 0.298
MOD_ProDKin_1 1 7 PF00069 0.433
MOD_ProDKin_1 234 240 PF00069 0.549
MOD_SUMO_rev_2 17 27 PF00179 0.533
MOD_SUMO_rev_2 194 201 PF00179 0.346
MOD_SUMO_rev_2 240 249 PF00179 0.465
TRG_DiLeu_BaEn_1 184 189 PF01217 0.318
TRG_DiLeu_BaEn_4 123 129 PF01217 0.375
TRG_ENDOCYTIC_2 178 181 PF00928 0.439
TRG_ENDOCYTIC_2 210 213 PF00928 0.337
TRG_ENDOCYTIC_2 47 50 PF00928 0.289
TRG_ER_diArg_1 158 160 PF00400 0.500
TRG_Pf-PMV_PEXEL_1 180 184 PF00026 0.291
TRG_Pf-PMV_PEXEL_1 251 255 PF00026 0.464

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I337 Leptomonas seymouri 67% 99%
A0A0S4J5L6 Bodo saltans 31% 100%
A0A1X0P9K4 Trypanosomatidae 38% 100%
A0A422MZB1 Trypanosoma rangeli 39% 100%
A4H7D4 Leishmania braziliensis 78% 100%
A4I9M4 Leishmania infantum 100% 100%
D0A1Z0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
E9B4M3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q3F3 Leishmania major 92% 100%
V5BRU6 Trypanosoma cruzi 37% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS