WW domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1279), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IKN2_LEIDO

TriTrypDb:

LdBPK_320450.1 , LdCL_320009400 , LDHU3_32.0550

Length:

291

Annotations

LeishMANIAdb annotations

Homologous to animal FAM210 mitochondrial proteins. This protein might have a mitochondrial transit signal.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005739	mitochondrion	5	1
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8IKN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IKN2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	55	57	PF00675	0.456
CLV_PCSK_KEX2_1	212	214	PF00082	0.558
CLV_PCSK_KEX2_1	223	225	PF00082	0.540
CLV_PCSK_KEX2_1	55	57	PF00082	0.456
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.558
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.540
DEG_APCC_DBOX_1	196	204	PF00400	0.362
DEG_Nend_UBRbox_1	1	4	PF02207	0.684
DOC_MAPK_gen_1	212	219	PF00069	0.358
DOC_MAPK_gen_1	8	16	PF00069	0.728
DOC_MAPK_HePTP_8	236	248	PF00069	0.385
DOC_MAPK_MEF2A_6	229	237	PF00069	0.362
DOC_MAPK_MEF2A_6	239	248	PF00069	0.344
DOC_PP1_RVXF_1	78	84	PF00149	0.638
DOC_USP7_MATH_1	40	44	PF00917	0.760
DOC_WW_Pin1_4	29	34	PF00397	0.726
DOC_WW_Pin1_4	56	61	PF00397	0.647
DOC_WW_Pin1_4	72	77	PF00397	0.655
LIG_14-3-3_CanoR_1	135	143	PF00244	0.738
LIG_14-3-3_CanoR_1	202	208	PF00244	0.228
LIG_14-3-3_CanoR_1	24	30	PF00244	0.729
LIG_14-3-3_CanoR_1	8	16	PF00244	0.671
LIG_BIR_III_4	128	132	PF00653	0.614
LIG_BRCT_BRCA1_1	205	209	PF00533	0.276
LIG_CtBP_PxDLS_1	50	56	PF00389	0.677
LIG_deltaCOP1_diTrp_1	103	112	PF00928	0.631
LIG_eIF4E_1	170	176	PF01652	0.476
LIG_FHA_1	128	134	PF00498	0.667
LIG_FHA_1	228	234	PF00498	0.303
LIG_FHA_1	99	105	PF00498	0.559
LIG_FHA_2	136	142	PF00498	0.741
LIG_FHA_2	65	71	PF00498	0.681
LIG_LIR_Apic_2	103	109	PF02991	0.556
LIG_LIR_Nem_3	114	119	PF02991	0.564
LIG_LIR_Nem_3	265	271	PF02991	0.633
LIG_NRBOX	15	21	PF00104	0.690
LIG_PCNA_yPIPBox_3	183	197	PF02747	0.475
LIG_Pex14_1	83	87	PF04695	0.561
LIG_Pex14_2	112	116	PF04695	0.540
LIG_Pex14_2	227	231	PF04695	0.324
LIG_Pex14_2	274	278	PF04695	0.537
LIG_Pex14_2	64	68	PF04695	0.688
LIG_SH2_CRK	96	100	PF00017	0.558
LIG_SH2_GRB2like	96	99	PF00017	0.561
LIG_SH2_SRC	178	181	PF00017	0.328
LIG_SH2_SRC	96	99	PF00017	0.609
LIG_SH2_STAP1	87	91	PF00017	0.653
LIG_SH2_STAT5	178	181	PF00017	0.328
LIG_SH2_STAT5	194	197	PF00017	0.315
LIG_SH3_3	70	76	PF00018	0.654
LIG_SH3_4	93	100	PF00018	0.630
LIG_SUMO_SIM_par_1	246	252	PF11976	0.410
LIG_TRAF2_1	60	63	PF00917	0.636
LIG_TYR_ITIM	176	181	PF00017	0.328
LIG_UBA3_1	267	272	PF00899	0.604
MOD_CDK_SPxK_1	29	35	PF00069	0.744
MOD_CK1_1	137	143	PF00069	0.712
MOD_CK1_1	43	49	PF00069	0.706
MOD_CK2_1	135	141	PF00069	0.708
MOD_CK2_1	28	34	PF00069	0.685
MOD_CK2_1	64	70	PF00069	0.658
MOD_DYRK1A_RPxSP_1	56	60	PF00069	0.690
MOD_GlcNHglycan	11	14	PF01048	0.523
MOD_GlcNHglycan	251	254	PF01048	0.475
MOD_GlcNHglycan	38	41	PF01048	0.539
MOD_GlcNHglycan	42	45	PF01048	0.502
MOD_GSK3_1	133	140	PF00069	0.679
MOD_GSK3_1	144	151	PF00069	0.733
MOD_GSK3_1	227	234	PF00069	0.351
MOD_GSK3_1	24	31	PF00069	0.711
MOD_GSK3_1	36	43	PF00069	0.749
MOD_GSK3_1	98	105	PF00069	0.572
MOD_N-GLC_1	144	149	PF02516	0.531
MOD_N-GLC_1	182	187	PF02516	0.449
MOD_N-GLC_1	29	34	PF02516	0.567
MOD_NEK2_1	119	124	PF00069	0.634
MOD_NEK2_1	134	139	PF00069	0.593
MOD_NEK2_1	203	208	PF00069	0.362
MOD_NEK2_1	227	232	PF00069	0.270
MOD_NEK2_1	246	251	PF00069	0.413
MOD_NEK2_1	274	279	PF00069	0.591
MOD_PKA_2	134	140	PF00069	0.683
MOD_PKA_2	23	29	PF00069	0.708
MOD_Plk_1	102	108	PF00069	0.590
MOD_Plk_1	182	188	PF00069	0.449
MOD_Plk_2-3	85	91	PF00069	0.586
MOD_Plk_4	15	21	PF00069	0.707
MOD_Plk_4	227	233	PF00069	0.349
MOD_Plk_4	263	269	PF00069	0.623
MOD_Plk_4	43	49	PF00069	0.678
MOD_ProDKin_1	29	35	PF00069	0.727
MOD_ProDKin_1	56	62	PF00069	0.652
MOD_ProDKin_1	72	78	PF00069	0.649
MOD_SUMO_rev_2	206	214	PF00179	0.362
MOD_SUMO_rev_2	215	225	PF00179	0.335
TRG_DiLeu_BaLyEn_6	251	256	PF01217	0.457
TRG_ENDOCYTIC_2	178	181	PF00928	0.328
TRG_ENDOCYTIC_2	96	99	PF00928	0.577
TRG_ER_diArg_1	5	8	PF00400	0.661

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I946	Leptomonas seymouri	62%	98%
A0A0S4J0N1	Bodo saltans	40%	100%
A0A1X0P6G8	Trypanosomatidae	42%	96%
A0A3R7LL16	Trypanosoma rangeli	44%	100%
A4HK24	Leishmania braziliensis	82%	100%
A4I7K8	Leishmania infantum	99%	100%
D0A0B3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	84%
E9B2G5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q5P1	Leishmania major	95%	100%
V5BS86	Trypanosoma cruzi	42%	95%