TPR_repeat/Tetratricopeptide_repeat_putative/Pfam:PF13414/Pfam:PF07719/Pfam:PF00515/Pfam:PF13428

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat/Tetratricopeptide repeat, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IKL8_LEIDO

TriTrypDb:

LdBPK_362190.1 , LdCL_360027600 , LDHU3_36.2840

Length:

330

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IKL8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IKL8

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	13
GO:0009987	cellular process	1	13

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	13
GO:0005515	protein binding	2	13
GO:0030544	Hsp70 protein binding	4	13
GO:0031072	heat shock protein binding	3	13
GO:0051879	Hsp90 protein binding	4	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	32	36	PF00656	0.618
CLV_NRD_NRD_1	126	128	PF00675	0.269
CLV_PCSK_KEX2_1	128	130	PF00082	0.460
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.346
CLV_PCSK_SKI1_1	114	118	PF00082	0.355
CLV_PCSK_SKI1_1	13	17	PF00082	0.552
CLV_PCSK_SKI1_1	140	144	PF00082	0.423
CLV_PCSK_SKI1_1	255	259	PF00082	0.522
CLV_PCSK_SKI1_1	4	8	PF00082	0.661
DOC_CYCLIN_yCln2_LP_2	90	96	PF00134	0.527
DOC_MAPK_gen_1	114	122	PF00069	0.262
DOC_PP2B_LxvP_1	71	74	PF13499	0.427
DOC_USP7_MATH_1	192	196	PF00917	0.746
DOC_USP7_UBL2_3	103	107	PF12436	0.482
DOC_WW_Pin1_4	184	189	PF00397	0.621
DOC_WW_Pin1_4	89	94	PF00397	0.454
LIG_14-3-3_CanoR_1	239	244	PF00244	0.696
LIG_14-3-3_CanoR_1	299	309	PF00244	0.541
LIG_14-3-3_CanoR_1	82	90	PF00244	0.412
LIG_CtBP_PxDLS_1	97	103	PF00389	0.410
LIG_FHA_1	304	310	PF00498	0.486
LIG_FHA_1	320	326	PF00498	0.509
LIG_FHA_1	76	82	PF00498	0.415
LIG_FHA_2	23	29	PF00498	0.568
LIG_FHA_2	273	279	PF00498	0.559
LIG_IRF3_LxIS_1	309	314	PF10401	0.510
LIG_LIR_Gen_1	25	34	PF02991	0.427
LIG_LIR_Nem_3	25	30	PF02991	0.497
LIG_LIR_Nem_3	315	321	PF02991	0.529
LIG_LIR_Nem_3	46	50	PF02991	0.354
LIG_PTB_Apo_2	49	56	PF02174	0.344
LIG_PTB_Phospho_1	49	55	PF10480	0.431
LIG_SH2_CRK	67	71	PF00017	0.471
LIG_SH2_GRB2like	183	186	PF00017	0.634
LIG_SH2_NCK_1	302	306	PF00017	0.528
LIG_SH2_STAP1	67	71	PF00017	0.319
LIG_SH2_STAT5	321	324	PF00017	0.502
LIG_SH2_STAT5	59	62	PF00017	0.323
LIG_SH2_STAT5	89	92	PF00017	0.375
LIG_SH3_3	6	12	PF00018	0.500
LIG_TRAF2_1	207	210	PF00917	0.614
LIG_WW_2	9	12	PF00397	0.472
MOD_CDK_SPK_2	186	191	PF00069	0.588
MOD_CDK_SPxxK_3	184	191	PF00069	0.565
MOD_CK1_1	194	200	PF00069	0.605
MOD_CK1_1	303	309	PF00069	0.536
MOD_CK1_1	83	89	PF00069	0.340
MOD_CK2_1	225	231	PF00069	0.633
MOD_CK2_1	265	271	PF00069	0.542
MOD_GlcNHglycan	162	165	PF01048	0.532
MOD_GlcNHglycan	271	275	PF01048	0.531
MOD_GlcNHglycan	85	88	PF01048	0.339
MOD_GSK3_1	191	198	PF00069	0.594
MOD_GSK3_1	22	29	PF00069	0.496
MOD_N-GLC_1	184	189	PF02516	0.659
MOD_N-GLC_1	83	88	PF02516	0.367
MOD_N-GLC_2	52	54	PF02516	0.340
MOD_NEK2_1	22	27	PF00069	0.535
MOD_NEK2_1	272	277	PF00069	0.490
MOD_NEK2_1	298	303	PF00069	0.637
MOD_PIKK_1	212	218	PF00454	0.592
MOD_PIKK_1	241	247	PF00454	0.531
MOD_PIKK_1	38	44	PF00454	0.457
MOD_PK_1	26	32	PF00069	0.383
MOD_PKA_2	195	201	PF00069	0.537
MOD_PKA_2	298	304	PF00069	0.587
MOD_PKB_1	237	245	PF00069	0.621
MOD_ProDKin_1	184	190	PF00069	0.596
MOD_ProDKin_1	89	95	PF00069	0.465
MOD_SUMO_for_1	207	210	PF00179	0.590
MOD_SUMO_for_1	264	267	PF00179	0.461
MOD_SUMO_rev_2	106	116	PF00179	0.359
MOD_SUMO_rev_2	41	50	PF00179	0.438
MOD_SUMO_rev_2	8	17	PF00179	0.464
TRG_DiLeu_BaEn_4	209	215	PF01217	0.579
TRG_DiLeu_BaLyEn_6	66	71	PF01217	0.391
TRG_ENDOCYTIC_2	67	70	PF00928	0.468
TRG_Pf-PMV_PEXEL_1	13	18	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	157	162	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7A6	Leptomonas seymouri	56%	100%
A0A0S4IZ49	Bodo saltans	38%	100%
A0A1X0NJW2	Trypanosomatidae	28%	77%
A0A1X0P800	Trypanosomatidae	39%	99%
A0A422N1V8	Trypanosoma rangeli	40%	100%
A4HP75	Leishmania braziliensis	76%	94%
A4IDI0	Leishmania infantum	99%	100%
D0A371	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9ASY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q1L5	Leishmania major	93%	100%
V5BKW9	Trypanosoma cruzi	39%	100%