Ciliary basal body-associated, B9 family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

b9 domain-containing protein 1

Species:

Leishmania donovani

UniProt:

A0A3Q8IKL7_LEIDO

TriTrypDb:

LdBPK_320290.1 , LdCL_320007800 , LDHU3_32.0370

Length:

234

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0032991	protein-containing complex	1	1
GO:0036038	MKS complex	2	1

Expansion

Sequence features

A0A3Q8IKL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IKL7

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0030030	cell projection organization	4	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0006996	organelle organization	4	1
GO:0022607	cellular component assembly	4	1
GO:0030031	cell projection assembly	5	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	164	166	PF00675	0.187
CLV_PCSK_SKI1_1	189	193	PF00082	0.242
DEG_Nend_UBRbox_3	1	3	PF02207	0.585
DEG_SPOP_SBC_1	104	108	PF00917	0.453
DOC_MAPK_gen_1	13	22	PF00069	0.567
DOC_MAPK_gen_1	165	172	PF00069	0.418
DOC_PP1_RVXF_1	191	198	PF00149	0.549
DOC_PP1_RVXF_1	215	221	PF00149	0.453
DOC_PP4_FxxP_1	111	114	PF00568	0.511
DOC_PP4_FxxP_1	44	47	PF00568	0.511
DOC_PP4_FxxP_1	97	100	PF00568	0.511
DOC_USP7_MATH_1	104	108	PF00917	0.452
DOC_USP7_MATH_1	126	130	PF00917	0.510
DOC_USP7_MATH_1	157	161	PF00917	0.456
LIG_BRCT_BRCA1_1	228	232	PF00533	0.620
LIG_deltaCOP1_diTrp_1	48	51	PF00928	0.511
LIG_EH_1	108	112	PF12763	0.511
LIG_FHA_1	137	143	PF00498	0.483
LIG_FHA_1	162	168	PF00498	0.447
LIG_FHA_2	198	204	PF00498	0.477
LIG_LIR_Apic_2	108	114	PF02991	0.402
LIG_LIR_Apic_2	41	47	PF02991	0.511
LIG_LIR_Apic_2	96	100	PF02991	0.402
LIG_LIR_Gen_1	213	223	PF02991	0.475
LIG_LIR_Gen_1	48	53	PF02991	0.477
LIG_LIR_Nem_3	213	218	PF02991	0.475
LIG_LIR_Nem_3	48	52	PF02991	0.431
LIG_PCNA_yPIPBox_3	13	26	PF02747	0.639
LIG_PDZ_Class_2	229	234	PF00595	0.549
LIG_Pex14_2	45	49	PF04695	0.511
LIG_Pex14_2	97	101	PF04695	0.511
LIG_SH2_GRB2like	74	77	PF00017	0.453
LIG_SH2_PTP2	215	218	PF00017	0.477
LIG_SH2_STAP1	74	78	PF00017	0.511
LIG_SH2_STAT5	215	218	PF00017	0.475
LIG_SH2_STAT5	94	97	PF00017	0.511
LIG_SUMO_SIM_par_1	116	122	PF11976	0.436
LIG_UBA3_1	181	189	PF00899	0.511
LIG_WRC_WIRS_1	181	186	PF05994	0.453
LIG_WRC_WIRS_1	94	99	PF05994	0.511
MOD_CK1_1	144	150	PF00069	0.496
MOD_CK1_1	174	180	PF00069	0.476
MOD_CK1_1	183	189	PF00069	0.462
MOD_CK2_1	227	233	PF00069	0.555
MOD_GlcNHglycan	143	146	PF01048	0.235
MOD_GlcNHglycan	159	162	PF01048	0.206
MOD_GlcNHglycan	228	232	PF01048	0.608
MOD_GlcNHglycan	55	58	PF01048	0.227
MOD_GSK3_1	157	164	PF00069	0.494
MOD_GSK3_1	193	200	PF00069	0.496
MOD_N-GLC_1	136	141	PF02516	0.250
MOD_N-GLC_1	218	223	PF02516	0.322
MOD_NEK2_1	103	108	PF00069	0.393
MOD_NEK2_1	116	121	PF00069	0.391
MOD_NEK2_1	172	177	PF00069	0.510
MOD_NEK2_1	218	223	PF00069	0.440
MOD_NEK2_1	227	232	PF00069	0.555
MOD_NEK2_1	38	43	PF00069	0.422
MOD_NEK2_1	51	56	PF00069	0.420
MOD_NEK2_1	95	100	PF00069	0.429
MOD_PIKK_1	136	142	PF00454	0.513
MOD_PIKK_1	38	44	PF00454	0.511
MOD_PIKK_1	79	85	PF00454	0.404
MOD_Plk_1	136	142	PF00069	0.453
MOD_Plk_1	193	199	PF00069	0.443
MOD_Plk_1	218	224	PF00069	0.509
MOD_Plk_4	144	150	PF00069	0.511
MOD_Plk_4	193	199	PF00069	0.456
MOD_Plk_4	33	39	PF00069	0.436
TRG_ENDOCYTIC_2	215	218	PF00928	0.453
TRG_ENDOCYTIC_2	94	97	PF00928	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7N8	Leptomonas seymouri	77%	95%
A0A0S4JNR0	Bodo saltans	37%	100%
A0A0S4JU44	Bodo saltans	39%	100%
A0A1X0P6K0	Trypanosomatidae	41%	74%
A0A422P116	Trypanosoma rangeli	44%	84%
A4I7J2	Leishmania infantum	100%	100%
D0A095	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	82%
E9B2E9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
P0C5J2	Rattus norvegicus	25%	100%
Q4Q5Q7	Leishmania major	96%	100%
Q503B7	Danio rerio	27%	100%
Q5BJ61	Xenopus tropicalis	27%	100%
Q6DFD7	Xenopus laevis	26%	100%
Q9R1S0	Mus musculus	25%	100%
Q9UPM9	Homo sapiens	25%	100%
V5BWV4	Trypanosoma cruzi	42%	84%