Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IKN8_LEIDO

TriTrypDb:

LdBPK_340490.1 , LdCL_340010000 , LDHU3_34.0660

Length:

717

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	13
GO:0032991	protein-containing complex	1	13
GO:0043226	organelle	2	13
GO:0043228	non-membrane-bounded organelle	3	13
GO:0043229	intracellular organelle	3	13
GO:0043232	intracellular non-membrane-bounded organelle	4	13
GO:0110165	cellular anatomical entity	1	13
GO:1990904	ribonucleoprotein complex	2	13
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0005730	nucleolus	5	4

Expansion

Sequence features

A0A3Q8IKN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IKN8

Function

Biological processes
Term	Name	Level	Count
GO:0000027	ribosomal large subunit assembly	7	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.547
CLV_NRD_NRD_1	294	296	PF00675	0.703
CLV_NRD_NRD_1	441	443	PF00675	0.614
CLV_NRD_NRD_1	515	517	PF00675	0.754
CLV_PCSK_KEX2_1	107	109	PF00082	0.547
CLV_PCSK_KEX2_1	294	296	PF00082	0.703
CLV_PCSK_KEX2_1	441	443	PF00082	0.614
CLV_PCSK_KEX2_1	697	699	PF00082	0.473
CLV_PCSK_PC1ET2_1	697	699	PF00082	0.462
CLV_PCSK_PC7_1	437	443	PF00082	0.530
CLV_PCSK_SKI1_1	155	159	PF00082	0.319
CLV_PCSK_SKI1_1	374	378	PF00082	0.341
CLV_PCSK_SKI1_1	386	390	PF00082	0.614
DEG_SPOP_SBC_1	185	189	PF00917	0.528
DEG_SPOP_SBC_1	208	212	PF00917	0.467
DOC_CYCLIN_yClb5_NLxxxL_5	649	657	PF00134	0.440
DOC_PP1_RVXF_1	134	141	PF00149	0.413
DOC_PP1_RVXF_1	414	420	PF00149	0.599
DOC_PP2B_LxvP_1	101	104	PF13499	0.530
DOC_PP2B_LxvP_1	703	706	PF13499	0.458
DOC_PP4_FxxP_1	428	431	PF00568	0.575
DOC_USP7_MATH_1	165	169	PF00917	0.553
DOC_USP7_MATH_1	184	188	PF00917	0.579
DOC_USP7_MATH_1	204	208	PF00917	0.378
DOC_USP7_MATH_1	283	287	PF00917	0.545
DOC_USP7_MATH_1	353	357	PF00917	0.513
DOC_USP7_MATH_1	415	419	PF00917	0.609
DOC_USP7_MATH_1	460	464	PF00917	0.826
DOC_USP7_MATH_1	467	471	PF00917	0.662
DOC_USP7_MATH_1	494	498	PF00917	0.629
DOC_USP7_MATH_1	502	506	PF00917	0.578
DOC_USP7_MATH_1	523	527	PF00917	0.705
DOC_USP7_MATH_1	545	549	PF00917	0.595
DOC_USP7_MATH_1	607	611	PF00917	0.596
DOC_USP7_MATH_1	656	660	PF00917	0.500
DOC_WW_Pin1_4	37	42	PF00397	0.487
DOC_WW_Pin1_4	427	432	PF00397	0.766
DOC_WW_Pin1_4	456	461	PF00397	0.681
DOC_WW_Pin1_4	510	515	PF00397	0.739
DOC_WW_Pin1_4	519	524	PF00397	0.673
DOC_WW_Pin1_4	571	576	PF00397	0.552
DOC_WW_Pin1_4	603	608	PF00397	0.661
DOC_WW_Pin1_4	81	86	PF00397	0.480
LIG_14-3-3_CanoR_1	107	115	PF00244	0.621
LIG_14-3-3_CanoR_1	294	300	PF00244	0.674
LIG_14-3-3_CanoR_1	427	431	PF00244	0.590
LIG_14-3-3_CanoR_1	458	468	PF00244	0.598
LIG_14-3-3_CanoR_1	508	514	PF00244	0.634
LIG_14-3-3_CanoR_1	644	650	PF00244	0.421
LIG_AP2alpha_2	13	15	PF02296	0.441
LIG_BIR_II_1	1	5	PF00653	0.556
LIG_BIR_III_4	264	268	PF00653	0.467
LIG_BRCT_BRCA1_1	210	214	PF00533	0.467
LIG_BRCT_BRCA1_1	249	253	PF00533	0.442
LIG_BRCT_BRCA1_1	31	35	PF00533	0.506
LIG_BRCT_BRCA1_1	355	359	PF00533	0.533
LIG_CSL_BTD_1	101	104	PF09270	0.528
LIG_FHA_1	110	116	PF00498	0.675
LIG_FHA_1	133	139	PF00498	0.382
LIG_FHA_1	200	206	PF00498	0.476
LIG_FHA_1	329	335	PF00498	0.555
LIG_FHA_1	373	379	PF00498	0.499
LIG_FHA_1	664	670	PF00498	0.446
LIG_FHA_2	513	519	PF00498	0.618
LIG_FHA_2	598	604	PF00498	0.607
LIG_LIR_Gen_1	212	219	PF02991	0.480
LIG_LIR_Gen_1	634	645	PF02991	0.452
LIG_LIR_Gen_1	96	104	PF02991	0.442
LIG_LIR_Nem_3	2	6	PF02991	0.557
LIG_LIR_Nem_3	211	217	PF02991	0.483
LIG_LIR_Nem_3	634	640	PF02991	0.453
LIG_LIR_Nem_3	96	101	PF02991	0.453
LIG_MLH1_MIPbox_1	211	215	PF16413	0.467
LIG_MYND_1	37	41	PF01753	0.467
LIG_Pex14_1	160	164	PF04695	0.408
LIG_Pex14_2	179	183	PF04695	0.378
LIG_SH2_CRK	343	347	PF00017	0.269
LIG_SH2_CRK	637	641	PF00017	0.450
LIG_SH2_PTP2	98	101	PF00017	0.506
LIG_SH2_STAP1	533	537	PF00017	0.523
LIG_SH2_STAP1	689	693	PF00017	0.436
LIG_SH2_STAT3	668	671	PF00017	0.407
LIG_SH2_STAT5	147	150	PF00017	0.356
LIG_SH2_STAT5	209	212	PF00017	0.467
LIG_SH2_STAT5	217	220	PF00017	0.506
LIG_SH2_STAT5	243	246	PF00017	0.300
LIG_SH2_STAT5	258	261	PF00017	0.463
LIG_SH2_STAT5	341	344	PF00017	0.355
LIG_SH2_STAT5	566	569	PF00017	0.639
LIG_SH2_STAT5	668	671	PF00017	0.407
LIG_SH2_STAT5	98	101	PF00017	0.526
LIG_SH3_2	11	16	PF14604	0.446
LIG_SH3_3	40	46	PF00018	0.467
LIG_SH3_3	408	414	PF00018	0.717
LIG_SH3_3	428	434	PF00018	0.473
LIG_SH3_3	5	11	PF00018	0.647
LIG_SUMO_SIM_par_1	201	207	PF11976	0.464
LIG_TRAF2_1	621	624	PF00917	0.466
LIG_WRC_WIRS_1	180	185	PF05994	0.425
MOD_CDC14_SPxK_1	513	516	PF00782	0.609
MOD_CDK_SPK_2	456	461	PF00069	0.581
MOD_CDK_SPK_2	81	86	PF00069	0.304
MOD_CDK_SPxK_1	510	516	PF00069	0.600
MOD_CDK_SPxxK_3	510	517	PF00069	0.604
MOD_CK1_1	207	213	PF00069	0.327
MOD_CK1_1	247	253	PF00069	0.299
MOD_CK1_1	278	284	PF00069	0.753
MOD_CK1_1	459	465	PF00069	0.790
MOD_CK1_1	470	476	PF00069	0.556
MOD_CK1_1	512	518	PF00069	0.759
MOD_CK1_1	524	530	PF00069	0.599
MOD_CK1_1	610	616	PF00069	0.541
MOD_CK2_1	389	395	PF00069	0.576
MOD_CK2_1	512	518	PF00069	0.674
MOD_CK2_1	571	577	PF00069	0.609
MOD_CK2_1	597	603	PF00069	0.608
MOD_GlcNHglycan	118	121	PF01048	0.518
MOD_GlcNHglycan	206	209	PF01048	0.316
MOD_GlcNHglycan	219	222	PF01048	0.286
MOD_GlcNHglycan	244	247	PF01048	0.539
MOD_GlcNHglycan	261	264	PF01048	0.323
MOD_GlcNHglycan	265	268	PF01048	0.363
MOD_GlcNHglycan	281	284	PF01048	0.726
MOD_GlcNHglycan	3	6	PF01048	0.657
MOD_GlcNHglycan	324	327	PF01048	0.339
MOD_GlcNHglycan	380	383	PF01048	0.411
MOD_GlcNHglycan	462	465	PF01048	0.678
MOD_GlcNHglycan	469	472	PF01048	0.633
MOD_GlcNHglycan	49	52	PF01048	0.270
MOD_GlcNHglycan	523	526	PF01048	0.655
MOD_GlcNHglycan	612	616	PF01048	0.562
MOD_GlcNHglycan	711	714	PF01048	0.586
MOD_GlcNHglycan	91	94	PF01048	0.320
MOD_GSK3_1	103	110	PF00069	0.491
MOD_GSK3_1	204	211	PF00069	0.356
MOD_GSK3_1	259	266	PF00069	0.346
MOD_GSK3_1	274	281	PF00069	0.538
MOD_GSK3_1	353	360	PF00069	0.298
MOD_GSK3_1	365	372	PF00069	0.285
MOD_GSK3_1	386	393	PF00069	0.633
MOD_GSK3_1	456	463	PF00069	0.642
MOD_GSK3_1	466	473	PF00069	0.580
MOD_GSK3_1	519	526	PF00069	0.741
MOD_GSK3_1	553	560	PF00069	0.726
MOD_GSK3_1	567	574	PF00069	0.597
MOD_GSK3_1	603	610	PF00069	0.628
MOD_GSK3_1	675	682	PF00069	0.444
MOD_GSK3_1	709	716	PF00069	0.548
MOD_N-GLC_1	327	332	PF02516	0.304
MOD_N-GLC_1	494	499	PF02516	0.593
MOD_N-GLC_2	124	126	PF02516	0.521
MOD_N-GLC_2	474	476	PF02516	0.583
MOD_NEK2_1	1	6	PF00069	0.627
MOD_NEK2_1	179	184	PF00069	0.474
MOD_NEK2_1	242	247	PF00069	0.407
MOD_NEK2_1	274	279	PF00069	0.536
MOD_NEK2_1	342	347	PF00069	0.349
MOD_NEK2_1	567	572	PF00069	0.660
MOD_NEK2_1	675	680	PF00069	0.420
MOD_NEK2_1	89	94	PF00069	0.298
MOD_NEK2_2	244	249	PF00069	0.352
MOD_NEK2_2	353	358	PF00069	0.326
MOD_NEK2_2	597	602	PF00069	0.577
MOD_PIKK_1	165	171	PF00454	0.579
MOD_PIKK_1	462	468	PF00454	0.682
MOD_PIKK_1	643	649	PF00454	0.421
MOD_PIKK_1	663	669	PF00454	0.410
MOD_PKA_1	107	113	PF00069	0.614
MOD_PKA_1	294	300	PF00069	0.672
MOD_PKA_2	106	112	PF00069	0.513
MOD_PKA_2	122	128	PF00069	0.558
MOD_PKA_2	15	21	PF00069	0.458
MOD_PKA_2	274	280	PF00069	0.544
MOD_PKA_2	294	300	PF00069	0.342
MOD_PKA_2	389	395	PF00069	0.618
MOD_PKA_2	426	432	PF00069	0.577
MOD_PKA_2	460	466	PF00069	0.595
MOD_PKA_2	643	649	PF00069	0.421
MOD_Plk_1	372	378	PF00069	0.368
MOD_Plk_1	446	452	PF00069	0.553
MOD_Plk_1	494	500	PF00069	0.564
MOD_Plk_1	545	551	PF00069	0.725
MOD_Plk_1	553	559	PF00069	0.578
MOD_Plk_4	210	216	PF00069	0.346
MOD_Plk_4	295	301	PF00069	0.578
MOD_Plk_4	372	378	PF00069	0.358
MOD_ProDKin_1	37	43	PF00069	0.332
MOD_ProDKin_1	427	433	PF00069	0.764
MOD_ProDKin_1	456	462	PF00069	0.681
MOD_ProDKin_1	510	516	PF00069	0.741
MOD_ProDKin_1	519	525	PF00069	0.671
MOD_ProDKin_1	571	577	PF00069	0.555
MOD_ProDKin_1	603	609	PF00069	0.620
MOD_ProDKin_1	81	87	PF00069	0.323
MOD_SUMO_rev_2	330	340	PF00179	0.304
MOD_SUMO_rev_2	690	699	PF00179	0.437
TRG_DiLeu_BaEn_1	626	631	PF01217	0.459
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.304
TRG_ENDOCYTIC_2	343	346	PF00928	0.336
TRG_ENDOCYTIC_2	637	640	PF00928	0.452
TRG_ENDOCYTIC_2	98	101	PF00928	0.391
TRG_ER_diArg_1	294	296	PF00400	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBY0	Leptomonas seymouri	41%	100%
A0A3Q8IGC4	Leishmania donovani	23%	100%
A0A3R7NL29	Trypanosoma rangeli	33%	97%
A4HAG2	Leishmania braziliensis	77%	100%
A4HDT7	Leishmania braziliensis	24%	100%
A4I9L7	Leishmania infantum	99%	100%
D0A1X8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	92%
E9AX72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9B4L5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q3G1	Leishmania major	93%	100%
Q4QAA4	Leishmania major	23%	100%