Zinc knuckle family protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleic acid binding protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IKH2_LEIDO

TriTrypDb:

LdBPK_363340.1 , LdCL_360040200 , LDHU3_36.4600

Length:

566

Annotations

Annotations by Jardim et al.

Nucleic acid binding, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IKH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IKH2

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0034250	positive regulation of amide metabolic process	6	1
GO:0045727	positive regulation of translation	7	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051247	positive regulation of protein metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1
GO:2000765	regulation of cytoplasmic translation	7	1
GO:2000767	positive regulation of cytoplasmic translation	8	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0005488	binding	1	11
GO:0008270	zinc ion binding	6	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003723	RNA binding	4	1
GO:0003727	single-stranded RNA binding	5	1
GO:0003729	mRNA binding	5	1
GO:0045182	translation regulator activity	1	1
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004540	RNA nuclease activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	350	352	PF00675	0.573
CLV_NRD_NRD_1	415	417	PF00675	0.448
CLV_NRD_NRD_1	502	504	PF00675	0.474
CLV_NRD_NRD_1	55	57	PF00675	0.355
CLV_NRD_NRD_1	73	75	PF00675	0.269
CLV_PCSK_KEX2_1	329	331	PF00082	0.517
CLV_PCSK_KEX2_1	350	352	PF00082	0.556
CLV_PCSK_KEX2_1	417	419	PF00082	0.472
CLV_PCSK_KEX2_1	442	444	PF00082	0.532
CLV_PCSK_KEX2_1	502	504	PF00082	0.474
CLV_PCSK_KEX2_1	55	57	PF00082	0.355
CLV_PCSK_KEX2_1	67	69	PF00082	0.340
CLV_PCSK_KEX2_1	73	75	PF00082	0.276
CLV_PCSK_KEX2_1	82	84	PF00082	0.501
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.517
CLV_PCSK_PC1ET2_1	417	419	PF00082	0.474
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.548
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.422
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.502
CLV_PCSK_PC7_1	51	57	PF00082	0.493
CLV_PCSK_SKI1_1	360	364	PF00082	0.473
CLV_PCSK_SKI1_1	418	422	PF00082	0.435
CLV_PCSK_SKI1_1	445	449	PF00082	0.670
CLV_PCSK_SKI1_1	539	543	PF00082	0.559
DOC_CYCLIN_RxL_1	536	546	PF00134	0.547
DOC_CYCLIN_yClb5_NLxxxL_5	62	69	PF00134	0.480
DOC_MAPK_gen_1	329	338	PF00069	0.435
DOC_MAPK_MEF2A_6	329	338	PF00069	0.454
DOC_PP1_RVXF_1	550	557	PF00149	0.539
DOC_USP7_MATH_1	179	183	PF00917	0.643
DOC_USP7_MATH_1	284	288	PF00917	0.754
DOC_USP7_MATH_1	293	297	PF00917	0.714
DOC_USP7_MATH_1	311	315	PF00917	0.685
DOC_USP7_MATH_2	276	282	PF00917	0.671
DOC_WW_Pin1_4	289	294	PF00397	0.757
LIG_14-3-3_CanoR_1	102	106	PF00244	0.405
LIG_14-3-3_CanoR_1	174	180	PF00244	0.460
LIG_14-3-3_CanoR_1	271	276	PF00244	0.773
LIG_14-3-3_CanoR_1	310	320	PF00244	0.624
LIG_14-3-3_CanoR_1	350	356	PF00244	0.569
LIG_14-3-3_CanoR_1	360	368	PF00244	0.405
LIG_14-3-3_CanoR_1	445	452	PF00244	0.657
LIG_14-3-3_CanoR_1	544	554	PF00244	0.574
LIG_14-3-3_CanoR_1	83	88	PF00244	0.783
LIG_APCC_ABBA_1	470	475	PF00400	0.516
LIG_BRCT_BRCA1_1	558	562	PF00533	0.587
LIG_Clathr_ClatBox_1	9	13	PF01394	0.807
LIG_FHA_1	231	237	PF00498	0.543
LIG_FHA_1	361	367	PF00498	0.435
LIG_FHA_1	392	398	PF00498	0.413
LIG_FHA_1	465	471	PF00498	0.393
LIG_FHA_1	532	538	PF00498	0.576
LIG_FHA_1	556	562	PF00498	0.532
LIG_FHA_2	290	296	PF00498	0.762
LIG_FHA_2	457	463	PF00498	0.444
LIG_GBD_Chelix_1	433	441	PF00786	0.446
LIG_LIR_Gen_1	390	401	PF02991	0.533
LIG_LIR_Nem_3	390	396	PF02991	0.503
LIG_LIR_Nem_3	490	495	PF02991	0.402
LIG_LIR_Nem_3	559	565	PF02991	0.629
LIG_LYPXL_S_1	491	495	PF13949	0.390
LIG_LYPXL_yS_3	492	495	PF13949	0.394
LIG_MYND_1	7	11	PF01753	0.803
LIG_PCNA_PIPBox_1	530	539	PF02747	0.589
LIG_PCNA_yPIPBox_3	525	537	PF02747	0.615
LIG_Pex14_2	382	386	PF04695	0.471
LIG_SH2_CRK	258	262	PF00017	0.732
LIG_SH2_PTP2	322	325	PF00017	0.613
LIG_SH2_STAP1	368	372	PF00017	0.475
LIG_SH2_STAT3	527	530	PF00017	0.661
LIG_SH2_STAT5	322	325	PF00017	0.619
LIG_SH2_STAT5	342	345	PF00017	0.236
LIG_SH2_STAT5	368	371	PF00017	0.444
LIG_SH2_STAT5	372	375	PF00017	0.496
LIG_SH2_STAT5	419	422	PF00017	0.535
LIG_SH2_STAT5	497	500	PF00017	0.441
LIG_SH3_3	314	320	PF00018	0.637
LIG_TRAF2_1	11	14	PF00917	0.806
LIG_TRAF2_1	91	94	PF00917	0.659
LIG_TYR_ITIM	121	126	PF00017	0.621
MOD_CDK_SPK_2	289	294	PF00069	0.634
MOD_CK1_1	27	33	PF00069	0.821
MOD_CK1_1	274	280	PF00069	0.755
MOD_CK1_1	287	293	PF00069	0.592
MOD_CK1_1	36	42	PF00069	0.676
MOD_CK1_1	426	432	PF00069	0.541
MOD_CK2_1	338	344	PF00069	0.510
MOD_CK2_1	543	549	PF00069	0.528
MOD_GlcNHglycan	170	173	PF01048	0.571
MOD_GlcNHglycan	26	29	PF01048	0.771
MOD_GlcNHglycan	269	274	PF01048	0.709
MOD_GlcNHglycan	280	283	PF01048	0.614
MOD_GlcNHglycan	289	292	PF01048	0.672
MOD_GlcNHglycan	425	428	PF01048	0.534
MOD_GSK3_1	137	144	PF00069	0.436
MOD_GSK3_1	148	155	PF00069	0.418
MOD_GSK3_1	168	175	PF00069	0.266
MOD_GSK3_1	24	31	PF00069	0.791
MOD_GSK3_1	265	272	PF00069	0.753
MOD_GSK3_1	274	281	PF00069	0.638
MOD_GSK3_1	289	296	PF00069	0.603
MOD_GSK3_1	32	39	PF00069	0.673
MOD_GSK3_1	387	394	PF00069	0.482
MOD_GSK3_1	497	504	PF00069	0.529
MOD_GSK3_1	517	524	PF00069	0.342
MOD_LATS_1	228	234	PF00433	0.579
MOD_N-GLC_1	287	292	PF02516	0.727
MOD_N-GLC_1	32	37	PF02516	0.730
MOD_N-GLC_1	351	356	PF02516	0.638
MOD_N-GLC_2	225	227	PF02516	0.494
MOD_N-GLC_2	64	66	PF02516	0.442
MOD_NEK2_1	137	142	PF00069	0.529
MOD_NEK2_1	152	157	PF00069	0.381
MOD_NEK2_1	166	171	PF00069	0.395
MOD_NEK2_1	501	506	PF00069	0.533
MOD_NEK2_2	497	502	PF00069	0.572
MOD_PIKK_1	153	159	PF00454	0.424
MOD_PIKK_1	16	22	PF00454	0.793
MOD_PIKK_1	28	34	PF00454	0.606
MOD_PK_1	83	89	PF00069	0.688
MOD_PKA_1	502	508	PF00069	0.589
MOD_PKA_2	101	107	PF00069	0.634
MOD_PKA_2	173	179	PF00069	0.454
MOD_PKA_2	265	271	PF00069	0.787
MOD_PKA_2	293	299	PF00069	0.788
MOD_PKA_2	501	507	PF00069	0.476
MOD_PKA_2	543	549	PF00069	0.572
MOD_PKB_1	416	424	PF00069	0.557
MOD_PKB_1	443	451	PF00069	0.647
MOD_Plk_1	397	403	PF00069	0.456
MOD_Plk_1	411	417	PF00069	0.520
MOD_Plk_2-3	265	271	PF00069	0.720
MOD_Plk_4	338	344	PF00069	0.472
MOD_Plk_4	39	45	PF00069	0.575
MOD_ProDKin_1	289	295	PF00069	0.758
TRG_DiLeu_BaLyEn_6	536	541	PF01217	0.621
TRG_ENDOCYTIC_2	123	126	PF00928	0.619
TRG_ENDOCYTIC_2	322	325	PF00928	0.613
TRG_ENDOCYTIC_2	359	362	PF00928	0.525
TRG_ENDOCYTIC_2	492	495	PF00928	0.394
TRG_ER_diArg_1	307	310	PF00400	0.746
TRG_ER_diArg_1	349	351	PF00400	0.687
TRG_ER_diArg_1	415	418	PF00400	0.459
TRG_ER_diArg_1	501	503	PF00400	0.564
TRG_ER_diArg_1	54	56	PF00400	0.355
TRG_ER_diArg_1	72	74	PF00400	0.276
TRG_NLS_Bipartite_1	67	86	PF00514	0.443
TRG_Pf-PMV_PEXEL_1	360	364	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	418	422	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	539	543	PF00026	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIN4	Leptomonas seymouri	75%	100%
A0A1X0P496	Trypanosomatidae	54%	100%
A0A3R7MHM2	Trypanosoma rangeli	53%	100%
A4HPI5	Leishmania braziliensis	86%	100%
A4IDA7	Leishmania infantum	100%	100%
D0A8E8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AT97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q1A0	Leishmania major	96%	100%
V5DA56	Trypanosoma cruzi	54%	100%