Esterase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endo-1,4-beta-xylanase z precursor-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IKN0_LEIDO

TriTrypDb:

LdBPK_201190.1 , LdCL_200016550

Length:

419

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 4
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IKN0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IKN0

Function

Biological processes
Term	Name	Level	Count
GO:0000272	polysaccharide catabolic process	5	3
GO:0005975	carbohydrate metabolic process	3	3
GO:0005976	polysaccharide metabolic process	4	3
GO:0008152	metabolic process	1	3
GO:0009056	catabolic process	2	3
GO:0009057	macromolecule catabolic process	4	3
GO:0009987	cellular process	1	3
GO:0010383	cell wall polysaccharide metabolic process	5	3
GO:0010410	hemicellulose metabolic process	6	3
GO:0016052	carbohydrate catabolic process	4	3
GO:0016998	cell wall macromolecule catabolic process	5	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044036	cell wall macromolecule metabolic process	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044248	cellular catabolic process	3	3
GO:0044260	obsolete cellular macromolecule metabolic process	3	3
GO:0044262	obsolete cellular carbohydrate metabolic process	3	3
GO:0044264	obsolete cellular polysaccharide metabolic process	4	3
GO:0044265	obsolete cellular macromolecule catabolic process	4	3
GO:0044347	cell wall polysaccharide catabolic process	6	3
GO:0045491	xylan metabolic process	7	3
GO:0045493	xylan catabolic process	8	3
GO:0071704	organic substance metabolic process	2	3
GO:1901575	organic substance catabolic process	3	3
GO:2000895	hemicellulose catabolic process	7	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016787	hydrolase activity	2	3
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	3
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	4	1
GO:0031176	endo-1,4-beta-xylanase activity	6	1
GO:0097599	xylanase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	203	205	PF00675	0.272
CLV_NRD_NRD_1	343	345	PF00675	0.347
CLV_NRD_NRD_1	386	388	PF00675	0.343
CLV_PCSK_KEX2_1	203	205	PF00082	0.272
CLV_PCSK_KEX2_1	343	345	PF00082	0.291
CLV_PCSK_KEX2_1	386	388	PF00082	0.343
CLV_PCSK_SKI1_1	354	358	PF00082	0.248
CLV_PCSK_SKI1_1	367	371	PF00082	0.305
DEG_SCF_FBW7_1	128	135	PF00400	0.339
DOC_CKS1_1	129	134	PF01111	0.357
DOC_MAPK_gen_1	203	210	PF00069	0.247
DOC_MAPK_gen_1	343	349	PF00069	0.384
DOC_MAPK_MEF2A_6	203	210	PF00069	0.274
DOC_MAPK_MEF2A_6	239	247	PF00069	0.222
DOC_PP1_RVXF_1	352	358	PF00149	0.249
DOC_PP1_RVXF_1	409	416	PF00149	0.504
DOC_PP4_FxxP_1	27	30	PF00568	0.490
DOC_PP4_FxxP_1	63	66	PF00568	0.347
DOC_USP7_MATH_1	66	70	PF00917	0.394
DOC_USP7_MATH_1	89	93	PF00917	0.393
DOC_WW_Pin1_4	11	16	PF00397	0.533
DOC_WW_Pin1_4	128	133	PF00397	0.365
DOC_WW_Pin1_4	4	9	PF00397	0.601
LIG_APCC_ABBA_1	275	280	PF00400	0.222
LIG_BIR_II_1	1	5	PF00653	0.555
LIG_eIF4E_1	205	211	PF01652	0.274
LIG_FHA_1	129	135	PF00498	0.398
LIG_FHA_1	182	188	PF00498	0.260
LIG_FHA_1	239	245	PF00498	0.337
LIG_FHA_1	270	276	PF00498	0.460
LIG_FHA_1	85	91	PF00498	0.463
LIG_FHA_2	181	187	PF00498	0.274
LIG_FHA_2	283	289	PF00498	0.274
LIG_FHA_2	308	314	PF00498	0.274
LIG_FHA_2	332	338	PF00498	0.251
LIG_FHA_2	48	54	PF00498	0.470
LIG_LIR_Apic_2	26	30	PF02991	0.485
LIG_LIR_Nem_3	202	208	PF02991	0.226
LIG_LIR_Nem_3	327	332	PF02991	0.304
LIG_LIR_Nem_3	58	64	PF02991	0.327
LIG_LYPXL_yS_3	205	208	PF13949	0.222
LIG_MYND_1	128	132	PF01753	0.341
LIG_PCNA_yPIPBox_3	284	298	PF02747	0.251
LIG_SH2_PTP2	147	150	PF00017	0.285
LIG_SH2_PTP2	190	193	PF00017	0.217
LIG_SH2_SRC	147	150	PF00017	0.285
LIG_SH2_SRC	190	193	PF00017	0.222
LIG_SH2_SRC	64	67	PF00017	0.309
LIG_SH2_STAT5	147	150	PF00017	0.271
LIG_SH2_STAT5	160	163	PF00017	0.349
LIG_SH2_STAT5	175	178	PF00017	0.383
LIG_SH2_STAT5	179	182	PF00017	0.300
LIG_SH2_STAT5	190	193	PF00017	0.195
LIG_SH2_STAT5	209	212	PF00017	0.134
LIG_SH2_STAT5	278	281	PF00017	0.244
LIG_SH2_STAT5	64	67	PF00017	0.455
LIG_SH3_2	152	157	PF14604	0.352
LIG_SH3_3	108	114	PF00018	0.518
LIG_SH3_3	126	132	PF00018	0.368
LIG_SH3_3	147	153	PF00018	0.307
LIG_SH3_3	158	164	PF00018	0.323
LIG_SH3_3	5	11	PF00018	0.623
LIG_SH3_3	69	75	PF00018	0.507
LIG_SUMO_SIM_anti_2	241	250	PF11976	0.274
LIG_SUMO_SIM_par_1	120	125	PF11976	0.418
LIG_TRAF2_1	183	186	PF00917	0.274
LIG_UBA3_1	243	248	PF00899	0.251
LIG_WRC_WIRS_1	24	29	PF05994	0.512
LIG_WW_1	192	195	PF00397	0.222
MOD_CDK_SPxxK_3	11	18	PF00069	0.517
MOD_CK1_1	199	205	PF00069	0.251
MOD_CK1_1	2	8	PF00069	0.562
MOD_CK1_1	249	255	PF00069	0.251
MOD_CK1_1	28	34	PF00069	0.523
MOD_CK1_1	333	339	PF00069	0.217
MOD_CK2_1	180	186	PF00069	0.274
MOD_CK2_1	47	53	PF00069	0.471
MOD_CMANNOS	395	398	PF00535	0.250
MOD_GlcNHglycan	1	4	PF01048	0.531
MOD_GlcNHglycan	111	114	PF01048	0.429
MOD_GlcNHglycan	199	202	PF01048	0.251
MOD_GlcNHglycan	251	254	PF01048	0.247
MOD_GlcNHglycan	321	324	PF01048	0.298
MOD_GSK3_1	10	17	PF00069	0.625
MOD_GSK3_1	128	135	PF00069	0.412
MOD_GSK3_1	177	184	PF00069	0.260
MOD_GSK3_1	298	305	PF00069	0.222
MOD_GSK3_1	80	87	PF00069	0.401
MOD_N-GLC_1	54	59	PF02516	0.381
MOD_N-GLC_2	156	158	PF02516	0.391
MOD_NEK2_1	247	252	PF00069	0.304
MOD_NEK2_1	307	312	PF00069	0.241
MOD_NEK2_1	324	329	PF00069	0.328
MOD_PIKK_1	25	31	PF00454	0.546
MOD_PKA_2	162	168	PF00069	0.478
MOD_Plk_1	411	417	PF00069	0.388
MOD_Plk_1	54	60	PF00069	0.296
MOD_Plk_2-3	269	275	PF00069	0.274
MOD_Plk_2-3	47	53	PF00069	0.341
MOD_Plk_4	411	417	PF00069	0.453
MOD_Plk_4	67	73	PF00069	0.332
MOD_ProDKin_1	11	17	PF00069	0.532
MOD_ProDKin_1	128	134	PF00069	0.359
MOD_ProDKin_1	4	10	PF00069	0.600
MOD_SUMO_rev_2	232	241	PF00179	0.274
TRG_ENDOCYTIC_2	147	150	PF00928	0.271
TRG_ENDOCYTIC_2	205	208	PF00928	0.222
TRG_ENDOCYTIC_2	317	320	PF00928	0.357
TRG_ER_diArg_1	203	205	PF00400	0.274
TRG_ER_diArg_1	342	344	PF00400	0.347
TRG_ER_diArg_1	386	388	PF00400	0.343
TRG_ER_diArg_1	41	44	PF00400	0.524
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.305

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM32	Leptomonas seymouri	56%	100%
A0A1X0NWX5	Trypanosomatidae	42%	100%
A4HYV9	Leishmania infantum	98%	100%
E9AUQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
P31471	Escherichia coli (strain K12)	25%	100%