RING-type E3 ubiquitin transferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IKK1_LEIDO

TriTrypDb:

LdBPK_362030.1 , LdCL_360025800 , LDHU3_36.2640

Length:

300

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	8
GO:0016020	membrane	2	7
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A0A3Q8IKK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IKK1

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	8
GO:0006511	ubiquitin-dependent protein catabolic process	7	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009056	catabolic process	2	8
GO:0009057	macromolecule catabolic process	4	8
GO:0009987	cellular process	1	8
GO:0019538	protein metabolic process	3	8
GO:0019941	modification-dependent protein catabolic process	6	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043632	modification-dependent macromolecule catabolic process	5	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044248	cellular catabolic process	3	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0044265	obsolete cellular macromolecule catabolic process	4	8
GO:0051603	proteolysis involved in protein catabolic process	5	8
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:1901575	organic substance catabolic process	3	8
GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	6	1
GO:0006950	response to stress	2	1
GO:0010033	response to organic substance	3	1
GO:0010243	response to organonitrogen compound	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0030163	protein catabolic process	4	1
GO:0033554	cellular response to stress	3	1
GO:0034976	response to endoplasmic reticulum stress	4	1
GO:0036503	ERAD pathway	5	1
GO:0042221	response to chemical	2	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071712	ER-associated misfolded protein catabolic process	6	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901698	response to nitrogen compound	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004842	ubiquitin-protein transferase activity	4	8
GO:0005488	binding	1	8
GO:0016740	transferase activity	2	8
GO:0019787	ubiquitin-like protein transferase activity	3	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0061630	ubiquitin protein ligase activity	5	8
GO:0061659	ubiquitin-like protein ligase activity	4	8
GO:0140096	catalytic activity, acting on a protein	2	8
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0044390	ubiquitin-like protein conjugating enzyme binding	4	1
GO:0016746	acyltransferase activity	3	1
GO:0061631	ubiquitin conjugating enzyme activity	5	1
GO:0061650	ubiquitin-like protein conjugating enzyme activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.564
CLV_PCSK_KEX2_1	130	132	PF00082	0.564
DEG_SPOP_SBC_1	89	93	PF00917	0.795
DOC_MAPK_MEF2A_6	175	182	PF00069	0.784
DOC_MAPK_MEF2A_6	281	289	PF00069	0.430
DOC_MAPK_NFAT4_5	175	183	PF00069	0.784
DOC_PP4_FxxP_1	115	118	PF00568	0.737
DOC_USP7_MATH_1	104	108	PF00917	0.814
DOC_USP7_MATH_1	129	133	PF00917	0.808
DOC_USP7_MATH_1	234	238	PF00917	0.584
DOC_USP7_MATH_1	263	267	PF00917	0.546
DOC_USP7_MATH_1	99	103	PF00917	0.811
DOC_WW_Pin1_4	2	7	PF00397	0.611
DOC_WW_Pin1_4	250	255	PF00397	0.565
DOC_WW_Pin1_4	272	277	PF00397	0.510
LIG_BRCT_BRCA1_1	183	187	PF00533	0.520
LIG_CORNRBOX	196	204	PF00104	0.287
LIG_deltaCOP1_diTrp_1	215	223	PF00928	0.452
LIG_FHA_1	19	25	PF00498	0.556
LIG_FHA_1	191	197	PF00498	0.447
LIG_FHA_1	269	275	PF00498	0.429
LIG_FHA_2	103	109	PF00498	0.708
LIG_FHA_2	17	23	PF00498	0.542
LIG_GBD_Chelix_1	279	287	PF00786	0.501
LIG_GBD_Chelix_1	289	297	PF00786	0.320
LIG_IRF3_LxIS_1	279	286	PF10401	0.462
LIG_LIR_Apic_2	112	118	PF02991	0.723
LIG_LIR_Gen_1	286	296	PF02991	0.436
LIG_LIR_Nem_3	286	291	PF02991	0.436
LIG_NRBOX	292	298	PF00104	0.410
LIG_Rb_LxCxE_1	26	49	PF01857	0.566
LIG_REV1ctd_RIR_1	112	117	PF16727	0.736
LIG_SH2_CRK	224	228	PF00017	0.459
LIG_SH3_3	103	109	PF00018	0.795
LIG_SH3_3	154	160	PF00018	0.746
LIG_SH3_3	271	277	PF00018	0.475
LIG_SH3_3	45	51	PF00018	0.556
LIG_SH3_3	83	89	PF00018	0.748
LIG_SUMO_SIM_anti_2	198	203	PF11976	0.380
LIG_SUMO_SIM_par_1	200	206	PF11976	0.501
LIG_TRAF2_1	109	112	PF00917	0.725
LIG_UBA3_1	65	71	PF00899	0.646
LIG_WW_3	156	160	PF00397	0.757
MOD_CK1_1	102	108	PF00069	0.796
MOD_CK1_1	116	122	PF00069	0.654
MOD_CK1_1	262	268	PF00069	0.558
MOD_CK1_1	275	281	PF00069	0.351
MOD_CK2_1	16	22	PF00069	0.542
MOD_CK2_1	234	240	PF00069	0.582
MOD_CK2_1	262	268	PF00069	0.581
MOD_CMANNOS	213	216	PF00535	0.663
MOD_GlcNHglycan	101	104	PF01048	0.591
MOD_GlcNHglycan	118	121	PF01048	0.396
MOD_GlcNHglycan	131	134	PF01048	0.531
MOD_GlcNHglycan	183	186	PF01048	0.568
MOD_GlcNHglycan	219	222	PF01048	0.673
MOD_GlcNHglycan	261	264	PF01048	0.762
MOD_GlcNHglycan	42	45	PF01048	0.324
MOD_GlcNHglycan	80	83	PF01048	0.631
MOD_GlcNHglycan	86	89	PF01048	0.571
MOD_GSK3_1	129	136	PF00069	0.745
MOD_GSK3_1	242	249	PF00069	0.569
MOD_GSK3_1	255	262	PF00069	0.551
MOD_GSK3_1	268	275	PF00069	0.519
MOD_GSK3_1	78	85	PF00069	0.744
MOD_GSK3_1	90	97	PF00069	0.695
MOD_N-GLC_1	234	239	PF02516	0.778
MOD_NEK2_1	1	6	PF00069	0.688
MOD_NEK2_1	283	288	PF00069	0.430
MOD_NEK2_2	203	208	PF00069	0.601
MOD_PIKK_1	134	140	PF00454	0.825
MOD_PIKK_1	234	240	PF00454	0.579
MOD_PIKK_1	246	252	PF00454	0.474
MOD_PKA_2	116	122	PF00069	0.736
MOD_PKA_2	129	135	PF00069	0.780
MOD_PKA_2	246	252	PF00069	0.599
MOD_Plk_2-3	268	274	PF00069	0.430
MOD_Plk_4	275	281	PF00069	0.342
MOD_ProDKin_1	2	8	PF00069	0.606
MOD_ProDKin_1	250	256	PF00069	0.566
MOD_ProDKin_1	272	278	PF00069	0.502
TRG_ENDOCYTIC_2	224	227	PF00928	0.418
TRG_ER_diArg_1	158	161	PF00400	0.737

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6L3	Leptomonas seymouri	56%	99%
A0A3R7KB29	Trypanosoma rangeli	42%	100%
A4HP59	Leishmania braziliensis	82%	100%
A4IDG5	Leishmania infantum	98%	100%
E9ASW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q1N0	Leishmania major	93%	100%